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1.
Reumatizam ; 63 Suppl 1: 27-30, 2016.
Artículo en Croata | MEDLINE | ID: mdl-29624296

RESUMEN

Fibromylagia (FM) is a complex chronic condition usually presenting with symptoms of widespread pain and fatigue, as well as sleep and cognitive disorders. The diagnosis is made by exclusion of other diseases and according to the EULAR criteria. The treatment of the disease is multidisciplinary and associated with a better understanding of the disease pathophysiology. The most commonly used drugs are tricylic antidepressants (TCA), serotonin and noradrenalin uptake inhibitors (SNRI), anticonvulsants, and opioids. For the purpose of reducing the patient's overall symptom burden, adjunctive therapy with medicines targeted at specific symptoms, including sleep disorders, symptoms of irritable bowel syndrome, or autoimmune diseases, should be considered. Current therapeutic models neither completely treat FM symptoms nor benefit all patients; therefore, further research on new therapeutic approaches is needed.


Asunto(s)
Fibromialgia/clasificación , Fibromialgia/terapia , Enfermedades Reumáticas/diagnóstico , Fibromialgia/diagnóstico , Humanos , Enfermedades Reumáticas/terapia
2.
Reumatizam ; 63(1): 14-9, 2016.
Artículo en Croata | MEDLINE | ID: mdl-29616538

RESUMEN

Systemic sclerosis (SSC) is an autoimmune disease associated with the risk of malignancies, especially lung cancer, among which adenocarcinoma and squamous cell carcinoma are the most frequent. A 63-year-old female patient with SSC was hospitalized due to blackouts, poor general condition, and changes in her fingers. Because of subsequent epileptic seizures resulting in weakness of the left side of her body, computerized tomography (CT) of the neurocranium was performed which showed metastatic lesions. A CT scan of the thoracic organs displayed pulmonary neoplasia in the right hilum, which were histologically evaluated as grade 2 squamous cell carcinoma. After one month of hospitalization with supportive therapy, the patient's clinical condition improved, and she was discharged into home care with recommendations for further oncological treatment. However, the patient died several days later. In comparison to adenocarcinomas, squamous cell carcinomas of the lungs usually develop through a significantly longer period. We consider that the unusually rapid development of the carcinoma in this patient was stimulated by the immunosuppressive effect of high doses of glucocorticoids that she had been taking for several years on her own initiative.


Asunto(s)
Neoplasias Encefálicas/inducido químicamente , Carcinoma de Células Escamosas/inducido químicamente , Glucocorticoides/administración & dosificación , Glucocorticoides/efectos adversos , Neoplasias Pulmonares/inducido químicamente , Esclerodermia Sistémica/tratamiento farmacológico , Neoplasias Encefálicas/diagnóstico por imagen , Resultado Fatal , Femenino , Humanos , Neoplasias Pulmonares/diagnóstico por imagen , Persona de Mediana Edad , Tomografía Computarizada por Rayos X
3.
Reumatizam ; 63(1): 10-3, 2016.
Artículo en Croata | MEDLINE | ID: mdl-29616537

RESUMEN

Polymyositis (PM) is an autoimmune disease which affects skeletal muscles. In young age, it usually occurs as an idiopathic disorder associated with specific autoantibodies (anti-Jo), while in older age it is often associated with neoplasms. It can present with symptoms of other autoimmune diseases, such as systemic sclerosis (SSc), a rare progressive disease characterized by collagen deposits in various tissues and organs. A 65-year-old patient, long-time smoker, came to the ER because of painful edema in the distal parts of his limbs and proximal muscle weakness of his arms and legs. Although his muscle enzymes were not increased, PM was confirmed by the characteristic pathohistological finding. The patient had sclerodermal skin lesions on his back, but he did not have other typical SSc symptoms, and the specific autoantibodies were negative. He received glucocorticoid therapy (GC) after we had finished screening for malignant tumors. He felt better, his muscle strength returned, and the limb edema disappeared. Four weeks later, he developed symptoms which are more typical of SSc, such as dysphagia, Raynaud's phenomenon, and skin thickening of the limbs that had been swollen. PM is often associated with SSc. It is not clear if the exacerbation of latent SSc was stimulated by GC, or if it was just a simple overlap of the two diseases with different onsets. There are no therapy guidelines for the treatment of this combination of diseases. Careful use of GC is necessary even if SSc symptoms are discreet, because of the well-known effects of GC in SSc.


Asunto(s)
Glucocorticoides/uso terapéutico , Polimiositis/complicaciones , Polimiositis/tratamiento farmacológico , Esclerodermia Sistémica/complicaciones , Esclerodermia Sistémica/tratamiento farmacológico , Anciano , Humanos , Masculino
4.
Reumatizam ; 62(1): 12-9, 2015.
Artículo en Croata | MEDLINE | ID: mdl-27024887

RESUMEN

Golimumab is a human monoclonal antibody which inhibits tumor necrosis factor-alpha (TNF-α) and is approved for the treatment of inflammatory arthritides (rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis) when the conventional non-pharmacological and pharmacological therapies fail to cause remission or low disease activity. In this retrospective study there were included patients with rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis who were treated in Croatia with golimumab, from June 2011 to June 2013. included and these retrospective data are compared with similar data from clinical trials and other available databases. Standard variables of disease activity and functional ability were observed. Results demonstrated significant efficacy of golimumab regarding lowring the disease activity and imrpving functional ability in pateints with these inflammatory rherumatic disease. In conclusion, in this retrospective study during two years treatment golimumab showed efficacy in decreasing disease activity and imrpove functional ability in patiemts with rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis.


Asunto(s)
Anticuerpos Monoclonales/uso terapéutico , Antirreumáticos/uso terapéutico , Artritis Psoriásica/tratamiento farmacológico , Artritis Reumatoide/tratamiento farmacológico , Espondilitis Anquilosante/tratamiento farmacológico , Artritis Psoriásica/fisiopatología , Artritis Reumatoide/fisiopatología , Croacia , Humanos , Estudios Retrospectivos , Espondilitis Anquilosante/fisiopatología
5.
Lijec Vjesn ; 136(7-8): 224-5, 2014.
Artículo en Croata | MEDLINE | ID: mdl-25327011

RESUMEN

Vasculitis is clinicopathologic process characterized by inflammation and damage of blood vessels, often resulting in complete or partial occlusion of the involved vessels and ischemic damage to the supplied organ or tissue. The vasculitides are a large group of heterogeneous diseases for which it has been assumed that pathogenesis is largely autoimmune. It may be a primary or secondary manifestation of a disease process and may affect single or multiple organs. Inflammation affects vessel's walls partly or completely resulting with the loss of vascular integrity. Vasculitides has been classified by whether inflammation predominantly damage small, medium, or large vessels.


Asunto(s)
Vasculitis/fisiopatología , Humanos
6.
Reumatizam ; 61(2): 24-30, 2014.
Artículo en Croata | MEDLINE | ID: mdl-25427391

RESUMEN

Rheumatoid arthritis (RA) is chronic inflammatory rheumatic disease which leads to joint damage, functional im- pairment and reduced quality of life. The disease should be recognized early when there is a "window of oppor- tunity" to apply adequate treatment which may prevent structural damage. As clinical presentation of RA is not always typical, great knowledge and clinical experience, including collaboration of rheumatologist, general practi- tioner and patient, are required. The treatment should be started immediately upon the diagnosis, while the choice of modality of treatment depends on the rheumatologist in accordance with the patient. The RA patients with the higher risk of aggressive disease need to be recognized because they require more aggressive treatment from the start. The goal of the treatment is remission or at least low disease activity. Current treatment of RA includes disease modifying antirheumatic drugs (DMARDs) synthetics and biologics, nonsteroidal antirheumatic drugs (NSAIDs), glucocorticoids, analgesics, and rarely cytostatics. The course of disease is usually fluctuating with the exchange of relapses and remissions. Recognition of the relapsing patient on time enables treatment intensification or modifications in treatment scheme. Special issue in RA represents glucocorticoid-induced osteoporosis (GIO) which should be prevented by usage of calcium and vitamin D supplements and treated by antiresorptive or osteoanabolic agents. Besides the treatment of the primary disease, the care of RA patients should consider comorbidities, side effects of treatment, complications of disease, and psychosocial aspects of chronic disease.


Asunto(s)
Antirreumáticos/uso terapéutico , Artritis Reumatoide/tratamiento farmacológico , Antiinflamatorios no Esteroideos/uso terapéutico , Artritis Reumatoide/diagnóstico , Productos Biológicos/uso terapéutico , Humanos , Recurrencia , Inducción de Remisión
7.
Reumatizam ; 61(1): 17-22, 2014.
Artículo en Croata | MEDLINE | ID: mdl-25509832

RESUMEN

It is a well-documented fact that sex hormones are implicated in the immune response and that androgens and estrogens modulate susceptibility and progression of autoimmune rheumatic diseases. Estrogens are considered to stimulate cell proliferation and humoral immune responses while androgens exert suppressive effects on both humoral and cellular immune responses. Autoimmune diseases are common in females, especially during the generative period, the most representative of estrogen-related autoimmune diseases being systemic lupus erythematosus. Estrogens and androgens are involved in the pathogenesis of the disease; both exogenous and endogenous estrogens are strong stimulators of cytokine production and disease activity. Some physiological conditions, as well as some drugs and chronic stress, can modulate hormone levels. Low levels of gonadal androgens have been detected in body fluids of both male and female rheumatoid arthritis patients, supporting the possibility of the pathogenic role for decreased androgen levels. Views on hormone replacement therapy or hormonal contraception in rheumatic diseases have been modified and in most rheumatic diseases, including rheumatoid arthritis, hormones are not prohibited. There are still controversies regarding systemic lupus; the new standpoint being that hormonal contraception is not contraindicated in women with inactive or stable active SLE, except for those with positive antiphospholipid antibodies.


Asunto(s)
Andrógenos , Estrógenos , Enfermedades Reumáticas , Femenino , Humanos , Lupus Eritematoso Sistémico , Masculino
8.
Rheumatol Int ; 33(11): 2943-8, 2013 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-23224499

RESUMEN

Helicobacter pylori (H. pylori) is suspected to be one of the factors triggering systemic sclerosis (SSc). Data on the possible role of H. pylori are lacking. The aim of this study was to assess the effect of H. pylori infection in SSc patients. Forty-two SSc patients without dyspeptic symptoms were recruited--26 were H. pylori-positive and 16 were H. pylori-negative on the basis of invasive test. We evaluated the disease severity using clinical and laboratory parameters according to the Medsger Severity Scale. The level of SSc activity was evaluated according to Valentini activity score. The prevalence of H. pylori infection in population of SSc patients is 62%. Severity of skin, gastrointestinal, and joint/tendon involvement was different between H. pylori-positive and -negative SSc patients (p < 0.001 for skin involvement, p = 0.002 and p = 0.03 for gastrointestinal and joint/tendon involvement, respectively) as well as erythrocyte sedimentation rate (p = 0.002). Severity score according to Medsger was higher in the H. pylori-positive than in the H. pylori-negative SSc patients (p < 0.001). Our data suggest that H. pylori infection correlates with severity of skin, gastrointestinal, and joint/tendon involvement in SSc patients. H. pylori-positive SSc patients showed higher severity score compared to H. pylori-negative. Therefore, H. pylori infection may play a role in the pathogenesis of SSc and also can provide some prognostic information.


Asunto(s)
Infecciones por Helicobacter/complicaciones , Helicobacter pylori/aislamiento & purificación , Esclerodermia Sistémica/complicaciones , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pronóstico , Factores de Riesgo , Esclerodermia Sistémica/diagnóstico , Índice de Severidad de la Enfermedad
9.
Reumatizam ; 60(2): 39-42, 2013.
Artículo en Croata | MEDLINE | ID: mdl-24979995

RESUMEN

The antineutrophil cytoplasmic antibody (ANCA) are associated with distinct forms of primary small vessel vasculitides, collectively reffered to as ANCA-associated vasculitis (AAV). ANCA were originally identified by IIF. Importantly, however, only ANCA directed to PR3 (PR3-ANCA) or MPO (MPO-ANCA) are relevant for the diagnosis AAV, there is international consensus that ANCA should be detected by a combination of IIF and antigen-specific assays, i.e. detection of PR3 and MPO-ANCA. Several novel technologies have become available for antigen-specific ANCA detection.


Asunto(s)
Vasculitis Asociada a Anticuerpos Citoplasmáticos Antineutrófilos/diagnóstico , Anticuerpos Anticitoplasma de Neutrófilos/análisis , Biomarcadores/sangre , Técnicas de Laboratorio Clínico , Humanos
10.
Reumatizam ; 60(2): 43-6, 2013.
Artículo en Croata | MEDLINE | ID: mdl-24979996

RESUMEN

The anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides are a group of uncommon diseases characterised by inflammatory cell infiltration and necrosis of blood vessel walls. ANCA there has been considerable progress towards understanding their pathogenesis. This results in endothelial activation with increased transmigration and adherence of neutrophils to vessel walls. Specific for granulomatosis with polyangiitis are nasal or oral inflammation and development of oral ulcers and purulent or bloody nasal discharge. The chest radiograph usually showed the presence of nodules or fixed infiltrates. Microscopic polyangiitis affects the smallest blood vessels and may also affect medium-sized vessels, demonstrates the tropism for the kidneys--glomerulonephritis and lungs--pulmonary capillaritis. The characteristic features of eosinophilic granulomatosis with polyangiitis are asthma, eosinophilia in peripheral blood, sinusitis and pulmonary infiltrates which may be transient, than mononeuritis multiplex. It is important to differentiate ANCA vasculitis and syndromes that may mimic them, particularly infection, malignancy and connective tissue disease.


Asunto(s)
Vasculitis Asociada a Anticuerpos Citoplasmáticos Antineutrófilos/diagnóstico , Anticuerpos Anticitoplasma de Neutrófilos/análisis , Síndrome de Churg-Strauss/diagnóstico , Diagnóstico Diferencial , Granulomatosis con Poliangitis/diagnóstico , Humanos , Poliangitis Microscópica/diagnóstico
11.
Reumatizam ; 60(1): 29-31, 2013.
Artículo en Croata | MEDLINE | ID: mdl-24003681

RESUMEN

Hypertrophic osteoarthropathy is a syndrome presenting with dclubbing, limbs enlargement, pain and swelling of foot and long bones osteitis. Hypertrophic osteoarthropathy is a rare paraneoplastic syndrome in the patients with primary or metastatic lung cancer. We report 39-year old female patient who presented with arthritis and paraneoplastic hypertrophic osteoarthropathy revealing lung adenocarcinoma.


Asunto(s)
Adenocarcinoma/diagnóstico por imagen , Neoplasias Pulmonares/diagnóstico por imagen , Osteoartropatía Hipertrófica Secundaria/etiología , Síndromes Paraneoplásicos/etiología , Adenocarcinoma/complicaciones , Adulto , Femenino , Humanos , Neoplasias Pulmonares/complicaciones , Radiografía
12.
Reumatizam ; 60(1): 14-8, 2013.
Artículo en Croata | MEDLINE | ID: mdl-24003678

RESUMEN

The objective was to analyse epidemiological tendencies of rheumatoid arthritis (RA) in Dalmatia County in order to identify possible spatial clusters of RA. Patient-interviewers were trained to administer telephone surveys. 197 RA patients controlled at Rheumatology and immunology department of Clinical hospital of Split were mapped to place of residence by telephone survey. Statistical evidence of clustering was determined by calculating Poisson probabilities in putative areas. Four clusters were identified; the largest one was in the region of Sinj. The female/male ratio was 5.79:1. Majority of RA patients were among age 50 to 59 (30.45 %). The results show inter-regional variations with the marked clusters in the north of Dalmatia suggesting that clusters with higher incidence of RA have specific genetic and environmental background. Prevalence of RA in female was higher than in current literature, while the age of onset 50-59 years is similar with data from recent studies.


Asunto(s)
Artritis Reumatoide/epidemiología , Croacia/epidemiología , Femenino , Encuestas Epidemiológicas , Humanos , Masculino , Persona de Mediana Edad , Prevalencia , Distribución por Sexo
13.
Wien Klin Wochenschr ; 135(15-16): 414-419, 2023 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-36583748

RESUMEN

OBJECTIVE: Previous studies have shown that Helicobacter pylori (HP) infection is associated with increased activity and severity of systemic sclerosis (SSc), hence we aimed to evaluate the effect of HP eradication on various symptoms and inflammatory indices. METHODS: The SSc patients without dyspeptic symptoms were prospectively enrolled in this 18-month cross-sectional study. Patients were divided into two groups based on determination of HP infection. The infected group was treated in accordance with the current HP eradication protocol. Assessment of disease activity, severity and organ involvement was performed every 6 months. RESULTS: A total of 42 consecutive SSc patients without dyspepsia and variable disease activity and severity were recruited. Levels of modified Rodnan skin score, erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) significantly decreased following HP eradication (p < 0.001, p < 0.001 and p = 0.001, respectively), and in the HP-negative patient group ESR and CRP values increased (p = 0.03, p = 0.002). Eradication of HP in the group of infected patients induced progressive and significant improvement of disease activity and severity over time compared to baseline (p < 0.01, p < 0.001, respectively), whereas in the HP-negative patient group these scores remained unchanged. In our study, HP eradication was associated with an improvement of clinical symptoms and disease activity. CONCLUSION: These findings suggest that HP detection and subsequent eradication could be beneficial in the management of SSc patients. Although, HP eradication seems to be advantageous in infected SSc patients, larger controlled studies are needed for a potential recommendation.


Asunto(s)
Dispepsia , Infecciones por Helicobacter , Helicobacter pylori , Esclerodermia Sistémica , Humanos , Helicobacter pylori/metabolismo , Estudios Transversales , Infecciones por Helicobacter/diagnóstico , Infecciones por Helicobacter/tratamiento farmacológico , Dispepsia/complicaciones , Dispepsia/tratamiento farmacológico , Proteína C-Reactiva/análisis , Esclerodermia Sistémica/complicaciones , Esclerodermia Sistémica/diagnóstico , Esclerodermia Sistémica/tratamiento farmacológico , Antibacterianos/uso terapéutico
14.
Reumatizam ; 59(1): 28-35, 2012.
Artículo en Croata | MEDLINE | ID: mdl-25486725

RESUMEN

Vaccine preventable infections occur more often in patients with autoimmune and chronic rheumatic diseases when compared to the general population. Most vaccines are immunogenic, efficacious and safe in those patients, even with immunosuppressive treatment, excluding rituximab. Live attenuated vaccines should be avoided in patients receiving long-term immunosuppressive therapy. The occurrence of adverse events and autoimmune phenomena is almost the same in vaccinated patients with rheumatic diseases and in vaccinated healthy individuals. A deeper research is needed regarding safety of vaccination and the influence of new immunomodulating drugs on efficacy of vaccination since the studies that were undertaken so far are retrospective or performed on small cohorts of patients. Evidence-based recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases developed by European League Against Rheumatism (EULAR) will help rheumatologists in making a decision about vaccinating their patients.


Asunto(s)
Enfermedades Autoinmunes , Enfermedades Reumáticas , Vacunación/efectos adversos , Contraindicaciones , Humanos , Inmunosupresores
15.
Reumatizam ; 59(1): 36-9, 2012.
Artículo en Croata | MEDLINE | ID: mdl-25486726

RESUMEN

Treatinent of systemic lupus erythematosus is very difficult because of heterogeneous clinical manifestations. Standard therapy includes non-steroidal anti-inflammatory drugs, glucocorticoids, anitimalarials and cytotoxic agents. A numerous biological agents have been investigated for treatment of the systemic lupus erythematosus. They are directed to B and T cell depletion, blockade of co-stimulatory molecules, inhibition of cytokines and complement modulation. Sirolimus, tacrolimus, autologous hematopoietic stem cell transplantation and allogenic mesenchymal stem cells transplantation have been also investigated for treatment of systemic lupus erythematosus.


Asunto(s)
Lupus Eritematoso Sistémico/terapia , Antiinflamatorios no Esteroideos/uso terapéutico , Trasplante de Células Madre Hematopoyéticas , Humanos
16.
Reumatizam ; 59(2): 51-2, 2012.
Artículo en Croata | MEDLINE | ID: mdl-23745456

RESUMEN

Polymyositis and Dermatomyositis are often connected with autoimmune diseases and are closely linked with specific autoantibodies. Clinical manifestations are mild in correlation with clinical picture ofmyositis related to malignancy. Pulmonary complications are main cause of mortality in overlap syndromes with autoimmune diseases. Infection, cardiovascular complications and underlying malignancy provide greater mortality risk.


Asunto(s)
Enfermedades Autoinmunes/diagnóstico , Enfermedades del Tejido Conjuntivo/diagnóstico , Dermatomiositis/diagnóstico , Neoplasias/diagnóstico , Polimiositis/diagnóstico , Enfermedades Autoinmunes/complicaciones , Enfermedades del Tejido Conjuntivo/inmunología , Dermatomiositis/inmunología , Humanos , Neoplasias/inmunología , Polimiositis/inmunología , Síndrome
17.
Reumatizam ; 58(2): 51-3, 2011.
Artículo en Croata | MEDLINE | ID: mdl-22232948

RESUMEN

The spondyloarthritides are group of interrelated and overlapping arthritic conditions which primarily include ankylosing spondylitis, reactive arthritis/Reiter's disease and arthritis associated with psoriasis and inflammatory bowel disease. They are characterised by the absence of rheumatoid factor and by association with HLA-B27 antigen. The main clinical features are inflammatory back pain, spondylitis, sacroileitis, asymmetric arthritis of lower limbs, enthesitis, dactylitis, besides fatigue, uveitis, skin and mucous membrane lesions, cardiac and pulmonary involvement. Although there are similarities among the spondyloarthritides, each of them have specific characteristic that help us to distinguish them.


Asunto(s)
Espondiloartritis/diagnóstico , Artritis Psoriásica/diagnóstico , Artritis Reactiva/diagnóstico , Humanos , Espondilitis Anquilosante/diagnóstico
18.
Coll Antropol ; 34 Suppl 2: 175-8, 2010 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-21302718

RESUMEN

During the last three decades scientists worldwide have investigated how ultraviolet radiation (UVR) influences the immune system. The vast majority of the researchers was primarily focused on the local immunomodulatory role of UVR. But today evidence is increasing in favor of plural immune activation and systemic reaction of the organism. Most of the attention is directed toward the regulatory T lymphocytes which are responsible for the local and systemic immunosuppressive response under the impact of sunlight. The role of regulatory T cells in autoimmune diseases is well studied on patients with systemic lupus erythematosus (SLE). Epidemiological research shows a proportional interdependence of latitude and prevalence of autoimmune diseases such as multiple sclerosis (MS), insulin-dependent diabetes mellitus (IDDM) and rheumatoid arthritis (RA). There is evidence that UVR has direct influence on the level of antibodies against the SNF2-superfamily helicase (Mi-2), distinctive for dermatomyositis (DM). On this basis a hypothesis is established that UVR is a risk factor for DM. A Croatian epidemiologic study o f systemic sclerosis (SSc) gave results consistent with the hypothesis that there is a higher prevalence of SSc in the Mediterranean regions of Croatia. Such discoveries encouraged further studies that found that not only regulatory T cells are responsible for a systemic immunosuppressive response, but that there is a complex interactive network of immune cells and mediators such as cytokines, neuropeptides, and chromophores like urocanic acid involved. Present findings require continued research on the importance of UVR on autoimmune disease prevalence and immunopathophysiology. Finally, it is necessary to distinguish whether UVR is a protective factor for some autoimmune diseases or a risk factor for their induction.


Asunto(s)
Enfermedades Autoinmunes/inmunología , Sistema Inmunológico/efectos de la radiación , Tolerancia Inmunológica/efectos de la radiación , Rayos Ultravioleta/efectos adversos , Enfermedades Autoinmunes/epidemiología , Humanos , Sistema Inmunológico/inmunología , Tolerancia Inmunológica/inmunología , Factores de Riesgo , Esclerodermia Sistémica/epidemiología , Esclerodermia Sistémica/inmunología , Linfocitos T Reguladores/inmunología , Linfocitos T Reguladores/efectos de la radiación
19.
Lijec Vjesn ; 137(3-4): 135, 2015.
Artículo en Croata | MEDLINE | ID: mdl-26065301
20.
Lijec Vjesn ; 132(5-6): 162-8, 2010.
Artículo en Croata | MEDLINE | ID: mdl-20677623

RESUMEN

Diffuse systemic sclerosis (SSc) is a chronic disease of unknown cause characterized by diffuse fibrosis and vascular abnormalities in the skin and internal organs. Pathogenesis of SSc involves immunologic mechanisms, vascular damage and activation of fibroblasts. SSc varies in severity and progression; most patients eventually develop visceral complications, which are the usual causes of death. No drug significantly influences the natural history of SSc overall, but various drugs are of value in treating specific symptoms or organ systems. This review discusses pathogenesis, clinical manifestations and possible treatment of SSc.


Asunto(s)
Esclerodermia Sistémica , Humanos , Esclerodermia Sistémica/diagnóstico , Esclerodermia Sistémica/patología , Esclerodermia Sistémica/fisiopatología , Esclerodermia Sistémica/terapia
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