RESUMEN
Background : Pharmacist-led transitions of care between hospital and community settings have been associated with decreased hospitalizations. Little data is available on the optimal conditions for their implantation.Purpose of research : The study aims to analyze the implementation of a pharmacist-led transition of care intervention among older adults with drug-related problems. The objectives are to describe the main characteristics of the intervention and to identify the facilitators and the barriers to its implementation.Methods : A single case study design including individual interviews (n = 10 interviews) and document analysis was preferred. Damschroder’s conceptual implementation framework guided the analysis.Results : The main characteristics of the intervention are the interdisciplinary collaboration and clarity of the involved professional’s roles, the time dedicated to the intervention and the improvement of interdisciplinary communication mechanisms. The implementation facilitators include the availability of leaders and clinical champion, as well as the perception and collaboration of professionals. The Barriers include the limitations in integrating the intervention into routine care in terms of time and resources, the adoption and lack of skills in using an electronic medical record and the difficult access to some patients for follow-ups.Conclusions : The analysis of the main characteristics of the intervention, the facilitators and the barriers to its implementation demonstrate the feasibility of this pharmacist-led transition of care intervention and the issues associated with its integration into routine care in the Canadian health system.
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Servicios Farmacéuticos , Farmacéuticos , Humanos , Anciano , Investigación Cualitativa , CanadáRESUMEN
BACKGROUND: There is considerable heterogeneity in studies on prenatal risk factors for congenital heart diseases (CHDs). We performed a meta-analyse of all non-genetic factors of CHDs. This report presents results of factors related to maternal chronic diseases and parental exposures. METHODS: A systematic search encompassing concepts of CHD and risk factors was used, using the following inclusion criteria: (1) original peer-reviewed articles, (2) quantifying the effects of risk factors for CHDs, (3) between 1989 and 2022. Pooled odds ratios (OR) and 95% confidence interval (CI) were calculated using a random effect model. RESULTS: Inclusion criteria were met for 170 studies. There was an association between being overweight/obese and CHDs (OR 1.26; 95% CI 1.15-1.37), with a dose-effect relationship. Pregestational diabetes (PGDM) was associated with CHDs (OR 3.51; 95% CI 2.86-4.3), without difference between type I and type II PGDM. The effect size of gestational diabetes was less than that of PGDM (OR 1.38;95% CI: 1.18-1.61). There was an association between CHDs and preeclampsia (OR 2.01; 95% CI 1.32-3.05), and paternal smoking (OR 1.32; 95% CI 1.03-1.70) and alcohol use (OR 1.50; 95%CI 1.08-2.08). A smaller association was found with maternal smoking and advanced maternal age. CONCLUSIONS: There exists robust evidence for increased risk of CHD in the presence of obesity, maternal diabetes, maternal smoking and increased maternal age. The effect sizes were relatively modest, except for PGDM. The robustness of the evidence decreased when CHDs were divided into subgroups, or when the analyses were restricted to severe CHDs.
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BACKGROUND: Transitions of care (TOC) is one of three key action areas identified in the World Health Organization (WHO)'s third Global Patient Safety Challenge, Medication Without Harm, released in 2017. Systematic reviews have shown that TOC interventions can improve health outcomes, although few studies have evaluated the role of the community pharmacist. OBJECTIVE: To evaluate the feasibility of a pharmacist-led TOC intervention for older adults at risk of drug-related problems. METHODS: Pragmatic feasibility study conducted in hospital and community pharmacies in a health region of Quebec, Canada. The interventions consisted of a pharmaceutical care plan developed by the hospital pharmacist and transferred at hospital discharge to the patients' community pharmacist, who completed patient consultations in the week following discharge and monthly for six months thereafter. Feasibility evaluations included recruitment, retention, time required, types of interventions, and modified classes of medications, based on clinical data entered in an electronic health record accessible to clinicians in all settings. RESULTS: Of the 90 recruited patients, 76 were discharged with a pharmaceutical care plan. The mean age of these 76 subjects was 79.5 years, and 52.6% were female. The most frequent inclusion criteria were 15 or more medications (57.9%), two or more emergency department visits (past three months), or one or more hospitalization (past twelve months) (42.1%). The hospital pharmacist interventions took a mean time of 222 min. The community pharmacist interventions took a mean time of 52 min and 32 min for the first and subsequent visits, respectively. Therapeutic goals were documented for 60.5% of patients. CONCLUSIONS: This study shows the feasibility of implementing a pharmacist-led TOC intervention in the Canadian context. Development of the TOC model in three health regions is currently being pursued along with the inclusion of primary care clinics who recently added pharmacists to their interdisciplinary teams.