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INTRODUCTION: Suturing is an essential skill for dental surgeons, yet there is limited evidence for objective measures of competence in this field, which can be applied to licensing or certification processes for dental surgeons to ensure patient safety. METHODS: In an objective structured clinical examination (OSCE), participants placed two simple interrupted sutures across a lower molar socket in different suturing environments: [A] commercial simulator, [B] suturing sponge mounted in a 3D printed model, [C] suturing sponge and [D] pig's jaw. Simulators [A] and [B] were mounted into phantom heads in dental chairs, and [C] and [D] were placed on bench tops. Performance indicators, overall task success, quality of sutures placed, length of suture remaining and time taken, were analysed against participants' characteristics such as previous suturing experience. RESULTS: Participants (n = 38) took significantly longer to successfully complete the sutures on models mounted in a phantom head. Time points at which each model differentiated between competent (n = 11) and novice (n = 27) participants were as follows: model A (3:26 min), B (2:41), C (2:05) and D (2:06). Model A showed a significant association between task completion and previous suturing experience (p = .006). CONCLUSION: Suturing simulators can be used to objectively differentiate between novice and competent dental surgeons. Model A demonstrated construct validity, as it reliably identified competence using time and task completion as objectively measurable parameters. Utilising model A, the candidate of unknown ability could be identified as appropriately skilled at intra-oral suturing. To ensure patient safety, further research is needed to identify other objective measures of competence in simulation environments.
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Competencia Clínica , Técnicas de Sutura , Certificación , Educación en Odontología , Humanos , Técnicas de Sutura/educación , SuturasRESUMEN
PURPOSE: To compare risks of interstitial lung disease (ILD) between patients treated with dronedarone versus other antiarrhythmics. METHODS: Parallel retrospective cohort studies were conducted in the United States Department of Defense Military Health System database (DoD) and the HealthCore Integrated Research Database (HIRD). Study patients were treated for atrial fibrillation (AF) with dronedarone, amiodarone, sotalol, or flecainide. Propensity score matching was employed to create analysis cohorts balanced on baseline variables considered potential confounders of treatment decisions. The study period of July 20, 2008 through September 30, 2014 included a 1-year baseline and minimum 6 months of follow-up, for patients with drugs dispensed between July 20, 2009 and March 31, 2014. Suspect ILD outcomes were reviewed by independent adjudicators. Cox proportional hazards regression compared risk of confirmed ILD between dronedarone and each comparator cohort. A sensitivity analysis examined the effect of broadening the outcome definition. RESULTS: A total 72 ILD cases (52 DoD; 20 HIRD) were confirmed among 27 892 patients. ILD risk was significantly higher among amiodarone than dronedarone initiators in DoD (HR = 2.5; 95% CI = 1.1-5.3, p = 0.02). No difference was detected in HIRD (HR = 1.0; 95% CI = 0.4-2.4). Corresponding risks in sotalol and flecainide exposure groups did not differ significantly from dronedarone in either database. CONCLUSIONS: ILD risk among AF patients initiated on dronedarone therapy was comparable to or lower than that of amiodarone initiators, and similar to that of new sotalol or flecainide users. This finding suggests that elevated ILD risk associated with amiodarone does not necessarily extend to dronedarone or other antiarrhythmic drugs.
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Fibrilación Atrial , Enfermedades Pulmonares Intersticiales , Antiarrítmicos/efectos adversos , Fibrilación Atrial/tratamiento farmacológico , Fibrilación Atrial/epidemiología , Dronedarona , Humanos , Enfermedades Pulmonares Intersticiales/inducido químicamente , Enfermedades Pulmonares Intersticiales/epidemiología , Estudios Retrospectivos , Estados Unidos/epidemiologíaRESUMEN
BACKGROUND: Outcome studies of nonsurgical root canal treatment (NSRCT) in permanent teeth of children are scarce. This study investigated survival and assessed the variables associated with failure of endodontically treated teeth (ETT) in 6- to 18-year-olds. METHODS: Records of subjects who received NSRCT at age 6-18 years at Boston University between 2007 and 2015 were assessed for the occurrence of untoward events. Kaplan-Meier survival curves were used to investigate the survival of ETT in the total sample. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) were estimated. RESULTS: The analysis included 341 patients (424 ETT). Kaplan-Meier survival curves differed according to age at treatment (log-rank P = 0.026), with survival being the lowest among the youngest age group. The estimated 5-year survival probability was 80% for 15- to 18-year-olds, 64.8% for 12- to 14-year-olds and 46.4% for 6- to 11-year-olds. Compared to age at treatment of 15-18 years, age at treatment of 6-11 years (aHR: 2.19, 95% CI 1.02-4.67) and 12-14 years (aHR: 2.02, 95% CI 1.15-3.55) was associated with an increased risk of ETT failure. In the total study sample, the estimated cumulative survival probability was 93.3% at 12 months, 88.0% at 24 months, 76.2% at 36 months, 71.0% at 48 months, and 69.1% at 60 months. CONCLUSIONS: In children, ETT are more likely to survive when NSRCTs are performed at an older age.
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Diente no Vital , Adolescente , Anciano , Niño , Fracaso de la Restauración Dental , Humanos , Modelos de Riesgos Proporcionales , Estudios Retrospectivos , Tratamiento del Conducto RadicularRESUMEN
BACKGROUND: Antiretroviral medications that are used as prophylaxis can prevent acquisition of human immunodeficiency virus type 1 (HIV-1) infection. However, in clinical trials among African women, the incidence of HIV-1 infection was not reduced, probably because of low adherence. Longer-acting methods of drug delivery, such as vaginal rings, may simplify use of antiretroviral medications and provide HIV-1 protection. METHODS: We conducted a phase 3, randomized, double-blind, placebo-controlled trial of a monthly vaginal ring containing dapivirine, a non-nucleoside HIV-1 reverse-transcriptase inhibitor, involving women between the ages of 18 and 45 years in Malawi, South Africa, Uganda, and Zimbabwe. RESULTS: Among the 2629 women who were enrolled, 168 HIV-1 infections occurred: 71 in the dapivirine group and 97 in the placebo group (incidence, 3.3 and 4.5 per 100 person-years, respectively). The incidence of HIV-1 infection in the dapivirine group was lower by 27% (95% confidence interval [CI], 1 to 46; P=0.046) than that in the placebo group. In an analysis that excluded data from two sites that had reduced rates of retention and adherence, the incidence of HIV-1 infection in the dapivirine group was lower by 37% (95% CI, 12 to 56; P=0.007) than that in the placebo group. In a post hoc analysis, higher rates of HIV-1 protection were observed among women over the age of 21 years (56%; 95% CI, 31 to 71; P<0.001) but not among those 21 years of age or younger (-27%; 95% CI, -133 to 31; P=0.45), a difference that was correlated with reduced adherence. The rates of adverse medical events and antiretroviral resistance among women who acquired HIV-1 infection were similar in the two groups. CONCLUSIONS: A monthly vaginal ring containing dapivirine reduced the risk of HIV-1 infection among African women, with increased efficacy in subgroups with evidence of increased adherence. (Funded by the National Institutes of Health; ClinicalTrials.gov number, NCT01617096 .).
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Infecciones por VIH/prevención & control , VIH-1 , Pirimidinas/administración & dosificación , Inhibidores de la Transcriptasa Inversa/administración & dosificación , Adolescente , Adulto , África Austral/epidemiología , Factores de Edad , Método Doble Ciego , Farmacorresistencia Viral , Femenino , Infecciones por VIH/epidemiología , Humanos , Incidencia , Persona de Mediana Edad , Cooperación del Paciente , Pirimidinas/efectos adversos , Inhibidores de la Transcriptasa Inversa/efectos adversos , Vagina , Adulto JovenRESUMEN
OBJECTIVES: Patient safety is an important issue in health care. In the United Kingdom, wrong site tooth extraction contributes to a significant proportion of adverse or harmful events, coined "never events." Therefore, patient safety within the field of dentistry is of paramount importance. This novel study aims to explore the teaching of patient safety to undergraduate dental students and their current attitudes to the subject. METHODS: Focus groups were held at Barts' and The London School of Medicine and Dentistry, QMUL in 2018 to ascertain the views and opinions of thirteen third-year dental undergraduate students. RESULTS: Thematic analysis was performed on verbatim transcripts. Key themes were highlighted. All students could provide a complete definition of patient safety and of "never events," with examples. There was a strong emphasis upon awareness of one's own competence and the need for effective communication to maintain patient safety. Small group teaching and the requirement for standardization of teaching were encouraged. The challenge of incorporation of the patient safety concept into the clinical routine without causing repetition during teaching was highlighted. CONCLUSION: The results show a positive attitude towards the concept and the teaching of patient safety. All students understood patient safety concepts and techniques used to prevent adverse or harmful events. This study proves that teaching on the subject was thought to be of value. It is crucial that the teaching of patient safety is introduced and built upon within the early years of dental undergraduate training so that its practice becomes second nature.
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Actitud del Personal de Salud , Odontología , Educación en Odontología , Seguridad del Paciente , Estudiantes de Odontología/psicología , Educación en Odontología/métodos , Educación en Odontología/normas , Femenino , Humanos , Masculino , Facultades de Odontología , Reino UnidoRESUMEN
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Informed consent in dental care and research for the older adult population: A systematic review. Mukherjee A, Livinski AA, Millum J, Chamut S, Boroumand SB, Iafolla TJ, Adesanya, MR, Dye BA. J Am Dent Assoc 2017; 148(4):211-20. SOURCE OF FUNDING: Mukherjee: NIDCR; Livinski: NIH Library; Millum: Fogarty International Center and NIH; Chamut: NIDCR; Boroumand: NIDCR consultant on Science and Policy; Iafolla: NIDCR; Adesanya: NIDCR; and Dye: NIDCR. TYPE OF STUDY/DESIGN: Systematic review.
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Atención Odontológica , Consentimiento Informado , Anciano , Humanos , PolíticasRESUMEN
BACKGROUND: The purpose of this systematic review is to summarize the literature examining associations between salivary biomarkers and cardiovascular disease (CVD) status. CONTENTS: An advanced search was conducted using MeSH terms related to salivary biomarkers and CVD, and entered into the PubMed, Web of Science, and Google Scholar search databases. Four hundred and thirty-three records were narrowed to 22 accepted articles. Included titles were assessed for quality using the Newcastle-Ottawa scale, and ranked into categories of low, moderate, or high. SUMMARY: A total of 40 salivary biomarkers were analyzed among accepted articles. The most studied markers were salivary creatine kinase isoform MB, C-reactive protein (CRP), matrix metalloproteinase-9, troponin I, myeloperoxidase, myoglobin, and brain natriuretic peptide. Salivary CRP provided the most consistent trends. Statistically significant increases of salivary CRP were present with CVD in every study that analyzed it. The remaining six markers demonstrated varying patterns. OUTLOOK: Existing studies provide insufficient data to draw definitive conclusions. Current research shows that there is an association between some salivary biomarkers and CVD, but the details of existing studies are conflicting. Despite inconclusive results, the diagnostic potential of saliva shows promise as a non-invasive means of cardiovascular risk assessment.
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Biomarcadores/análisis , Enfermedades Cardiovasculares/diagnóstico , Saliva/metabolismo , Proteína C-Reactiva/análisis , Enfermedades Cardiovasculares/metabolismo , Enfermedades Cardiovasculares/patología , Humanos , Metaloproteinasa 9 de la Matriz/análisisRESUMEN
PURPOSE: This study examined the potential risk of cardiovascular (CV) events associated with modafinil and the consistency of the risk estimates across databases. METHODS: A retrospective, inception cohort design of patients who initiated treatment with modafinil between 2006 and 2008 was used in three US health care claims databases. Modafinil users were matched with nonusers. Patients were further divided into two cohorts of obstructive sleep apnea (OSA) and non-OSA (NOSA) cohorts. Endpoints of interest, including myocardial infarction (MI), stroke, CV hospitalizations, and all-cause death, were assessed using incidence rates and Cox proportional hazard ratios (HRs), adjusted for potential confounding factors. RESULTS: The cohorts included a total of 175 524 patients in MarketScan CM; 77 266-in IMS LifeLink; and 8174-in MarketScan Medicaid. No increased risk for MI in the OSA and NOSA cohorts was observed across all three databases. The risks of CV hospitalization in the OSA and NOSA cohorts were not different between the modafinil users and nonusers, except for IMS LifeLink database where the HR was lower than one in the modafinil users compared with the nonusers (HR, 0.69; 95% confidence interval [CI], 0.54 to 0.87). For OSA patients with prior stroke, an adjusted HR of 1.96 (95% CI, 1.02 to 3.76) was observed for stroke among modafinil users compared with nonusers. Among the NOSA, the HRs for all-cause death in the OSA were inconsistent across databases. CONCLUSIONS: Except for few CV outcomes, applying one common protocol generated consistent risk estimates of CV events following modafinil use across cohorts and databases.
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Modafinilo/efectos adversos , Infarto del Miocardio/epidemiología , Síndromes de la Apnea del Sueño/tratamiento farmacológico , Accidente Cerebrovascular/epidemiología , Promotores de la Vigilia/efectos adversos , Reclamos Administrativos en el Cuidado de la Salud/estadística & datos numéricos , Adolescente , Adulto , Anciano , Causas de Muerte , Factores de Confusión Epidemiológicos , Bases de Datos Factuales/estadística & datos numéricos , Femenino , Estudios de Seguimiento , Hospitalización/estadística & datos numéricos , Humanos , Masculino , Persona de Mediana Edad , Modafinilo/administración & dosificación , Infarto del Miocardio/inducido químicamente , Infarto del Miocardio/terapia , Farmacoepidemiología/métodos , Modelos de Riesgos Proporcionales , Estudios Retrospectivos , Medición de Riesgo/métodos , Factores de Riesgo , Accidente Cerebrovascular/inducido químicamente , Accidente Cerebrovascular/terapia , Estados Unidos/epidemiología , Promotores de la Vigilia/administración & dosificación , Adulto JovenRESUMEN
AIMS: Distal Cervical Caries (DCC) of the mandibular second molar (Md2M) is primarily related to retained mesially impacted third molars (Md3M). Treatment of this condition indicates the removal of the Md3M and the restoration of the Md2M and, on occasions, the loss of the Md2M. The aim of this study was to determine the incidence, treatment outcomes for patients, and calculate costs related to Md2M DCC. METHODS: A review of 121 patients who had Md3M removed due to Md2M DCC was undertaken to determine the treatment outcomes for patients. The number of patients affected by DCC of Md2M was calculated from the incidence of DCC (15%) in a cohort of patients requiring Md3M removal (1100) and the annual number of patients undergoing third molar surgery in England. Direct costs were calculated using NHS and independent treatment tariffs and indirect costs from Office of National Statistics (ONS). RESULTS: It is estimated that 152,000 patients in England undergo third molar removal on an annual basis. Approximately 27,000 Md3M are removed annually due to DCC of the Md2M; costing £27 m to treat with additional costs of £28 m if dental implant replacement of the Md2M is included. Total cost for treating Md2M DCC: £55 m/annum. CONCLUSIONS: Treating Md2M DCC and its consequences is expensive for healthcare funders such as the NHS and for patients. Md2M DCC is avoidable if patients who are at risk have prophylactic Md3M removal. This would offer potential and substantial savings in the financial cost of treating an otherwise avoidable disease.
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Diente Molar/cirugía , Caries Radicular/epidemiología , Diente Impactado/cirugía , Inglaterra/epidemiología , Femenino , Humanos , Incidencia , Masculino , Mandíbula , Tercer Molar/cirugía , Caries Radicular/economía , Caries Radicular/etiología , Caries Radicular/cirugía , Diente Impactado/complicaciones , Diente Impactado/economíaRESUMEN
OBJECTIVES: Determine the long-term risk of hysterectomy and ectopic pregnancy in women using the quinacrine hydrochloride pellet system of permanent contraception (QS) relative to the comparable risk in women using Copper T intrauterine device (IUD) or tubal ligation surgery (TL) for long-term or permanent contraception. METHODS: This was a retrospective cohort study, conducted in the Northern Vietnamese provinces of Ha Nam, Nam Dinh, Ninh Binh and Thai Binh. Women who had their first QS procedure, last IUD insertion or TL between 1989 and 1996 were interviewed regarding post-procedure health outcomes approximately 16 years post exposure. RESULTS: A 95% response rate resulted in 21,040 completed interviews. Overall incidence rates were low for both outcomes (91/100,000 women years of follow-up and 22/100,000 women years of follow-up for hysterectomy and ectopic pregnancy, respectively). After accounting for variations in baseline characteristics between women choosing QS vs. the other two contraceptive methods, no significant excess hazard of either hysterectomy or ectopic pregnancy was associated with QS. CONCLUSIONS: No significant excess long-term risk of hysterectomy or ectopic pregnancy was found among a large group of women using QS vs. IUD or TL for contraception after an average 16 years of follow-up.
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Histerectomía/estadística & datos numéricos , Dispositivos Intrauterinos/efectos adversos , Embarazo Ectópico/etiología , Quinacrina/efectos adversos , Esterilización Tubaria/efectos adversos , Adolescente , Adulto , Femenino , Humanos , Incidencia , Modelos Logísticos , Persona de Mediana Edad , Embarazo , Embarazo Ectópico/epidemiología , Puntaje de Propensión , Estudios Retrospectivos , Factores de Riesgo , Vietnam/epidemiología , Adulto JovenRESUMEN
INTRODUCTION: The objective of this study was to investigate the association between incisor crowding, irregularity, and periodontal disease progression in the anterior teeth. METHODS: Data collected over 35 years from men enrolled in the Veterans Affairs Dental Longitudinal Study included information concerning pocket depth and alveolar bone loss. Plaster casts of the maxillary (n = 400) and mandibular (n = 408) arches were available for baseline measurements. Periodontal disease in the anterior teeth was defined as per arch sum of pathologic pocket depth and sum of teeth with any alveolar bone loss in the anterior sextants. Incisor malalignment status was defined by the anterior tooth size-arch length discrepancy index and Little's Irregularity Index. Adjusted mixed effects linear models computed the beta (ß) estimates and 95% confidence intervals (95% CI) of the amounts of change in periodontal disease outcomes by the level of malalignment. RESULTS: In the anterior maxillary arch, crowding and spacing were significantly associated with an increased per-arch sum of pathologic pocket depth (ß, 0.70 mm; 95% CI, 0.20-1.21, and ß, 0.49 mm; 95% CI, 0.06-0.91, respectively). In the anterior mandibular arch, incisor crowding and irregularity were significantly associated with an increased per-arch sum of pathologic pocket depth (mild crowding: ß, 0.47 mm; 95% CI, 0.01-0.93; severe irregularity: ß, 0.94 mm; 95% CI, 0.50-1.38), and the sum number of teeth with alveolar bone loss (mild and moderate-to-severe crowding: ß, 0.45 teeth; 95% CI, 0.08-0.82; and ß, 0.45 teeth; 95% CI, 0.13-0.83, respectively; moderate irregularity: ß, 0.34 teeth; 95% CI, 0.06-0.62). CONCLUSIONS: Certain incisor malalignment traits (ie, maxillary incisor crowding, maxillary incisor spacing, mandibular incisor mild crowding, mandibular incisor moderate-to-severe crowding, mandibular incisor moderate irregularity, and mandibular incisor severe irregularity) are associated with significant periodontal disease progression.
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Progresión de la Enfermedad , Incisivo/patología , Maloclusión/complicaciones , Enfermedades Periodontales/etiología , Adolescente , Adulto , Pérdida de Hueso Alveolar/etiología , Pérdida de Hueso Alveolar/patología , Boston , Niño , Arco Dental/patología , Índice de Placa Dental , Enfermedades de las Encías/patología , Humanos , Incisivo/anatomía & histología , Estudios Longitudinales , Masculino , Maloclusión/clasificación , Maloclusión/patología , Enfermedades Mandibulares/etiología , Enfermedades Mandibulares/patología , Enfermedades Maxilares/etiología , Enfermedades Maxilares/patología , Enfermedades Periodontales/patología , Índice Periodontal , Bolsa Periodontal/patología , Factores de Riesgo , Estadísticas no Paramétricas , Estados Unidos , Veteranos , Adulto JovenRESUMEN
OBJECTIVES: To determine the long-term risk of reproductive tract cancer in women using the quinacrine hydrochloride pellet system of permanent contraception (QS) relative to the comparable risk in women using Copper T intrauterine device (IUD) or tubal ligation surgery (TL) for long-term or permanent contraception. METHODS: This was a retrospective cohort study, conducted in the Northern Vietnamese provinces of Ha Nam, Nam Dinh, Ninh Binh and Thai Binh. Women who had their first QS procedure, last IUD insertion or TL between 1989 and 1996 were interviewed regarding post-procedure health outcomes, particularly reproductive tract cancers. RESULTS: A 95% response rate resulted in 21,040 completed interviews. Reproductive cancer incidence rates were very low (5.77/100,000 women years of follow-up time; 95%CI = 3.72-8.94). No significant excess hazard of reproductive tract cancer was associated with QS. CONCLUSIONS: No significant excess long-term risk of reproductive tract cancer was found after an average 16 years of follow-up among a large group of women using QS vs. IUD/TL for contraception.
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Anticonceptivos Femeninos/efectos adversos , Dispositivos Anticonceptivos/efectos adversos , Neoplasias de los Genitales Femeninos/epidemiología , Quinacrina/efectos adversos , Estudios de Cohortes , Femenino , Humanos , Estudios Retrospectivos , Factores de Riesgo , Vietnam/epidemiologíaRESUMEN
INTRODUCTION: Our objective was to examine the Teen Oral Health-related Quality of Life (TOQOL) questionnaire for use in adults receiving orthodontic treatment and assess validity and reliability by age group. METHODS: Teenagers from 10 to 18 years and adults 18 and over completed surveys at the orthodontic clinic at Boston University. The survey consisted of sociodemographic information, dental behavior questions, and the TOQOL instrument. Malocclusion severity was assessed using the Index of Orthodontic Treatment Need. RESULTS: Overall, 161 teens and 146 adults participated. The mean ages were 13 years for the teens and 32 years for the adults. Subjects were represented by both sexes and diverse racial and ethnic backgrounds. In general, scores overall and by domains were higher for adults than for teens, signifying a greater effect of the malocclusion on the quality of life. Mean TOQOL scores as well as emotional and social domain scores (P <0.001) were worse (17.6) in adults than in teens (11.9; P <0.01). Construct validity was supported by strong a association of TOQOL scores with self-reported oral health. The Cronbach alpha was higher in adults overall and for all domains (0.75 in adults compared with 0.68 in teens). CONCLUSIONS: Adults who come for orthodontic treatment appear to be more affected by their malocclusion than are teens. The total TOQOL score and the emotional and social domains were significantly higher for adults. The total TOQOL score and the emotional and social domains were significantly higher (worse) for adults than teens. This project suggested that TOQOL may be a useful way to measure the impact of malocclusion on the quality of life in both adults and teens.
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Maloclusión , Salud Bucal , Ortodoncia Correctiva , Calidad de Vida , Autoinforme , Adolescente , Adulto , Factores de Edad , Estudios Transversales , Femenino , Humanos , Masculino , Maloclusión/terapia , Aceptación de la Atención de SaludRESUMEN
BACKGROUND: Racial disparities in dental care have previously been shown in the Veterans Health Administration (VA)-a controlled access setting valuing equitable, high-quality care. OBJECTIVES: The aim of this study is to examine current disparities in dental care by focusing on the receipt of root canal therapy (RCT) versus tooth extraction. RESEARCH DESIGN: This is a retrospective analysis of data contained in the VA's electronic health records. We performed logistic regressions on the independent measures along with a facility-specific random effect, using dependent binary variables that distinguished RCT from tooth extraction procedures. SUBJECTS: VA outpatients who had at least 1 tooth extraction or RCT visit in the VA in fiscal year 2011. MEASURES: A dependent binary measure of tooth extraction or RCT. Other measures are medical record data on medical comorbidities, dental morbidity, prior dental utilization, and demographic characteristics. RESULTS: The overall rate of preferred tooth-preserving RCT was 18.1% during the study period. Black and Asian patients were most dissimilar with respect to dental morbidity, medical and psychological disorders, and black patients had the least amount of eligibility for comprehensive dental care. After adjustment for known confounding factors of RCT, black patients had the lowest RCT rates, whereas Asians had the highest. CONCLUSIONS: Current quality improvement efforts and a value to improve the equity of care are not sufficient to address racial/ethnic disparities in VA dental care; rather more targeted efforts will be needed to achieve equity for all.
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Atención Odontológica/organización & administración , Accesibilidad a los Servicios de Salud/organización & administración , Disparidades en Atención de Salud/organización & administración , Grupos Raciales/estadística & datos numéricos , Negro o Afroamericano/estadística & datos numéricos , Anciano , Anciano de 80 o más Años , Femenino , Disparidades en Atención de Salud/etnología , Hispánicos o Latinos/estadística & datos numéricos , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Tratamiento del Conducto Radicular/estadística & datos numéricos , Extracción Dental/estadística & datos numéricos , Estados Unidos , United States Department of Veterans Affairs/estadística & datos numéricos , Población Blanca/estadística & datos numéricosRESUMEN
Epidemiologic studies show that 11% of the world's population is over 60 years of age; this is projected to increase, by 2050, to 22% of the population. Oral aging is a current focus of several organizations including the Federation Dentaire Internationale, the World Health Organization and the American and Japanese Dental Associations. In their Tokyo Declaration, the Japanese Association identified the elderly population as one of its main target groups. One of the WHO goals is for each person to retain more than 20 teeth by age 80, despite the fact that the prevalence of periodontal disease is continuously rising as the population is aging. Every species has its own characteristic lifespan, which is determined by its evolutionary history and is modified by multiple diverse factors, including biological mechanisms. In humans, the gradual accumulation of products of cellular metabolism and extensive DNA damage contribute to the aging process. Aging is thought to be associated with a low-grade inflammatory phenotype in mammals, called 'inflammaging', and is the result of autophagic capacity impairing so-called 'housekeeping activities' in the cells, resulting in protein aggregation, mitochondrial dysfunction and oxidative stress. Delayed stem-cell proliferation, associated with aging, may impact the maintenance and survival of a living being, but excessive proliferation could also result in depleted reserves of stem cells. Studies are needed to address the association of delayed cell proliferation and wound healing with the onset of periodontal diseases and response to treatment. The effects of systemic diseases, medications, psychological effects and decreased interest or ability in performing oral-hygiene practices are thought to result in periodontal diseases, and ultimately in tooth loss, in aged individuals. Together with an aging population comes a responsibility for 'healthy' and 'successful' aging. This article describes the changing global demographic profile and the effects of an aging society on the prevalence and incidence of periodontal diseases. We review the definitions of normal and successful aging, the principles of geriatric medicine and the highlights of biological aging at cellular, tissue and systems levels.
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Envejecimiento/fisiología , Demografía , Enfermedades Periodontales/epidemiología , Anciano , Anciano de 80 o más Años , Proliferación Celular , Daño del ADN , Epigenómica , Humanos , Inflamación , Higiene Bucal , Enfermedades Periodontales/complicaciones , Enfermedades Periodontales/inmunología , Dinámica Poblacional/tendencias , Vigilancia de la Población , Prevalencia , Células Madre , Pérdida de Diente , Organización Mundial de la Salud , Cicatrización de HeridasRESUMEN
BACKGROUND AND OBJECTIVES: Inappropriate use of analgesic drugs has become increasingly pervasive over the past decade. Currently, drug abuse potential is primarily assessed post-marketing; no validated tools are available to assess this potential in phase II and III clinical trials. This paper describes the development and feasibility testing of a Misuse, Abuse, and Diversion Drug Event Reporting System (MADDERS), which aims to identify potentially abuse-related events and classify them according to a recently developed classification scheme, allowing the quantification of these events in clinical trials. METHODS: The system was initially conceived and designed with input from experts and patients, followed by field-testing to assess its feasibility and content validity in both completed and ongoing clinical trials. RESULTS: The results suggest that MADDERS is a feasible system with initial validity. It showed higher rates of the triggering events in subjects taking medications with known abuse potential than in patients taking medications without abuse potential. Additionally, experts agreed on the classification of most abuse-related events in MADDERS. DISCUSSION AND CONCLUSIONS: MADDERS is a new systematic approach to collect information on potentially abuse-related events in clinical trials and classify them. The system has demonstrated feasibility for implementation. Additional research is ongoing to further evaluate its validity. SCIENTIFIC SIGNIFICANCE: Currently, there are no validated tools to assess drug abuse potential during clinical trials. Because of its ease of implementation, its systematic approach, and its preliminary validation results, MADDERS could provide such a tool for clinical trials. (Am J Addict 2016;25:641-651).
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Analgésicos/farmacología , Ensayos Clínicos Fase III como Asunto , Trastornos Relacionados con Sustancias , Adolescente , Adulto , Niño , Ensayos Clínicos Fase III como Asunto/métodos , Ensayos Clínicos Fase III como Asunto/normas , Servicios de Información sobre Medicamentos/organización & administración , Estudios de Factibilidad , Femenino , Humanos , Prescripción Inadecuada/prevención & control , Masculino , Persona de Mediana Edad , Uso Excesivo de Medicamentos Recetados/prevención & control , Gestión de Riesgos/métodos , Trastornos Relacionados con Sustancias/epidemiología , Trastornos Relacionados con Sustancias/etiología , Trastornos Relacionados con Sustancias/prevención & control , Estados UnidosRESUMEN
OBJECTIVES: A systematic review of the literature was undertaken to assess the evidence to support a specific time interval between periodontal maintenance (PM) visits. METHODS: Relevant articles were identified through searches in MEDLINE, EMBASE and PubMed using specific search terms, until April, 2014, resulting in 1095 abstracts and/or titles with possible relevance. Critical Appraisal Skills Programme (CASP) guidelines were used to evaluate the strength of studies and synthesize findings. If mean recall interval was not reported for study groups, authors were contacted to attempt to retrieve this information. RESULTS: Eight cohort studies met the inclusion criteria. No randomized control trials were found. All included studies assessed the effect of PM recall intervals in terms of compliance with a recommended regimen (3-6 months) as a primary outcome. Shorter PM intervals (3-6 months) favored more teeth retention but also statistically insignificant differences between RC and IC/EC, or converse findings are also found. In the 2 studies reporting mean recall interval in groups, significant tooth loss differences were noted as the interval neared the 12 month limit. CONCLUSIONS: Evidence for a specific recall interval (e.g. every 3 months) for all patients following periodontal therapy is weak. Further studies, such as RCTs or large electronic database evaluations would be appropriate. The merits of risk-based recommendations over fixed recall interval regimens should be explored.
Asunto(s)
Higiene Bucal , Cooperación del Paciente , Humanos , Pérdida de Diente/prevención & controlRESUMEN
We used data from Boston Medical Center, Massachusetts, to determine whether dental-related emergency department (ED) visits and costs increased when Medicaid coverage for adult dental care was reduced in July 2010. In this retrospective study of existing data, we examined the safety-net hospital's dental-related ED visits and costs for 3 years before and 2 years after Massachusetts Health Care Reform. Dental-related ED visits increased 2% the first and 14% the second year after Medicaid cuts. Percentage increases were highest among older adults, minorities, and persons receiving charity care, Medicaid, and Medicare.
Asunto(s)
Atención Odontológica/estadística & datos numéricos , Servicio de Urgencia en Hospital/estadística & datos numéricos , Costos de Hospital/estadística & datos numéricos , Medicaid/organización & administración , Proveedores de Redes de Seguridad/economía , Adulto , Anciano , Presupuestos , Atención Odontológica/economía , Servicio de Urgencia en Hospital/economía , Femenino , Reforma de la Atención de Salud/economía , Reforma de la Atención de Salud/organización & administración , Humanos , Masculino , Massachusetts , Medicaid/economía , Persona de Mediana Edad , Estudios Retrospectivos , Enfermedades Estomatognáticas/economía , Estados Unidos , Adulto JovenRESUMEN
AIM: To test whether the number of teeth, an inverse proxy for composite oral infection scores is associated with better survival. MATERIALS AND METHODS: The Kuopio Oral Health and Heart study initiated a case-control study in 1995-1996 consisting of 256 consecutive coronary artery disease patients and 250 age and gender-matched controls. We appended the mortality data and formulated a longitudinal study. By May 31st, 2011, 124 mortalities had occurred and 80 of which were of cardiovascular origin. Using Cox proportional hazards models, we assessed the association of the teeth group (Teethgrp) - consisting of 10 teeth - with cardiovascular and all-cause mortality after 15.8 years of median follow-up. RESULTS: In multivariate models, with the edentulous state as reference, one level increase in Teethgrp was associated with significantly increased survival from cardiovascular disease (CVD) mortality with a Hazard Ratio (HR) 0.73, p-value = 0.02 but not with all-cause mortality (HR = 0.87, p = 0.13). The findings were not mediated by C-reactive protein (CRP) levels ≥3 mg/L or by median fibrinogen levels, but were mediated by CRP levels >5 mg/L. CONCLUSION: Each increment of 10 teeth from the edentulous state was associated with a 27% improved CVD survival, independent of low-grade systemic inflammation.
Asunto(s)
Proteína C-Reactiva/análisis , Enfermedad de la Arteria Coronaria/mortalidad , Dentición , Fibrinógeno/análisis , Factores de Edad , Anciano , Índice de Masa Corporal , Estudios de Casos y Controles , Estudios de Cohortes , Cálculos Dentales/epidemiología , Caries Dental/epidemiología , Diabetes Mellitus/epidemiología , Femenino , Finlandia/epidemiología , Estudios de Seguimiento , Humanos , Hipertensión/epidemiología , Lipoproteínas/sangre , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Boca Edéntula/epidemiología , Enfermedades Periapicales/epidemiología , Pericoronitis/epidemiología , Enfermedades Periodontales/epidemiología , Estudios Prospectivos , Fumar/epidemiologíaRESUMEN
Immediate skin-to-skin contact (SSC) after birth benefits the health of mothers and newborns by increasing breastfeeding rates, stabilizing the newborn's temperature, and encouraging bonding (Moore, Anderson, Bergman, & Dowswell, 2012). Although immediate SSC after a vaginal birth was common practice at our hospital, it was rare in the operating room (OR) following a cesarean birth. To address this practice problem, we conducted a project to evaluate the feasibility of implementing SSC in the OR.