RESUMEN
BACKGROUND: This prospective multicenter randomized clinical trial was designed to evaluate the long-term angiographic and clinical outcomes of elective treatment with the GR-II stent compared with the Palmaz-Schatz (PS) stent in patients with coronary stenoses. METHODS AND RESULTS: Seven hundred fifty-five patients with myocardial ischemia and de novo native coronary stenoses in 3- to 4-mm vessels were randomly assigned to the PS (375 patients) or the GR-II stent (380 patients). The primary end point was 12-month target lesion revascularization (TLR)-free survival. Angiography was performed at baseline and at follow-up in the first 300 consecutive patients to assess the frequency of angiographic restenosis. Procedure success was 98.5% for the GR-II stent and 99.4% for the PS stent (P:=0.19). At 30 days, patients assigned to the GR-II stent had a higher stent thrombosis rate (3.9% versus 0.3% for PS stent, P:<0.001) and TLR rate (3.9% versus 0.5% for PS stent, P:<0.001). The GR-II group had a higher follow-up restenosis frequency (47.3% versus 20.6% for the PS group, P:<0.001) and a lower 12-month TLR-free survival rate (71.7% versus 83.9% for the PS group, P:<0. 001). Multivariate logistic regression analysis identified a smaller final stent minimal lumen diameter (odds ratio [OR] 2.49, 95% CI 1. 56 to 3.98; P:<0.001), diabetes mellitus (OR 2.14, 95% CI 1.42 to 3. 22; P:<0.001), and use of the GR-II stent (OR 1.78, 95% CI 1.20 to 2. 64; P:<0.01) as independent determinants of 12-month TLR. CONCLUSIONS: On the basis of these long-term follow-up data, we conclude that use of the GR-II stent should be limited to the acute treatment of abrupt or threatened closure after failed conventional balloon angioplasty procedures.
Asunto(s)
Enfermedad Coronaria/terapia , Trombosis Coronaria/etiología , Stents , Análisis de Varianza , Angiografía Coronaria , Enfermedad Coronaria/mortalidad , Complicaciones de la Diabetes , Supervivencia sin Enfermedad , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Recurrencia , Análisis de Regresión , Stents/efectos adversos , Resultado del TratamientoRESUMEN
Sixty-one full-term, appropriate-weight black newborns had higher heart rates, replicating a racial heart rate difference, but did not differ significantly in systolic blood pressure from 71 white newborns. Systolic blood pressure in the newborn is related both to the total number of feedings from birth and to the total fluid intake.
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Población Negra , Presión Sanguínea , Frecuencia Cardíaca , Recién Nacido , Población Blanca , Humanos , Sueño , Clase Social , Estados UnidosRESUMEN
Calving and weaning data from crossbred calves sired by five Bos indicus breeds and one Bos taurus breed were evaluated. Data included calving and weaning records of F1 calves out of multiparous Hereford cows and sired by Angus, Gray Brahman, Gir, Indu-Brazil, Nellore, and Red Brahman bulls. At calving, Angus-sired calves had shorter gestations and lower (more desirable) calving ease scores and were smaller than Bos indicus-sired calves. Among the Bos indicus crosses, Gir calves had the shortest gestations, lowest calving ease scores, lightest birth weights (P less than .05), and smallest cannon bone lengths and heart girths. Nellore calves had the longest gestations (P less than .05) and largest heart girths. Calves by Indu-Brazil sires had the highest calving ease scores, highest birth weights (P less than .05), and greatest cannon bone lengths (P less than .05). Gray Brahman- and Red Brahman-sired calves were similar and intermediate for all calving characters. At weaning, Angus-sired calves had gained slightly faster than the Gir crosses and weighed more but were shorter at the hip than Gir crosses. Gir calves gained the least preweaning, weighed the least, and were shortest at weaning of the Bos indicus crosses. The Nellore and Indu-Brazil crosses were intermediate in preweaning gain and weaning weight to the Gir and the Red and Gray Brahman but were tallest at weaning. Gray Brahman and Red Brahman calves gained the most and were heaviest at weaning but were not as tall as the Nellore and Indu-Brazil.
Asunto(s)
Cruzamiento , Bovinos/fisiología , Trabajo de Parto/genética , Destete , Animales , Peso al Nacer/genética , Bovinos/genética , Bovinos/crecimiento & desarrollo , Enfermedades de los Bovinos/genética , Distocia/genética , Distocia/veterinaria , Femenino , Análisis de los Mínimos Cuadrados , Masculino , Embarazo , Caracteres SexualesRESUMEN
Postweaning, feedlot, and carcass data from crossbred calves sired by five Bos indicus breeds and one Bos taurus breed were evaluated. Data included records from F1 calves out of multiparous Hereford cows sired by Angus, Gray Brahman, Gir, Indu-Brazil, Nellore, and Red Brahman bulls. The Zebu crosses grew faster postweaning and were heavier and taller as yearlings than the Angus crosses (P < .05). Among the Zebu-sired calves, the Red and Gray Brahman crosses were faster gaining and were heavier at a year of age than the Gir, Indu-Brazil, and Nellore. The Nellore crosses were significantly taller than the Gray Brahman- and Gir-sired crosses; the Indu-Brazil and Red Brahman were intermediate. Angus crosses were lightest on and off feed but were not significantly different from Gir, and Red and Gray Brahman were heaviest (P < .05). The Nellore and Indu-Brazil were similar in initial weight, but Indu-Brazil calves were similar to Red and Gray Brahman for final weight. The Angus cross was more desirable (P < .05) in marbling score and quality grade although the Nellore crosses had the most desirable score and grade of the Zebu crosses. Gir crosses had higher skeletal maturity scores (P < .05) than Nellore, Gray Brahman, Indu-Brazil, and Angus crosses; Red Brahman crosses were intermediate Angus crosses had the lightest carcasses but not significantly lighter than the Indu-Brazil, Gir, or Nellore. Red Brahman-cross carcasses were heaviest and Gray Brahman-cross carcasses were intermediate.(ABSTRACT TRUNCATED AT 250 WORDS)
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Envejecimiento/fisiología , Composición Corporal/fisiología , Peso Corporal/fisiología , Cruzamiento , Bovinos/crecimiento & desarrollo , Animales , Bovinos/genética , Bovinos/fisiología , Cruzamientos Genéticos , Femenino , Análisis de los Mínimos Cuadrados , Masculino , Desarrollo de Músculos , Músculo Esquelético/anatomía & histología , Músculo Esquelético/crecimiento & desarrollo , Aumento de Peso/fisiologíaAsunto(s)
Encéfalo/fisiología , Condicionamiento Psicológico/fisiología , Tálamo/fisiología , Estimulación Acústica , Animales , Corteza Auditiva/fisiología , Gatos , Corteza Cerebral/fisiología , Electrodos Implantados , Potenciales Evocados , Femenino , Cuerpos Geniculados/fisiología , Colículos Inferiores/fisiología , Estimulación Luminosa , Formación Reticular/fisiología , Colículos Superiores/fisiología , Corteza Visual/fisiologíaRESUMEN
Click stimuli were presented during sleep to newborns from a low socioeconomic class urban population in Northeastern United States. Eighty-three black newborns showed less immediate poststimulus deceleration than did 67 white newborns. This difference was independent of heart rate level, and could not be accounted for by any of the perinatal variables studied, including birthweight and gestational age. These results suggest that in this population, black newborns differ from white newborns in the pattern of phasic heart rate responses to stimuli. This constitutes evidence for an additional difference in heart rate regulation in black as compared to white newborns from this population, since prior work reported differences in tonic heart rate level during sleep between black and white newborns.