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1.
CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia.
J Med Chem;
64(4): 1835-1843, 2021 02 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33591756
2.
Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma.
J Med Chem;
63(13): 6648-6676, 2020 07 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32130004
3.
5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett;
19(2): 451-8, 2009 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19054673
4.
5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett;
19(21): 6047-52, 2009 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19796938
5.
Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett;
19(22): 6404-12, 2009 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19818610
6.
ATLAS--a high-throughput affinity-based screening technology for soluble proteins: technology application using p38 MAP kinase.
Assay Drug Dev Technol;
6(1): 55-68, 2008 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-18336086
7.
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents.
Bioorg Med Chem Lett;
18(20): 5635-9, 2008 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18796353
8.
Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett;
18(18): 5002-5, 2008 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18722768
9.
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties.
Bioorg Med Chem Lett;
18(11): 3421-6, 2008 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18442904
10.
Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett;
18(12): 3616-21, 2008 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18487044
11.
Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase.
Bioorg Med Chem Lett;
18(14): 4181-5, 2008 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18554907
12.
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments.
Bioorg Med Chem Lett;
18(11): 3446-55, 2008 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18457949
13.
4-(1,1-Dioxo-1,4-dihydro-1lambda6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett;
18(16): 4628-32, 2008 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18662878
14.
The P450cam G248E mutant covalently binds its prosthetic heme group.
Biochemistry;
44(10): 4091-9, 2005 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15751986
15.
Covalent attachment of the heme prosthetic group in the CYP4F cytochrome P450 family.
Biochemistry;
41(18): 5931-7, 2002 May 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-11980497
16.
Participation of histidine-51 in catalysis by horse liver alcohol dehydrogenase.
Biochemistry;
43(11): 3014-26, 2004 Mar 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-15023053
17.
Autocatalytic mechanism and consequences of covalent heme attachment in the cytochrome P4504A family.
J Biol Chem;
277(15): 12755-61, 2002 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-11821421
18.
Characterization of heparin binding by a peptide from amyloid P component using capillary electrophoresis, surface plasmon resonance and isothermal titration calorimetry.
Eur J Biochem;
269(12): 2860-7, 2002 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-12071948
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