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1.

Unprecedented Benzoquinone Motifs Reveal Post-Oligomerizational Modification of Proanthocyanidins.

Jing, Shu-Xi; Ferreira, Daneel; Pandey, Pankaj; Klein, Larry L; Chittiboyina, Amar Gopal; McAlpine, James B; Lankin, David C; Alania, Yvette; Reis-Havlat, Mariana; Bedran-Russo, Ana K; Chen, Shao-Nong; Pauli, Guido F.

J Org Chem; 88(19): 13490-13503, 2023 10 06.

Artículo en Inglés | MEDLINE | ID: mdl-37748101

2.

Antimycobacterial Rufomycin Analogues from Streptomyces atratus Strain MJM3502.

Zhou, Bin; Shetye, Gauri; Yu, Yang; Santarsiero, Bernard D; Klein, Larry L; Abad-Zapatero, Cele; Wolf, Nina M; Cheng, Jinhua; Jin, Yingyu; Lee, Hanki; Suh, Joo-Won; Lee, Hyun; Bisson, Jonathan; McAlpine, James B; Chen, Shao-Nong; Cho, Sang-Hyun; Franzblau, Scott G; Pauli, Guido F.

J Nat Prod; 83(3): 657-667, 2020 03 27.

Artículo en Inglés | MEDLINE | ID: mdl-32031795

3.

Residual Complexity Does Impact Organic Chemistry and Drug Discovery: The Case of Rufomyazine and Rufomycin.

Choules, Mary P; Klein, Larry L; Lankin, David C; McAlpine, James B; Cho, Sang-Hyun; Cheng, Jinhua; Lee, Hanki; Suh, Joo-Won; Jaki, Birgit U; Franzblau, Scott G; Pauli, Guido F.

J Org Chem; 83(12): 6664-6672, 2018 06 15.

Artículo en Inglés | MEDLINE | ID: mdl-29792329

4.

A novel indigoid anti-tuberculosis agent.

Klein, Larry L; Petukhova, Valentina; Wan, Baojie; Wang, Yuehong; Santasiero, Bernard D; Lankin, David C; Pauli, Guido F; Franzblau, Scott G.

Bioorg Med Chem Lett; 24(1): 268-70, 2014 Jan 01.

Artículo en Inglés | MEDLINE | ID: mdl-24314672

5.

Quantification of a botanical negative marker without an identical standard: ginkgotoxin in Ginkgo biloba.

Liu, Yang; Chen, Shao-Nong; McAlpine, James B; Klein, Larry L; Friesen, J Brent; Lankin, David C; Pauli, Guido F.

J Nat Prod; 77(3): 611-7, 2014 Mar 28.

Artículo en Inglés | MEDLINE | ID: mdl-24432981

6.

Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis.

Hwang, Chang Hwa; Jaki, Birgit U; Klein, Larry L; Lankin, David C; McAlpine, James B; Napolitano, José G; Fryling, Nicole A; Franzblau, Scott G; Cho, Sang Hyun; Stamets, Paul E; Wang, Yuehong; Pauli, Guido F.

J Nat Prod; 76(10): 1916-22, 2013 Oct 25.

Artículo en Inglés | MEDLINE | ID: mdl-24087924

7.

Synthesis of Substituted Isatins.

Klein, Larry L; Tufano, Michael D.

Tetrahedron Lett; 54(8): 1008-1011, 2013 Feb 01.

Artículo en Inglés | MEDLINE | ID: mdl-23467398

8.

Anti-Microbial Activity of Aliphatic Alcohols from Chinese Black Cardamom (Amomum tsao-ko) against Mycobacterium tuberculosis H37Rv

Lee, So Young; Shetye, Gauri S; Son, So-Ri; Lee, Hyun; Klein, Larry L; Yoshihara, Jeffrey K; Ma, Rui; Franzblau, Scott G; Cho, Sanghyun; Jang, Dae Sik.

Plants (Basel); 12(1)2022 Dec 21.

Artículo en Inglés | MEDLINE | ID: mdl-36616162

9.

Design of Novel Phosphopantetheine Adenylyltransferase Inhibitors: A Potential New Approach to Tackle Mycobacterium tuberculosis.

Primi, Marina C; Tavares, Maurício T; Klein, Larry L; Izard, Tina; Sant'Anna, Carlos M R; Franzblau, Scott G; Ferreira, Elizabeth I.

Curr Top Med Chem; 21(13): 1186-1197, 2021.

Artículo en Inglés | MEDLINE | ID: mdl-34323186

10.

Identification of proteasome gene regulation in a rat model for HIV protease inhibitor-induced hyperlipidemia.

Waring, Jeffrey F; Ciurlionis, Rita; Marsh, Kennan; Klein, Larry L; Degoey, David A; Randolph, John T; Spear, Brian; Kempf, Dale J.

Arch Toxicol; 84(4): 263-70, 2010 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-20213465

11.

Synthesis and evaluation of inhibitors of cytochrome P450 3A (CYP3A) for pharmacokinetic enhancement of drugs.

Flentge, Charles A; Randolph, John T; Huang, Peggy P; Klein, Larry L; Marsh, Kennan C; Harlan, John E; Kempf, Dale J.

Bioorg Med Chem Lett; 19(18): 5444-8, 2009 Sep 15.

Artículo en Inglés | MEDLINE | ID: mdl-19679477

12.

Synthesis, antiviral activity, and conformational studies of a P3 aza-peptide analog of a potent macrocyclic tripeptide HCV protease inhibitor.

Randolph, John T; Zhang, Xiaolin; Huang, Peggy P; Klein, Larry L; Kurtz, Kevin A; Konstantinidis, Alex K; He, Wenping; Kati, Warren M; Kempf, Dale J.

Bioorg Med Chem Lett; 18(8): 2745-50, 2008 Apr 15.

Artículo en Inglés | MEDLINE | ID: mdl-18375121

13.

Hepatitis C NS5B polymerase inhibitors: 4,4-Dialkyl-1-hydroxy-3-oxo-3,4-dihydronaphthalene-3-yl benzothiadiazine derivatives.

Hutchinson, Douglas K; Rosenberg, Teresa; Klein, Larry L; Bosse, Todd D; Larson, Daniel P; He, Wenping; Jiang, Wen W; Kati, Warren M; Kohlbrenner, William E; Liu, Yaya; Masse, Sherie V; Middleton, Tim; Molla, Akhteruzzaman; Montgomery, Debra A; Beno, David W A; Stewart, Kent D; Stoll, Vincent S; Kempf, Dale J.

Bioorg Med Chem Lett; 18(14): 3887-90, 2008 Jul 15.

Artículo en Inglés | MEDLINE | ID: mdl-18599294

14.

Pharmacokinetic enhancement of the hepatitis C virus protease inhibitors VX-950 and SCH 503034 by co-dosing with ritonavir.

Kempf, Dale J; Klein, Cheri; Chen, Hui-Ju; Klein, Larry L; Yeung, Clinton; Randolph, John T; Lau, Yau Y; Chovan, Linda E; Guan, Zhiwen; Hernandez, Lisa; Turner, Teresa M; Dandliker, Peter J; Marsh, Kennan C.

Antivir Chem Chemother; 18(3): 163-7, 2007.

Artículo en Inglés | MEDLINE | ID: mdl-17626600

15.

QSAR-driven design, synthesis and discovery of potent chalcone derivatives with antitubercular activity.

Gomes, Marcelo N; Braga, Rodolpho C; Grzelak, Edyta M; Neves, Bruno J; Muratov, Eugene; Ma, Rui; Klein, Larry L; Cho, Sanghyun; Oliveira, Guilherme R; Franzblau, Scott G; Andrade, Carolina Horta.

Eur J Med Chem; 137: 126-138, 2017 Sep 08.

Artículo en Inglés | MEDLINE | ID: mdl-28582669

16.

The Generally Useful Estimate of Solvent Systems (GUESS) method enables the rapid purification of methylpyridoxine regioisomers by countercurrent chromatography.

Liu, Yang; Friesen, J Brent; Klein, Larry L; McAlpine, James B; Lankin, David C; Pauli, Guido F; Chen, Shao-Nong.

J Chromatogr A; 1426: 248-51, 2015 Dec 24.

Artículo en Inglés | MEDLINE | ID: mdl-26680272

17.

P1-substituted symmetry-based human immunodeficiency virus protease inhibitors with potent antiviral activity against drug-resistant viruses.

Degoey, David A; Grampovnik, David J; Chen, Hui-Ju; Flosi, William J; Klein, Larry L; Dekhtyar, Tatyana; Stoll, Vincent; Mamo, Mulugeta; Molla, Akhteruzzaman; Kempf, Dale J.

J Med Chem; 54(20): 7094-104, 2011 Oct 27.

Artículo en Inglés | MEDLINE | ID: mdl-21899332

18.

Water-soluble prodrugs of the human immunodeficiency virus protease inhibitors lopinavir and ritonavir.

DeGoey, David A; Grampovnik, David J; Flosi, William J; Marsh, Kennan C; Wang, Xiu C; Klein, Larry L; McDaniel, Keith F; Liu, Yaya; Long, Michelle A; Kati, Warren M; Molla, Akhteruzzaman; Kempf, Dale J.

J Med Chem; 52(9): 2964-70, 2009 May 14.

Artículo en Inglés | MEDLINE | ID: mdl-19348416

19.

Inhibitors of hepatitis C virus polymerase: synthesis and biological characterization of unsymmetrical dialkyl-hydroxynaphthalenoyl-benzothiadiazines.

Wagner, Rolf; Larson, Daniel P; Beno, David W A; Bosse, Todd D; Darbyshire, John F; Gao, Yi; Gates, Bradley D; He, Wenping; Henry, Rodger F; Hernandez, Lisa E; Hutchinson, Douglas K; Jiang, Wen W; Kati, Warren M; Klein, Larry L; Koev, Gennadiy; Kohlbrenner, William; Krueger, A Chris; Liu, Jinrong; Liu, Yaya; Long, Michelle A; Maring, Clarence J; Masse, Sherie V; Middleton, Tim; Montgomery, Debra A; Pratt, John K; Stuart, Patricia; Molla, Akhteruzzaman; Kempf, Dale J.

J Med Chem; 52(6): 1659-69, 2009 Mar 26.

Artículo en Inglés | MEDLINE | ID: mdl-19226162

20.

Synthesis and biological characterization of B-ring amino analogues of potent benzothiadiazine hepatitis C virus polymerase inhibitors.

Randolph, John T; Flentge, Charles A; Huang, Peggy P; Hutchinson, Douglas K; Klein, Larry L; Lim, Hock B; Mondal, Rubina; Reisch, Thomas; Montgomery, Debra A; Jiang, Wen W; Masse, Sherie V; Hernandez, Lisa E; Henry, Rodger F; Liu, Yaya; Koev, Gennadiy; Kati, Warren M; Stewart, Kent D; Beno, David W A; Molla, Akhteruzzaman; Kempf, Dale J.

J Med Chem; 52(10): 3174-83, 2009 May 28.

Artículo en Inglés | MEDLINE | ID: mdl-19402666

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