Detalles de la búsqueda
1.
Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents.
Arch Toxicol;
2024 May 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-38789714
2.
Effect of Oxime Encapsulation on Acetylcholinesterase Reactivation: Pharmacokinetic Study of the Asoxime-Cucurbit[7]uril Complex in Mice Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry.
Mol Pharm;
18(6): 2416-2427, 2021 06 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34019427
3.
Development of versatile and potent monoquaternary reactivators of acetylcholinesterase.
Arch Toxicol;
95(3): 985-1001, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33517499
4.
HI-6 oxime (an acetylcholinesterase reactivator): blood plasma pharmacokinetics and organ distribution in experimental pigs.
Neuro Endocrinol Lett;
35 Suppl 2: 191-6, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25638385
5.
Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition.
Eur J Med Chem;
266: 116130, 2024 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38218127
6.
Pharmacokinetic study of two acetylcholinesterase reactivators, trimedoxime and newly synthesized oxime K027, in rat plasma.
J Appl Toxicol;
33(1): 18-23, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21717485
7.
Oximes: inhibitors of human recombinant acetylcholinesterase. A structure-activity relationship (SAR) study.
Int J Mol Sci;
14(8): 16882-900, 2013 Aug 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-23959117
8.
The measured CSF/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24 h after donepezil treatment in patients with Alzheimer's disease.
Biomed Pharmacother;
159: 114223, 2023 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-36630846
9.
Development of submicromolar 17ß-HSD10 inhibitors and their in vitro and in vivo evaluation.
Eur J Med Chem;
258: 115593, 2023 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37390508
10.
Combined approach to demonstrate acetylcholinesterase activity changes in the rat brain following tabun intoxication and its treatment.
Toxicol Mech Methods;
22(1): 60-6, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21851296
11.
The ability of oxime mixtures to increase the reactivating and therapeutic efficacy of antidotal treatment of cyclosarin poisoning in rats and mice.
Acta Medica (Hradec Kralove);
55(1): 27-31, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22696932
12.
Novel D2/5-HT receptor modulators related to cariprazine with potential implication to schizophrenia treatment.
Eur J Med Chem;
232: 114193, 2022 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35176563
13.
Changes of rat plasma total low molecular weight antioxidant level after tabun exposure and consequent treatment by acetylcholinesterase reactivators.
J Enzyme Inhib Med Chem;
26(1): 93-7, 2011 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-20569082
14.
A comparison of the neuroprotective efficacy of individual oxime (HI-6) and combinations of oximes (HI-6+trimedoxime, HI-6+K203) in soman-poisoned rats.
Drug Chem Toxicol;
34(3): 233-9, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-21649476
15.
A comparison of the reactivating and therapeutic efficacy of chosen combinations of oximes with individual oximes against VX in rats and mice.
Int J Toxicol;
30(5): 562-7, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22013137
16.
A comparison of reactivating and therapeutic efficacy of bispyridinium acetylcholinesterase reactivator KR-22934 with the oxime K203 and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
Toxicol Mech Methods;
21(3): 241-5, 2011 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21142778
17.
Memantine and Its Combination with Acetylcholinesterase Inhibitors in Pharmacological Pretreatment of Soman Poisoning in Mice.
Neurotox Res;
39(5): 1487-1494, 2021 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-34292503
18.
Determination of K869, a Novel Oxime Reactivator of Acetylcholinesterase, in Rat Body Fluids and Tissues by Liquid-Chromatography Methods: Pharmacokinetic Study.
J Pharm Sci;
110(4): 1842-1852, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33545185
19.
Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors.
Eur J Med Chem;
219: 113434, 2021 Jul 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33892271
20.
The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of tabun poisoning in rats and mice.
J Appl Toxicol;
30(2): 120-4, 2010 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19746406