Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients: The CONDI-2 echocardiographic sub-study.

Background: Remote ischaemic conditioning (RIC) applied to the arm by inflation and deflation of a pneumatic cuff has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention (PPCI). However, the effect of RIC on left ventricular ejection fraction (LVEF) following infarct healing remains unknown. Objective: To investigate whether RIC applied in the ambulance before PPCI can improve left ventricular (LV) function in STEMI patients 3 months following infarction. Methods: Echocardiography was performed in a total of 694 patients from the CONDI-2 study a median of 112 days (IQR 63) after the initial admission. LVEF and LV end-diastolic and end-systolic volumes were calculated using the modified Simpsons biplane method of disks. LV global longitudinal strain (GLS) was estimated using 2-dimensional cine-loops with a frame rate > 55 frames/second, measured in the three standard apical views. Results: There was no difference in the measured echocardiographic parameters in the RIC group as compared to the control group, including LV EF, LV GLS, tricuspid annular plane systolic excursion or left ventricular volumes. In the control group, 32% had an ejection fraction < 50% compared to 37% in the RIC group (p = 0.129). Conclusion: In this largest to date randomized imaging study of RIC, RIC as an adjunct to PPCI was not associated with a change in echocardiographic measures of cardiac function compared to standard PPCI alone.

Long-term outcome after normal myocardial perfusion imaging in suspected ischaemic heart disease
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INTRODUCTION: Ischaemic heart disease (IHD) is the leading cause of mortality in the Western world. Therefore, to focus on those at risk of having IHD while at the same time avoiding unnecessary patient concern, it is important to have diagnostic tools capable of refuting an IHD diagnosis. Within the past 30 years, myocardial perfusion imaging (MPI) has been used increasingly to detect myocardial perfusion defects. MPI is a safe and non-invasive method with a sensitivity and specificity of > 90%. The aim of this study was to evaluate the long-term prognostic outcome after a normal MPI. 
Methods: The study population comprised patients referred for MPI from one single department of cardiology with invasive facilities, from 2008 to 2009. The patients' demographics and the results of the MPIs were collected from their medical records. Only patients without known IHD and with a normal MPI were included. After a follow-up period of 7.8 years (range: 6.8-8.8 years), a retrospective database search was performed. The major outcomes were all-cause mortality, cardiac events defined as nonfatal myocardial infarct or coronary revascularisation by percutaneous coron-ary intervention or coronary artery bypass grafting. 
Results: The risk of a cardiac event or death following a normal MPI was 9.6% during long-term follow-up, with an estimated annual death rate of 1.4% per year (95% confidence interval: 0.8-2.5%). This was not different from the background population. 
Conclusion: A normal MPI predicts a favourable long-term prognostic outcome. 
Funding: none.
 Trial registration: FSEID-00002257.

[Congenital trans-mesenteric hernia with incarceration in a five-year-old boy].

This is a case report of a five-year-old boy, presenting with abdominal pain and signs of gastrointestinal emergency imitating appendicitis. Diagnostic laparoscopy revealed an incarcerated internal hernia involving 50 cm of ischaemic small bowel. Bowel resection and primary anastomosis was performed. The post-operative outcome was uneventful. We wish to shed light on a seldom but important differential diagnosis to appendicitis in children, and raise attention to internal hernias in patients presenting with acute abdomen, whether it is due to congenital defects or a post-operative complication.

[Cardiac arrest after sudden cessation of alcohol consumption].

Chronic alcohol abuse can cause both acute and chronic health problems. Unfortunately, sudden cessation is problematic, with risk of complications ranging from mild to lethal. We report a case of a 60-year-old man with substantial alcohol abuse, who suffered cardiac arrest after sudden withdrawal of alcohol. No other cause of death was found despite thorough examination. Alcohol withdrawal syndrome is a potentially fatal condition and the risks of sudden withdrawal should be recognized and treated.