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1.

A thrombospondin-dependent pathway for a protective ER stress response.

Lynch, Jeffrey M; Maillet, Marjorie; Vanhoutte, Davy; Schloemer, Aryn; Sargent, Michelle A; Blair, N Scott; Lynch, Kaari A; Okada, Tetsuya; Aronow, Bruce J; Osinska, Hanna; Prywes, Ron; Lorenz, John N; Mori, Kazutoshi; Lawler, Jack; Robbins, Jeffrey; Molkentin, Jeffery D.

Cell; 149(6): 1257-68, 2012 Jun 08.

Artículo en Inglés | MEDLINE | ID: mdl-22682248

2.

Thrombospondins in the tumor microenvironment.

Petrik, James; Lauks, Sylvia; Garlisi, Bianca; Lawler, Jack.

Semin Cell Dev Biol; 155(Pt B): 3-11, 2024 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-37286406

3.

Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis.

Eroglu, Cagla; Allen, Nicola J; Susman, Michael W; O'Rourke, Nancy A; Park, Chan Young; Ozkan, Engin; Chakraborty, Chandrani; Mulinyawe, Sara B; Annis, Douglas S; Huberman, Andrew D; Green, Eric M; Lawler, Jack; Dolmetsch, Ricardo; Garcia, K Christopher; Smith, Stephen J; Luo, Z David; Rosenthal, Arnon; Mosher, Deane F; Barres, Ben A.

Cell; 139(2): 380-92, 2009 Oct 16.

Artículo en Inglés | MEDLINE | ID: mdl-19818485

4.

Counter regulation of tumor angiogenesis by vascular endothelial growth factor and thrombospondin-1.

Lawler, Jack.

Semin Cancer Biol; 86(Pt 2): 126-135, 2022 11.

Artículo en Inglés | MEDLINE | ID: mdl-36191900

5.

Addition of an Fc-IgG induces receptor clustering and increases the in vitro efficacy and in vivo anti-tumor properties of the thrombospondin-1 type I repeats (3TSR) in a mouse model of advanced stage ovarian cancer.

Matuszewska, Kathy; Ten Kortenaar, Simone; Pereira, Madison; Santry, Lisa A; Petrik, Duncan; Lo, Kin-Ming; Bridle, Byram W; Wootton, Sarah K; Lawler, Jack; Petrik, Jim.

Gynecol Oncol; 164(1): 154-169, 2022 01.

Artículo en Inglés | MEDLINE | ID: mdl-34799137

6.

Antiangiogenic Variant of TSP-1 Targets Tumor Cells in Glioblastomas.

Choi, Sung Hugh; Tamura, Kaoru; Khajuria, Rajiv Kumar; Bhere, Deepak; Nesterenko, Irina; Lawler, Jack; Shah, Khalid.

Mol Ther; 32(5): 1595, 2024 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-38702134

7.

Antiangiogenic Variant of TSP-1 Targets Tumor Cells in Glioblastomas.

Choi, Sung Hugh; Tamura, Kaoru; Khajuria, Rajiv Kumar; Bhere, Deepak; Nesterenko, Irina; Lawler, Jack; Shah, Khalid.

Mol Ther; 2024 May 05.

Artículo en Inglés | MEDLINE | ID: mdl-38710183

8.

Fluvastatin inhibits intimal hyperplasia in wild-type but not Thbs1-null mice.

Desai, Pratik; Helkin, Alex; Odugbesi, Adeola; Stein, Jeff; Bruch, David; Lawler, Jack; Maier, Kristopher G; Gahtan, Vivian.

J Surg Res; 210: 1-7, 2017 04.

Artículo en Inglés | MEDLINE | ID: mdl-28457315

9.

Combined therapy with thrombospondin-1 type I repeats (3TSR) and chemotherapy induces regression and significantly improves survival in a preclinical model of advanced stage epithelial ovarian cancer.

Russell, Samantha; Duquette, Mark; Liu, Joyce; Drapkin, Ronny; Lawler, Jack; Petrik, Jim.

FASEB J; 29(2): 576-88, 2015 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-25395453

10.

Antiangiogenic variant of TSP-1 targets tumor cells in glioblastomas.

Choi, Sung Hugh; Tamura, Kaoru; Khajuria, Rajiv Kumar; Bhere, Deepak; Nesterenko, Irina; Lawler, Jack; Shah, Khalid.

Mol Ther; 23(2): 235-43, 2015 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-25358253

11.

The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1.

Qin, Liuliang; Zhao, Dezheng; Xu, Jianfeng; Ren, Xianghui; Terwilliger, Ernest F; Parangi, Sareh; Lawler, Jack; Dvorak, Harold F; Zeng, Huiyan.

Blood; 121(11): 2154-64, 2013 Mar 14.

Artículo en Inglés | MEDLINE | ID: mdl-23315169

12.

Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner.

Xie, Liang; Duncan, Michael B; Pahler, Jessica; Sugimoto, Hikaru; Martino, Margot; Lively, Julie; Mundel, Thomas; Soubasakos, Mary; Rubin, Kristofer; Takeda, Takaaki; Inoue, Masahiro; Lawler, Jack; Hynes, Richard O; Hanahan, Douglas; Kalluri, Raghu.

Proc Natl Acad Sci U S A; 108(24): 9939-44, 2011 Jun 14.

Artículo en Inglés | MEDLINE | ID: mdl-21622854

13.

When is a thrombogenic matrix not thrombogenic?

Lawler, Jack.

Blood; 128(12): 1543-4, 2016 09 22.

Artículo en Inglés | MEDLINE | ID: mdl-27658700

14.

Priming of the vascular endothelial growth factor signaling pathway by thrombospondin-1, CD36, and spleen tyrosine kinase.

Kazerounian, Shideh; Duquette, Mark; Reyes, Millys A; Lawler, James T; Song, Keli; Perruzzi, Carole; Primo, Luca; Khosravi-Far, Roya; Bussolino, Federico; Rabinovitz, Isaac; Lawler, Jack.

Blood; 117(17): 4658-66, 2011 Apr 28.

Artículo en Inglés | MEDLINE | ID: mdl-21378271

15.

Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis.

Shaked, Yuval; Bertolini, Francesco; Man, Shan; Rogers, Michael S; Cervi, Dave; Foutz, Thomas; Rawn, Kimberley; Voskas, Daniel; Dumont, Daniel J; Ben-David, Yaacov; Lawler, Jack; Henkin, Jack; Huber, Jim; Hicklin, Daniel J; D'Amato, Robert J; Kerbel, Robert S.

Cancer Cell; 7(1): 101-11, 2005 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-15652753

16.

B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression.

Nucera, Carmelo; Porrello, Alessandro; Antonello, Zeus Andrea; Mekel, Michal; Nehs, Matthew A; Giordano, Thomas J; Gerald, Damien; Benjamin, Laura E; Priolo, Carmen; Puxeddu, Efisio; Finn, Stephen; Jarzab, Barbara; Hodin, Richard A; Pontecorvi, Alfredo; Nose, Vânia; Lawler, Jack; Parangi, Sareh.

Proc Natl Acad Sci U S A; 107(23): 10649-54, 2010 Jun 08.

Artículo en Inglés | MEDLINE | ID: mdl-20498063

17.

The Tyrosine Kinase Inhibitor Lenvatinib Inhibits Anaplastic Thyroid Carcinoma Growth by Targeting Pericytes in the Tumor Microenvironment.

Iesato, Asumi; Li, Stephanie; Sadow, Peter M; Abbasian, Mohammadreza; Nazarian, Ara; Lawler, Jack; Nucera, Carmelo.

Thyroid; 33(7): 835-848, 2023 07.

Artículo en Inglés | MEDLINE | ID: mdl-37171127

18.

Thrombospondin-1-deficient mice are not protected from bleomycin-induced pulmonary fibrosis.

Ezzie, Michael E; Piper, Melissa G; Montague, Christine; Newland, Christie A; Opalek, Judy M; Baran, Chris; Ali, Naeem; Brigstock, David; Lawler, Jack; Marsh, Clay B.

Am J Respir Cell Mol Biol; 44(4): 556-61, 2011 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-20581099

19.

Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer.

Nucera, Carmelo; Nehs, Matthew A; Nagarkatti, Sushruta S; Sadow, Peter M; Mekel, Michal; Fischer, Andrew H; Lin, Paul S; Bollag, Gideon E; Lawler, Jack; Hodin, Richard A; Parangi, Sareh.

Oncologist; 16(3): 296-309, 2011.

Artículo en Inglés | MEDLINE | ID: mdl-21355020

20.

The structure of the Ca²+-binding, glycosylated F-spondin domain of F-spondin - A C2-domain variant in an extracellular matrix protein.

Tan, Kemin; Lawler, Jack.

BMC Struct Biol; 11: 22, 2011 May 10.

Artículo en Inglés | MEDLINE | ID: mdl-21569239

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A thrombospondin-dependent pathway for a protective ER stress response.

Thrombospondins in the tumor microenvironment.

Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis.

Counter regulation of tumor angiogenesis by vascular endothelial growth factor and thrombospondin-1.

Addition of an Fc-IgG induces receptor clustering and increases the in vitro efficacy and in vivo anti-tumor properties of the thrombospondin-1 type I repeats (3TSR) in a mouse model of advanced stage ovarian cancer.

Antiangiogenic Variant of TSP-1 Targets Tumor Cells in Glioblastomas.

Antiangiogenic Variant of TSP-1 Targets Tumor Cells in Glioblastomas.

Fluvastatin inhibits intimal hyperplasia in wild-type but not Thbs1-null mice.

Combined therapy with thrombospondin-1 type I repeats (3TSR) and chemotherapy induces regression and significantly improves survival in a preclinical model of advanced stage epithelial ovarian cancer.

Antiangiogenic variant of TSP-1 targets tumor cells in glioblastomas.

The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1.

Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner.

When is a thrombogenic matrix not thrombogenic?

Priming of the vascular endothelial growth factor signaling pathway by thrombospondin-1, CD36, and spleen tyrosine kinase.

Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis.

B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression.

The Tyrosine Kinase Inhibitor Lenvatinib Inhibits Anaplastic Thyroid Carcinoma Growth by Targeting Pericytes in the Tumor Microenvironment.

Thrombospondin-1-deficient mice are not protected from bleomycin-induced pulmonary fibrosis.

Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer.

The structure of the Ca²+-binding, glycosylated F-spondin domain of F-spondin - A C2-domain variant in an extracellular matrix protein.