Analysis of the Efficacy of a Sublingual Bacterial Vaccine in the Prophylaxis of Recurrent Urinary Tract Infection.

OBJECTIVES: Recurrent urinary tract infections (R-UTIs) are very common amongst women, and alternatives to antibacterial prophylaxis are necessary. This study evaluates the effectiveness of a sublingual bacterial vaccine for the prophylaxis of R-UTIs. METHODS: We conducted a quasi-experimental pretest-posttest study of 166 women diagnosed with R-UTIs. Both before and after the start of treatment with the vaccine, we analysed the total number of R-UTI episodes, the urine culture results, and the type and number of antibiotic packages consumed. Symptoms and urine cultures were evaluated 3, 6, 9, 12, 18, and 24 months after initiating treatment with the vaccine. RESULTS: The mean time of follow-up after vaccination was 1.7 years. After vaccination, there was a 54.6% reduction in episodes of UTI, and a 56.2% reduction in positive urine cultures. At 3 months, 74.4% of the patients had no R-UTI, the rate falling to 68.1% at 6 months, 52.4% at 12 months, and 44.5% at 24 months. The cumulative probability of maintaining negative urine cultures was 76% at 3 months, 37% at 12 months, and 18% at 2 years. CONCLUSIONS: The use of a sublingual bacterial vaccine for the prophylaxis of R-UTIs in women is an effective treatment that contributes to a reduction in the number of UTI episodes.

Ureterocele bilateral con litiasis / Bilateral ureterocele with lithiasis

El ureterocele es una dilatación quística del extremo intravesical del uréter, que puede asociarse a duplicación ureteral y a reflujo vésico-ureteral. Su diagnóstico suele realizarse en la edad pediátrica, siendo raro en la edad adulta. La mayoría de los casos sintomáticos debutan con infecciones de repetición, siendo más infrecuente la presencia de litiasis y excepcional el carácter bilateral. Presentamos el caso de una paciente de 65 años en estudio por infecciones de repetición de difícil manejo con tratamiento antibiótico que finalmente fue diagnosticada y tratada quirúrgicamente de ureterocele bilateral con presencia de litiasis, presentando posteriormente resolución de sus infecciones urinarias de repetición (AU)

Ureterocele is a cystic dilatation of the intravesical end of the ureter, which may be associated with ureteral duplication and vesicoureteral reflux. Diagnosis is made usually in childhood, being rare in adulthood. Most symptomatic patients present recurrent infections, whereas the presence of lithiasis is more infrequent and the bilateral character is exceptional. We report the case of a 65-year-old woman under study for recurrent infections difficult to manage with antibiotic treatment who was finally diagnosed and treated surgically of bilateral ureterocele with presence of lithiasis, subsequently presenting resolution of her recurrent urinary tract infections (AU)

Litiasis de gran tamaño impactada en meato uretral / Large size stone impacted in urethral meatus

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Uropatía obstructiva por acodamiento de catéter doble J / Obstructive uropathy due to double J catheter bending

No disponible