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Bioorg Med Chem Lett
; 12(4): 529-32, 2002 Feb 25.
Artículo
en Inglés
| MEDLINE
| ID: mdl-11844665
RESUMEN
A combinatorial library of 300HIV protease inhibitors has been synthesized. The library was screened against recombinant wild-type and mutant HIV-1 protease enzymes. The pharmacokinetics of the library was evaluated by dosing in dogs. Compounds that are notably more potent than indinavir and have favorable pharmacokinetic properties were identified.