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1.

Cycloserine and Linezolid for Tuberculosis Meningitis: Pharmacokinetic Evidence of Potential Usefulness.

Kempker, Russell R; Smith, Alison G C; Avaliani, Teona; Gujabidze, Mariam; Bakuradze, Tinatin; Sabanadze, Shorena; Avaliani, Zaza; Collins, Jeffrey M; Blumberg, Henry M; Alshaer, Mohammad H; Peloquin, Charles A; Kipiani, Maia.

Clin Infect Dis; 75(4): 682-689, 2022 09 10.

Artículo en Inglés | MEDLINE | ID: mdl-34849645

2.

Linezolid Exposure Is Associated with Cytopenias in Patients Treated for Multidrug-Resistant Tuberculosis.

Graciaa, Daniel S; Kipiani, Maia; Magee, Matthew J; Mikiashvili, Lali; Barbakadze, Ketevan; Bablishvili, Nino; Auld, Sara C; Alghamdi, Wael A; Alshaer, Mohammad H; Peloquin, Charles A; Avaliani, Zaza; Blumberg, Henry M; Kempker, Russell R.

Antimicrob Agents Chemother; 66(9): e0040822, 2022 09 20.

Artículo en Inglés | MEDLINE | ID: mdl-35916515

3.

Pharmacokinetics of bedaquiline, delamanid and clofazimine in patients with multidrug-resistant tuberculosis.

Alghamdi, Wael A; Al-Shaer, Mohammad H; Kipiani, Maia; Barbakadze, Ketevan; Mikiashvili, Lali; Kempker, Russell R; Peloquin, Charles A.

J Antimicrob Chemother; 76(4): 1019-1024, 2021 03 12.

Artículo en Inglés | MEDLINE | ID: mdl-33378452

4.

Population Pharmacokinetics of Linezolid in Tuberculosis Patients: Dosing Regimen Simulation and Target Attainment Analysis.

Alghamdi, Wael A; Al-Shaer, Mohammad H; An, Guohua; Alsultan, Abdullah; Kipiani, Maia; Barbakadze, Ketevan; Mikiashvili, Lali; Ashkin, David; Griffith, David E; Cegielski, J Peter; Kempker, Russell R; Peloquin, Charles A.

Antimicrob Agents Chemother; 64(10)2020 09 21.

Artículo en Inglés | MEDLINE | ID: mdl-32778547

5.

Cycloserine Population Pharmacokinetics and Pharmacodynamics in Patients with Tuberculosis.

Alghamdi, Wael A; Alsultan, Abdullah; Al-Shaer, Mohammad H; An, Guohua; Ahmed, Shahriar; Alkabab, Yosra; Banu, Sayera; Barbakadze, Ketevan; Houpt, Eric; Kipiani, Maia; Mikiashvili, Lali; Schmidt, Stephan; Heysell, Scott K; Kempker, Russell R; Cegielski, J Peter; Peloquin, Charles A.

Antimicrob Agents Chemother; 63(5)2019 05.

Artículo en Inglés | MEDLINE | ID: mdl-30858211

6.

Fluoroquinolones in Drug-Resistant Tuberculosis: Culture Conversion and Pharmacokinetic/Pharmacodynamic Target Attainment To Guide Dose Selection.

Al-Shaer, Mohammad H; Alghamdi, Wael A; Alsultan, Abdullah; An, Guohua; Ahmed, Shahriar; Alkabab, Yosra; Banu, Sayera; Barbakadze, Ketevan; Houpt, Eric; Kipiani, Maia; Mikiashvili, Lali; Cegielski, J Peter; Kempker, Russell R; Heysell, Scott K; Peloquin, Charles A.

Antimicrob Agents Chemother; 63(7)2019 07.

Artículo en Inglés | MEDLINE | ID: mdl-31061152

7.

Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis.

Ahmad, Nafees; Ahuja, Shama D; Akkerman, Onno W; Alffenaar, Jan-Willem C; Anderson, Laura F; Baghaei, Parvaneh; Bang, Didi; Barry, Pennan M; Bastos, Mayara L; Behera, Digamber; Benedetti, Andrea; Bisson, Gregory P; Boeree, Martin J; Bonnet, Maryline; Brode, Sarah K; Brust, James C M; Cai, Ying; Caumes, Eric; Cegielski, J Peter; Centis, Rosella; Chan, Pei-Chun; Chan, Edward D; Chang, Kwok-Chiu; Charles, Macarthur; Cirule, Andra; Dalcolmo, Margareth Pretti; D'Ambrosio, Lia; de Vries, Gerard; Dheda, Keertan; Esmail, Aliasgar; Flood, Jennifer; Fox, Gregory J; Fréchet-Jachym, Mathilde; Fregona, Geisa; Gayoso, Regina; Gegia, Medea; Gler, Maria Tarcela; Gu, Sue; Guglielmetti, Lorenzo; Holtz, Timothy H; Hughes, Jennifer; Isaakidis, Petros; Jarlsberg, Leah; Kempker, Russell R; Keshavjee, Salmaan; Khan, Faiz Ahmad; Kipiani, Maia; Koenig, Serena P; Koh, Won-Jung; Kritski, Afranio.

Lancet; 392(10150): 821-834, 2018 09 08.

Artículo en Inglés | MEDLINE | ID: mdl-30215381

8.

Reply to Upton et al.

Kempker, Russell R; Kipiani, Maia; Peloquin, Charles A.

Clin Infect Dis; 77(1): 158-159, 2023 07 05.

Artículo en Inglés | MEDLINE | ID: mdl-36978221

9.

Acquired Drug Resistance in Mycobacterium tuberculosis and Poor Outcomes among Patients with Multidrug-Resistant Tuberculosis.

Kempker, Russell R; Kipiani, Maia; Mirtskhulava, Veriko; Tukvadze, Nestani; Magee, Matthew J; Blumberg, Henry M.

Emerg Infect Dis; 21(6): 992-1001, 2015 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-25993036

10.

Significant clinical impact of a rapid molecular diagnostic test (Genotype MTBDRplus assay) to detect multidrug-resistant tuberculosis.

Kipiani, Maia; Mirtskhulava, Veriko; Tukvadze, Nestani; Magee, Matthew; Blumberg, Henry M; Kempker, Russell R.

Clin Infect Dis; 59(11): 1559-66, 2014 Dec 01.

Artículo en Inglés | MEDLINE | ID: mdl-25091301

11.

Combined cerebrospinal fluid metabolomic and cytokine profiling in tuberculosis meningitis reveals robust and prolonged changes in immunometabolic networks.

Tomalka, Jeffrey; Sharma, Ashish; Smith, Alison G C; Avaliani, Teona; Gujabidze, Mariam; Bakuradze, Tinatin; Sabanadze, Shorena; Jones, Dean P; Avaliani, Zaza; Kipiani, Maia; Kempker, Russell R; Collins, Jeffrey M.

Tuberculosis (Edinb); 144: 102462, 2024 01.

Artículo en Inglés | MEDLINE | ID: mdl-38070353

12.

HIV co-infection increases the risk of post-tuberculosis mortality among persons who initiated treatment for drug-resistant tuberculosis.

Salindri, Argita D; Kipiani, Maia; Lomtadze, Nino; Tukvadze, Nestani; Avaliani, Zaza; Blumberg, Henry M; Masyn, Katherine E; Rothenberg, Richard B; Kempker, Russell R; Magee, Matthew J.

medRxiv; 2024 Mar 26.

Artículo en Inglés | MEDLINE | ID: mdl-37293036

13.

Combined cerebrospinal fluid metabolomic and cytokine profiling in tuberculosis meningitis reveals robust and prolonged changes in immunometabolic networks.

Tomalka, Jeff; Sharma, Ashish; Smith, Alison G C; Avaliani, Teona; Gujabidze, Mariam; Bakuradze, Tinatin; Sabanadze, Shorena; Jones, Dean P; Avaliani, Zaza; Kipiani, Maia; Kempker, Russell R; Collins, Jeffrey M.

medRxiv; 2023 Jun 29.

Artículo en Inglés | MEDLINE | ID: mdl-37425849

14.

The effect of anti-tuberculosis drug pharmacokinetics on QTc prolongation.

Jin, Yutong; Benkeser, David; Kipiani, Maia; Maranchick, Nicole F; Mikiashvili, Lali; Barbakadze, Ketevan; Avaliani, Zaza; Alghamdi, Wael A; Alshaer, Mohammad H; Peloquin, Charles A; Blumberg, Henry M; Kempker, Russell R.

Int J Antimicrob Agents; 62(4): 106939, 2023 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-37517627

15.

Pharmacometabolomics in TB Meningitis - understanding the pharmacokinetic, metabolic, and immune factors associated with anti-TB drug concentrations in cerebrospinal fluid.

Collins, Jeffrey M; Kipiani, Maia; Jin, Yutong; Sharma, Ashish A; Tomalka, Jeffrey A; Avaliani, Teona; Gujabidze, Mariam; Bakuradze, Tinatin; Sabanadze, Shorena; Avaliani, Zaza; Blumberg, Henry M; Benkeser, David; Jones, Dean P; Peloquin, Charles; Kempker, Russell R.

medRxiv; 2023 Dec 15.

Artículo en Inglés | MEDLINE | ID: mdl-38168338

16.

Long term outcomes of patients with tuberculous meningitis: The impact of drug resistance.

Evans, Emily E; Avaliani, Teona; Gujabidze, Mariam; Bakuradze, Tinatin; Kipiani, Maia; Sabanadze, Shorena; Smith, Alison G C; Avaliani, Zaza; Collins, Jeffrey M; Kempker, Russell R.

PLoS One; 17(6): e0270201, 2022.

Artículo en Inglés | MEDLINE | ID: mdl-35749509

17.

Cerebrospinal fluid concentrations of fluoroquinolones and carbapenems in tuberculosis meningitis.

Maranchick, Nicole F; Alshaer, Mohammad H; Smith, Alison G C; Avaliani, Teona; Gujabidze, Mariam; Bakuradze, Tinatin; Sabanadze, Shorena; Avaliani, Zaza; Kipiani, Maia; Peloquin, Charles A; Kempker, Russell R.

Front Pharmacol; 13: 1048653, 2022.

Artículo en Inglés | MEDLINE | ID: mdl-36578553

18.

Xpert MTB/RIF Use Is Associated With Earlier Treatment Initiation and Culture Conversion Among Patients With Sputum Smear-Negative Multidrug-Resistant Tuberculosis.

Kipiani, Maia; Graciaa, Daniel S; Buziashvili, Mariana; Darchia, Lasha; Avaliani, Zaza; Tabagari, Nino; Mirtskhulava, Veriko; Kempker, Russell R.

Open Forum Infect Dis; 8(12): ofab551, 2021 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-34877367

19.

Does optimized adherence support improve treatment outcomes in RR / MDR-TB patients on 18-20 months regimen in Tbilisi, Georgia?

Jomidava, Tinatin; Khogali, Mohammed; Sereda, Yuliia; Avaliani, Zaza; Davitashvili, Malkhaz; Madzgharashvili, Mikheil; Tukvadze, Nestan; Chaphurishvili, Lali; Chincharauli, Mamuka; Kipiani, Maia.

J Infect Dev Ctries; 15(9.1): 34S-42S, 2021 09 29.

Artículo en Inglés | MEDLINE | ID: mdl-34609958

20.

Drug-associated adverse events in the treatment of multidrug-resistant tuberculosis: an individual patient data meta-analysis.

Lan, Zhiyi; Ahmad, Nafees; Baghaei, Parvaneh; Barkane, Linda; Benedetti, Andrea; Brode, Sarah K; Brust, James C M; Campbell, Jonathon R; Chang, Vicky Wai Lai; Falzon, Dennis; Guglielmetti, Lorenzo; Isaakidis, Petros; Kempker, Russell R; Kipiani, Maia; Kuksa, Liga; Lange, Christoph; Laniado-Laborín, Rafael; Nahid, Payam; Rodrigues, Denise; Singla, Rupak; Udwadia, Zarir F; Menzies, Dick.

Lancet Respir Med; 8(4): 383-394, 2020 04.

Artículo en Inglés | MEDLINE | ID: mdl-32192585

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Cycloserine and Linezolid for Tuberculosis Meningitis: Pharmacokinetic Evidence of Potential Usefulness.

Linezolid Exposure Is Associated with Cytopenias in Patients Treated for Multidrug-Resistant Tuberculosis.

Pharmacokinetics of bedaquiline, delamanid and clofazimine in patients with multidrug-resistant tuberculosis.

Population Pharmacokinetics of Linezolid in Tuberculosis Patients: Dosing Regimen Simulation and Target Attainment Analysis.

Cycloserine Population Pharmacokinetics and Pharmacodynamics in Patients with Tuberculosis.

Fluoroquinolones in Drug-Resistant Tuberculosis: Culture Conversion and Pharmacokinetic/Pharmacodynamic Target Attainment To Guide Dose Selection.

Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis.

Reply to Upton et al.

Acquired Drug Resistance in Mycobacterium tuberculosis and Poor Outcomes among Patients with Multidrug-Resistant Tuberculosis.

Significant clinical impact of a rapid molecular diagnostic test (Genotype MTBDRplus assay) to detect multidrug-resistant tuberculosis.

Combined cerebrospinal fluid metabolomic and cytokine profiling in tuberculosis meningitis reveals robust and prolonged changes in immunometabolic networks.

HIV co-infection increases the risk of post-tuberculosis mortality among persons who initiated treatment for drug-resistant tuberculosis.

Combined cerebrospinal fluid metabolomic and cytokine profiling in tuberculosis meningitis reveals robust and prolonged changes in immunometabolic networks.

The effect of anti-tuberculosis drug pharmacokinetics on QTc prolongation.

Pharmacometabolomics in TB Meningitis - understanding the pharmacokinetic, metabolic, and immune factors associated with anti-TB drug concentrations in cerebrospinal fluid.

Long term outcomes of patients with tuberculous meningitis: The impact of drug resistance.

Cerebrospinal fluid concentrations of fluoroquinolones and carbapenems in tuberculosis meningitis.

Xpert MTB/RIF Use Is Associated With Earlier Treatment Initiation and Culture Conversion Among Patients With Sputum Smear-Negative Multidrug-Resistant Tuberculosis.

Does optimized adherence support improve treatment outcomes in RR / MDR-TB patients on 18-20 months regimen in Tbilisi, Georgia?

Drug-associated adverse events in the treatment of multidrug-resistant tuberculosis: an individual patient data meta-analysis.