RESUMEN
Regulatory T cells (T(reg)) have an essential role in maintaining immune tolerance in the gut. The functional CD4(+) T(reg) express the transcription factor forkhead box protein 3 (FoxP3) or a CD25(high) in humans. Further, depletion of elevated granulocytes/monocytes by extracorporeal adsorption (GMA) induces immunomodulation in patients with ulcerative colitis (UC). We investigated the impact of GMA on T(reg). Thirty-one UC patients, clinical activity index (CAI) 12.1 +/- 2.97, refractory to conventional medications including intravenous corticosteroid and 13 healthy controls (HC), were included. Patients received five GMA sessions over 5 weeks. Biopsies from the rectal mucosa and blood samples at baseline and post-GMA were immunostained with anti-CD4/FoxP3 and anti-CD4/CD25 antibodies for immunohistochemistry and flow cytometry. Following GMA, 22 of 31 patients achieved remission (CAI Asunto(s)
Antígenos CD4/análisis
, Colitis Ulcerosa/inmunología
, Factores de Transcripción Forkhead/análisis
, Subunidad alfa del Receptor de Interleucina-2/análisis
, Linfocitos T Reguladores/inmunología
, Adsorción
, Adulto
, Estudios de Casos y Controles
, Colitis Ulcerosa/tratamiento farmacológico
, Colitis Ulcerosa/terapia
, Femenino
, Citometría de Flujo
, Glucocorticoides/uso terapéutico
, Granulocitos/fisiología
, Humanos
, Inmunohistoquímica
, Leucaféresis
, Masculino
, Persona de Mediana Edad
, Monocitos/fisiología
, Estadísticas no Paramétricas
, Resultado del Tratamiento