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Sci Rep ; 7: 40922, 2017 01 19.
Artículo en Inglés | MEDLINE | ID: mdl-28102349

RESUMEN

A new technique for manufacturing a patient-specific dosimetric phantom using three-dimensional printing (PSDP_3DP) was developed, and its geometrical and dosimetric accuracy was analyzed. External body contours and structures of the spine and metallic fixation screws (MFS) were delineated from CT images of a patient with MFS who underwent stereotactic body radiation therapy for spine metastasis. Contours were converted into a STereoLithography file format using in-house program. A hollow, four-section PSDP was designed and manufactured using three types of 3DP to allow filling with a muscle-equivalent liquid and insertion of dosimeters. To evaluate the geometrical accuracy of PSDP_3DP, CT images were obtained and compared with patient CT data for volume, mean density, and Dice similarity coefficient for contours. The dose distribution in the PSDP_3DP was calculated by applying the same beam parameters as for the patient, and the dosimetric characteristics of the PSDP_3DP were compared with the patient plan. The registered CT of the PSDP_3DP was well matched with that of the real patient CT in the axial, coronal, and sagittal planes. The physical accuracy and dosimetric characteristics of PSDP_3DP were comparable to those of a real patient. The ability to manufacture a PSDP representing an extreme patient condition was demonstrated.


Asunto(s)
Neoplasias Óseas/radioterapia , Tornillos Óseos , Planificación de la Radioterapia Asistida por Computador/métodos , Neoplasias Óseas/diagnóstico por imagen , Humanos , Fantasmas de Imagen , Impresión Tridimensional , Planificación de la Radioterapia Asistida por Computador/instrumentación , Columna Vertebral/diagnóstico por imagen , Tomografía Computarizada por Rayos X
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