Management of a nontraumatic extracranial internal carotid aneurysm with external carotid transposition.

Primary aneurysms of the extracranial internal carotid artery are exceptionally rare, with only a very few reports in the medical literature that are not related to known connective tissue disease or antecedent trauma. The natural history of these entities has not been precisely defined. Nevertheless, the embolic risk that an aneurysm at this location represents mandates prompt intervention when identified. We present the case of a 42-year-old female who was found to have a 3-cm aneurysm of the right extracranial internal carotid artery after seeing a physician for refractory headaches. In an austere environment with limited resources, this patient was successfully managed with the use of external carotid transposition to the distal internal carotid artery, cephalad to the aneurysm.

Temporal changes of aortic neck morphology in abdominal aortic aneurysms.

OBJECTIVES: This study characterized temporal changes in the infrarenal aortic aneurysm neck in patients with small, untreated abdominal aortic aneurysms (AAA). METHODS: Patients with infrarenal AAA who had contrast-enhanced computed tomography (CT) scans separated by >6 months were identified and their images reviewed. Infrarenal neck diameter and length were measured along with aneurysm diameter. Comparisons between the interval CT scans were made and analysis of factors affecting neck changes performed. RESULTS: Sixty patients met inclusion criteria with an imaging interval of 3.8 years (median, 3.4 years; range, 0.75-9.6 years). During the interval, there was an increase in proximal and distal neck diameters of 1.1 mm (SD, 2.2) (0.28 mm/y) and 1.0 mm (SD, 3.0) (0.26 mm/y), respectively. During the same interval, the neck length decreased by 4 mm (SD, 11) (1 mm/y). A neck length of <15 mm was present in 10 patients (17%) at the initial imaging. Four of the remaining 50 patients experienced an interval decrease in neck length to <15 mm, all of whom had initial lengths of 15 to 20 mm. Medications had no association with changes in neck morphology; however, diabetes correlated with a slower rate of neck shortening (P = .001). CONCLUSION: The natural history of the aneurysm neck is one of expansion and shortening that will not affect most patients under surveillance. Patients with marginal neck lengths (range, 15-20 mm) at the initial imaging are more likely to experience loss of neck length that may negatively affect endovascular suitability.

Effect of temporary shunting on extremity vascular injury: an outcome analysis from the Global War on Terror vascular injury initiative.

OBJECTIVE: Extremity vascular injury during the current war has been defined by anecdotal description and case series. These reports focused on estimation of short-term limb viability and technical description of commonly used adjuncts. Temporary vascular shunting (TVS) has been advocated in current care structures, yet mostly due to war environments, broader statistical scrutiny is lacking. This study's purpose is to provide perspective on TVS's impact on limb salvage, and estimate longer-term freedom from amputation. METHODS: Data from the Joint Theater Trauma Registry (JTTR), Balad Vascular Registry (BVR), Walter Reed Vascular Registry (WRVR), electronic medical records, and patient interviews were collected on American Troops sustaining extremity vascular injury from June 2003 through December 2007. Those in whom arterial TVS utilization was identified comprise the TVS group. These were compared with controls with similar injury date and anatomic location managed without TVS. Descriptive statistics were employed establishing overall univariate predictors of amputation and comparison between groups. Proportional-hazards modeling, with propensity score adjustment for systemic injury severity and Level 2 care, characterized risk factors of limb loss and effect of TVS. Freedom from amputation was estimated using Kaplan Meier log-rank methods. RESULTS: Cases and controls consisted of 64 and 61 extremity arterial injuries, respectively. Mean follow-up was 22 months (range: 1-54 months). The TVS group was more severely injured (mean injury severity score [ISS]: 18 [SD = 10] TVS vs. 15 [SD = 10] control, P = .05) and more likely to receive Level 2 care (TVS: 26%; control: 10%, P = .02). Overall, a total of 26 amputations occurred (21%). Penetrating blasts, compared with gunshot wounds, were associated with amputation (30% vs. 6%, P = .002). After propensity score adjustment, use of TVS suggested a reduced risk of amputation (relative risk [RR] = 0.47; 95% confidence interval [CI] [0.18-1.19]; P = .11). Venous repair was associated with limb salvage (RR = 0.2; 95% CI [0.04-0.99], P = .05). Associated fracture (RR = 5.0; 95% CI [1.45-17.28], P = .01), and elevated mangled extremity severity score (MESS) ([MESS 5-7] RR = 3.5, 95% CI [0.97-12.36], P = .06; [MESS 8-12] RR = 16.4; 95% CI (3.79-70.79), P < .001) predicted amputation. Amputation-free survival was 78% in the TVS group and 77% in the control group at three years (P = .5). CONCLUSION: Temporary vascular shunting used as a damage control adjunct in management of wartime extremity vascular injury does not lead to worse outcomes. Benefit from TVS is suggested, but not statistically significant. Injury specific variables of venous ligation, associated fracture, and penetrating blast mechanism are associated with amputation. Amputation-free survival after vascular injury in Operation Iraqi Freedom is 79% at three years. Further studies to statistically define any possible benefits of TVS are needed.

Endovascular versus open management of blunt traumatic aortic disruption at two military trauma centers: comparison of in-hospital variables.

BACKGROUND: Blunt traumatic aortic disruption (BTAD) carries significant mortality and morbidity. Traditional open repair has appreciable risks of perioperative mortality and spinal cord ischemic complications. Endovascular repair may reduce the incidence of these adverse outcomes. We present the experience at two military trauma centers with thoracic aortic endografting for trauma (TAET) and compare this with recent open experience. METHODS: A review of inpatient records was performed. All patients undergoing open repair or TAET for acute BTAD were studied. Collected data included demographics, injury characteristics, and in-hospital variables. Descriptive statistics were calculated with two-tailed t-tests performed for comparison of continuous variables. RESULTS: Five open and eight TAET repairs were performed. Mean age was 32 years (range 28-50) in the TAET group and 35 (25-57) in the open group. All patients, except one TAET, had at least one associated injury with thoracic injuries predominating. Twelve BTAD were just distal to the left subclavian artery. One injury, treated with TAET, was just proximal to the celiac. Operative blood loss averaged 298 +/- 394 mL in the TAET group vs. 2,400 +/- 3,800 mL in the open group (p = 0.18). Crystalloid infusions were similarly reduced in TAET patients, 1,019 +/- 532 mL vs. 4,860 +/- 1,547 mL, p < 0.05), as were red blood cell transfusions, 1.6 units vs. 5.0 units (p = 0.12). The majority of patients [6/8 (75%) TAET, 5/5 (100%) open] experienced an inpatient complication (p = 0.09). All open patients had at least one infectious complication. There were no inpatient deaths related to aortic injury or spinal cord ischemic complications. CONCLUSIONS: TAET is feasible for the treatment of BTAD in military trauma centers. It is important for military centers to accomplish this with adequate results as endovascular technologies are now being taken to the battlefield. Decreased blood loss and resuscitation requirements compared to open repair are likely contributors to improved outcomes with TAET.

Development and implementation of endovascular capabilities in wartime.

BACKGROUND: Endovascular techniques are widespread in the management of civilian trauma and provide standard treatment for select injuries. Despite the commonality of this less invasive technology, there have been no reports on its use in wartime. The objective of this study was to describe the implementation of endovascular capability at a level III surgical facility in Iraq and illustrate the effectiveness of catheter-based techniques. METHODS: From September 1, 2004 through April 30, 2007, injuries at the Air Force Theater Hospital, Balad, Iraq, were registered in a database and reviewed. Patients in whom endovascular procedures were performed comprise the study group (N = 139). RESULTS: During this period, 150 catheter-based procedures were performed, including placement of 39 vena cava filters. The 111 nonfilter procedures were performed in the setting of extremity (N = 72), cervical (N = 19), and torso (N = 20) injuries. Of the diagnostic procedures, an abnormal finding was present in 67 (61%) cases, and 47 of these underwent either open surgical repair (N = 30) or endovascular treatment (N = 17). Endovascular therapies fell into three categories: embolization (N = 10), covered stent placement (N = 5), or miscellaneous (N = 2). The technical success rate of endovascular treatments was 100%, and procedure-related complications were uncommon (N = 4; 3%). CONCLUSION: This report is the first to demonstrate the effectiveness of diagnostic and therapeutic endovascular capability in the management of acute wartime injury. Implementation of this capability has unique requirements related to imaging and a trauma-specific endovascular inventory. Once established, however, endovascular capability markedly expands the injury management armamentarium and, in certain cases, provides the preferred treatment.

Endovascular treatment of innominate artery stenosis in a bovine aortic arch--a case report.

Recent reports have established the feasibility and safety of percutaneous transluminal angioplasty and stent placement in the treatment of innominate artery occlusive disease. Although the long-term durability of these endovascular approaches has not been clearly established, they are particularly attractive in patients who are not considered good candidates for surgical reconstruction. The authors present a case involving a morbidly obese Hispanic woman who had undergone previous coronary artery bypass and complained of right visual symptoms, dizziness, and right upper extremity claudication. Because of her unusual bovine anatomy and the desire to avoid reoperating in her chest, a unique approach with a left subclavian-to-carotid bypass and innominate artery angioplasty and stenting was used.

Does the efficacy of dorsalis pedis artery bypasses vary among diabetic patients of different ethnic backgrounds?

Hispanic patients suffer from a high rate of leg amputations, far beyond what would be expected from the high prevalence of diabetes in this population. This raises questions about the efficacy of bypass operations across ethnic lines. We focused this review on dorsalis pedis bypasses, as these are frequently performed in diabetic patients. We compared outcomes between Hispanics and non-Hispanics and sought to identify factors predictive of failure or complications. The authors conducted a retrospective review of 144 dorsalis pedis bypasses in 106 men and 29 women with a mean age of 62 years. Eighty-two percent were Hispanic; 96% of cases were done for tissue loss, and 4% for rest pain. Twenty-five percent of patients experienced perioperative complications; these were more frequent in non-Hispanics than Hispanics (40% vs 22%, p = 0.05). The most frequent complications were wound related (11%). The 30-day mortality was 1.5% and 30-day graft thrombosis was 5%. Follow-up ranged from 1 to 62 months and averaged 12 months. Eighty-one percent of the limbs at risk were saved, although 36% of cases required minor foot amputations. Estimated primary graft patency was 68% at 30 months. The 30-month Kaplan-Meier curves for primary patency, assisted patency, and limb salvage were not statistically different between Hispanics and non-Hispanics (p > 0.4). Grafts that remained patent had higher duplex-derived intraoperative flow velocities in the dorsalis pedis artery than grafts that eventually failed (121 +/-69 vs 74 +/-26 cm/sec, p = 0.02). In grafts that remained patent, dorsalis pedis velocity decreased from the perioperative period to the 8 to 12 weeks time point, whereas no change was seen in grafts that eventually failed (mean decline of 48 +/-76 vs 1 +/-58 cm/sec, p = 0.02). No other factors were predictive of graft failure. The results of dorsalis pedis bypass in Hispanic patients compare favorably to those seen in other ethnic groups. This suggests that other factors must account for the high amputation rates seen in Hispanics, such as a frequent occurrence of nonreconstructible disease or unaccounted for cardiovascular risk factors. The usefulness of duplex-derived flow velocities in the dorsalis pedis to predict long-term graft patency warrants further investigation.

Duplex screening for asymptomatic carotid artery disease in Hispanic diabetic patients undergoing lower extremity revascularization: is it a worthwhile endeavor?

Screening for carotid artery disease in patients with systemic manifestations of atherosclerosis (e.g., peripheral vascular disease or coronary artery disease) has been recommended. We have been anecdotally impressed by what appears to be a unique atherosclerotic disease pattern in the Hispanic patient population of South Texas. To determine the prevalence of significant carotid artery disease in Hispanic patients with diabetes presenting with limb-threatening ischemia and to identify factors predictive of occurrence, we conducted a year-long prospective study of 92 consecutive patients undergoing infrainguinal bypass for limb salvage at The University of Texas Health Science Center in San Antonio. Peak systolic and end diastolic velocities in both internal carotid arteries were recorded by perioperative color duplex scanning. We found that the presence of a carotid artery stenosis did not correlate with any variables other than advanced age and presence of a bruit. Only 2 patients had a greater than 80% stenosis. We concluded that screening for carotid artery disease in diabetic Hispanics with critical lower extremity ischemia cannot be justified in younger patients. Even in patients older than 60 years, the presence of high-grade stenosis and, therefore, the need for carotid endarterectomy, is unlikely. However, screening in older patients is recommended to identify persons with moderate stenosis (peak systolic velocity greater than 175 cm/sec) whose disease is more likely to progress.

Penetrating femoropopliteal injury during modern warfare: experience of the Balad Vascular Registry.

OBJECTIVE: Wounding patterns, methods of repair, and outcomes from femoropopliteal injury have been documented in recent civilian literature. In Operation Iraqi Freedom, as in past conflicts, these injuries continue to be a therapeutic challenge. Therefore, the objective of the current study is to document the pattern of femoropopliteal injuries, methods of repair, and early outcomes during the current military campaign in Iraq. METHODS: From September 1, 2004, to April 30, 2007, all vascular injuries arriving at the Air Force Theater Hospital (the central echelon III medical facility in Iraq; equivalent to a civilian level I trauma center), Balad Air Base, Iraq were prospectively entered into a registry. From this, injuries involving the lower extremities were reviewed. RESULTS: During the 32-month study period, 9289 battle-related casualties were assessed. Of these, 488 (5.3%) were diagnosed with 513 vascular injuries, and 142 casualties sustained 145 injuries in the femoropopliteal domain. Femoral level injury was present in 100, and popliteal level injury occurred in 45. Injuries consisted of 59 isolated arterial, 11 isolated venous, and 75 combined. Fifty-eight casualties were evacuated from forward locations. Temporary arterial shunts were placed in 43, of which 40 (93%) were patent on arrival at our facility. Our group used shunts for early reperfusion before orthopedic fixation, during mass casualty care, or autogenous vein harvest in 11 cases. Arterial repair was accomplished with autogenous vein in 118 (88%), primary means in nine (7%), or ligation in seven (5%). Venous injury was repaired in 62 (72%). Associated fracture was present in 55 (38%), and nerve injury was noted in 19 (13%). Early limb loss due to femoropopliteal penetrating injury occurred in 10 (6.9%). Early mortality was 3.5% (n = 5). CONCLUSIONS: Femoropopliteal vascular injury remains a significant reality in modern warfare. Femoral injuries appear more prevalent than those in the popliteal region. Early results of in-theater repair are comparable with contemporary civilian reports and are improved from the Vietnam era. Rapid evacuation and damage control maneuvers such as temporary shunting and early fasciotomy assist timely definitive repair and appear effective.

Arteriographic evidence of pseudoocclusion of the popliteal artery: don't be fooled.

Individuals with chronic lower extremity pain or lifestyle limiting claudication often undergo angiography prior to intervention. Occasionally initial angiographic findings are not indicative of a true pathologic process. Described below are two such cases. Both of the patients described had iliofemoral atherosclerotic disease with arteriographic suggestion of popliteal artery occlusion. However, their medical histories, noninvasive vascular studies, and arteriograms were not consistent with chronic popliteal artery occlusion. On subsequent arteriogram with knee flexion, the occlusions were found to be positional or pseudooccluded. Pseudoocclusion of the popliteal artery (POPA) does not require intervention, and therefore it is necessary to differentiate it from other pathologic processes. Discrimination of POPA from atherosclerotic occlusion, popliteal artery entrapment syndrome, cystic adventitial disease, and vasculitis is possible through history and exam. Arteriography is helpful because a lack of contralateral disease or collateral circulation may indicate a positional occlusion.

Safety and efficacy of reteplase for the treatment of acute arterial occlusion: complexity of underlying lesion predicts outcome.

We evaluated both the safety and efficacy of reteplase for treatment of acute arterial occlusion as well as outcomes based on treatment of the underlying lesion. From November 2000 to February 2004, reteplase was used to treat arterial occlusions in 81 patients. Catheter-directed intrathrombus thrombolysis was performed with reteplase (0.5 units/hr) continuous infusion. Percutaneous mechanical thrombectomy (Angiojet) was performed in 61% (n = 50) of patients prior to thrombolysis. Unmasking of significant lesions resulted in endovascular intervention (39.5%), open surgical repair (24.6%), or both endovascular and surgical repair (9.8%) of the lesion. No lesion was found in 25.9% of patients. Major and minor complication rates as well as restoration of patency, limb salvage, and amputation-free survival were evaluated. Eighty-one patients received reteplase therapy (median = 10.3 +/- 5.3 units, 19.5 +/- 7.4 hr) followed by next-day arteriogram to assess thrombus removal. Technical success was achieved in 96.2% (n = 78) of cases. Kaplan-Meier life table analysis revealed overall primary patency rates of 76.3%, 60.1%, and 51.6%, at 1, 6, and 12 months, respectively. Overall amputation-free survival rates were 86.4%, 76.4%, and 69.7% at 1, 6, and 12 months, respectively. When subdivided into postlysis intervention, the lysis-only group achieved increased patency (p = 0.0143) and increased limb salvage (p = 0.0219) at 1 year compared to the lysis and endovascular intervention and the lysis and surgical groups. The 30-day complication rate was 17.3% (n = 14), with a major complication rate of 4.9% (n = 4) and a minor complication rate of 12.3% (n = 10). There were no intracranial hemorrhagic complications. Intra-arterial catheter-directed infusion of reteplase for acute lower extremity ischemia is safe and efficacious, as shown by the low risk of bleeding complications, high limb salvage rates, and low mortality rates in this study. The complexity of the lesion that is unmasked through thrombolytic therapy is a predictor of patency and limb salvage.

Graft patency is not the only clinical predictor of success after exclusion and bypass of popliteal artery aneurysms.

PURPOSE: The traditional measure of success after exclusion and bypass of popliteal artery aneurysm (PAA) is graft patency. In addition to fate of the bypass, we hypothesize that late outcome after surgical treatment of PAA is influenced by completeness of exclusion. METHODS: Thirty patients who underwent 41 reconstructions for PAA over a 10-year period were reviewed. RESULTS: Excluded PAAs were examined with duplex ultrasound scan for size, patency, and patent feeding branches; bypass grafts and native inflow and outflow arteries were examined for patency and size. Thirty-six limbs were available for follow-up (mean follow-up period, 46 +/- 42 months). Only two aneurysms (5.6%) appeared patent on duplex ultrasound scan, but five limbs had patent arterial branches communicating with thrombosed excluded PAAs. PAA diameter decreased from 2.5 +/- 0.8 cm to 1.7 +/- 0.5 cm (P <.0001) in most. However, 12 excluded PAAs (33%) showed significant enlargement from 2.2 +/- 0.9 cm to 2.8 +/- 1.0 cm (P =.002). A quarter of enlarging excluded PAA were associated with new compressive symptoms. Three methods of PAA exclusion were used: proximal and distal ligation with short segment isolation (type 1), proximal and distal ligation with long segment isolation (type 2), and single ligature (type 3). In univariate analysis, type of exclusion significantly influenced late size of excluded PAA (P =.004). Type 1 exclusion was superior to both type 2 and 3 exclusions in producing aneurysm diameter reduction. Type 3 exclusion resulted in aneurysm growth. In addition, excluded aneurysms with visualized feeding branches were associated with significant growth compared with PAAs without feeding branches (P =.006). Graft primary and assisted primary patency rates at 5 years were 86% +/- 9.4% and 92% +/- 7.4%, respectively. Although graft diameter and native donor artery diameter significantly increased, this did not adversely affect graft patency. CONCLUSION: Enlargement of excluded PAA after surgical treatment can cause compressive symptoms. Exclusion requires adequate vascular isolation to prevent late PAA enlargement, with proximal and distal arterial ligation best performed adjacent to the aneurysm. Vein graft enlargement occurs, but this enlargement does not adversely influence patency.

Use of a silastic silo for closure of the abdominal wall in a pediatric patient receiving a cadaveric split liver.

Presented is the successful management of a difficult abdominal wall closure after pediatric liver transplantation. A 5-week-old boy with biliary atresia underwent urgent cadaveric split liver transplantation. The left lateral segment of an adult donor was utilized. Postoperatively, abdominal skin and fascia could not be closed. A SILASTIC (Dow Corning, Midland, MI) silo was applied, and complete closure was possible 6 days later.