RESUMEN
OBJECTIVE: To find out the possible effects of paroxetine on gastrointestinal smooth muscles in vitro as they can cause severe nausea and vomiting at the start of therapy which later settles down. METHODS: Power lab (USA) was used for recording the contractions of ileal smooth muscle of rabbits in response to acetylcholine, serotonin and paroxetine. RESULTS: The percent responses with acetylcholine, serotonin and paroxetine were 100, 158.7 and 6.45 percent respectively indicating that acetylcholine and serotonin causes an increase in contractility of isolated ileal smooth muscle in comparison to paroxetine which has a depressant effect on motility. CONCLUSIONS: Inability of paroxetine to enhance the serotonergic transmission in vitro causes a decrease in its qualitative response.