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1.

Ibuprofen, Flurbiprofen, Etoricoxib or Paracetamol Do Not Influence ACE2 Expression and Activity In Vitro or in Mice and Do Not Exacerbate In-Vitro SARS-CoV-2 Infection.

de Bruin, Natasja; Schneider, Ann-Kathrin; Reus, Philipp; Talmon, Sonja; Ciesek, Sandra; Bojkova, Denisa; Cinatl, Jindrich; Lodhi, Imran; Charlesworth, Bruce; Sinclair, Simon; Pennick, Graham; Laughey, William F; Gribbon, Philip; Kannt, Aimo; Schiffmann, Susanne.

Int J Mol Sci; 23(3)2022 Jan 19.

Artículo en Inglés | MEDLINE | ID: mdl-35162972

2.

AMPKß1 and AMPKß2 define an isoform-specific gene signature in human pluripotent stem cells, differentially mediating cardiac lineage specification.

Ziegler, Nicole; Bader, Erik; Epanchintsev, Alexey; Margerie, Daniel; Kannt, Aimo; Schmoll, Dieter.

J Biol Chem; 295(51): 17659-17671, 2020 12 18.

Artículo en Inglés | MEDLINE | ID: mdl-33454005

3.

The Novel Phosphate and Bile Acid Sequestrant Polymer SAR442357 Delays Disease Progression in a Rat Model of Diabetic Nephropathy.

Castañeda, Tamara R; Méndez, María; Davison, Ian; Elvert, Ralf; Schwahn, Uwe; Boldina, Galina; Rocher, Corinne; Scherer, Petra; Singh, Kuldeep; Bangari, Dinesh S; Falkenhahn, Mechthilde; Kannt, Aimo; Konkar, Anish; Larsen, Philip J; Arbeeny, Cynthia; Dhal, Pradeep K; Hübschle, Thomas.

J Pharmacol Exp Ther; 376(2): 190-203, 2021 02.

Artículo en Inglés | MEDLINE | ID: mdl-33203659

4.

Mastiha has efficacy in immune-mediated inflammatory diseases through a microRNA-155 Th17 dependent action.

Amerikanou, Charalampia; Papada, Efstathia; Gioxari, Aristea; Smyrnioudis, Ilias; Kleftaki, Stamatia-Angeliki; Valsamidou, Evdokia; Bruns, Victoria; Banerjee, Rajarshi; Trivella, Maria Giovanna; Milic, Natasa; Medic-Stojanoska, Milica; Gastaldelli, Amalia; Kannt, Aimo; Dedoussis, George V; Kaliora, Andriana C.

Pharmacol Res; 171: 105753, 2021 09.

Artículo en Inglés | MEDLINE | ID: mdl-34224858

5.

Effects of Whole-Body Adenylyl Cyclase 5 (Adcy5) Deficiency on Systemic Insulin Sensitivity and Adipose Tissue.

Dommel, Sebastian; Hoffmann, Anne; Berger, Claudia; Kern, Matthias; Klöting, Nora; Kannt, Aimo; Blüher, Matthias.

Int J Mol Sci; 22(9)2021 Apr 21.

Artículo en Inglés | MEDLINE | ID: mdl-33919448

6.

Novel Inhibitors of Nicotinamide-N-Methyltransferase for the Treatment of Metabolic Disorders.

Kannt, Aimo; Rajagopal, Sridharan; Hallur, Mahanandeesha S; Swamy, Indu; Kristam, Rajendra; Dhakshinamoorthy, Saravanakumar; Czech, Joerg; Zech, Gernot; Schreuder, Herman; Ruf, Sven.

Molecules; 26(4)2021 Feb 13.

Artículo en Inglés | MEDLINE | ID: mdl-33668468

7.

Incretin combination therapy for the treatment of non-alcoholic steatohepatitis.

Kannt, Aimo; Madsen, Andreas Nygaard; Kammermeier, Claire; Elvert, Ralf; Klöckener, Tim; Bossart, Martin; Haack, Torsten; Evers, Andreas; Lorenz, Katrin; Hennerici, Wolfgang; Rocher, Corinne; Böcskei, Zsolt; Guillemot, Jean-Claude; Mikol, Vincent; Pattou, Francois; Staels, Bart; Wagner, Michael.

Diabetes Obes Metab; 22(8): 1328-1338, 2020 08.

Artículo en Inglés | MEDLINE | ID: mdl-32196896

8.

Identification and characterisation of carnostatine (SAN9812), a potent and selective carnosinase (CN1) inhibitor with in vivo activity.

Qiu, Jiedong; Hauske, Sibylle J; Zhang, Shiqi; Rodriguez-Niño, Angelica; Albrecht, Thomas; Pastene, Diego O; van den Born, Jacob; van Goor, Harry; Ruf, Sven; Kohlmann, Markus; Teufel, Michael; Krämer, Bernhard K; Hammes, Hans-Peter; Peters, Verena; Yard, Benito A; Kannt, Aimo.

Amino Acids; 51(1): 7-16, 2019 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-29922921

9.

Running on mixed fuel-dual agonistic approach of GLP-1 and GCG receptors leads to beneficial impact on body weight and blood glucose control: A comparative study between mice and non-human primates.

Elvert, Ralf; Herling, Andreas W; Bossart, Martin; Weiss, Tilo; Zhang, Baohong; Wenski, Pierre; Wandschneider, Jörn; Kleutsch, Sabrina; Butty, Uwe; Kannt, Aimo; Wagner, Michael; Haack, Torsten; Evers, Andreas; Dudda, Angela; Lorenz, Martin; Keil, Stefanie; Larsen, Philip J.

Diabetes Obes Metab; 20(8): 1836-1851, 2018 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-29938884

10.

Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase.

Ruf, Sven; Hallur, Mahanandeesha Siddappa; Anchan, Nisha K; Swamy, Indu N; Murugesan, Karthikai Raj; Sarkar, Sayantani; Narasimhulu, Lokesh Kananti; Putta, V P Rama Kishore; Shaik, Shama; Chandrasekar, Devaraj Venkatapura; Mane, Vishal Subhash; Kadnur, Sanjay Venkatachalapathi; Suresh, Juluri; Bhamidipati, Ravi Kanth; Singh, Manvi; Burri, Raghunadha Reddy; Kristam, Rajendra; Schreuder, Herman; Czech, Joerg; Rudolph, Christine; Marker, Alexander; Langer, Thomas; Mullangi, Ramesh; Yura, Takeshi; Gosu, Ramachandraiah; Kannt, Aimo; Dhakshinamoorthy, Saravanakumar; Rajagopal, Sridharan.

Bioorg Med Chem Lett; 28(5): 922-925, 2018 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-29433927

11.

GPR17 gene disruption does not alter food intake or glucose homeostasis in mice.

Mastaitis, Jason; Min, Soo; Elvert, Ralf; Kannt, Aimo; Xin, Yurong; Ochoa, Francisca; Gale, Nicholas W; Valenzuela, David M; Murphy, Andrew J; Yancopoulos, George D; Gromada, Jesper.

Proc Natl Acad Sci U S A; 112(6): 1845-9, 2015 Feb 10.

Artículo en Inglés | MEDLINE | ID: mdl-25624481

12.

Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide.

Swaminathan, Srinivasan; Birudukota, Swarnakumari; Thakur, Manish Kumar; Parveen, Reejuana; Kandan, Saravanan; Juluri, Suresh; Shaik, Shama; Anand, Niranjan Naranapura; Burri, Raghunadha Reddy; Kristam, Rajendra; Hallur, Mahanandeesha Siddappa; Rajagopal, Sridharan; Schreuder, Herman; Langer, Thomas; Rudolph, Christine; Ruf, Sven; Dhakshinamoorthy, Saravanakumar; Gosu, Ramachandraiah; Kannt, Aimo.

Biochem Biophys Res Commun; 491(2): 416-422, 2017 09 16.

Artículo en Inglés | MEDLINE | ID: mdl-28720493

13.

Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling.

Winkel, Angelika F; Engel, Christian K; Margerie, Daniel; Kannt, Aimo; Szillat, Hauke; Glombik, Heiner; Kallus, Christopher; Ruf, Sven; Güssregen, Stefan; Riedel, Jens; Herling, Andreas W; von Knethen, Andreas; Weigert, Andreas; Brüne, Bernhard; Schmoll, Dieter.

J Biol Chem; 290(47): 28446-28455, 2015 Nov 20.

Artículo en Inglés | MEDLINE | ID: mdl-26459563

14.

Smoking and Other Risk Factors in Type 2 Diabetes.

Kannt, Aimo.

N Engl J Med; 379(26): 2574, 2018 Dec 27.

Artículo en Inglés | MEDLINE | ID: mdl-30586514

15.

Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance.

Kannt, Aimo; Pfenninger, Anja; Teichert, Lenore; Tönjes, Anke; Dietrich, Arne; Schön, Michael R; Klöting, Nora; Blüher, Matthias.

Diabetologia; 58(4): 799-808, 2015 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-25596852

16.

An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD).

Vacca, Michele; Kamzolas, Ioannis; Harder, Lea Mørch; Oakley, Fiona; Trautwein, Christian; Hatting, Maximilian; Ross, Trenton; Bernardo, Barbara; Oldenburger, Anouk; Hjuler, Sara Toftegaard; Ksiazek, Iwona; Lindén, Daniel; Schuppan, Detlef; Rodriguez-Cuenca, Sergio; Tonini, Maria Manuela; Castañeda, Tamara R; Kannt, Aimo; Rodrigues, Cecília M P; Cockell, Simon; Govaere, Olivier; Daly, Ann K; Allison, Michael; Honnens de Lichtenberg, Kristian; Kim, Yong Ook; Lindblom, Anna; Oldham, Stephanie; Andréasson, Anne-Christine; Schlerman, Franklin; Marioneaux, Jonathon; Sanyal, Arun; Afonso, Marta B; Younes, Ramy; Amano, Yuichiro; Friedman, Scott L; Wang, Shuang; Bhattacharya, Dipankar; Simon, Eric; Paradis, Valérie; Burt, Alastair; Grypari, Ioanna Maria; Davies, Susan; Driessen, Ann; Yashiro, Hiroaki; Pors, Susanne; Worm Andersen, Maja; Feigh, Michael; Yunis, Carla; Bedossa, Pierre; Stewart, Michelle; Cater, Heather L.

Nat Metab; 2024 Jun 12.

Artículo en Inglés | MEDLINE | ID: mdl-38867022

17.

Drug repurposing for the treatment of COVID-19: Targeting nafamostat to the lungs by a liposomal delivery system.

Reus, Philipp; Guthmann, Hadar; Uhlig, Nadja; Agbaria, Majd; Issmail, Leila; Eberlein, Valentina; Nordling-David, Mirjam M; Jbara-Agbaria, Doaa; Ciesek, Sandra; Bojkova, Denisa; Cinatl, Jindrich; Burger-Kentischer, Anke; Rupp, Steffen; Zaliani, Andrea; Grunwald, Thomas; Gribbon, Philip; Kannt, Aimo; Golomb, Gershon.

J Control Release; 364: 654-671, 2023 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-37939853

18.

Association Between Serum Carnosinase Concentration and Activity and Renal Function Impairment in a Type-2 Diabetes Cohort.

Qiu, Jiedong; Yard, Benito A; Krämer, Bernhard K; van Goor, Harry; van Dijk, Peter; Kannt, Aimo.

Front Pharmacol; 13: 899057, 2022.

Artículo en Inglés | MEDLINE | ID: mdl-35873562

19.

Analysis of 16 studies in nine rodent models does not support the hypothesis that diabetic polyuria is a main reason of urinary bladder enlargement.

Yesilyurt, Zeynep E; Matthes, Jan; Hintermann, Edith; Castañeda, Tamara R; Elvert, Ralf; Beltran-Ornelas, Jesus H; Silva-Velasco, Diana L; Xia, Ning; Kannt, Aimo; Christen, Urs; Centurión, David; Li, Huige; Pautz, Andrea; Arioglu-Inan, Ebru; Michel, Martin C.

Front Physiol; 13: 923555, 2022.

Artículo en Inglés | MEDLINE | ID: mdl-36003651

20.

Association of Dietary Patterns with MRI Markers of Hepatic Inflammation and Fibrosis in the MAST4HEALTH Study.

Amanatidou, Athina I; Kaliora, Andriana C; Amerikanou, Charalampia; Stojanoski, Stefan; Milosevic, Natasa; Vezou, Chara; Beribaka, Mirjana; Banerjee, Rajarshi; Kalafati, Ioanna-Panagiota; Smyrnioudis, Ilias; Kurth, Mary Jo; Kannt, Aimo; Francino, M Pilar; Visvikis-Siest, Sophie; Deloukas, Panos; Llorens, Carlos; Marascio, Fernando; Milic, Natasa; Medic-Stojanoska, Milica; Gastaldelli, Amalia; Trivella, Maria Giovanna; Dedoussis, George V.

Int J Environ Res Public Health; 19(2)2022 01 16.

Artículo en Inglés | MEDLINE | ID: mdl-35055797

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