RESUMEN
Objective: Febrile seizure is the most common worrisome neurologic disorder in children in terms of parental point of view. The purpose of this study was to answer distressing parents' questions about the prevalence and possibility of febrile seizure recurrence. Materials & Methods: 140 patients who were admitted due to the first febrile seizure in the six months (March up to September) of the year 2015 were enrolled to this study. Exclusion criteria include central nervous system infection, non-confirmed febrile seizure and lack of parental acceptance forlong-term inclusion in this study. All children were followed in terms of second febrile seizure during one year follow-up from the time of first febrile seizure. (3 sentences were deleted). Results: Recurrence of febrile seizure was 25.7 % during one-year follow-up. Significant risk factors for recurrence include: age less than one year old, male gender, seizure with low level of fever, family history of epilepsy, family history of febrile seizure, complex febrile seizure (focal and repeated in 24 hours), seizure duration more than 15 minutes and parental indifference to the onset of fever in their children before seizure occurrence. Although duration of fever before seizure, failureto thrive, positive history of admission in neonatal period, dystocia at birth delivery and children with day care staying were associated with greater febrile seizure recurrence; but, they did not have significant relationship with recurrence rate. Prophylaxis with benzodiazepine reduced the recurrence rate. Conclusion: Chance of febrile seizure recurrence in one-year follow-up increased in presence of risk factors expressed in finding part. Parental indifference to the onset of fever in their children that is starting before seizure was a considerable risk factor in terms of recurrence prevalence. We recommended to emphasis on parental education about this new finding as a risk factor for febrile seizure in order to prevent its future recurrence.
RESUMEN
BACKGROUND AND OBJECTIVE: Vitamin D deficiency during pregnancy has important health implications for the mother and infant. This study was designed to determine the prevalence of hypovitaminosis D in pregnancy and to examine the probable correlation between serum concentrations of 25-hydroxyvitamin D [25(OH)D] in maternal blood and in neonates' cord blood. As yet, few studies have examined this phenomenon in the Iranian population; thus, this research adds to a small body of literature. METHODS: Sixty-seven full-term pregnant mothers were enrolled serially from a referring general hospital in Zanjan, a province located west of Tehran. All participating mothers delivered their babies via typical vaginal delivery. Samples of maternal and cord blood were collected on the day of delivery. Serum concentrations of calcium, phosphorus, 25(OH)D and alkaline phosphatase were measured in the samples. 25(OH)D concentrations <25 nmol/L were considered to be indicative of hypovitaminosis D. RESULTS: Mean maternal serum 25(OH)D was 19.4 +/- 3.9 nmol/L, and cord blood 25(OH)D was 16.7 +/- 2.9 nmol/L. Hypovitaminosis D was detected in 86% of the women and in 75% of the newborns during winter and 46% of the mothers and 35% of the newborns during summer. A positive correlation was found between maternal and cord blood 25(OH)D (r = 0.55, p < 0.001). CONCLUSIONS: We observed a high prevalence of physiologically significant hypovitaminosis D among pregnant women and their newborns, the magnitude of which warrants public health intervention.