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1.

Synthesis of NVS-BPTF-1 and evaluation of its biological activity.

Mélin, Léa; Calosing, Cyrus; Kharenko, Olesya A; Hansen, Henrik C; Gagnon, Alexandre.

Bioorg Med Chem Lett; 47: 128208, 2021 09 01.

Artículo en Inglés | MEDLINE | ID: mdl-34146702

2.

Novel approaches to targeting BRD4.

Kharenko, Olesya A; Hansen, Henrik C.

Drug Discov Today Technol; 24: 19-24, 2017 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-29233295

3.

RVX-297- a novel BD2 selective inhibitor of BET bromodomains.

Kharenko, Olesya A; Gesner, Emily M; Patel, Reena G; Norek, Karen; White, Andre; Fontano, Eric; Suto, Robert K; Young, Peter R; McLure, Kevin G; Hansen, Henrik C.

Biochem Biophys Res Commun; 477(1): 62-67, 2016 08 12.

Artículo en Inglés | MEDLINE | ID: mdl-27282480

4.

Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design.

Duffy, Bryan C; Liu, Shuang; Martin, Gregory S; Wang, Ruifang; Hsia, Ming Min; Zhao, He; Guo, Cheng; Ellis, Michael; Quinn, John F; Kharenko, Olesya A; Norek, Karen; Gesner, Emily M; Young, Peter R; McLure, Kevin G; Wagner, Gregory S; Lakshminarasimhan, Damodharan; White, Andre; Suto, Robert K; Hansen, Henrik C; Kitchen, Douglas B.

Bioorg Med Chem Lett; 25(14): 2818-23, 2015 Jul 15.

Artículo en Inglés | MEDLINE | ID: mdl-26022843

5.

Molecular mechanisms in the activation of abscisic acid receptor PYR1.

Dorosh, Lyudmyla; Kharenko, Olesya A; Rajagopalan, Nandhakishore; Loewen, Michele C; Stepanova, Maria.

PLoS Comput Biol; 9(6): e1003114, 2013.

Artículo en Inglés | MEDLINE | ID: mdl-23825939

6.

Identification and characterization of interactions between abscisic acid and mitochondrial adenine nucleotide translocators.

Kharenko, Olesya A; Boyd, Jason; Nelson, Ken M; Abrams, Suzanne R; Loewen, Michele C.

Biochem J; 437(1): 117-23, 2011 Jul 01.

Artículo en Inglés | MEDLINE | ID: mdl-21473740

7.

Combination of ZEN-3694 with CDK4/6 inhibitors reverses acquired resistance to CDK4/6 inhibitors in ER-positive breast cancer.

Kharenko, Olesya A; Patel, Reena G; Calosing, Cyrus; van der Horst, Edward H.

Cancer Gene Ther; 29(6): 859-869, 2022 06.

Artículo en Inglés | MEDLINE | ID: mdl-34385584

8.

Breaking boundaries: Pan BETi disrupt 3D chromatin structure, BD2-selective BETi are strictly epigenetic transcriptional regulators.

Tsujikawa, Laura M; Kharenko, Olesya A; Stotz, Stephanie C; Rakai, Brooke D; Sarsons, Christopher D; Gilham, Dean; Wasiak, Sylwia; Fu, Li; Sweeney, Michael; Johansson, Jan O; Wong, Norman C W; Kulikowski, Ewelina.

Biomed Pharmacother; 152: 113230, 2022 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-35687908

9.

Design and Synthesis of LM146, a Potent Inhibitor of PB1 with an Improved Selectivity Profile over SMARCA2.

Mélin, Léa; Gesner, Emily; Attwell, Sarah; Kharenko, Olesya A; van der Horst, Edward H; Hansen, Henrik C; Gagnon, Alexandre.

ACS Omega; 6(33): 21327-21338, 2021 Aug 24.

Artículo en Inglés | MEDLINE | ID: mdl-34471737

10.

Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine.

Kharenko, Olesya A; Patel, Reena G; Brown, S David; Calosing, Cyrus; White, Andre; Lakshminarasimhan, Damodharan; Suto, Robert K; Duffy, Bryan C; Kitchen, Douglas B; McLure, Kevin G; Hansen, Henrik C; van der Horst, Edward H; Young, Peter R.

J Med Chem; 61(18): 8202-8211, 2018 09 27.

Artículo en Inglés | MEDLINE | ID: mdl-30165024

11.

Metal-induced folding of a designed metalloprotein.

Kharenko, Olesya A; Ogawa, Michael Y.

J Inorg Biochem; 98(11): 1971-4, 2004 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-15522423

12.

Abscisic acid binds to recombinant Arabidopsis thaliana G-protein coupled receptor-type G-protein 1 in Sacaromycese cerevisiae and in vitro.

Kharenko, Olesya A; Choudhary, Pooja; Loewen, Michele C.

Plant Physiol Biochem; 68: 32-6, 2013 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-23624020

13.

Identification and characterization of interactions between abscisic acid and human heat shock protein 70 family members.

Kharenko, Olesya A; Polichuk, Devin; Nelson, Ken M; Abrams, Suzanne R; Loewen, Michele C.

J Biochem; 154(4): 383-91, 2013 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-23975754

14.

RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist.

McLure, Kevin G; Gesner, Emily M; Tsujikawa, Laura; Kharenko, Olesya A; Attwell, Sarah; Campeau, Eric; Wasiak, Sylwia; Stein, Adam; White, Andre; Fontano, Eric; Suto, Robert K; Wong, Norman C W; Wagner, Gregory S; Hansen, Henrik C; Young, Peter R.

PLoS One; 8(12): e83190, 2013.

Artículo en Inglés | MEDLINE | ID: mdl-24391744

15.

Evidence that a miniature CuI metalloprotein undergoes collisional electron transfer in the inverted Marcus region.

Hong, Jing; Kharenko, Olesya A; Fan, Jiufeng; Xie, Fei; Petros, Amy K; Gibney, Brian R; Ogawa, Michael Y.

Angew Chem Int Ed Engl; 45(37): 6137-40, 2006 Sep 18.

Artículo en Inglés | MEDLINE | ID: mdl-16927358

16.

Incorporating electron-transfer functionality into synthetic metalloproteins from the bottom-up.

Hong, Jing; Kharenko, Olesya A; Ogawa, Michael Y.

Inorg Chem; 45(25): 9974-84, 2006 Dec 11.

Artículo en Inglés | MEDLINE | ID: mdl-17140193

17.

Cu(I) luminescence from the tetranuclear Cu4S4 cofactor of a synthetic 4-helix bundle.

Kharenko, Olesya A; Kennedy, David C; Demeler, Borries; Maroney, Michael J; Ogawa, Michael Y.

J Am Chem Soc; 127(21): 7678-9, 2005 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-15913348

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