Not Who You Are, But Who You Are With: Re-examining Women's Less Satisfying Sexual Debuts.

Gender differences in appraisals of first intercourse are among the largest in sexuality research, with women indicating less satisfying "sexual debuts" than men. Dispositional or "actor-level" explanations for this gender gap are pervasive, yet research has largely examined heterosexual debuts in which actor gender and partner gender are confounded. We assessed whether women's less satisfying sexual debuts are better explained by actor gender or partner gender, comparing experiences of women who debuted with men (WDM) with those of men and women who debuted with women (MDW, WDW). Retrospective accounts of sexual debut were collected from 3033 adults. At first intercourse, we found that WDW had equal physical and emotional satisfaction to MDW, and more satisfaction than WDM, suggesting satisfaction gaps owing to partner gender, not actor gender. This pattern did not extend to a comparison event (first masturbation), where WDW and WDM had similar satisfaction, but less satisfaction than MDW, suggesting an actor gender gap. To identify sources of satisfaction gaps, we probed for corresponding differences in the circumstances of sexual debut. Sexual circumstances were more strongly implicated than nonsexual ones, with relative deprivation of glans stimulation explaining relative dissatisfaction at first intercourse, but not first masturbation, and orgasm explaining it at both. Findings challenge the view that the satisfaction gap at first intercourse reflects an inherent difference between genders. Indeed, they demonstrate similarities when partner gender does not differ and suggest strategies for ensuring equal sexual satisfaction-and equal sexual rights realization-at (hetero) sexual debut.

Machine learning uncovers the most robust self-report predictors of relationship quality across 43 longitudinal couples studies.

Given the powerful implications of relationship quality for health and well-being, a central mission of relationship science is explaining why some romantic relationships thrive more than others. This large-scale project used machine learning (i.e., Random Forests) to 1) quantify the extent to which relationship quality is predictable and 2) identify which constructs reliably predict relationship quality. Across 43 dyadic longitudinal datasets from 29 laboratories, the top relationship-specific predictors of relationship quality were perceived-partner commitment, appreciation, sexual satisfaction, perceived-partner satisfaction, and conflict. The top individual-difference predictors were life satisfaction, negative affect, depression, attachment avoidance, and attachment anxiety. Overall, relationship-specific variables predicted up to 45% of variance at baseline, and up to 18% of variance at the end of each study. Individual differences also performed well (21% and 12%, respectively). Actor-reported variables (i.e., own relationship-specific and individual-difference variables) predicted two to four times more variance than partner-reported variables (i.e., the partner's ratings on those variables). Importantly, individual differences and partner reports had no predictive effects beyond actor-reported relationship-specific variables alone. These findings imply that the sum of all individual differences and partner experiences exert their influence on relationship quality via a person's own relationship-specific experiences, and effects due to moderation by individual differences and moderation by partner-reports may be quite small. Finally, relationship-quality change (i.e., increases or decreases in relationship quality over the course of a study) was largely unpredictable from any combination of self-report variables. This collective effort should guide future models of relationships.

Understanding When a Partner Is Not in the Mood: Sexual Communal Strength in Couples Transitioning to Parenthood.

Situations in which one partner is interested in having sex but the other partner is not "in the mood" are common in relationships. We extend previous work on sexual communal strength-the motivation to be responsive to a partner's sexual needs-to demonstrate that in addition to the motivation to meet a partner's need to have sex, the motivation to be understanding about a partner's need not to engage in sex is uniquely associated with sexual and relationship satisfaction. In Study 1, we adapted a measure of sexual communal strength for having sex (SCSS) to create a new measure of sexual communal strength for not having sex (SCSN). We demonstrated that SCSN is distinct from SCSS and associated with more positive and less negative responses to an imagined situation of sexual rejection. In Study 2, both SCSS and SCSN were uniquely associated with greater sexual and relationship satisfaction in couples transitioning to parenthood-a time when many couples experience changes to their sexual relationship. Having a partner who is higher in SCSN is associated with greater sexual satisfaction and relationship quality for new mothers but not new fathers, suggesting that during the transition to parenthood, it might be more important for women to have a partner who is understanding about their need not to engage in sex. The results suggest that the motivation to be understanding about a partner's need not to engage in sex may be an additional way that partners can show communal care in their sexual relationships.

Orgasm Consistency in Mixed-Gender Couples: Actor, Partner, and Discrepancy Effects from Dyadic Response Surface Analysis.

The potential link between orgasm consistency (i.e., the percentage of time an individual experiences orgasm during sexual interactions with a partner) and sexual satisfaction in mixed-gender sexual relationships remains underexamined in the literature. We combined two dyadic samples (N = 725 couples) and utilized Dyadic Response Surface Analysis (DRSA) to examine how both partners' orgasm consistency and their discrepancy of orgasm consistency predict both partners' sexual satisfaction. We found that partners' discrepancy in orgasm consistency was not uniquely connected to higher sexual satisfaction for either women or men; rather, the overall consistency of orgasm was connected to better sexual satisfaction for both partners. In addition, there was some evidence tentatively suggesting that men were more likely than women to report lower sexual satisfaction if his partner was orgasming more consistently than he was, as opposed to her reporting lower sexual satisfaction from him orgasming more consistently than she was; though this appears to be a rare scenario as only 5.9% of couples had women who orgasmed more consistently than men. This study may assist educators and clinicians as they help couples consider the sexual scripts surrounding orgasm consistency, and how they can attend to each others' desires in a way that maximizes sexual satisfaction for both partners.

A video intervention to improve patient understanding of tumor genomic testing in patients with cancer.

INTRODUCTION: Tumor genomic testing (TGT) is standard-of-care for most patients with advanced/metastatic cancer. Despite established guidelines, patient education prior to TGT is frequently omitted. The purpose of this study was to evaluate the impact of a concise 4 min video for patient education prior to TGT. METHODS: Based on a quality improvement cycle, an animated video was created to be applicable to any cancer type, incorporating culturally diverse images, available in English and Spanish. Patients undergoing standard-of-care TGT were enrolled at a tertiary academic institution and completed survey instruments prior to video viewing (T1) and immediately post-viewing (T2). Instruments included: (1) 10-question objective genomic knowledge; (2) 10-question video message-specific knowledge; (3) 11-question Trust in Provider; (4) attitudes regarding TGT. RESULTS: A total of 150 participants were enrolled. For the primary objective, there was a significant increase in video message-specific knowledge (median 10 point increase; p < 0.0001) with no significant change in genomic knowledge/understanding (p = 0.89) or trust in physician/provider (p = 0.59). Results for five questions significantly improved, including the likelihood of TGT impact on treatment decision, incidental germline findings, and cost of testing. Improvement in video message-specific knowledge was consistent across demographic groups, including age, income, and education. CONCLUSIONS: A concise, 3-4 min, broadly applicable video incorporating culturally diverse images administered prior to TGT significantly improved video message-specific knowledge across all demographic groups. This resource is publicly available at http://www.tumor-testing.com, with a goal to efficiently educate and empower patients regarding TGT while addressing guidelines within the flow of clinical practice.

Half Empty and Half Full? Biased Perceptions of Compassionate Love and Effects of Dyadic Complementarity.

The prevailing theory on relationship judgments for interaction attributes suggests individuals tend to underestimate a romantic partner's expressions of compassionate love and that such underestimation is beneficial for the relationship. Yet, limited research has incorporated dyadic perspectives to assess how biased perceptions are associated with both partners' outcomes. In two daily studies of couples, we used distinct analytical approaches (Truth and Bias Model; Dyadic Response Surface Analysis) to inform perspectives on how biased perceptions are interrelated and predict relationship satisfaction. Consistent with prior research, people demonstrated an underestimation bias. However, there were differential effects of biased perceptions for actors versus partners: Underestimation predicted lower actor satisfaction but generally higher satisfaction for partners. Furthermore, we find evidence for complementarity effects: partners' directional biases were inversely related, and couples were more satisfied when partners had opposing patterns of directional bias. Findings help integrate theoretical perspectives on the adaptive role of biased relationship perceptions.

Literature-Based Discovery to Elucidate the Biological Links between Resistant Hypertension and COVID-19.

Multiple studies have reported new or exacerbated persistent or resistant hypertension in patients previously infected with COVID-19. We used literature-based discovery to identify and prioritize multi-scalar explanatory biology that relates resistant hypertension to COVID-19. Cross-domain text mining of 33+ million PubMed articles within a comprehensive knowledge graph was performed using SemNet 2.0. Unsupervised rank aggregation determined which concepts were most relevant utilizing the normalized HeteSim score. A series of simulations identified concepts directly related to COVID-19 and resistant hypertension or connected via one of three renin-angiotensin-aldosterone system hub nodes (mineralocorticoid receptor, epithelial sodium channel, angiotensin I receptor). The top-ranking concepts relating COVID-19 to resistant hypertension included: cGMP-dependent protein kinase II, MAP3K1, haspin, ral guanine nucleotide exchange factor, N-(3-Oxododecanoyl)-L-homoserine lactone, aspartic endopeptidases, metabotropic glutamate receptors, choline-phosphate cytidylyltransferase, protein tyrosine phosphatase, tat genes, MAP3K10, uridine kinase, dicer enzyme, CMD1B, USP17L2, FLNA, exportin 5, somatotropin releasing hormone, beta-melanocyte stimulating hormone, pegylated leptin, beta-lipoprotein, corticotropin, growth hormone-releasing peptide 2, pro-opiomelanocortin, alpha-melanocyte stimulating hormone, prolactin, thyroid hormone, poly-beta-hydroxybutyrate depolymerase, CR 1392, BCR-ABL fusion gene, high density lipoprotein sphingomyelin, pregnancy-associated murine protein 1, recQ4 helicase, immunoglobulin heavy chain variable domain, aglycotransferrin, host cell factor C1, ATP6V0D1, imipramine demethylase, TRIM40, H3C2 gene, COL1A1+COL1A2 gene, QARS gene, VPS54, TPM2, MPST, EXOSC2, ribosomal protein S10, TAP-144, gonadotropins, human gonadotropin releasing hormone 1, beta-lipotropin, octreotide, salmon calcitonin, des-n-octanoyl ghrelin, liraglutide, gastrins. Concepts were mapped to six physiological themes: altered endocrine function, 23.1%; inflammation or cytokine storm, 21.3%; lipid metabolism and atherosclerosis, 17.6%; sympathetic input to blood pressure regulation, 16.7%; altered entry of COVID-19 virus, 14.8%; and unknown, 6.5%.

An inexpensive drivable cannulated microelectrode array for simultaneous unit recording and drug infusion in the same brain nucleus of behaving rats.

Neurons are functionally segregated into discrete populations that perform specific computations. These computations, mediated by neuron-neuron electrochemical signaling, form the neural basis of behavior. Thus fundamental to a brain-based understanding of behavior is the precise determination of the contribution made by specific neurotransmitters to behaviorally relevant neural activity. To facilitate this understanding, we have developed a cannulated microelectrode array for use in behaving rats that enables simultaneous neural ensemble recordings and local infusion of drugs in the same brain nucleus. The system is inexpensive, easy to use, and produces robust and quantitatively reproducible drug effects on recorded neurons.

When Tonight Is Not the Night: Sexual Rejection Behaviors and Satisfaction in Romantic Relationships.

In most long-term romantic relationships, partners experience sexual conflicts of interest in which one partner declines the other partner's sexual advances. We investigated the distinct ways people reject a partner's advances (i.e., with reassuring, hostile, assertive, and deflecting behaviors) in Studies 1 and 2. Using cross-sectional (Study 3) and daily experience methods (Study 4), we investigated how perceptions of a partner's rejection behaviors are linked with the rejected partner's relationship and sexual satisfaction. We found robust evidence that perceived partner reassuring behaviors were associated with greater satisfaction, whereas perceived partner hostile behaviors were associated with lower levels of satisfaction. Perceived partner responsiveness was a key mechanism underlying the effects. Findings for assertive and deflecting behaviors were limited, but the effect of deflecting behaviors was qualified by levels of hostile behaviors for sexual satisfaction. Findings provide the first empirical investigation of the specific ways partners can decline one another's advances to preserve satisfaction.

Sexual Nostalgia as a Response to Unmet Sexual and Relational Needs: The Role of Attachment Avoidance.

Romantic relationships help people meet needs for connection and emotional and sexual fulfillment. In the current research, we investigate an unexplored response to feeling sexually and relationally unfulfilled: reflecting on positive sexual experiences with past partners (or sexual nostalgia). Across three studies, people low in attachment avoidance (i.e., comfortable with closeness) who were (a) single or (b) sexually or relationally dissatisfied reported greater sexual nostalgia, whereas people high in attachment avoidance (i.e., value autonomy) did not calibrate their feelings of sexual nostalgia based on their current relationship status or satisfaction. Sexual fantasies about past partners (i.e., sexual nostalgia) were distinct from other types of sexual fantasies (Study 1) and the effects could not be attributed to general nostalgia (Study 2) or sexual desire (Study 3). Chronic sexual nostalgia detracted from satisfaction over time. The findings have implications for theories of nostalgia and attachment and for managing unfulfilled needs in relationships.

Not in the mood? Men under- (not over-) perceive their partner's sexual desire in established intimate relationships.

Men's sexual overperception bias-where men tend to perceive greater sexual interest in women's behavior than actually exists-is a well-documented finding in previous research. All of the existing research, however, has tested this effect in the context of initial encounters or for fictitious or unknown targets. No research currently exists on how people perceive their romantic partner's sexual desire in the context of ongoing, intimate relationships. In 3 dyadic studies, we provide evidence that men in established romantic relationships err in the direction of the opposite bias and underperceive their romantic partner's sexual desire. We also demonstrate that this underperception bias is functional (particularly for men) in that it is associated with their partner feeling more satisfied and committed to the relationship. In addition, people are particularly likely to underperceive their partner's desire on days when they are motivated to avoid sexual rejection, and men's underperception bias is, in part, accounted for by men's higher general levels of sexual desire than women. The current studies extend previous findings on sexual perceptual biases and demonstrate the important role of context in men's judgments of a partner's sexual interest. (PsycINFO Database Record

Intermittent-access binge consumption of sweet high-fat liquid does not require opioid or dopamine receptors in the nucleus accumbens.

Binge eating disorders are characterized by episodes of intense consumption of high-calorie food. In recently developed animal models of binge eating, rats given intermittent access to such food escalate their consumption over time. Consumption of calorie-dense food is associated with neurochemical changes in the nucleus accumbens, including dopamine release and alterations in dopamine and opioid receptor expression. Therefore, we hypothesized that binge-like consumption on intermittent access schedules is dependent on opioid and/or dopamine neurotransmission in the accumbens. To test this hypothesis, we asked whether injection of dopamine and opioid receptor antagonists into the core and shell of the accumbens reduced consumption of a sweet high-fat liquid in rats with and without a history of intermittent binge access to the liquid. Although injection of a µ opioid agonist increased consumption, none of the antagonists (including µ opioid, δ opioid, κ opioid, D1 dopamine and D2 dopamine receptor antagonists, as well as the broad-spectrum opioid receptor antagonist naltrexone) reduced consumption, and this was the case whether or not the animals had a prior history of intermittent access. These results suggest that consumption of sweet, fatty food does not require opioid or dopamine receptor activation in the accumbens even under intermittent access conditions that resemble human binge episodes.

Intermittent access to sweet high-fat liquid induces increased palatability and motivation to consume in a rat model of binge consumption.

Binge eating disorders are characterized by discrete episodes of rapid and excessive food consumption. In rats, giving intermittent access to sweet fat food mimics this aspect of binge eating. These models typically employ solid food; however, the total amount consumed depends on motivation, palatability and satiety, which are difficult to dissociate with solid food. In contrast, lick microstructure analysis can be used to dissociate these parameters when the ingestant is a liquid. Therefore, we developed a binge model using a liquid emulsion composed of corn oil, heavy cream and sugar. We show that rats given intermittent access to this high-fat emulsion develop binge-like behavior comparable to that previously observed with solid high-fat food. One feature of this behavior was a gradual escalation in consumption across 2.5 weeks of intermittent access, which was not apparent in rats given lower-fat liquid on the same access schedule. Lick microstructure analysis suggests that this escalation was due at least in part to increases in both motivation to consume and palatability-driven consumption.

Invigoration of reward seeking by cue and proximity encoding in the nucleus accumbens.

A key function of the nucleus accumbens is to promote vigorous reward seeking, but the corresponding neural mechanism has not been identified despite many years of research. Here, we study cued flexible approach behavior, a form of reward seeking that strongly depends on the accumbens, and we describe a robust, single-cell neural correlate of behavioral vigor in the excitatory response of accumbens neurons to reward-predictive cues. Well before locomotion begins, this cue-evoked excitation predicts both the movement initiation latency and the speed of subsequent flexible approach responses, but not those of stereotyped, inflexible responses. Moreover, the excitation simultaneously signals the subject's proximity to the approach target, a signal that appears to mediate greater response vigor on trials that begin with the subject closer to the target. These results demonstrate a neural mechanism for response invigoration whereby accumbens neuronal encoding of reward availability and target proximity together drive the onset and speed of reward-seeking locomotion.