Eugenol Reduced ΜPO, CD45 and HMGB1 Expression and Attenuated the Expression of Leukocyte Infiltration Markers in the Intestinal Tissue in Biliopancreatic Duct Ligation-Induced Pancreatitis in Rats.

Background and Objectives: Inflammation and dysregulation in the intestinal barrier function in acute pancreatitis (AP) trigger pancreatic lesions, systemic inflammatory response, and multiple organ dysfunction. Eugenol, as the main component of clove (Syzygium aromaticum), is known for its antioxidant and anti-inflammatory properties. We studied the potentially beneficial effect of eugenol in a rodent model of biliopancreatic duct ligation-induced AP. Materials and Methods: Rats were randomly divided into three groups: Sham, AP, and AP + eugenol (15 mg/kg/day). Serum TNFα, IL-6, IL-18, and resistin levels, as well as IL-6, TNFα, MPO, HMGB1, and CD45 tissue expression, were determined at various timepoints after the induction of AP. Results: Eugenol attenuated hyperemia and inflammatory cell infiltration in the intestinal mucosal, submucosal, and muscular layers. IL-6 and resistin serum levels were significantly reduced in the AP + eugenol group, while serum TNFα and IL-18 levels remained unaffected overall. TNFα pancreatic and intestinal expression was attenuated by eugenol at 72 h, while IL-6 expression was affected only in the pancreas. MPO, CD45, and HMGB1 intestinal expression was significantly reduced in eugenol-treated rats. Conclusions: Eugenol managed to attenuate the inflammatory response in the intestine in duct ligation-induced AP in rats.

Giant malignant Triton tumour of the posterior mediastinum.

Outsized tumours of the mediastinum are always present a challenge for the thoracic surgeon. This is a case report of a giant malignant Triton tumour occupying almost the entire right hemithorax. The patient presented in the accident and emergency (A&E) with severe dyspnoea. He referred a history of surgically excised fibromyxomatous sarcoma of the left lower limb with 2 local recurrences. The imaging studies revealed apart the giant neoplasm, total right lung atelectasis and pleural effusion. After diagnostic evacuation of the pleural effusion and bronchoscopy, the patient operated through a right postero-lateral thoracotomy; a giant well-encapsulated tumour not invading any anatomic structures or lymph nodes originated from the posterior mediastinum was excised radically. The patient recovered well and received radiotherapy after the operation for preventing local recurrence.