Detalles de la búsqueda
1.
Application of Covalent Binding Body Burden in the HµREL Human Hepatocyte Coculture Model for Reactivity Risk Assessment of Metabolically Low Turnover Drugs.
Chem Res Toxicol;
37(4): 540-544, 2024 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38530825
2.
Metabolism and disposition of JNJ-10450232 (NTM-006) in rats, dogs, monkeys and humans.
Regul Toxicol Pharmacol;
: 105379, 2023 Mar 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-36931586
3.
Bifunctionalized isotopologs as calibrants for standard-free quantitation of drug metabolites in plasma by liquid chromatography coupled with radiometry and mass spectrometry.
Biomed Chromatogr;
36(1): e5242, 2022 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-34519061
4.
Reductive Desulfuration as an Important Tool in Detection of Small Molecule Modifications to Payload of Antibody Drug Conjugates.
Anal Chem;
91(3): 2368-2375, 2019 02 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30609358
5.
Discovery of novel benzo[b]thiophene tetrazoles as non-carboxylate GPR40 agonists.
Bioorg Med Chem Lett;
28(3): 429-436, 2018 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29258772
6.
Standard-Free Bioanalytical Approach for Absolute Quantitation of Drug Metabolites Utilizing Biosynthesis of Reciprocal Radio and Stable Isotopologues and Its Application.
Anal Chem;
89(16): 8399-8404, 2017 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28696683
7.
In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozin.
Br J Clin Pharmacol;
83(5): 1082-1096, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-27862160
8.
Cytochrome P450 induction response in tethered spheroids as a three-dimensional human hepatocyte in vitro model.
J Appl Toxicol;
36(2): 320-9, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26201057
9.
A nonradioactive approach to investigate the metabolism of therapeutic peptides by tagging with 127i and using inductively-coupled plasma mass spectrometry analysis.
Drug Metab Dispos;
43(1): 17-26, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25315343
10.
Contribution of metabolites to P450 inhibition-based drug-drug interactions: scholarship from the drug metabolism leadership group of the innovation and quality consortium metabolite group.
Drug Metab Dispos;
43(4): 620-30, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25655830
11.
Metabolism and excretion of canagliflozin in mice, rats, dogs, and humans.
Drug Metab Dispos;
42(5): 903-16, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-24568888
12.
Free radical metabolism of raloxifene in human liver microsomes.
Xenobiotica;
42(8): 737-47, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22375838
13.
Overcoming the genotoxicity of a pyrrolidine substituted arylindenopyrimidine as a potent dual adenosine A(2A)/A(1) antagonist by minimizing bioactivation to an iminium ion reactive intermediate.
Chem Res Toxicol;
24(7): 1012-30, 2011 Jul 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-21667953
14.
Spirocyclic Thiohydantoin Antagonists of F877L and Wild-Type Androgen Receptor for Castration-Resistant Prostate Cancer.
ACS Med Chem Lett;
12(8): 1245-1252, 2021 Aug 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34422225
15.
Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC).
J Med Chem;
64(2): 909-924, 2021 01 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-33470111
16.
The conduct of in vitro studies to address time-dependent inhibition of drug-metabolizing enzymes: a perspective of the pharmaceutical research and manufacturers of America.
Drug Metab Dispos;
37(7): 1355-70, 2009 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-19359406
17.
Discovery of a GPR40 Superagonist: The Impact of Aryl Propionic Acid α-Fluorination.
ACS Med Chem Lett;
10(1): 16-21, 2019 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30655940
18.
Reproducing human and cross-species drug toxicities using a Liver-Chip.
Sci Transl Med;
11(517)2019 11 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31694927
19.
Fasiglifam (TAK-875): Mechanistic Investigation and Retrospective Identification of Hazards for Drug Induced Liver Injury.
Toxicol Sci;
163(2): 374-384, 2018 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28206647
20.
Pharmacokinetics of sirolimus (rapamycin) in subjects with mild to moderate hepatic impairment.
J Clin Pharmacol;
45(12): 1368-72, 2005 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-16291711