Detalles de la búsqueda
1.
Cortical bone mineral density is increased by the cathepsin K inhibitor ONO-5334, which leads to a robust increase in bone strength: results from a 16-month study in ovariectomised cynomolgus monkeys.
J Bone Miner Metab;
37(4): 636-647, 2019 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-30357565
2.
Combination therapy with ONO-KK1-300-01, a cathepsin K inhibitor, and parathyroid hormone results in additive beneficial effect on bone mineral density in ovariectomized rats.
J Bone Miner Metab;
34(1): 33-40, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25762435
3.
Attenuation of Antiresorptive Action in Withdrawal of Minodronic Acid for Three Months After Treatment for Twelve Months in Ovariectomized Rats.
Calcif Tissue Int;
97(4): 402-11, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26048283
4.
Expression of CysLT2 receptors in asthma lung, and their possible role in bronchoconstriction.
Allergol Int;
64(4): 351-8, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26433531
5.
Effect of intermittent and daily regimens of minodronic Acid on bone metabolism in an ovariectomized rat model of osteoporosis.
Calcif Tissue Int;
95(2): 166-73, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24903232
6.
ONO-5334, a cathepsin K inhibitor, improves bone strength by preferentially increasing cortical bone mass in ovariectomized rats.
J Bone Miner Metab;
32(6): 645-52, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-24317478
7.
Effects of the Cathepsin K Inhibitor ONO-5334 and Concomitant Use of ONO-5334 with Methotrexate on Collagen-Induced Arthritis in Cynomolgus Monkeys.
Int J Rheumatol;
2019: 5710340, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-30906325
8.
Discovery of long-acting N-(cyanomethyl)-N-alkyl-L-prolinamide inhibitors of dipeptidyl peptidase IV.
Bioorg Med Chem;
16(1): 190-208, 2008 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17962025
9.
Neutrophil elastase activity in acute lung injury and respiratory distress syndrome.
Respirology;
13(4): 581-4, 2008 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-18410258
10.
Increased expression of CysLT2 receptors in the lung of asthmatic mice and role in allergic responses.
Prostaglandins Leukot Essent Fatty Acids;
131: 24-31, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29628047
11.
Inhibition of neutrophil elastase attenuates gut mucosal injury evoked by acute alveolar hypoxia in rabbits.
Shock;
28(1): 101-5, 2007 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-17483739
12.
CysLT2 receptor activation is involved in LTC4-induced lung air-trapping in guinea pigs.
Eur J Pharmacol;
794: 147-153, 2017 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-27887950
13.
A new CysLT1 and CysLT2 receptors-mediated anaphylaxis guinea pig model.
Prostaglandins Leukot Essent Fatty Acids;
119: 18-24, 2017 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-28410666
14.
Minodronic acid ameliorates vertebral bone strength by increasing bone mineral density in 9-month treatment of ovariectomized cynomolgus monkeys.
Bone;
88: 157-164, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27155564
15.
Effects of 16-month treatment with the cathepsin K inhibitor ONO-5334 on bone markers, mineral density, strength and histomorphometry in ovariectomized cynomolgus monkeys.
Bone;
86: 43-52, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26921823
16.
Induction of creatine kinase release from cultured osteoclasts via the pharmacological action of aminobisphosphonates.
Springerplus;
4: 59, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25664231
17.
Leukotriene C4 induces bronchoconstriction and airway vascular hyperpermeability via the cysteinyl leukotriene receptor 2 in S-hexyl glutathione-treated guinea pigs.
Eur J Pharmacol;
754: 98-104, 2015 May 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-25704617
18.
IOP-Lowering Effect of ONO-9054, A Novel Dual Agonist of Prostanoid EP3 and FP Receptors, in Monkeys.
Invest Ophthalmol Vis Sci;
56(4): 2547-52, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25788650
19.
Effects of ONO-6950, a novel dual cysteinyl leukotriene 1 and 2 receptors antagonist, in a guinea pig model of asthma.
Eur J Pharmacol;
765: 242-8, 2015 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26318198
20.
The role of neutrophil elastase in acute lung injury.
Eur J Pharmacol;
451(1): 1-10, 2002 Sep 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-12223222