Detalles de la búsqueda
1.
Design, synthesis and in silico insights of novel 1,2,3-triazole benzenesulfonamide derivatives as potential carbonic anhydrase IX and XII inhibitors with promising anticancer activity.
Bioorg Chem;
144: 107154, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38309003
2.
Methanesulfonamide derivatives as gastric safe anti-inflammatory agents: Design, synthesis, selective COX-2 inhibitory activity, histopathological and histochemical studies.
Bioorg Chem;
140: 106787, 2023 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37597439
3.
Novel N-methylsulfonyl-indole derivatives: biological activity and COX-2/5-LOX inhibitory effect with improved gastro protective profile and reduced cardio vascular risks.
J Enzyme Inhib Med Chem;
38(1): 246-266, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36458373
4.
Trimethoxyphenyl containing compounds: Synthesis, biological evaluation, nitric oxide release, modeling, histochemical and histopathological studies.
Bioorg Chem;
124: 105806, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35436752
5.
Design, synthesis, and biological evaluation of novel pyrido-dipyrimidines as dual topoisomerase II/FLT3 inhibitors in leukemia cells.
Bioorg Chem;
122: 105752, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35339926
6.
Design and synthesis of new indole drug candidates to treat Alzheimer's disease and targeting neuro-inflammation using a multi-target-directed ligand (MTDL) strategy.
J Enzyme Inhib Med Chem;
37(1): 2660-2678, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36146947
7.
Design, synthesis, stereochemical determination, molecular docking study, in silico pre-ADMET prediction and anti-proliferative activities of indole-pyrimidine derivatives as Mcl-1 inhibitors.
Bioorg Chem;
116: 105335, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34509795
8.
New pyrazolopyrimidine derivatives with anticancer activity: Design, synthesis, PIM-1 inhibition, molecular docking study and molecular dynamics.
Bioorg Chem;
100: 103944, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32450389
9.
A multicomponent reaction to design antimalarial pyridyl-indole derivatives: Synthesis, biological activities and molecular docking.
Bioorg Chem;
97: 103673, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32106041
10.
New pyrazole derivatives possessing amino/methanesulphonyl pharmacophore with good gastric safety profile: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory activity and histopathological studies.
Bioorg Chem;
95: 103540, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31911297
11.
2-Thiopyrimidine/chalcone hybrids: design, synthesis, ADMET prediction, and anticancer evaluation as STAT3/STAT5a inhibitors.
J Enzyme Inhib Med Chem;
35(1): 864-879, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-32208772
12.
Design and synthesis of new benzoxazole/benzothiazole-phthalimide hybrids as antitumor-apoptotic agents.
Bioorg Chem;
89: 102978, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31136900
13.
Synthesis and biological evaluation of tetrazole derivatives as TNF-α, IL-6 and COX-2 inhibitors with antimicrobial activity: Computational analysis, molecular modeling study and region-specific cyclization using 2D NMR tools.
Bioorg Chem;
92: 103301, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31563696
14.
COX-1/COX-2 inhibition assays and histopathological study of the new designed anti-inflammatory agent with a pyrazolopyrimidine core.
Bioorg Chem;
86: 235-253, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30716621
15.
Azole-hydrazone derivatives: Design, synthesis, in vitro biological evaluation, dual EGFR/HER2 inhibitory activity, cell cycle analysis and molecular docking study as anticancer agents.
Bioorg Chem;
76: 67-80, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29153588
16.
Design, synthesis, and biological evaluation of novel 1,2-diaryl-4-substituted-benzylidene-5(4H)-imidazolone derivatives as cytotoxic agents and COX-2/LOX inhibitors.
Arch Pharm (Weinheim);
351(3-4): e1700311, 2018 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-29400411
17.
Novel tetrazole and cyanamide derivatives as inhibitors of cyclooxygenase-2 enzyme: design, synthesis, anti-inflammatory evaluation, ulcerogenic liability and docking study.
J Enzyme Inhib Med Chem;
32(1): 805-820, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-28587532
18.
RETRACTED: Design, synthesis, structure-activity relationship and kinase inhibitory activity of substituted 3-methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ones.
Bioorg Med Chem Lett;
26(13): 3093-3097, 2016 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27189674
19.
Cyclooxygenase-2 and 15-lipoxygenase inhibition, synthesis, anti-inflammatory activity and ulcer liability of new celecoxib analogues: Determination of region-specific pyrazole ring formation by NOESY.
Bioorg Med Chem Lett;
26(12): 2893-2899, 2016 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27158139
20.
3-methyl-2-phenyl-1-substituted-indole derivatives as indomethacin analogs: design, synthesis and biological evaluation as potential anti-inflammatory and analgesic agents.
J Enzyme Inhib Med Chem;
31(2): 318-24, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-25798690