RESUMEN
The efficient generation of high-quality random numbers is essential in the operation of cryptographic modules. The quality of a random number generator is evaluated by the min-entropy of its entropy source. The typical method used to achieve high min-entropy of the output sequence is an entropy accumulation based on a hash function. This is grounded in the famous Leftover Hash Lemma, which guarantees a lower bound on the min-entropy of the output sequence. However, the hash function-based entropy accumulation has slow speed in general. For a practical perspective, we need a new efficient entropy accumulation with the theoretical background for the min-entropy of the output sequence. In this work, we obtain the theoretical bound for the min-entropy of the output random sequence through the very efficient entropy accumulation using only bitwise XOR operations, where the input sequences from the entropy source are independent. Moreover, we examine our theoretical results by applying them to the quantum random number generator that uses dark shot noise arising from image sensor pixels as its entropy source.
RESUMEN
Acquired hemophilia is a rare disorder caused by autoantibodies to factor VIII (FVIII) (also referred to as factor VIII inhibitors or anti-FVIII) and may be associated with pregnancy, underlying malignancy, or autoimmune disorders. A 33-month-old girl who presented with hematochezia and ecchymotic skin lesions was diagnosed with Mycoplasma pneumoniae pneumonia by serology and polymerase chain reaction. Hematologic studies showed a prolonged activated partial thromboplastin time (aPTT), partially corrected mixing test for aPTT, reduced levels of FVIII, and the presence of antibodies against FVIII. She was treated conservatively with prednisone and intravenous immunoglobulin (IVIG) without FVIII transfusion and recovered without sequelae. This report provides the first description of acquired hemophilia due to anti-FVIII in association with M. pneumoniae in Korea. We discuss this case in the context of the current literature on acquired hemophilia in children.