Treatment of Polycystic Ovary Syndrome-Related Infertility Using a Combination of Compound Xuanju Capsules and Hormones: A Meta-Analysis.

Objective: Our aim was to perform a meta-analysis to compare the therapeutic effects of compound Xuanju capsules combined with hormone therapy vs hormone therapy alone in polycystic ovary syndrome (PCOS)-related infertility. Methods: Electronic databases including PubMed, The Cochrane Library, Web of Science, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Wanfang Data and VIP database were manually searched. The quality of included studies was evaluated based on Cochrane Systematic Review standards, and the valid data were extracted for meta-analysis using RevMan 5.3 software (Cochrane Review). Results: A total of 14 randomized controlled trials (RCTs) including 1249 patients were included in the study. Meta-analysis showed that patients in the compound Xuanju capsule + hormone therapy group had higher estradiol (E2) levels and overall rates of effective treatment than patients in the hormone therapy alone group. Moreover, they exhibited lower levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as lower Kupperman scores, than the hormone therapy alone group. Conclusions: The combination of compound Xuanju capsules and hormone therapy is more effective than hormone therapy alone in the treatment of PCOS-related infertility. However, the quality of current studies is low, and high-quality clinical trials are warranted.

Treatment of Circadian Disorder with Premature Ovarian Insufficiency With the Nourishing Yin and Tonifying Yang Sequential Method with Femoston.

Objective: The clinical effects of the nourishing Yin and tonifying Yang sequential method with Femoston was explored in treating circadian disorder with premature ovarian insufficiency (POI). Method: We enrolled 600 patients with circadian disorder and POI in a prospective study and divided the patients into 2 groups: an experimental and a control group. Both groups were treated with Femoston and the experimental group also received nourishing Yin and tonifying Yang sequential method. We observed the overall response rate, Kupperman Index, number of adverse events, and the levels of prostaglandin E2 (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), total cholesterol (TC), triglycerices (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), as well as peak systolic velocity (PSV), pulsatility index (PI), resistance index (RI), maximum ovarian diameter (MOD) and antral follicle count (AFC). Results: The experimental group also exhibited elevated TC, TG, LDL-C, MOD and AFC after treatment, whereas the control group did not. Compared with the control group, the experimental group had a higher overall response rate, E2, FSH, LH, HDL-C, PSV, MOD, AFC, a lower Kupperman Index, TC, TG, LDL-C, PI, RI and number of adverse events. Conclusions: In patients with circadian disorder with POI, the nourishing Yin and tonifying Yang sequential method with Femoston improved ovarian function, blood supply to the ovaries and sex hormone levels and lowered blood lipids with acceptable safety parameters.