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1.

The transcriptional and epigenomic foundations of ground state pluripotency.

Marks, Hendrik; Kalkan, Tüzer; Menafra, Roberta; Denissov, Sergey; Jones, Kenneth; Hofemeister, Helmut; Nichols, Jennifer; Kranz, Andrea; Stewart, A Francis; Smith, Austin; Stunnenberg, Hendrik G.

Cell; 149(3): 590-604, 2012 Apr 27.

Artículo en Inglés | MEDLINE | ID: mdl-22541430

2.

Defined conditions for propagation and manipulation of mouse embryonic stem cells.

Mulas, Carla; Kalkan, Tüzer; von Meyenn, Ferdinand; Leitch, Harry G; Nichols, Jennifer; Smith, Austin.

Development; 146(6)2019 03 26.

Artículo en Inglés | MEDLINE | ID: mdl-30914406

3.

Tracking the embryonic stem cell transition from ground state pluripotency.

Kalkan, Tüzer; Olova, Nelly; Roode, Mila; Mulas, Carla; Lee, Heather J; Nett, Isabelle; Marks, Hendrik; Walker, Rachael; Stunnenberg, Hendrik G; Lilley, Kathryn S; Nichols, Jennifer; Reik, Wolf; Bertone, Paul; Smith, Austin.

Development; 144(7): 1221-1234, 2017 04 01.

Artículo en Inglés | MEDLINE | ID: mdl-28174249

4.

Selection and dynamics of embryonic stem cell integration into early mouse embryos.

Alexandrova, Stoyana; Kalkan, Tuzer; Humphreys, Peter; Riddell, Andrew; Scognamiglio, Roberta; Trumpp, Andreas; Nichols, Jennifer.

Development; 143(1): 24-34, 2016 Jan 01.

Artículo en Inglés | MEDLINE | ID: mdl-26586221

5.

Correction: Defined conditions for propagation and manipulation of mouse embryonic stem cells (doi:10.1242/dev.173146).

Mulas, Carla; Kalkan, Tüzer; von Meyenn, Ferdinand; Leitch, Harry G; Nichols, Jennifer; Smith, Austin.

Development; 146(7)2019 Apr 11.

Artículo en Inglés | MEDLINE | ID: mdl-30975648

6.

A genome-wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation.

Yang, Shen-Hsi; Kalkan, Tuzer; Morrisroe, Claire; Smith, Austin; Sharrocks, Andrew D.

PLoS Genet; 8(12): e1003112, 2012.

Artículo en Inglés | MEDLINE | ID: mdl-23271975

7.

The ground state of pluripotency.

Wray, Jason; Kalkan, Tuzer; Smith, Austin G.

Biochem Soc Trans; 38(4): 1027-32, 2010 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-20658998

8.

Complementary Activity of ETV5, RBPJ, and TCF3 Drives Formative Transition from Naive Pluripotency.

Kalkan, Tüzer; Bornelöv, Susanne; Mulas, Carla; Diamanti, Evangelia; Lohoff, Tim; Ralser, Meryem; Middelkamp, Sjors; Lombard, Patrick; Nichols, Jennifer; Smith, Austin.

Cell Stem Cell; 24(5): 785-801.e7, 2019 05 02.

Artículo en Inglés | MEDLINE | ID: mdl-31031137

9.

NODAL Secures Pluripotency upon Embryonic Stem Cell Progression from the Ground State.

Mulas, Carla; Kalkan, Tüzer; Smith, Austin.

Stem Cell Reports; 9(1): 77-91, 2017 07 11.

Artículo en Inglés | MEDLINE | ID: mdl-28669603

10.

A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation.

Li, Meng Amy; Amaral, Paulo P; Cheung, Priscilla; Bergmann, Jan H; Kinoshita, Masaki; Kalkan, Tüzer; Ralser, Meryem; Robson, Sam; von Meyenn, Ferdinand; Paramor, Maike; Yang, Fengtang; Chen, Caifu; Nichols, Jennifer; Spector, David L; Kouzarides, Tony; He, Lin; Smith, Austin.

Elife; 62017 08 18.

Artículo en Inglés | MEDLINE | ID: mdl-28820723

11.

Dynamics of gene silencing during X inactivation using allele-specific RNA-seq.

Marks, Hendrik; Kerstens, Hindrik H D; Barakat, Tahsin Stefan; Splinter, Erik; Dirks, René A M; van Mierlo, Guido; Joshi, Onkar; Wang, Shuang-Yin; Babak, Tomas; Albers, Cornelis A; Kalkan, Tüzer; Smith, Austin; Jouneau, Alice; de Laat, Wouter; Gribnau, Joost; Stunnenberg, Hendrik G.

Genome Biol; 16: 149, 2015 Aug 03.

Artículo en Inglés | MEDLINE | ID: mdl-26235224

12.

Mapping the route from naive pluripotency to lineage specification.

Kalkan, Tüzer; Smith, Austin.

Philos Trans R Soc Lond B Biol Sci; 369(1657)2014 Dec 05.

Artículo en Inglés | MEDLINE | ID: mdl-25349449

13.

A model-based analysis of culture-dependent phenotypes of mESCs.

Herberg, Maria; Kalkan, Tüzer; Glauche, Ingmar; Smith, Austin; Roeder, Ingo.

PLoS One; 9(3): e92496, 2014.

Artículo en Inglés | MEDLINE | ID: mdl-24643025

14.

Otx2 and Oct4 drive early enhancer activation during embryonic stem cell transition from naive pluripotency.

Yang, Shen-Hsi; Kalkan, Tüzer; Morissroe, Claire; Marks, Hendrik; Stunnenberg, Hendrik; Smith, Austin; Sharrocks, Andrew D.

Cell Rep; 7(6): 1968-81, 2014 Jun 26.

Artículo en Inglés | MEDLINE | ID: mdl-24931607

15.

NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment.

Reynolds, Nicola; Latos, Paulina; Hynes-Allen, Antony; Loos, Remco; Leaford, Donna; O'Shaughnessy, Aoife; Mosaku, Olukunbi; Signolet, Jason; Brennecke, Philip; Kalkan, Tüzer; Costello, Ita; Humphreys, Peter; Mansfield, William; Nakagawa, Kentaro; Strouboulis, John; Behrens, Axel; Bertone, Paul; Hendrich, Brian.

Cell Stem Cell; 10(5): 583-94, 2012 May 04.

Artículo en Inglés | MEDLINE | ID: mdl-22560079

16.

Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation.

Wray, Jason; Kalkan, Tüzer; Gomez-Lopez, Sandra; Eckardt, Dominik; Cook, Andrew; Kemler, Rolf; Smith, Austin.

Nat Cell Biol; 13(7): 838-45, 2011 Jun 19.

Artículo en Inglés | MEDLINE | ID: mdl-21685889

17.

Erratum to: Dynamics of gene silencing during X inactivation using allele-specific RNA-seq.

Marks, Hendrik; Kerstens, Hindrik H D; Barakat, Tahsin Stefan; Splinter, Erik; Dirks, René A M; van Mierlo, Guido; Joshi, Onkar; Wang, Shuang-Yin; Babak, Tomas; Albers, Cornelis A; Kalkan, Tüzer; Smith, Austin; Jouneau, Alice; de Laat, Wouter; Gribnau, Joost; Stunnenberg, Hendrik G.

Genome Biol; 17: 22, 2016 Feb 05.

Artículo en Inglés | MEDLINE | ID: mdl-26850229

18.

Tumor necrosis factor-receptor-associated factor-4 is a positive regulator of transforming growth factor-beta signaling that affects neural crest formation.

Kalkan, Tuzer; Iwasaki, Yasuno; Park, Chong Yon; Thomsen, Gerald H.

Mol Biol Cell; 20(14): 3436-50, 2009 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-19458200

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