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1.

The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.

Canon, Jude; Rex, Karen; Saiki, Anne Y; Mohr, Christopher; Cooke, Keegan; Bagal, Dhanashri; Gaida, Kevin; Holt, Tyler; Knutson, Charles G; Koppada, Neelima; Lanman, Brian A; Werner, Jonathan; Rapaport, Aaron S; San Miguel, Tisha; Ortiz, Roberto; Osgood, Tao; Sun, Ji-Rong; Zhu, Xiaochun; McCarter, John D; Volak, Laurie P; Houk, Brett E; Fakih, Marwan G; O'Neil, Bert H; Price, Timothy J; Falchook, Gerald S; Desai, Jayesh; Kuo, James; Govindan, Ramaswamy; Hong, David S; Ouyang, Wenjun; Henary, Haby; Arvedson, Tara; Cee, Victor J; Lipford, J Russell.

Nature; 575(7781): 217-223, 2019 11.

Artículo en Inglés | MEDLINE | ID: mdl-31666701

2.

Addressing Atropisomerism in the Development of Sotorasib, a Covalent Inhibitor of KRAS G12C: Structural, Analytical, and Synthetic Considerations.

Lanman, Brian A; Parsons, Andrew T; Zech, Stephan G.

Acc Chem Res; 55(20): 2892-2903, 2022 10 18.

Artículo en Inglés | MEDLINE | ID: mdl-36178208

3.

Half-life extension of peptidic APJ agonists by N-terminal lipid conjugation.

Reed, Anthony B; Lanman, Brian A; Holder, Jerry Ryan; Yang, Bryant H; Ma, Ji; Humphreys, Sara C; Wang, Zhican; Chan, Joyce C Y; Miranda, Les P; Swaminath, Gayathri; Allen, John G.

Bioorg Med Chem Lett; 30(21): 127499, 2020 11 01.

Artículo en Inglés | MEDLINE | ID: mdl-32858124

4.

Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors.

Wu, Bin; Wang, Hui-Ling; Cee, Victor J; Lanman, Brian A; Nixey, Thomas; Pettus, Liping; Reed, Anthony B; Wurz, Ryan P; Guerrero, Nadia; Sastri, Christine; Winston, Jeff; Lipford, J Russell; Lee, Matthew R; Mohr, Christopher; Andrews, Kristin L; Tasker, Andrew S.

Bioorg Med Chem Lett; 25(4): 775-80, 2015 Feb 15.

Artículo en Inglés | MEDLINE | ID: mdl-25616902

5.

The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors.

Wang, Hui-Ling; Cee, Victor J; Chavez, Frank; Lanman, Brian A; Reed, Anthony B; Wu, Bin; Guerrero, Nadia; Lipford, J Russell; Sastri, Christine; Winston, Jeff; Andrews, Kristin L; Huang, Xin; Lee, Matthew R; Mohr, Christopher; Xu, Yang; Zhou, Yihong; Tasker, Andrew S.

Bioorg Med Chem Lett; 25(4): 834-40, 2015 Feb 15.

Artículo en Inglés | MEDLINE | ID: mdl-25597005

6.

The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors.

Wurz, Ryan P; Pettus, Liping H; Jackson, Claire; Wu, Bin; Wang, Hui-Ling; Herberich, Brad; Cee, Victor; Lanman, Brian A; Reed, Anthony B; Chavez, Frank; Nixey, Thomas; Laszlo, Jimmy; Wang, Paul; Nguyen, Yen; Sastri, Christine; Guerrero, Nadia; Winston, Jeff; Lipford, J Russell; Lee, Matthew R; Andrews, Kristin L; Mohr, Christopher; Xu, Yang; Zhou, Yihong; Reid, Darren L; Tasker, Andrew S.

Bioorg Med Chem Lett; 25(4): 847-55, 2015 Feb 15.

Artículo en Inglés | MEDLINE | ID: mdl-25599837

7.

Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.

Lanman, Brian A; Reed, Anthony B; Cee, Victor J; Hong, Fang-Tsao; Pettus, Liping H; Wurz, Ryan P; Andrews, Kristin L; Jiang, Jian; McCarter, John D; Mullady, Erin L; San Miguel, Tisha; Subramanian, Raju; Wang, Ling; Whittington, Douglas A; Wu, Tian; Zalameda, Leeanne; Zhang, Nancy; Tasker, Andrew S; Hughes, Paul E; Norman, Mark H.

Bioorg Med Chem Lett; 24(24): 5630-5634, 2014 Dec 15.

Artículo en Inglés | MEDLINE | ID: mdl-25466188

8.

Novel 5- and 6-subtituted benzothiazoles with improved physicochemical properties: potent S1P1 agonists with in vivo lymphocyte-depleting activity.

Frohn, Mike; Cee, Victor J; Lanman, Brian A; Pickrell, Alexander J; Golden, Jennifer; Rivenzon-Segal, Dalia; Middleton, Scot; Fiorino, Mike; Xu, Han; Schrag, Michael; Xu, Yang; McElvain, Michele; Muller, Kristine; Siu, Jerry; Bürli, Roland.

Bioorg Med Chem Lett; 22(1): 628-33, 2012 Jan 01.

Artículo en Inglés | MEDLINE | ID: mdl-22100314

9.

Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups.

Reed, Anthony B; Lanman, Brian A; Neira, Susana; Harrington, Paul E; Sham, Kelvin K C; Frohn, Mike; Pickrell, Alexander J; Tasker, Andrew S; Gore, Anu; Fiorino, Mike; Itano, Andrea; McElvain, Michele; Middleton, Scot; Morrison, Henry; Xu, Han; Xu, Yang; Wong, Min; Cee, Victor J.

Bioorg Med Chem Lett; 22(4): 1779-83, 2012 Feb 15.

Artículo en Inglés | MEDLINE | ID: mdl-22257889

10.

Quinolinone-based agonists of S1P1: use of a N-scan SAR strategy to optimize in vitro and in vivo activity.

Pennington, Lewis D; Croghan, Michael D; Sham, Kelvin K C; Pickrell, Alexander J; Harrington, Paul E; Frohn, Michael J; Lanman, Brian A; Reed, Anthony B; Lee, Matthew R; Xu, Han; McElvain, Michele; Xu, Yang; Zhang, Xuxia; Fiorino, Michael; Horner, Michelle; Morrison, Henry G; Arnett, Heather A; Fotsch, Christopher; Tasker, Andrew S; Wong, Min; Cee, Victor J.

Bioorg Med Chem Lett; 22(1): 527-31, 2012 Jan 01.

Artículo en Inglés | MEDLINE | ID: mdl-22104144

11.

Discovery of a Covalent Inhibitor of KRAS^G12C (AMG 510) for the Treatment of Solid Tumors.

Lanman, Brian A; Allen, Jennifer R; Allen, John G; Amegadzie, Albert K; Ashton, Kate S; Booker, Shon K; Chen, Jian Jeffrey; Chen, Ning; Frohn, Michael J; Goodman, Guy; Kopecky, David J; Liu, Longbin; Lopez, Patricia; Low, Jonathan D; Ma, Vu; Minatti, Ana E; Nguyen, Thomas T; Nishimura, Nobuko; Pickrell, Alexander J; Reed, Anthony B; Shin, Youngsook; Siegmund, Aaron C; Tamayo, Nuria A; Tegley, Christopher M; Walton, Mary C; Wang, Hui-Ling; Wurz, Ryan P; Xue, May; Yang, Kevin C; Achanta, Pragathi; Bartberger, Michael D; Canon, Jude; Hollis, L Steven; McCarter, John D; Mohr, Christopher; Rex, Karen; Saiki, Anne Y; San Miguel, Tisha; Volak, Laurie P; Wang, Kevin H; Whittington, Douglas A; Zech, Stephan G; Lipford, J Russell; Cee, Victor J.

J Med Chem; 63(1): 52-65, 2020 01 09.

Artículo en Inglés | MEDLINE | ID: mdl-31820981

12.

Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRAS^G12C.

Shin, Youngsook; Jeong, Joon Won; Wurz, Ryan P; Achanta, Pragathi; Arvedson, Tara; Bartberger, Michael D; Campuzano, Iain D G; Fucini, Ray; Hansen, Stig K; Ingersoll, John; Iwig, Jeffrey S; Lipford, J Russell; Ma, Vu; Kopecky, David J; McCarter, John; San Miguel, Tisha; Mohr, Christopher; Sabet, Sudi; Saiki, Anne Y; Sawayama, Andrew; Sethofer, Steven; Tegley, Christopher M; Volak, Laurie P; Yang, Kevin; Lanman, Brian A; Erlanson, Daniel A; Cee, Victor J.

ACS Med Chem Lett; 10(9): 1302-1308, 2019 Sep 12.

Artículo en Inglés | MEDLINE | ID: mdl-31531201

13.

Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies.

Wang, Hui-Ling; Andrews, Kristin L; Booker, Shon K; Canon, Jude; Cee, Victor J; Chavez, Frank; Chen, Yuping; Eastwood, Heather; Guerrero, Nadia; Herberich, Brad; Hickman, Dean; Lanman, Brian A; Laszlo, Jimmy; Lee, Matthew R; Lipford, J Russell; Mattson, Bethany; Mohr, Christopher; Nguyen, Yen; Norman, Mark H; Pettus, Liping H; Powers, David; Reed, Anthony B; Rex, Karen; Sastri, Christine; Tamayo, Nuria; Wang, Paul; Winston, Jeffrey T; Wu, Bin; Wu, Qiong; Wu, Tian; Wurz, Ryan P; Xu, Yang; Zhou, Yihong; Tasker, Andrew S.

J Med Chem; 62(3): 1523-1540, 2019 02 14.

Artículo en Inglés | MEDLINE | ID: mdl-30624936

14.

EVALUATION OF STRATEGIES FOR THE SYNTHESIS OF THE GUANIDINE HEMIAMINAL PORTION OF PALAU'AMINE.

Lanman, Brian A; Overman, Larry E.

Heterocycles; 70: 557-570, 2006 Dec 31.

Artículo en Inglés | MEDLINE | ID: mdl-19079749

15.

Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors.

Cee, Victor J; Chavez, Frank; Herberich, Bradley; Lanman, Brian A; Pettus, Liping H; Reed, Anthony B; Wu, Bin; Wurz, Ryan P; Andrews, Kristin L; Chen, Jie; Hickman, Dean; Laszlo, Jimmy; Lee, Matthew R; Guerrero, Nadia; Mattson, Bethany K; Nguyen, Yen; Mohr, Christopher; Rex, Karen; Sastri, Christine E; Wang, Paul; Wu, Qiong; Wu, Tian; Xu, Yang; Zhou, Yihong; Winston, Jeffrey T; Lipford, J Russell; Tasker, Andrew S; Wang, Hui-Ling.

ACS Med Chem Lett; 7(4): 408-12, 2016 Apr 14.

Artículo en Inglés | MEDLINE | ID: mdl-27096050

16.

Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors.

Pettus, Liping H; Andrews, Kristin L; Booker, Shon K; Chen, Jie; Cee, Victor J; Chavez, Frank; Chen, Yuping; Eastwood, Heather; Guerrero, Nadia; Herberich, Bradley; Hickman, Dean; Lanman, Brian A; Laszlo, Jimmy; Lee, Matthew R; Lipford, J Russell; Mattson, Bethany; Mohr, Christopher; Nguyen, Yen; Norman, Mark H; Powers, David; Reed, Anthony B; Rex, Karen; Sastri, Christine; Tamayo, Nuria; Wang, Paul; Winston, Jeffrey T; Wu, Bin; Wu, Tian; Wurz, Ryan P; Xu, Yang; Zhou, Yihong; Tasker, Andrew S; Wang, Hui-Ling.

J Med Chem; 59(13): 6407-30, 2016 07 14.

Artículo en Inglés | MEDLINE | ID: mdl-27285051

17.

Efficient, stereoselective synthesis of trans-2,5-disubstituted morpholines.

Lanman, Brian A; Myers, Andrew G.

Org Lett; 6(6): 1045-7, 2004 Mar 18.

Artículo en Inglés | MEDLINE | ID: mdl-15012096

18.

Addressing supply issues for natural products in the clinic.

Lanman, Brian A.

Science; 358(6360): 166-167, 2017 10 13.

Artículo en Inglés | MEDLINE | ID: mdl-29026028

19.

Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core.

Harrington, Paul E; Croghan, Michael D; Fotsch, Christopher; Frohn, Mike; Lanman, Brian A; Pennington, Lewis D; Pickrell, Alexander J; Reed, Anthony B; Sham, Kelvin K C; Tasker, Andrew; Arnett, Heather A; Fiorino, Michael; Lee, Matthew R; McElvain, Michele; Morrison, Henry G; Xu, Han; Xu, Yang; Zhang, Xuxia; Wong, Min; Cee, Victor J.

ACS Med Chem Lett; 3(1): 74-8, 2012 Jan 12.

Artículo en Inglés | MEDLINE | ID: mdl-24900374

20.

Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.

Smith, Adrian L; D'Angelo, Noel D; Bo, Yunxin Y; Booker, Shon K; Cee, Victor J; Herberich, Brad; Hong, Fang-Tsao; Jackson, Claire L M; Lanman, Brian A; Liu, Longbin; Nishimura, Nobuko; Pettus, Liping H; Reed, Anthony B; Tadesse, Seifu; Tamayo, Nuria A; Wurz, Ryan P; Yang, Kevin; Andrews, Kristin L; Whittington, Douglas A; McCarter, John D; Miguel, Tisha San; Zalameda, Leeanne; Jiang, Jian; Subramanian, Raju; Mullady, Erin L; Caenepeel, Sean; Freeman, Daniel J; Wang, Ling; Zhang, Nancy; Wu, Tian; Hughes, Paul E; Norman, Mark H.

J Med Chem; 55(11): 5188-219, 2012 Jun 14.

Artículo en Inglés | MEDLINE | ID: mdl-22548365

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