RESUMEN
Over the past decades, asymmetric catalysis has been intensely investigated as a powerful tool for the preparation of numerous chiral biologically active compounds. However, developing general and practical strategies for preparation of both enantiomers of a chiral molecule via asymmetric catalysis is still a challenge, particularly when the two enantiomers of a chiral catalyst are not easily prepared from natural chiral sources. Inspired by the biologic system, we report herein an unprecedented catalytic enantiodivergent Michael addition of pyridazinones to enones by subtle adjustment of achiral amino moiety of dipeptide phosphine catalysts. These two dipeptide phosphine catalysts, P5 and P8, could deliver both enantiomers of a series of N2-alkylpyridazinones in good yields (up to 99%) with high enantioselectivities (up to 99% ee) via the catalyst-controlled enantiodivergent addition of pyridazinones to enones.
RESUMEN
A chiral phosphine-catalyzed tandem Michael addition of tryptamine-derived oxindoles to ynones has been developed, which provides facile access to a series of optically enriched spiro[pyrrolidine-3,3'-oxindole] compounds in good yields with good to excellent enantio- (up to 97% ee) and diastereoselectivities (up to 20 : 1 dr). Mechanistic studies indicate that this tandem reaction proceeds via an intermolecular aza-Michael/intramolecular Michael addition process.
RESUMEN
Forest landscape restoration has been an attractive issue since the catastrophic fire took place on the northern slope of Great Xing'an Mountains in 1987. Based on the China forest inventory data and employing Kendall Bivariate and Distances Correlation Analyses, an investigation was made to search for what changes of the forest coverage pattern being happened in this area during the past 13 years after fire, and how the fire severity, foster type and terrain factors influenced the restoration of forest coverage. The results showed that the forest coverage in 2000 changed a lot, in comparing with that in 1987 before fire. The percentage of non-stocked land area and coverage grade declined markedly, with lower coverage grade increased. Among all test factors, fire severity which was inversely correlated with forest coverage grade was the key one. Though the regeneration measures didn't markedly affect forest coverage restoration within a short period, they might shorten the cycle of forest succession and promote the productivity of coniferous forest in the future. Among three terrain factors, slope was the strongest one affecting forest coverage, followed by position and aspect.