Prognostic significance of prognostic nutritional index and systemic immune-inflammation index in patients after curative breast cancer resection: a retrospective cohort study.

BACKGROUND: Nutritional status and inflammation are closely associated with poor outcome in malignant tumors. However, the prognostic impact of postoperative in these variables on breast cancer (BC) remains inconclusive. We aimed to determine whether prognostic nutritional index (PNI), systemic immune-inflammation index (SII), neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) affect two long-term outcomes among patients after curative resection of BC. METHODS: We retrospectively reviewed 508 patients with BC treated with curative surgery between February 5, 2013 and May 26, 2020. All patients were divided into 3 groups based on tertiles (T1-T3) of PNI, SII, NLR, and PLR. The effects of four indexes on disease-free survival (DFS) and overall survival (OS) have been evaluated using Cox proportional hazards models and Kaplan-Meier method. RESULTS: Compared with PNI-lowest cases, patients with highest PNI showed significantly longer DFS (multivariate adjusted hazard ratio [HR] = 0.37, 95% confident interval [CI] 0.19-0.70, P for trend = 0.002), whereas higher PLR seemed to be marginally associated with poorer DFS (P for trend = 0.086 and 0.074, respectively). Subgroup analyses indicate the potential modification effects of family history of BC and radiotherapy on the prognosis value of PNI to DFS in BC patients (P for interaction = 0.004 and 0.025, respectively). In addition, the levels of three inflammatory indices, namely SII, NLR, and PLR might be positively related with increased age at diagnosis (all P for trend < 0.001). CONCLUSIONS: A high PNI was associated with better DFS, supporting its roles as prognostic parameters for patients with BC. The nutritional status and systemic immune may exert great effects on patient prognosis. Further studies are warrant to explore the prognosis value of PLR.

[The clinical characteristics of primary intracranial germinoma].

OBJECTIVE: To analyse the clinical characteristics of intracranial germinoma. METHODS: Retrospective analysis was applied to study the clinical characteristics of 26 intracranial germ cell tumor patients admitted to our hospital during 1991-2003. The clinical, biochemical and imaging profiles including human chorionic gonadotropin-beta, alphafetoprotein, MRI and CT as well as treatments were analysed. RESULTS: 26 intracranial germ cell tumor patients were admitted to our hospital during 1991-2003, accounting for 0.9% of all intracranial tumors (3020 cases) at the same time. Among these patients 19 cases (73.1%) were primary intracranial germinoma, 9 patients (47.4%) were female and 10 patients (52.6%) were male. 13 patients (68.4%) were younger than 20 years. 14 patients (73.7%) had headache, vomiting and nausea, 8 patients (42.1%) had diabetes insipidus, 5 patients (26.3%) had hypopituitarism. 9 patients' tumors (47.3%) were in pine region, 7 patients' tumors (38.8%) were in sellar region. 14 patients (73.7%) were treated wit radiotherapy and all of them were discharged with good condition. 10 patients were treated with operation (7 patients accepted radiotherapy after operation) and 2 of them died after operation. CONCLUSIONS: Intracranial germinoma mainly affects female children and adolescents, pine and suprasellar regions are the commonly involved regions, the most common manifestations of intracranial germinoma are headache, vomiting, nausea, diabetes insipidus and hypopituitarism. Radiotherapy has good efficacy in the treatment of intracranial germinoma.