Flexible Ti3 C2 Tx MXene Bonded Bio-Derived Carbon Fibers Support Tin Disulfide for Fast and Stable Sodium Storage.

High energy density and flexible electrodes, which have high mechanical properties and electrochemical stability, are critical to the development of wearable electronics. In this work, a free-standing MXene bonded SnS2 composited nitrogen-doped carbon fibers (MXene/SnS2 @NCFs) film is reported as a flexible anode for sodium-ion batteries. SnS2 nanoparticles with high-capacity properties are covalently decorated in bio-derived nitrogen-doped 1D carbon fibers (SnS2 @NCFs) and further assembled with highly conductive MXene sheets. The addition of bacterial cellulose (BC) can further improve the flexibility of the film. The unique 3D structure of points, lines, and planes can not only offset the disadvantage of low conductivity of SnS2 nanoparticles but also expand the distance between MXene sheets, which is conducive to the penetration of electrolytes. More importantly, the MXene sheets and N-doped 1D carbon fibers (NCFs) can accommodate the large volume expansion of SnS2 nanoparticles and trap polysulfide during the cycle. The MXene/SnS2 @NCFs film exhibits better sodium storage and excellent rate performance compared to the SnS2 @NCFs. The in situ XRD and ex situ (XRD, XPS, and HRTEM) techniques are used to analyze the sodiation process and to deeply study the reaction mechanism of the films. Finally, the quasi-solid-state full cells with MXene/SnS2 @NCFs and Na3 V2 (PO4 )3 @carbon cloth (NVP@CC) fully demonstrate the application potential of the flexible electrodes.

Review of Design Routines of MXene Materials for Magnesium-Ion Energy Storage Device.

Renewable energy storage using electrochemical storage devices is extensively used in various field applications. High-power density supercapacitors and high-energy density rechargeable batteries are some of the most effective devices, while lithium-ion batteries (LIBs) are the most common. Due to the scarcity of Li resources and serious safety concerns during the construction of LIBs, development of safer and cheaper technologies with high performance is warranted. Magnesium is one of the most abundant and replaceable elements on earth, and it is safe as it does not generate dendrite following cycling. However, the lack of suitable electrode materials remains a critical issue in developing electrochemical energy storage devices. 2D MXenes can be used to construct composites with different dimensions, owing to their suitable physicochemical properties and unique magnesium-ion adsorption structure. In this study, the construction strategies of MXene in different dimensions, including its physicochemical properties as an electrode material in magnesium ion energy storage devices are reviewed. Research advancements of MXene and MXene-based composites in various kinds of magnesium-ion storage devices are also analyzed to understand its energy storage mechanisms. Finally, current opportunities, challenges, and future prospects are also briefly discussed to provide crucial information for future research.

Fabrication and Evaluation of Multiwalled Carbon Nanotube-Containing Bijels and Bijels-Derived Porous Nanocomposites.

Structures having continuous porous networks are of great interest for applications in areas such as separation, energy storage, and tissue engineering. Bicontinuous interfacially jammed emulsion gels ("bijels") have been actively investigated as templates for fabricating useful structures for such applications. However, the fabrication of bijels-templated porous nanocomposites incorporated with reinforcing or functional nanoparticles (or nanofibers) to provide specific, targeted functions is still a challenge, stemming from the difficulties of fabricating functional nanoparticle-containing bijels. In this study, bijels-derived porous nanocomposites incorporated with multiwalled carbon nanotubes (MWCNTs), which possessed interconnected channels inside the structures, were made via a facile phase inversion technique for bijels fabrication. For the composite manufacture, in the first step of bijels fabrication, MWCNT adsorption into the oil phase of bijels was observed. It was revealed that MWCNTs were physically absorbed into the oil-rich phase without disrupting the bicontinuous structure of bijels. The successful fabrication of non-crosslinked and crosslinked porous structures containing MWCNTs was evidenced through imaging by confocal laser scanning microscopy and scanning electron microscopy, respectively. For potential controlled release applications, an anticancer drug, doxorubicin hydrochloride (DOX), was incorporated into bijels-derived structures and nanocomposites. The in vitro DOX release profiles from drug delivery systems based on bijels-derived MWCNT-containing nanocomposites suggested that the photothermal effect of MWCNTs initiated by near-infrared irradiation could modulate the drug release behavior. Overall, this study has developed a facile approach to fabricate bijels-templated bicontinuous porous structures incorporated with functional nanoparticles (or nanofibers) and opened an avenue for making MWCNT-containing porous nanocomposites for controlled drug release applications.

A Modified Single-Frequency PPP Method for the Positioning and Time Transfer with BDS-3.

In this paper, time-frequency transfer and positioning experiments with signal coexistence in the BDS system were conducted using the four types of open service signals of the BDS-3 satellite (B1I, B1C, B2a, and B3I), as well as the B2I signals broadcast by the BDS-2 satellites. The experiments used the single-frequency PPP (precise point positioning) method. The experiment validated a modified version of the group and phase ionospheric correction (GRAPHIC) technique. The results demonstrate that, with a single frequency, 18 selected stations may provide positioning results accurate to within a few decimeters. The positioning accuracy of five frequencies signals is improved by 40.4%, 32.2%, 80.3%, 12.4%, and 10.3% when compared to the positioning accuracy of the same signals when using the general observation approach. Currently, the frequency stability may be as precise as dual frequencies with BDS.

miR-23a-3p is involved in drug resistance by directly targeting the influx drug transporter organic anion-transporting polypeptide 2.

OBJECTIVE: Drug transporters are involved in the drug resistance of individuals with drug-resistant epilepsy by influencing the intracerebral transport of antiepileptic drugs (AEDs). The expression of drug transporters is associated with microRNAs. We previously revealed that miR-23a-3p levels were elevated in the blood of patients with intractable epilepsy. Additionally, the influx drug transporter organic anion-transporting polypeptide 2 (Oatp2) is involved in the intracerebral transport of valproic acid (VPA), the most commonly used AED; repeated seizures lead to decreased expression of Oatp2. However, the role of miR-23a-3p in the expression of Oatp2 and in the development of drug resistance has not been established. Herein, we aimed to determine the potential role of miR-23a-3p in VPA-resistant epilepsy through in vivo and in vitro experiments. METHODS: Epilepsy was elicited after status epilepticus (SE) was induced by lithium-pilocarpine in adult Sprague-Dawley rats, followed by VPA treatment to select rats with VPA resistance. The expression of miR-23a-3p was detected by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). A miR-23a-3p inhibitor was intracerebrally injected into VPA-resistant rats, and histological staining and Morris water maze tests were performed to evaluate brain damage and learning/memory functions in these rats. Subsequently, a dual-luciferase reporter assay and a VPA uptake assay were performed in brain microvascular endothelial cells (BMECs) to investigate the underlying mechanism of action of miR-23a-3p. RESULTS: Our results indicated that compared to that in control rats, miR-23a-3p was elevated in VPA-resistant rats. Intracerebral injection of a miR-23a-3p inhibitor reduced brain damage and the associated deficits in learning and memory functions in rats with VPA resistance. Further investigation indicated that Oatp2 was the direct target of miR-23a-3p, and it was negatively regulated by miR-23a-3p in the brain and BMECs. Furthermore, we demonstrated that miR-23a-3p reduced VPA uptake in BMECs by regulating Oatp2 expression. CONCLUSIONS: miR-23a-3p is involved in VPA resistance in epilepsy by directly targeting the influx drug transporter Oatp2, indicating that miR-23a-3p could be a potential therapeutic target for intractable epilepsy.

Phase Inversion-Based Technique for Fabricating Bijels and Bijels-Derived Structures with Tunable Microstructures.

Bicontinuous interfacially jammed emulsion gels ("bijels") are a new class of soft matter containing two interpenetrating continuous phases. They have great potential for applications in many areas. However, difficulties in fabricating bijels and controlling structural features of interest have posed severe barriers to their wide applications. In this study, a phase inversion-based technique was developed for fabricating bijels and bijels-derived structures. The effects of varying the composition of casting solutions for the fabrication of bijels on the porosity, oil-to-water percentage, and domain size of bijels were investigated. Composite bijels prepared from two organic monomers were also made, demonstrating the flexibility of the phase inversion-based technique for the fabrication of bijels. Interestingly, the incorporation of a second monomer into the casting solution also affected the porosity and domain size of bijels formed, which may provide a new strategy for the controlled fabrication of bijels. Doxorubicin hydrochloride (DOX, as a model drug)-loaded bijels-derived hybrid hydrogels comprising two continuous phases were successfully made, with one phase being cross-linked alginate that carried the drug. Controlled release of DOX from the bijels-derived structures could be achieved. In vitro degradation study indicated that cross-linking of alginate in bijels-derived hybrid hydrogels controlled alginate degradation, thereby affecting the DOX release behavior. Our current work has provided a facile and reproducible protocol for the controlled fabrication of bijels and bijels-derived structures, which facilitates expanding their applications in the biomedical field.

Fibulin-5 contributes to colorectal cancer cell apoptosis via the ROS/MAPK and Akt signal pathways by downregulating transient receptor potential cation channel subfamily V member 1.

Fibulin-5, a multifunctional extracellular matrix (ECM) protein, is secreted into the ECM, regulating metastasis and invasion in many malignant tumors. However, its role in colorectal cancer (CRC) has not been reported. In this study, we detected the expression of fibulin-5 in 56 CRC patients and eight CRC cell lines, revealing that fibulin-5 was expressed lower in CRC tumor tissues than in peritumor tissues. Furthermore, our study verified that fibulin-5 promoted cell apoptosis and reactive oxygen species (ROS) production by inhibiting transient receptor potential cation channel subfamily V member 1 (TRPV1) in CRC cells. Moreover, NAC (the scavenger of ROS), SB203580 (the inhibitor of p38), PD98059 (the inhibitor of ERK), and SC79 (the activator of Akt) were used to uncover that fibulin-5 induced apoptosis through the ROS/mitogen-activated protein kinase and Akt signal pathways by downregulating TRPV1. Together, these results suggest that fibulin-5 might serve as a novel drug target for the treatment of CRC patients.

A Highly Conductive MOF of Graphene Analogue Ni3 (HITP)2 as a Sulfur Host for High-Performance Lithium-Sulfur Batteries.

Lithium-sulfur (Li-S) batteries have been considered as one of the most promising energy storage systems owing to their high theoretical capacity and energy density. However, their commercial applications are obstructed by sluggish reaction kinetics and rapid capacity degradation mainly caused by polysulfide shuttling. Herein, the first attempt to utilize a highly conductive metal-organic framework (MOF) of Ni3 (HITP)2 graphene analogue as the sulfur host material to trap and transform polysulfides for high-performance Li-S batteries is made. Besides, the traditional conductive additive acetylene black is replaced by carbon nanotubes to construct matrix conduction networks for triggering the rate and cycling performance of the active cathode. As a result, the S@Ni3 (HITP)2 with sulfur content of 65.5 wt% shows excellent sulfur utilization, rate performance, and cyclic durability. It delivers a high initial capacity of 1302.9 mAh g-1 and good capacity retention of 848.9 mAh g-1 after 100 cycles at 0.2 C. Highly reversible discharge capacities of 807.4 and 629.6 mAh g-1 are obtained at 0.5 and 1 C for 150 and 300 cycles, respectively. Such kinds of pristine MOFs with high conductivity and abundant polar sites reveal broad promising prospect for application in the field of high-performance Li-S batteries.

Thermally Reduced Graphene/MXene Film for Enhanced Li-ion Storage.

Two-dimensional transition-metal carbides called MXenes are emerging electrode materials for energy storage due to their metallic electrical conductivity and low ion diffusion barrier. In this work, we combined Ti2 CTx MXene with graphene oxide (GO) followed by a thermal treatment to fabricate flexible rGO/Ti2 CTr film, in which electrochemically active rGO and Ti2 CTr nanosheets impede the stacking of layers and synergistically interact producing ionically and electronically conducting electrodes. The effect of the thermal treatment on the electrochemical performance of Ti2 CTx is evaluated. As anode for Li-ion storage, the thermally treated Ti2 CTr possesses a higher capacity in comparison to as-prepared Ti2 CTx . The freestanding hybrid rGO/Ti2 CTr films exhibit excellent reversible capacity (700 mAh g-1 at 0.1 Ag-1 ), cycling stability and rate performance. Additionally, flexible rGO/Ti3 C2 Tr films are made using the same method and also present improved capacity. Therefore, this study provides a simple, yet effective, approach to combine rGO with different MXenes, which can enhance their electrochemical properties for Li-ion batteries.

Constructing a high-density linkage map for Gossypium hirsutum × Gossypium barbadense and identifying QTLs for lint percentage.

To introgress the good fiber quality and yield from Gossypium barbadense into a commercial Upland cotton variety, a high-density simple sequence repeat (SSR) genetic linkage map was developed from a BC1 F1 population of Gossypium hirsutum × Gossypium barbadense. The map comprised 2,292 loci and covered 5115.16 centiMorgan (cM) of the cotton AD genome, with an average marker interval of 2.23 cM. Of the marker order for 1,577 common loci on this new map, 90.36% agrees well with the marker order on the D genome sequence genetic map. Compared with five published high-density SSR genetic maps, 53.14% of marker loci were newly discovered in this map. Twenty-six quantitative trait loci (QTLs) for lint percentage (LP) were identified on nine chromosomes. Nine stable or common QTLs could be used for marker-assisted selection. Fifty percent of the QTLs were from G. barbadense and increased LP by 1.07%-2.41%. These results indicated that the map could be used for screening chromosome substitution segments from G. barbadense in the Upland cotton background, identifying QTLs or genes from G. barbadense, and further developing the gene pyramiding effect for improving fiber yield and quality.

[Clinicopathological significance of Sox17 and ß-catenin protein of Wnt in oligodendroglioma].

OBJECTIVE: To investigate the expression of Sox17 and ß-catenin proteins in oligodendroglioma, and its clinical significance. METHODS: One hundred cases of oligodendroglioma of different grades and 10 cases of surrounding benign tissue from First Affiliated Hospital of Xinjiang Medical University from 2003 to 2013 were assessed by immunohistochemistry for Sox17 and ß-catenin protein expression. The clinicopathologic characteristics and outcome of patients with oligodendroglioma were evaluated by Kaplan-Meien and Cox regression analyses. RESULTS: Sox17 was expressed in 10/10, 82% (41/50) and 62% (31/50) of normal control, oligodendroglioma and anaplastic oligodendroglioma, respectively. ß-catenin was expressed in 2/10, 22% (11/50), and 52% (26/50) of normal control, oligodendroglioma and anaplastic oligodendroglioma, respectively. The differences of Sox17 and ß-catenin expression between normal control and different types of oligodendroglioma were statistically significant. Univariate analysis showed that the expression of Sox17 protein (P = 0.000), ß-catenin protein (P = 0.033), tumor position (P = 0.001), radiotherapy (P = 0.077), and chemotherapy (P = 0.000) were significant prognostic factors. CONCLUSIONS: Oligodendrogliomas with expression of Sox17 protein, but not ß-catenin, have better prognosis. Evaluation of Sox17 and ß-catenin protein expression is important for accurate pathological diagnosis, prognostication and guiding treatment.

Flexible TiVCTx MXene film for high-performance magnesium-ion storage device.

Magnesium-based battery system has emerged as the potential candidate to beyond Li-ion battery system due to the numerous advantageous of magnesium anode, such as natural abundance, high capacity and dendrites free. However, the selection of cathode materials and the intercalation of magnesium-ions in the cathode host material remains a challenge due to the strong interaction of highly polar divalent magnesium ions with the cathode material, making the diffusion of magnesium ions relatively difficult. Herein, the flexible TiVCTx MXene film was developed via a facile and economical approach. As the cathode host material for magnesium-ion storage, the freestanding TiVCTx MXene film displays a high specific capacity of 111 and 135 mAh g-1 at a current density of 0.05 A g-1 for magnesium-ion batteries (MIB) and Mg/Li hybrid batteries (MLHB). Furthermore, a long-term cycling stability over 1000 cycles was demonstrated and a detailed investigation of the unique long activation phenomenon of MXene films during cycling. More importantly, the reaction mechanism of magnesium-ion storage was validated, i.e., the MXene interlayer spacing variation with the reversible Mg2+ diffusion behavior. This work reveals the magnesium storage mechanism of MXene materials and provides a new pathway for high-performance storage of magnesium-ion cathode materials.

Ultrasonic reduction: an unconventional route to exsolute Ag from perovskite La(Ag)FeO3-δ for enhanced catalytic oxidation activity.

We explore an uncommon ultrasonic reduction method to exsolute Ag from perovskite La0.87Ag0.03FeO3-δ, forming a composite with enhanced catalytic oxidation activity. Such a mild exsolution is based on the coupling effect of ultrasonic cavitation and reducible BH4-, and holds great potential in the fields of energy and environment catalysis.

Multi-interface Combination of Bimetallic Selenide and V4C3Tx MXene for High-Rate and Ultrastable Sodium Storage Devices.

Sodium-ion batteries (SIBs) have great potential as electrochemical energy storage systems; however, their commercial viability is limited by the lack of anode materials with fast charge/discharge rates and long lifetimes. These challenges were addressed by developing a multi-interface design strategy using FCSe (FeSe2/CoSe2) nanoparticles on V4C3Tx MXene nanosheets as conductive substrates. The heterogeneous interface created between the two materials provided high-speed transport of sodium ions, suppressed the chalking-off of nanoparticles, and improved the cycling stability. Additionally, the Fe-Co bonds generated at the interface effectively relieved mechanical stress, further enhancing the electrode durability. The C@FCSe@V4C3 electrode exhibited high-speed charging and discharging characteristics, and maintained a high specific capacity of 260.5 mAh g-1 even after 15,000 cycles at 10 A g-1, with a capacity retention rate of 50.2% at an ultrahigh current density of 20 A g-1. Furthermore, the composite displayed a good cycling capability in the fast discharge and slow charge mode. This demonstrates its promising commercial potential. This multi-interface design strategy provides insights and guidance for solving the reversibility and cycling problems of transformed selenide anode materials.

Prevalence, outcomes and associated factors of SARS-CoV-2 infection in psoriasis patients of Southwest China: a cross-sectional survey.

In this study we aimed to investigate the prevalence of SARS-CoV-2 infection in psoriasis patients, and outcomes of SARS-CoV-2 infection and associated risk factors. A cross-sectional survey was conducted from February 2023 to March 2023. Information was obtained with online questionnaire about psoriasis patients on demographic characteristics, clinical characteristics, SARS-CoV-2 infection and outcomes, vaccination, and routine protection against COVID-19. Logistic regression analysis was used to explore risk factors with SARS-CoV-2 infection and exacerbation of psoriasis. A total of 613 participants were recruited. 516 (84.2%) were infected, and associated factors were sex, working status, routine protection against COVID-19, COVID-19 vaccination, impaired nail, infection exacerbate psoriasis, and severity of psoriasis. Among the patients infected with SARS-CoV-2, 30 (5.8%) required hospitalization, 122 (23.6%) had psoriasis exacerbation due to SARS-CoV-2 infection, and associated factors were subtype of psoriasis, discontinuation of psoriasis treatment during SARS-CoV-2 infection, response following COVID-19 vaccination, and severity of psoriasis. Booster dose vaccination contributed a low probability of COVID-19 sequelae. COVID-19 vaccine's effectiveness was unsatisfactory, while booster dose vaccination reduced the occurrence of COVID-19 sequelae in psoriasis patients of Southwest China. Patients treated with psoriasis shown to be safe, without a higher incidence of SARS-CoV-2 infection or COVID-19hospitalization compared to untreated patients. Stopping treatment during SARS-CoV-2 infection led to psoriasis exacerbation, so psoriasis treatment could be continued except severe adverse reaction.

[Clinicopathologic significance of ß-catenin protein and loss of heterozygosity on 10q in medulloblastoma].

OBJECTIVE: To study the expression of ß-catenin protein and the status of loss of heterozygosity (LOH) on chromsome 10q in medulloblastoma, with clinical correlation. METHODS: Immunohistochemical study for ß-catenin protein was carried out in 50 cases of medulloblastoma encountered in the First Affiliated Hospital of Xinjiang Medical University during the period from 2002 to 2011, including 32 cases of classic medulloblastoma, 13 cases of desmoplastic medulloblastoma and 5 cases of medulloblastoma with extensive nodularity. The status of LOH on 10q was also detected by fluorescence in-situ hybridization. The clinicopathologic characteristics and prognostic parameters were studied by Kaplan-Meien and Cox analysis. RESULTS: The rates of expression of ß-catenin protein in classic medulloblastoma, desmoplastic medulloblastoma and medulloblastoma with extensive nodularity were 53.1% (17/32), 4/13 and 1/5, respectively. The rate of LOH on 10q was 33.3% (8/24) in classic medulloblastoma and 2/11 in desmoplastic medulloblastoma. There was no statistically significant difference between the two tumor types. Univariate analysis showed that the expression of ß-catenin protein (P = 0.022), lack of LOH on 10q (P = 0.020), extensiveness of tumor resection (P < 0.01), radiotherapy (P = 0.002) and chemotherapy (P < 0.01) represented important prognostic factors. CONCLUSIONS: Medulloblastoma with expression of ß-catenin protein and without LOH on 10q carries a better prognosis. Assessment of these parameters is helpful in evaluating prognosis and subsequent patient management.

[Clinical and pathologic analysis of astrocytic tumors with loss of heterozygosity on chromosome 10q].

OBJECTIVE: To study the correlation between loss of heterozygosity (LOH) on chromosome 10q and pathologic features, pathogenesis, prognosis of astrocytic tumors. METHODS: LOH on 10q was studied by interphase fluorescence in-situ hybridization (FISH) in 85 cases of astrocytic tumor, including 35 cases of WHO grade II tumors and 50 cases of WHO grade IV tumors. RESULTS: LOH on 10q was detected in 6 cases (17.1%) of diffuse astrocytoma (WHO grade II) and 34 cases (68.0%) of glioblastoma (WHO grade IV). 10q polysomy was detected in 7 cases (20.0%) of diffuse astrocytoma and 11 cases (22.0%) of glioblastoma. The rates of LOH on 10q in young age group and elderly group were 36.4% (12/33) and 82.4% (28/34), respectively. The difference was of statistical significance (P < 0.05). The rates of LOH on 10q in the diffuse astrocytoma and glioblastoma were 21.4% (6/28) and 87.2% (34/39), respectively. The difference was also statistically significant (P < 0.05). Univariate survival analysis showed that patient age, pathologic grade and 10q on LOH correlated with duration of survival (P < 0.05). CONCLUSIONS: There are correlation between 10q LOH, patient age and pathologic grade of astrocytic tumors. LOH on 10q is also related to the pathogenesis of astrocytic tumors and is helpful in predicting prognosis.

[Blastic plasmacytoid dendritic cell neoplasm: a clinicopathologic study].

OBJECTIVE: To study the clinicopathologic features and differential diagnosis of blastic plasmacytoid dendritic cell neoplasm. METHODS: The clinical, morphology and immunophenotypic features were analyzed in 3 cases of blastic plasmacytoid dendritic cell neoplasm, with review of literature. RESULTS: The pathologic changes of these tumors accorded with that of blastic plasmacytoid dendritic cell neoplasm, and they also had new characteristics, including lineage other than T, B, myeloid and NK cells, and immunophenotypes of CD56(+) CD4(-) CD123(+) TdT(+) CD43(+) CD68(+) , CD56(+) CD4(+) CD123(-) TdT(+) CD43(+) CD68(-) and CD56(+) CD4(+) CD123(-/+) TdT(-) CD43(+) CD68(+) in the 3 cases, respectively. Bone marrow involvement was found 5 years later in case 1, and was then stable after chemotherapy; case 2 and case 3 were died 5 and 2 months after diagnosis, respectively. CONCLUSION: Blastic plasmacytoid dendritic cell neoplasm is a heterogeneous group of lymphoproliferative disorders, with different clinical, morphologic and immunophenotypic features.

A model for the early identification of sentinel lymph node metastasis in patients with breast cancer based on contrast-enhanced ultrasound and clinical features.

The present study was designed to establish a model for the early identification of sentinel lymph node (SLN) metastasis in patients with breast cancer (BC). The SLN metastasis predictive model was established with a retrospective training set of 365 patients with BC and was re-evaluated using a prospective validation set of 402 patients with BC. The multivariable analysis indicated that the tumor diameter [odds ratio (OR), 1.189; 95% confidence interval (CI), 1.124-1.257; P<0.001], menopause (OR, 1.011; 95% CI, 0.603-1.436; P<0.001), estrogen receptor (ER) expression (OR, 3.199; 95% CI, 1.077-6.567; P=0.043) and contrast-enhanced ultrasonography (CEUS) type (OR, 10.563; 95% CI, 6.890-28.372; P<0.001) were independent predictors of SLN status in patients with BC. The SLN metastasis predictive model was as follows: (0.173 × tumor diameter)-(4.490 × menopause) + (2.322 × ER) + (5.445 × CEUS type)-1.9521. In the training set, the model was highly sensitive (83.6%) and specific (94.3%) for the early identification of SLN metastasis. Similarly, in the validation set, the model was highly sensitive (70.4%) and specific (89.5%) for the early identification of SLN metastasis in patients with BC. Overall, in the present study, a model was successfully established to predict SLN metastasis in patients with BC that includes tumor diameter, menopausal status, ER expression and CEUS detection.

MXene/ZIF-67/PAN Nanofiber Film for Ultra-sensitive Pressure Sensors.

Flexible pressure sensors may be used in electronic skin (e-skin), artificial intelligence devices, and disease diagnosis, which require a large response range and high sensitivity. An appropriate design of the structure of the active layer can help effectively solve this problem. Herein, we aim at developing a wearable pressure sensor using the MXene/ZIF-67/polyacrylonitrile (PAN) nanofiber film, fabricated by electrospinning technology. Owing to the rough structure and three-dimensional network architecture, the MXene/ZIF-67/PAN film-based device displays a broad working range (0-100 kPa), good sensitivity (62.8 kPa-1), robust mechanical stability (over 10,000 cycles), and fast response/recovery time (10/8 ms). Moreover, the fabricated pressure sensors can be used to detect and differentiate between different body motion information, including elbow bending, finger movements, and wrist pulses. Overall, this design of a rough three-dimensional conductive network structure shows potential in the field of wearable electronics and medical devices.