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1.

Spousal Influence on Diabetes Self-care: Moderating Effects of Distress and Relationship Quality on Glycemic Control.

Soriano, Emily C; Lenhard, James M; Gonzalez, Jeffrey S; Tennen, Howard; Chow, Sy-Miin; Otto, Amy K; Perndorfer, Christine; Shen, Biing-Jiun; Siegel, Scott D; Laurenceau, Jean-Philippe.

Ann Behav Med; 55(2): 123-132, 2021 03 16.

Artículo en Inglés | MEDLINE | ID: mdl-32491154

2.

Discovery of a novel series of guanidinebenzoates as gut-restricted enteropeptidase and trypsin dual inhibitors for the treatment of metabolic syndrome.

Zhang, Xuqing; Zhu, Bin; Sun, Weimei; Wang, Mina; Albarazanji, Kamal; Ghosh, Brahma; Cummings, Maxwell; Lenhard, James; Leonard, James; Macielag, Mark; Lanter, James.

Bioorg Med Chem Lett; 40: 127939, 2021 05 15.

Artículo en Inglés | MEDLINE | ID: mdl-33713780

3.

Impaired glucose partitioning in primary myotubes from severely obese women with type 2 diabetes.

Zou, Kai; Turner, Kristen; Zheng, Donghai; Hinkley, J Matthew; Kugler, Benjamin A; Hornby, Pamela J; Lenhard, James; Jones, Terry E; Pories, Walter J; Dohm, G Lynis; Houmard, Joseph A.

Am J Physiol Cell Physiol; 319(6): C1011-C1019, 2020 12 01.

Artículo en Inglés | MEDLINE | ID: mdl-32966127

4.

Targeting Enteropeptidase with Reversible Covalent Inhibitors To Achieve Metabolic Benefits.

Sun, Weimei; Zhang, Xuqing; Cummings, Maxwell D; Albarazanji, Kamal; Wu, Jiejun; Wang, Mina; Alexander, Richard; Zhu, Bin; Zhang, YueMei; Leonard, James; Lanter, James; Lenhard, James.

J Pharmacol Exp Ther; 375(3): 510-521, 2020 12.

Artículo en Inglés | MEDLINE | ID: mdl-33033171

5.

Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice.

Albarazanji, Kamal; Jennis, Matthew; Cavanaugh, Cassandre R; Lang, Wensheng; Singh, Bhanu; Lanter, James C; Lenhard, James M; Hornby, Pamela J.

Am J Physiol Gastrointest Liver Physiol; 316(5): G653-G667, 2019 05 01.

Artículo en Inglés | MEDLINE | ID: mdl-30920846

6.

Altered tricarboxylic acid cycle flux in primary myotubes from severely obese humans.

Zou, Kai; Hinkley, J Matthew; Park, Sanghee; Zheng, Donghai; Jones, Terry E; Pories, Walter J; Hornby, Pamela J; Lenhard, James; Dohm, G Lynis; Houmard, Joseph A.

Int J Obes (Lond); 43(4): 895-905, 2019 04.

Artículo en Inglés | MEDLINE | ID: mdl-29892037

7.

Potent Sodium/Glucose Cotransporter SGLT1/2 Dual Inhibition Improves Glycemic Control Without Marked Gastrointestinal Adaptation or Colonic Microbiota Changes in Rodents.

Du, Fuyong; Hinke, Simon A; Cavanaugh, Cassandre; Polidori, David; Wallace, Nathanial; Kirchner, Thomas; Jennis, Matthew; Lang, Wensheng; Kuo, Gee-Hong; Gaul, Micheal D; Lenhard, James; Demarest, Keith; Ajami, Nadim J; Liang, Yin; Hornby, Pamela J.

J Pharmacol Exp Ther; 365(3): 676-687, 2018 06.

Artículo en Inglés | MEDLINE | ID: mdl-29674332

8.

A candidate-gene association study of topiramate-induced weight loss in obese patients with and without type 2 diabetes mellitus.

Li, Qingqin S; Lenhard, James M; Zhan, Yiping; Konvicka, Karel; Athanasiou, Maria C; Strauss, Richard S; Francke, Stephan.

Pharmacogenet Genomics; 26(2): 53-65, 2016 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-26524290

9.

4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: part 2. Pyridazine-based analogs.

Yang, Shyh-Ming; Tang, Yuting; Rano, Thomas; Lu, Huajun; Kuo, Gee-Hong; Gaul, Michael D; Li, Yaxin; Ho, George; Lang, Wensheng; Conway, James G; Liang, Yin; Lenhard, James M; Demarest, Keith T; Murray, William V.

Bioorg Med Chem Lett; 24(5): 1437-41, 2014 Mar 01.

Artículo en Inglés | MEDLINE | ID: mdl-24405703

10.

4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: urea-based analogs.

Yang, Shyh-Ming; Tang, Yuting; Zhang, Rui; Lu, Huajun; Kuo, Gee-Hong; Gaul, Michael D; Li, Yaxin; Ho, George; Conway, James G; Liang, Yin; Lenhard, James M; Demarest, Keith T; Murray, William V.

Bioorg Med Chem Lett; 23(24): 6773-6, 2013 Dec 15.

Artículo en Inglés | MEDLINE | ID: mdl-24153205

11.

Time course metabolome of Roux-en-Y gastric bypass confirms correlation between leptin, body weight and the microbiome.

Seridi, Loqmane; Leo, Gregory C; Dohm, G Lynis; Pories, Walter J; Lenhard, James.

PLoS One; 13(5): e0198156, 2018.

Artículo en Inglés | MEDLINE | ID: mdl-29851973

12.

Preclinical developments in type 2 diabetes.

Lenhard, James M; Gottschalk, William K.

Adv Drug Deliv Rev; 54(9): 1199-212, 2002 Nov 05.

Artículo en Inglés | MEDLINE | ID: mdl-12393301

13.

Structure-based design of potent retinoid X receptor alpha agonists.

Haffner, Curt D; Lenhard, James M; Miller, Aaron B; McDougald, Darryl L; Dwornik, Kate; Ittoop, Olivia R; Gampe, Robert T; Xu, H Eric; Blanchard, Steve; Montana, Valerie G; Consler, Tom G; Bledsoe, Randy K; Ayscue, Andrea; Croom, Dallas.

J Med Chem; 47(8): 2010-29, 2004 Apr 08.

Artículo en Inglés | MEDLINE | ID: mdl-15056000

14.

Thioredoxin-mimetic peptide CB3 lowers MAPKinase activity in the Zucker rat brain.

Cohen-Kutner, Moshe; Khomsky, Lena; Trus, Michael; Ben-Yehuda, Hila; Lenhard, James M; Liang, Yin; Martin, Tonya; Atlas, Daphne.

Redox Biol; 2: 447-56, 2014.

Artículo en Inglés | MEDLINE | ID: mdl-24624334

15.

Lipogenic enzymes as therapeutic targets for obesity and diabetes.

Lenhard, James M.

Curr Pharm Des; 17(4): 325-31, 2011.

Artículo en Inglés | MEDLINE | ID: mdl-21375498

16.

Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents.

Patch, Raymond J; Searle, Lily L; Kim, Alexander J; De, Debyendu; Zhu, Xizhen; Askari, Hossein B; O'Neill, John C; Abad, Marta C; Rentzeperis, Dionisios; Liu, Jianying; Kemmerer, Michael; Lin, Ling; Kasturi, Jyotsna; Geisler, John G; Lenhard, James M; Player, Mark R; Gaul, Micheal D.

J Med Chem; 54(3): 788-808, 2011 Feb 10.

Artículo en Inglés | MEDLINE | ID: mdl-21218783

17.

Diabetogenic effect of a series of tricyclic delta opioid agonists structurally related to cyproheptadine.

Codd, Ellen E; Baker, Judith; Brandt, Michael R; Bryant, Stewart; Cai, Chaozhong; Carson, John R; Chevalier, Kristen M; Colburn, Raymond W; Coogan, Timothy P; Dax, Scott L; Decorte, Bart; Kemmerer, Michael; Legrand, Edmund K; Lenhard, James M; Leone, Angelique M; Lin, Ling; Mabus, John R; McDonnell, Mark E; McMillian, Michael K; McNally, James J; Stone, Dennis J; Wang, Charles Y; Zhang, Sui-Po; Flores, Christopher M.

Toxicol Sci; 117(2): 493-504, 2010 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-20616206

18.

MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema.

Gregoire, Francine M; Zhang, Fang; Clarke, Holly J; Gustafson, Thomas A; Sears, Dorothy D; Favelyukis, Svetlana; Lenhard, James; Rentzeperis, Dennis; Clemens, L Edward; Mu, Yi; Lavan, Brian E.

Mol Endocrinol; 23(7): 975-88, 2009 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-19389808

19.

2-Cyano-4-fluoro-1-thiovalylpyrrolidine analogues as potent inhibitors of DPP-IV.

Haffner, Curt D; McDougald, Darryl L; Reister, Steven M; Thompson, Brian D; Conlee, Christopher; Fang, Jing; Bass, Jonathan; Lenhard, James M; Croom, Dallas; Secosky-Chang, Melissa B; Tomaszek, Thaddeus; McConn, Donavon; Wells-Knecht, Kevin; Johnson, Paul R.

Bioorg Med Chem Lett; 15(23): 5257-61, 2005 Dec 01.

Artículo en Inglés | MEDLINE | ID: mdl-16168640

20.

Select HIV protease inhibitors alter bone and fat metabolism ex vivo.

Jain, Renu G; Lenhard, James M.

J Biol Chem; 277(22): 19247-50, 2002 May 31.

Artículo en Inglés | MEDLINE | ID: mdl-11937496

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