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1.

Phosphoinositide 3-kinase as a therapeutic target in angiogenic disease.

Wu, Wenyi; Xia, Xiaobo; Tang, Luosheng; Luo, Jing; Xiong, Siqi; Ma, Gaoen; Lei, Hetian.

Exp Eye Res; 236: 109646, 2023 11.

Artículo en Inglés | MEDLINE | ID: mdl-37716399

2.

Ligand-independent activation of platelet-derived growth factor receptor ß promotes vitreous-induced contraction of retinal pigment epithelial cells.

Duan, Yajian; Wu, Wenyi; Cui, Jing; Matsubara, Joanne Aiko; Kazlauskas, Andrius; Ma, Gaoen; Li, Xiaorong; Lei, Hetian.

BMC Ophthalmol; 23(1): 344, 2023 Aug 03.

Artículo en Inglés | MEDLINE | ID: mdl-37537538

3.

Idelalisib inhibits experimental proliferative vitroretinopathy.

Dong, Lijun; Han, Haote; Huang, Xionggao; Ma, Gaoen; Fang, Dong; Qi, Hui; Han, Zhuo; Wang, Luping; Tian, Jingkui; Vanhaesebroeck, Bart; Zhang, Guoming; Zhang, Shaochong; Lei, Hetian.

Lab Invest; 102(12): 1296-1303, 2022 12.

Artículo en Inglés | MEDLINE | ID: mdl-35854067

4.

The roles of mouse double minute 2 (MDM2) oncoprotein in ocular diseases: A review.

Jiang, Heng; Luo, Jing; Lei, Hetian.

Exp Eye Res; 217: 108910, 2022 04.

Artículo en Inglés | MEDLINE | ID: mdl-34998788

5.

Normal vitreous promotes angiogenesis via activation of Axl.

Wu, Wenyi; Xia, Xiaobo; Tang, Luosheng; Yao, Fei; Xu, Huizuo; Lei, Hetian.

FASEB J; 35(1): e21152, 2021 01.

Artículo en Inglés | MEDLINE | ID: mdl-33151576

6.

A robust method for protein depletion based on gene editing.

Yang, Yanhui; Wu, Wenyi; Liu, Tong; Dong, Lijun; Lei, Hetian.

Methods; 194: 3-11, 2021 10.

Artículo en Inglés | MEDLINE | ID: mdl-33705859

7.

AAV-mediated in vivo genome editing in vascular endothelial cells.

Wu, Wenyi; Yang, Yanhui; Yao, Fei; Dong, Lijun; Xia, Xiaobo; Zhang, Shaochong; Lei, Hetian.

Methods; 194: 12-17, 2021 10.

Artículo en Inglés | MEDLINE | ID: mdl-33309782

8.

Chalcomoracin prevents vitreous-induced activation of AKT and migration of retinal pigment epithelial cells.

Han, Haote; Yang, Yanhui; Liu, Bing; Tian, Jingkui; Dong, Lijun; Qi, Hui; Zhu, Wei; Wang, Jiantao; Lei, Hetian.

J Cell Mol Med; 25(19): 9102-9111, 2021 10.

Artículo en Inglés | MEDLINE | ID: mdl-34432370

9.

Normal vitreous promotes angiogenesi via the epidermal growth factor receptor.

You, Mengling; Xia, Xiaobo; Li, Haibo; Wu, Jiayu; Rong, Rong; Zeng, Zhou; Xiong, Kun; Huang, Jufang; Tang, Luosheng; Lei, Hetian; Wu, Wenyi; Ji, Dan.

FASEB J; 34(11): 14799-14809, 2020 11.

Artículo en Inglés | MEDLINE | ID: mdl-32910506

10.

Exosomes mediate an epithelial-mesenchymal transition cascade in retinal pigment epithelial cells: Implications for proliferative vitreoretinopathy.

Zhang, Yao; Wang, Kaizhe; Pan, Jiabin; Yang, Shuai; Yao, Haipei; Li, Min; Li, Hui; Lei, Hetian; Jin, Haiying; Wang, Fang.

J Cell Mol Med; 24(22): 13324-13335, 2020 11.

Artículo en Inglés | MEDLINE | ID: mdl-33047885

11.

Phosphoinositide 3-kinase Î´ inactivation prevents vitreous-induced activation of AKT/MDM2/p53 and migration of retinal pigment epithelial cells.

Han, Haote; Chen, Na; Huang, Xionggao; Liu, Bing; Tian, Jingkui; Lei, Hetian.

J Biol Chem; 294(42): 15408-15417, 2019 10 18.

Artículo en Inglés | MEDLINE | ID: mdl-31467081

12.

PDGFRß plays an essential role in patient vitreous-stimulated contraction of retinal pigment epithelial cells from epiretinal membranes.

Yang, Yanhui; Huang, Xionggao; Ma, Gaoen; Cui, Jing; Matsubara, Joanne Aiko; Kazlauskas, Andrius; Zhao, Jun; Wang, Jiantao; Lei, Hetian.

Exp Eye Res; 197: 108116, 2020 08.

Artículo en Inglés | MEDLINE | ID: mdl-32561481

13.

Idelalisib inhibits vitreous-induced Akt activation and proliferation of retinal pigment epithelial cells from epiretinal membranes.

Xin, Tianyi; Han, Haote; Wu, Wenyi; Huang, Xionggao; Cui, Jing; Matsubara, Joanne Aiko; Song, Jingyuan; Wang, Fang; Colyer, Marcus; Lei, Hetian.

Exp Eye Res; 190: 107884, 2020 01.

Artículo en Inglés | MEDLINE | ID: mdl-31786159

14.

Progress in the application of CRISPR: From gene to base editing.

Wu, Wenyi; Yang, Yanhui; Lei, Hetian.

Med Res Rev; 39(2): 665-683, 2019 03.

Artículo en Inglés | MEDLINE | ID: mdl-30171624

15.

Blockade of MDM2 with inactive Cas9 prevents epithelial to mesenchymal transition in retinal pigment epithelial cells.

Liu, Bing; Song, Jingyuan; Han, Haote; Hu, Zhengping; Chen, Na; Cui, Jing; Matsubara, Joanne Aiko; Zhong, Jingxiang; Lei, Hetian.

Lab Invest; 99(12): 1874-1886, 2019 12.

Artículo en Inglés | MEDLINE | ID: mdl-31439892

16.

Inactive Cas9 blocks vitreous-induced expression of Mdm2 and proliferation and survival of retinal pigment epithelial cells.

Chen, Na; Hu, Zhengping; Yang, Yanhui; Han, Haote; Lei, Hetian.

Exp Eye Res; 186: 107716, 2019 09.

Artículo en Inglés | MEDLINE | ID: mdl-31278903

17.

The Clustered, Regularly Interspaced, Short Palindromic Repeats-associated Endonuclease 9 (CRISPR/Cas9)-created MDM2 T309G Mutation Enhances Vitreous-induced Expression of MDM2 and Proliferation and Survival of Cells.

Duan, Yajian; Ma, Gaoen; Huang, Xionggao; D'Amore, Patricia A; Zhang, Feng; Lei, Hetian.

J Biol Chem; 291(31): 16339-47, 2016 07 29.

Artículo en Inglés | MEDLINE | ID: mdl-27246850

18.

Application of CRISPR-Cas9 in eye disease.

Wu, Wenyi; Tang, Luosheng; D'Amore, Patricia A; Lei, Hetian.

Exp Eye Res; 161: 116-123, 2017 08.

Artículo en Inglés | MEDLINE | ID: mdl-28619505

19.

The current CRISPR methods.

Lei, Hetian; Liu, Guei-Sheung.

Methods; 194: 1-2, 2021 10.

Artículo en Inglés | MEDLINE | ID: mdl-34389459

20.

Correction: Phosphoinositide 3-kinase Î´ inactivation prevents vitreous-induced activation of AKT/MDM2/p53 and migration of retinal pigment epithelial cells.