Búsqueda | Portal de Búsqueda de la BVS España

1.

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations.

Intlekofer, Andrew M; Shih, Alan H; Wang, Bo; Nazir, Abbas; Rustenburg, Ariën S; Albanese, Steven K; Patel, Minal; Famulare, Christopher; Correa, Fabian M; Takemoto, Naofumi; Durani, Vidushi; Liu, Hui; Taylor, Justin; Farnoud, Noushin; Papaemmanuil, Elli; Cross, Justin R; Tallman, Martin S; Arcila, Maria E; Roshal, Mikhail; Petsko, Gregory A; Wu, Bin; Choe, Sung; Konteatis, Zenon D; Biller, Scott A; Chodera, John D; Thompson, Craig B; Levine, Ross L; Stein, Eytan M.

Nature; 559(7712): 125-129, 2018 07.

Artículo en Inglés | MEDLINE | ID: mdl-29950729

2.

Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads.

Li, Mingzong; Konteatis, Zenon; Nagaraja, Nelamangala; Chen, Yue; Zhou, Shubao; Ma, Guangning; Gross, Stefan; Marjon, Katya; Hyer, Marc L; Mandley, Everton; Lein, Max; Padyana, Anil K; Jin, Lei; Tong, Shuilong; Peters, Rachel; Murtie, Joshua; Travins, Jeremy; Medeiros, Matthew; Liu, Peng; Frank, Victoria; Judd, Evan T; Biller, Scott A; Marks, Kevin M; Sui, Zhihua; Reznik, Samuel K.

J Med Chem; 65(6): 4600-4615, 2022 03 24.

Artículo en Inglés | MEDLINE | ID: mdl-35293760

3.

Discovery of a novel class of non-ATP site DFG-out state p38 inhibitors utilizing computationally assisted virtual fragment-based drug design (vFBDD).

Moffett, Kristofer; Konteatis, Zenon; Nguyen, Duyan; Shetty, Rupa; Ludington, Jennifer; Fujimoto, Ted; Lee, Kyoung-Jin; Chai, Xiaomei; Namboodiri, Haridasan; Karpusas, Michael; Dorsey, Bruce; Guarnieri, Frank; Bukhtiyarova, Marina; Springman, Eric; Michelotti, Enrique.

Bioorg Med Chem Lett; 21(23): 7155-65, 2011 Dec 01.

Artículo en Inglés | MEDLINE | ID: mdl-22014550

4.

Transplant-insert-constrain-relax-assemble (TICRA): protein-ligand complex structure modeling and application to kinases.

Meshkat, Siavash; Klon, Anthony E; Zou, Jinming; Wiseman, Jeffrey S; Konteatis, Zenon.

J Chem Inf Model; 51(1): 52-60, 2011 Jan 24.

Artículo en Inglés | MEDLINE | ID: mdl-21117680

5.

Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.

Konteatis, Zenon; Travins, Jeremy; Gross, Stefan; Marjon, Katya; Barnett, Amelia; Mandley, Everton; Nicolay, Brandon; Nagaraja, Raj; Chen, Yue; Sun, Yabo; Liu, Zhixiao; Yu, Jie; Ye, Zhixiong; Jiang, Fan; Wei, Wentao; Fang, Cheng; Gao, Yi; Kalev, Peter; Hyer, Marc L; DeLaBarre, Byron; Jin, Lei; Padyana, Anil K; Dang, Lenny; Murtie, Joshua; Biller, Scott A; Sui, Zhihua; Marks, Kevin M.

J Med Chem; 64(8): 4430-4449, 2021 04 22.

Artículo en Inglés | MEDLINE | ID: mdl-33829783

6.

MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage.

Kalev, Peter; Hyer, Marc L; Gross, Stefan; Konteatis, Zenon; Chen, Chi-Chao; Fletcher, Mark; Lein, Max; Aguado-Fraile, Elia; Frank, Victoria; Barnett, Amelia; Mandley, Everton; Goldford, Joshua; Chen, Yue; Sellers, Katie; Hayes, Sebastian; Lizotte, Kate; Quang, Phong; Tuncay, Yesim; Clasquin, Michelle; Peters, Rachel; Weier, Jaclyn; Simone, Eric; Murtie, Joshua; Liu, Wei; Nagaraja, Raj; Dang, Lenny; Sui, Zhihua; Biller, Scott A; Travins, Jeremy; Marks, Kevin M; Marjon, Katya.

Cancer Cell; 39(2): 209-224.e11, 2021 02 08.

Artículo en Inglés | MEDLINE | ID: mdl-33450196

7.

Molecular mechanisms mediating relapse following ivosidenib monotherapy in IDH1-mutant relapsed or refractory AML.

Choe, Sung; Wang, Hongfang; DiNardo, Courtney D; Stein, Eytan M; de Botton, Stéphane; Roboz, Gail J; Altman, Jessica K; Mims, Alice S; Watts, Justin M; Pollyea, Daniel A; Fathi, Amir T; Tallman, Martin S; Kantarjian, Hagop M; Stone, Richard M; Quek, Lynn; Konteatis, Zenon; Dang, Lenny; Nicolay, Brandon; Nejad, Parham; Liu, Guowen; Zhang, Vickie; Liu, Hua; Goldwasser, Meredith; Liu, Wei; Marks, Kevin; Bowden, Chris; Biller, Scott A; Attar, Eyal C; Wu, Bin.

Blood Adv; 4(9): 1894-1905, 2020 05 12.

Artículo en Inglés | MEDLINE | ID: mdl-32380538

8.

Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma.

Konteatis, Zenon; Artin, Erin; Nicolay, Brandon; Straley, Kimberly; Padyana, Anil K; Jin, Lei; Chen, Yue; Narayaraswamy, Rohini; Tong, Shuilong; Wang, Feng; Zhou, Ding; Cui, Dawei; Cai, Zhenwei; Luo, Zhiyong; Fang, Cheng; Tang, Huachun; Lv, Xiaobing; Nagaraja, Raj; Yang, Hua; Su, Shin-San M; Sui, Zhihua; Dang, Lenny; Yen, Katharine; Popovici-Muller, Janeta; Codega, Paolo; Campos, Carl; Mellinghoff, Ingo K; Biller, Scott A.

ACS Med Chem Lett; 11(2): 101-107, 2020 Feb 13.

Artículo en Inglés | MEDLINE | ID: mdl-32071674

9.

AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.

Yen, Katharine; Travins, Jeremy; Wang, Fang; David, Muriel D; Artin, Erin; Straley, Kimberly; Padyana, Anil; Gross, Stefan; DeLaBarre, Byron; Tobin, Erica; Chen, Yue; Nagaraja, Raj; Choe, Sung; Jin, Lei; Konteatis, Zenon; Cianchetta, Giovanni; Saunders, Jeffrey O; Salituro, Francesco G; Quivoron, Cyril; Opolon, Paule; Bawa, Olivia; Saada, Véronique; Paci, Angelo; Broutin, Sophie; Bernard, Olivier A; de Botton, Stéphane; Marteyn, Benoît S; Pilichowska, Monika; Xu, YingXia; Fang, Cheng; Jiang, Fan; Wei, Wentao; Jin, Shengfang; Silverman, Lee; Liu, Wei; Yang, Hua; Dang, Lenny; Dorsch, Marion; Penard-Lacronique, Virginie; Biller, Scott A; Su, Shin-San Michael.

Cancer Discov; 7(5): 478-493, 2017 05.

Artículo en Inglés | MEDLINE | ID: mdl-28193778

10.

What makes a good fragment in fragment-based drug discovery?

Konteatis, Zenon.

Expert Opin Drug Discov; 16(7): 723-726, 2021 07.

Artículo en Inglés | MEDLINE | ID: mdl-33769176

11.

MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis.

Marjon, Katya; Cameron, Michael J; Quang, Phong; Clasquin, Michelle F; Mandley, Everton; Kunii, Kaiko; McVay, Michael; Choe, Sung; Kernytsky, Andrew; Gross, Stefan; Konteatis, Zenon; Murtie, Joshua; Blake, Michelle L; Travins, Jeremy; Dorsch, Marion; Biller, Scott A; Marks, Kevin M.

Cell Rep; 15(3): 574-587, 2016 Apr 19.

Artículo en Inglés | MEDLINE | ID: mdl-27068473

12.

Design strategies for computational fragment-based drug design.

Konteatis, Zenon D.

Methods Mol Biol; 1289: 137-44, 2015.

Artículo en Inglés | MEDLINE | ID: mdl-25709038

13.

Computational approach to de novo discovery of fragment binding for novel protein states.

Konteatis, Zenon D; Klon, Anthony E; Zou, Jinming; Meshkat, Siavash.

Methods Enzymol; 493: 357-80, 2011.

Artículo en Inglés | MEDLINE | ID: mdl-21371598

14.

In silico fragment-based drug design.

Konteatis, Zenon D.

Expert Opin Drug Discov; 5(11): 1047-65, 2010 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-22827744

15.

Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor.

Duffy, Joseph L; Kirk, Brian A; Konteatis, Zenon; Campbell, Elizabeth L; Liang, Rui; Brady, Edward J; Candelore, Mari Rios; Ding, Victor D H; Jiang, Guoqiang; Liu, Frank; Qureshi, Sajjad A; Saperstein, Richard; Szalkowski, Deborah; Tong, Sharon; Tota, Lauri M; Xie, Dan; Yang, Xiaodong; Zafian, Peter; Zheng, Song; Chapman, Kevin T; Zhang, Bei B; Tata, James R.

Bioorg Med Chem Lett; 15(5): 1401-5, 2005 Mar 01.

Artículo en Inglés | MEDLINE | ID: mdl-15713396

Portal de Búsqueda de la BVS España

Información y Conocimiento para la Salud

Configurar filtros

Su selección (0)

Formato de exportación:

Exportar: