Detalles de la búsqueda
1.
Identification of novel GPR81 agonist lead series for target biology evaluation.
Bioorg Med Chem Lett;
30(4): 126953, 2020 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31932225
2.
Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction.
J Med Chem;
65(17): 11485-11496, 2022 09 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-36005476
3.
Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.
Bioorg Med Chem;
19(10): 3039-53, 2011 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21515056
4.
Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma.
J Med Chem;
62(17): 7769-7787, 2019 09 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31415176
5.
Involvement of the metabolic sensor GPR81 in cardiovascular control.
JCI Insight;
2(19)2017 10 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28978803
6.
Correction to "Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction".
J Med Chem;
65(19): 13482, 2022 Oct 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36190771
7.
Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986).
J Med Chem;
59(20): 9457-9472, 2016 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-27690432
8.
AT2-selective angiotensin II analogues containing tyrosine-functionalized 5,5-bicyclic thiazabicycloalkane dipeptide mimetics.
J Med Chem;
47(24): 6009-19, 2004 Nov 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-15537355
9.
Vinyl sulfide cyclized analogues of angiotensin II with high affinity and full agonist activity at the AT(1) receptor.
J Med Chem;
45(9): 1767-77, 2002 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-11960488
10.
Synthesis and functionalization of cyclic sulfonimidamides: a novel chiral heterocyclic carboxylic Acid bioisostere.
ACS Med Chem Lett;
3(7): 574-8, 2012 Jul 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900513
11.
Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).
J Med Chem;
55(23): 10610-29, 2012 Dec 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-23116186
12.
Making medicinal chemistry more effective--application of Lean Sigma to improve processes, speed and quality.
Drug Discov Today;
14(11-12): 598-604, 2009 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-19508922
Resultados
1 -
12
de 12
1
Próxima >
>>