[Feasibility of monogenic control of blood cholesterol content for the Kirghiz population]. / O vozmozhnosti monogennogo kontrolia kontsentratsii kholesterina v krovi dlia kyrgyzskoi populiatsii.

The samples presented by 67 pedigrees ascertained from the Kirghiz population via proband having an early myocardial infarction were analysed for ischemic heart disease. It is shown that these pathologies are not accompanied by high increase in the cholesterol level, as is usual for the European populations. Segregation analysis of the cholesterol level was performed and a possibility of monogenic control of this trait was demonstrated.

[Segregation analysis of certain anthroposcopic characteristics. I. Alternative signs with penetration independent of age]. / Segregationnyi analiz nekotorykh antroposkopicheskikh kharakteristik. I. Al'ternativnye priznaki s nezavisimoi ot vozrasta penetrantnost'iu.

Genetic analysis of a number of anthroposcopic traits was attempted using a sample of pedigrees from the Kirgiz population. We used methods of binary trait segregation analysis, which allowed us to analyze pedigrees of arbitrary structure. The genetic model applied was based on the monogenic diallelic mode of inheritance with arbitrary genotype penetrances and allowed for different phenotypic expressions of a genotype in males and females. The hypothesis of monogenic diallelic inheritance could not be rejected for the following 12 traits: ability to roll the tongue, earlobe, auricular tubercle, nose shape, base of the nose, accreted eyebrows, fold of the upper eyelid, margin of the auricle, vertex hair whorl, cheekbones, cheek dimples, and height of the nose bridge. Sex dimorphism was demonstrated for the latter five traits. Problems of the relationship between sample informativeness and precision of parameter estimation are discussed.

[Segregation analysis of some anthroposcopic characteristics. II. Age dependence and signs with three phenotypic variants]. / Segregationnyi analiz nekotorykh antroposkopicheskikh kharakteristik. II. Vozrastnaia zavisimost' i priznaki s tremia fenotipicheskimi proiavleniiami.

Results of genetic analysis of three anthroposcopic traits, performed on a sample of pedigrees from a Kyrgyz population, are presented. The segregation analysis method used allows analysis of pedigrees of arbitrary structure with account of age dependence of genotype penetrances. The method involves analysis of not only binary traits, but also of traits with three phenotypic.

[The characteristics of the lipid-hormonal interrelations in young men with a history of myocardial infarct (based on family registry data in Novosibirsk and Bishkek)]. / Osobennosti lipidno-gormonal'nykh vzaimosviazei u molodykh muzhchin, perenesshikh infarkt miokarda (po materialam semeinykh registrov v Novosibirske i Bishkeke).

Altogether 226 male probands who suffered large-focal or transmural myocardial infarction (MI) before reaching 50 years were examined in Novosibirsk and Bishkek in one stage according to the unified program. In Novosibirsk all the probands were Russians whereas in Bishkek 75 probands were Kirghizs and 71 were Russians. The probands were examined within a period of 1 to 3 years after MI. The lipid and lipoprotein plasma content was determined by standardized methods on a Tekhnikon AAP autoanalyzer. The content of thyroid hormones, insulin and cortisol was measured by means of RIA-kits and that of apolipoprotein B (ApoB) by radial immunodiffusion. It turned out that the patients from Novosibirsk demonstrated the highest content of cholesterol, low density lipoprotein cholesterol, the highest index of atherogenicity, the highest concentration of ApoB, and hyperinsulinemia. In the probands of both nationalities from Bishkek, the lipid spectrum did not differ substantially from the populational norm, the content of ApoB in the Russian probands was slightly lower than in those from Novosibirsk whereas in Kirghizs, the least content of thyroxin was recorded.

[The prevalence of the main risk factors among probands who have had a myocardial infarct at a young age and among their relatives (based on family registry data in Bishkek and Novosibirsk)]. / Rasprostranennost' osnovnykh faktorov riska sredi probandov, perenesshikh infarkt miokarda v molodom vozraste, i ikh rodstvennikov (po materialam semeinykh registrov v Bishkeke i Novosibirske).

Macrofocal or transmural myocardial infarction at the age under 50 in probands served the criterion for selection of 136 families in Bishkek and Novosibirsk (66 Kirghiz and 70 Russian families, respectively). Main risk factors in probands and their families were determined according to WHO methodological recommendations. Essential hypertension was more prevalent in probands and their families in Bishkek, while hypercholesterolemia was more common in Novosibirsk families. Smoking was documented in Bishkek and Novosibirsk probands in equal proportions, though there were more smokers among probands' sons in Bishkek. Overweight occurred with equal frequency in probands' wives and daughters in both cities, but in probands and their sons in Novosibirsk this risk factor appeared more prevalent. Novosibirsk cases of reduced levels of high-density lipoproteins cholesterol and triiodothyronine, elevated concentrations of apolipoprotein B and immunoreactive insulin outnumbered those in Bishkek.

Prevalence of ischaemic heart disease risk factors among the male population in Frunze aged 40-59 years and results of a five-year prevention programme.

The study analyses, first, the prevalence of risk factors of ischaemic heart disease among the male population of the city of Bishkek, aged 40-59 years (n = 5246) and, second, the efficacy of a preventive programme according to the development of risk factors in groups exposed to preventive measures of various intensity during 5 years. The prevalence of IHD risk factors in the given population was very high. In the group exposed to active preventive intervention a decrease in the prevalence of arterial hypertension, hypercholesterolaemia, smoking and low physical activity was registered after 5 years, compared to a group without active prevention.