Synthesis and characterization of Craig-type antiaromatic species with [4n + 2] π electrons.

Antiaromaticity is extended from aromaticity as a complement to describe the unsaturated cyclic molecules with antiaromatic destabilization. To prepare antiaromatic species is a particularly challenging goal in synthetic chemistry because of the thermodynamic instability of such molecules. Among that, both Hückel and Möbius antiaromatic species have been reported, whereas the Craig one has not been realized to date. Here, we report the first example of planar Craig antiaromatic species. Eight Craig antiaromatic compounds were synthesized by deprotonation-induced reduction process and were fully characterized as follows. Single-crystal X-ray crystallography showed that these complexes have planar structures composed of fused five-membered rings with clearly alternating carbon-carbon bond lengths. In addition, proton NMR (1H NMR) spectroscopy in these structures showed distinctive upfield shifts of the proton peaks to the range of antiaromatic peripheral hydrogens. Experimental spectroscopy observations, along with density-functional theory (DFT) calculations, provided evidence for the Craig antiaromaticity of these complexes. Further study experimentally and theoretically revealed that the strong exothermicity of the acid-base neutralization process was the driving force for this challenging transformation forming Craig antiaromatic species. Our findings complete a full cycle of aromatic chemistry, opening an avenue for the development of new class of antiaromatic systems.

Ultrathin Ni-Fe MOF Nanosheets: Efficient and Durable Water Oxidation at High Current Densities.

Efficient, durable, and economical electrocatalysts are crucial for advancing energy technology by facilitating the oxygen evolution reaction (OER). Here, ultrathin Ni-Fe metal-organic skeleton (MOF) nanosheets were created in situ on nickel foam (NiFe-UMNs/NF). The catalyst exhibited excellent OER catalytical abilities, with only 269 mV overpotentials at 250 mA cm-2. Besides, when integrated with Pt/C/NF, NiFe-UMNs/NF held the potential for application in industrial alkaline water electrolysis with an initial voltage retention of approximately 86% following a continuous operation of 100 h at a current density of 250 mA cm-2. The super performance of the NiFe-UMNs/NF catalyst was attributed to ultrathin morphology, super hydrophilicity, and synergistic effects between Ni and Fe within the MOF. In situ Raman showed that NiFe-UMNs were converted to NiFeOOH as the active species in the OER process. Density functional theory revealed that iron doping accelerated the rate-determining step and reduced the OER reaction energy barrier. This work elucidated a promising electrocatalyst for OER and enriched the practical implementation of MOF materials.

High CO-Tolerant Ru-Based Catalysts by Constructing an Oxide Blocking Layer.

CO poisoning of Pt-group metal catalysts is a long-standing problem, particularly for hydrogen oxidation reaction in proton exchange membrane fuel cells. Here, we report a catalyst of Ru oxide-coated Ru supported on TiO2 (Ru@RuO2/TiO2), which can tolerate 1-3% CO, enhanced by about 2 orders of magnitude over the classic PtRu/C catalyst, for hydrogen electrooxidation in a rotating disk electrode test. This catalyst can work stably in 1% CO/H2 for 50 h. About 20% of active sites can survive even in a pure CO environment. The high CO tolerance is not via a traditional bifunctional mechanism, i.e., oxide promoting CO oxidation, but rather via hydrous metal oxide shell blocking CO adsorption. An ab initio molecular dynamics (AIMD) simulation indicates that water confined in grain boundaries of the Ru oxide layer and Ru surface can suppress the diffusion and adsorption of CO. This oxide blocking layer approach opens a promising avenue for the design of high CO-tolerant electrocatalysts for fuel cells.

Insights into reaction mechanisms of ethanol electrooxidation at the Pt/Au(111) interfaces using density functional theory.

Understanding ethanol electrooxidation reaction kinetics is fundamental to the development of direct ethanol fuel cells. The utilization of binary PtAu catalysts has been reported recently as an effective strategy to enhance ethanol electrocatalytic oxidation; however, the catalytic reaction mechanisms are still unclear. In this work, we systematically studied the ethanol electrooxidation reaction mechanisms on Pt/Au(111) model surfaces at an atomic level through high level density functional theory (DFT) calculations; particularly the flat (111) terrace and the stepped (111) × (110) and (111) × (100) interfaces with diverse surface atomic arrangements were considered, respectively. It was found that for ethanol dissociation, the flat (111) terrace is more active than the stepped (111) × (110) and (111) × (100) interfaces. The stepped interfaces, however, could activate water from the aqueous electrolyte solution to form adsorbed OH* at the electrode potential below 0.53 V vs. SHE (standard hydrogen electrode), which is of great importance in coupling with the CH3CO* intermediate formed from ethanol dissociation to produce acetic acid as the final product of the ethanol electrooxidation reaction without releasing CO2. The C-C bond splitting process for ethanol oxidation to form C1 products was very limited. The terrace sites can facilitate both ethanol decomposition and acetic acid formation at the electrode potential above 0.53 V vs. SHE. Our results clearly identify the fact that for ethanol electrooxidation reactions, with an increase in electrode potential, the active sites on Pt/Au(111) surfaces change from those at the stepped interfaces to the flat terrace sites.

Layered double hydroxide-based electrocatalysts for the oxygen evolution reaction: identification and tailoring of active sites, and superaerophobic nanoarray electrode assembly.

The electrocatalytic oxygen evolution reaction (OER) is a critical half-cell reaction for hydrogen production via water electrolysis. However, the practical OER suffers from sluggish kinetics and thus requires efficient electrocatalysts. Transition metal-based layered double hydroxides (LDHs) represent one of the most active classes of OER catalysts. An in-depth understanding of the activity of LDH based electrocatalysts can promote further rational design and active site regulation of high-performance electrocatalysts. In this review, the fundamental understanding of the structural characteristics of LDHs is demonstrated first, then comparisons and in-depth discussions of recent advances in LDHs as highly active OER catalysts in alkaline media are offered, which include both experimental and computational methods. On top of the active site identification and structural characterization of LDHs on an atomic scale, strategies to promote the OER activity are summarised, including doping, intercalation and defect-making. Furthermore, the concept of superaerophobicity, which has a profound impact on the performance of gas evolution electrodes, is explored to enhance LDHs and their derivatives for a large scale OER. In addition, certain operating standards for OER measurements are proposed to avoid inconsistency in evaluating the OER activity of LDHs. Finally, several key challenges in using LDHs as anode materials for large scale water splitting, such as the issue of stability and the adoption of membrane-electrode-assembly based electrolysers, are emphasized to shed light on future research directions.

Supercooled melt structure and dynamics of single-chain nanoparticles: A computer simulation study.

By using coarse-grained molecular dynamics simulations, we have investigated the structure and dynamics of supercooled single-chain cross-linked nanoparticle (SCNP) melts having a range of cross-linking degrees ϕ. We find a nearly linear increase in glass-transition temperature (Tg) with increasing ϕ. Correspondingly, we have also experimentally synthesized a series of polystyrene-based SCNPs and have found that the measured Tg estimated from differential scanning calorimetry is qualitatively consistent with the trend predicted by our simulation estimates. Experimentally, an increase in Tg as large as ΔTg = 61 K for ϕ = 0.36 is found compared with their linear chain counterparts, indicating that the changes in dynamics with cross-links are quite appreciable. We attribute the increase in Tg to the enlarged effective hard-core volume and the corresponding reduction in the free volume of the polymer segments. Topological constraints evidently frustrate the local packing. In addition, the introduction of intra-molecular cross-linking bonds slows down the structural relaxation and simultaneously enhances the local coupling motion on the length scales within SCNPs. Consequently, a more pronounced dynamical heterogeneity (DH) is observed for larger ϕ, as quantified by measuring the dynamical correlation length through the four-point susceptibility parameter, χ4. The increase in DH is directly related to the enhanced local cooperative motion derived from intra-molecular cross-linking bonds and structural heterogeneity derived from the cross-linking process. These results shed new light on the influence of intra-molecular topological constraints on the segmental dynamics of polymer melts.

Understanding of Dynamic Contacting Behaviors of Underwater Gas Bubbles on Solid Surfaces.

Understanding of dynamic behaviors of gas bubbles on solid surfaces has significant impacts on gas-involving electrochemical reactions, mineral flotation, and so on in industry. Contact angle (θ) is widely employed to characterize the wetting behaviors of bubbles on solid surfaces; however, it usually fluctuates within the bubble's advancing (θa) and receding (θr) range. Although the term of most-stable contact angle (θms) was defined previously as the closest valuable approximation for thermodynamically meaningful contact angle for a droplet on a solid surface, it has not been widely studied; and the precise θms measurement methods are inadequate to describe bubbles' wetting behaviors on solid surfaces. Herein, we proposed to take θms as the mean value of θa and θr, as a more accurate descriptor of gas bubbles' dynamic behaviors on nonideal solid surfaces, similar to the definition of droplets' θms on solid surfaces. The feasibility and accuracy of the proposed θms have been evidenced by recording the bubbles' contacting behaviors on solid surfaces with varied wettabilities. In addition, it was found that the contact angle hysteresis (δ), as the difference between θa and θr, reached its maximum value when θms approached 90°, regardless of the roughness (r) of the substrates. Finally, built on the above concept, the lateral adhesion force (f) of the gas bubble on the solid interface, which worked on the three-phase contact line (TPCL) of an individual bubble on a solid surface against its lateral motion during the bubble advancing or receding process, was described quantitatively by combining θa, θr, and the liquid-gas interfacial tension (γlg). Experimental and theoretical data jointly confirmed that f reached its maximum value at θms ∼ 90°, namely, a "super-sticky" state, which described the dynamically most sluggish movement of the bubble along the solid surface.

Pseudopod-associated protein KIF20B promotes Gli1-induced epithelial-mesenchymal transition modulated by pseudopodial actin dynamic in human colorectal cancer.

Kinesin family member 20B (KIF20B) has been reported to have an oncogenic role in bladder and hepatocellular cancer cells, but its role in colorectal cancer (CRC) progression remains unclear. In this study, we assessed the mRNA and protein levels of KIF20B in CRC tissues using qRT-PCR and immunohistochemistry, respectively. KIF20B was overexpressed in CRC tissues and was associated with cancer invasion and metastasis. Mechanistically, KIF20B overexpression promoted the epithelial-mesenchymal transition (EMT) process mediated by glioma-associated oncogene 1 (Gli1) as well as CRC cell migration and invasion. Interestingly, KIF20B was localized in pseudopod protrusions of CRC cells and influenced the formation of cell protrusions, especially the EMT-related invadopodia. Moreover, intracellular actin dynamic participated in the modulation of the Gli1-mediated EMT and EMT-related cell pseudopod protrusion formation induced by KIF20B. We identified a role for KIF20B in CRC progression and revealed a correlation between KIF20B expression in CRC tissues and patient prognosis. The underlying mechanism was associated with the Gli1-mediated EMT and EMT-related cell protrusion formation modulated by intracellular actin dynamic. Thus, KIF20B may be a potential biomarker and promising treatment target for CRC.

Insights into the mechanism of electrochemical ozone production via water splitting on the Ni and Sb doped SnO2 catalyst.

The H2O splitting mechanism is a very attractive alternative used in electrochemistry for the formation of O3. The most efficient catalysts employed for this reaction at room temperature are SnO2-based, in particular the Ni/Sb-SnO2 catalyst. In order to investigate the H2O splitting mechanism density functional theory (DFT) was performed on a Ni/Sb-SnO2 surface with oxygen vacancies. By calculating different SnO2 facets, the (110) facet was deemed most stable, and further doped with Sb and Ni. On this surface, the H2O splitting mechanism was modelled paying particular attention to the final two steps, the formation of O2 and O3. Previous studies on ß-PbO2 have shown that the final step in the reaction (the formation of O3) occurs via an Eley-Rideal style interaction where surface O2 desorbs before attacking surface O to form O3. It is revealed that for Ni/Sb-SnO2, although the overall reaction is the same the surface mechanism is different. The formation of O3 is found to occur through a Langmuir-Hinshelwood mechanism as opposed to the Eley-Rideal mechanism. In addition to this the relevant adsorption energies (Eads), Gibb's free energy (ΔGrxn) and activation barriers (Eact) for the final two steps modelled in the gas phase have been shown, providing the basis for a tool to develop new materials with higher current efficiencies.

An insight into methanol oxidation mechanisms on RuO2(100) under an aqueous environment by DFT calculations.

In this work, we have studied methanol oxidation mechanisms on RuO2(100) by using density functional theory (DFT) calculations and ab initio molecular dynamics (MD) simulations with some explicit interfacial water molecules. The overall mechanisms are identified as: CH3OH* → CH3O* → HCHO* → HCH(OH)2* → HCHOOH* → HCOOH* → mono-HCOO* → CO2*, without CO formation. This study provides a theoretical insight into C1 molecule oxidation mechanisms at atomic levels on metal oxide surfaces under an aqueous environment.

Elucidation of the surface structure-selectivity relationship in ethanol electro-oxidation over platinum by density functional theory.

We have successfully built a general framework to comprehend the structure-selectivity relationship in ethanol electrooxidation on platinum by density functional theory calculations. Based on the reaction mechanisms on three basal planes and five stepped surfaces, it was found that only (110) and n(111) × (110) sites can enhance CO2 selectivity but other non-selective step sites are more beneficial to activity.

Electrochemical interfacial influences on deoxygenation and hydrogenation reactions in CO reduction on a Cu(100) surface.

Electroreduction of CO2 to hydrocarbons on a copper surface has attracted much attention in the last few decades for providing a sustainable way for energy storage. During the CO2 and further CO electroreduction processes, deoxygenation that is C-O bond dissociation, and hydrogenation that is C-H bond formation, are two main types of surface reactions catalyzed by the copper electrode. In this work, by performing the state-of-the-art constrained ab initio molecular dynamics simulations, we have systematically investigated deoxygenation and hydrogenation reactions involving two important intermediates, COHads and CHOads, under various conditions of (i) on a Cu(100) surface without water molecules, (ii) at the water/Cu(100) interface and (iii) at the charged water/Cu(100) interface, in order to elucidate the electrochemical interfacial influences. It has been found that the electrochemical interface can facilitate considerably the C-O bond dissociation via changing the reaction mechanisms. However, C-H bond formation has not been affected by the presence of water or electrical charge. Furthermore, the promotional roles of an aqueous environment and negative electrode potential in deoxygenation have been clarified, respectively. This fundamental study provides an atomic level insight into the significance of the electrochemical interface towards electrocatalysis, which is of general importance for understanding electrochemistry.

Methanol electro-oxidation on platinum modified tungsten carbides in direct methanol fuel cells: a DFT study.

In exploration of low-cost electrocatalysts for direct methanol fuel cells (DMFCs), Pt modified tungsten carbide (WC) materials are found to be great potential candidates for decreasing Pt usage whilst exhibiting satisfactory reactivity. In this work, the mechanisms, onset potentials and activity for electrooxidation of methanol were studied on a series of Pt-modified WC catalysts where the bare W-terminated WC(0001) substrate was employed. In the surface energy calculations of a series of Pt-modified WC models, we found that the feasible structures are mono- and bi-layer Pt-modified WCs. The tri-layer Pt-modified WC model is not thermodynamically stable where the top layer Pt atoms tend to accumulate and form particles or clusters rather than being dispersed as a layer. We further calculated the mechanisms of methanol oxidation on the feasible models via methanol dehydrogenation to CO involving C-H and O-H bonds dissociating subsequently, and further CO oxidation with the C-O bond association. The onset potentials for the oxidation reactions over the Pt-modified WC catalysts were determined thermodynamically by water dissociation to surface OH* species. The activities of these Pt-modified WC catalysts were estimated from the calculated kinetic data. It has been found that the bi-layer Pt-modified WC catalysts may provide a good reactivity and an onset oxidation potential comparable to pure Pt and serve as promising electrocatalysts for DMFCs with a significant decrease in Pt usage.

Significance of ß-dehydrogenation in ethanol electro-oxidation on platinum doped with Ru, Rh, Pd, Os and Ir.

In the exploration of highly efficient direct ethanol fuel cells (DEFCs), how to promote the CO2 selectivity is a key issue which remains to be solved. Some advances have been made, for example, using bimetallic electrocatalysts, Rh has been found to be an efficient additive to platinum to obtain high CO2 selectivity experimentally. In this work, the mechanism of ethanol electrooxidation is investigated using the first principles method. It is found that CH3CHOH* is the key intermediate during ethanol electrooxidation and the activity of ß-dehydrogenation is the rate determining factor that affects the completeness of ethanol oxidation. In addition, a series of transition metals (Ru, Rh, Pd, Os and Ir) are alloyed on the top layer of Pt(111) in order to analyze their effects. The elementary steps, α-, ß-C-H bond and C-C bond dissociations, are calculated on these bimetallic M/Pt(111) surfaces and the formation potential of OH* from water dissociation is also calculated. We find that the active metals increase the activity of ß-dehydrogenation but lower the OH* formation potential resulting in the active site being blocked. By considering both ß-dehydrogenation and OH* formation, Ru, Os and Ir are identified to be unsuitable for the promotion of CO2 selectivity and only Rh is able to increase the selectivity of CO2 in DEFCs.

The origin of high activity but low CO(2) selectivity on binary PtSn in the direct ethanol fuel cell.

The most active binary PtSn catalyst for direct ethanol fuel cell applications has been studied at 20 °C and 60 °C, using variable temperature electrochemical in situ FTIR. In comparison with Pt, binary PtSn inhibits ethanol dissociation to CO(a), but promotes partial oxidation to acetaldehyde and acetic acid. Increasing the temperature from 20 °C to 60 °C facilitates both ethanol dissociation to CO(a) and then further oxidation to CO2, leading to an increased selectivity towards CO2; however, acetaldehyde and acetic acid are still the main products. Potential-dependent phase diagrams for surface oxidants of OH(a) formation on Pt(111), Pt(211) and Sn modified Pt(111) and Pt(211) surfaces have been determined using density functional theory (DFT) calculations. It is shown that Sn promotes the formation of OH(a) with a lower onset potential on the Pt(111) surface, whereas an increase in the onset potential is found upon modification of the (211) surface. In addition, Sn inhibits the Pt(211) step edge with respect to ethanol C-C bond breaking compared with that found on the pure Pt, which reduces the formation of CO(a). Sn was also found to facilitate ethanol dehydrogenation and partial oxidation to acetaldehyde and acetic acid which, combined with the more facile OH(a) formation on the Pt(111) surface, gives us a clear understanding of the experimentally determined results. This combined electrochemical in situ FTIR and DFT study provides, for the first time, an insight into the long-term puzzling features of the high activity but low CO2 production found on binary PtSn ethanol fuel cell catalysts.

Constructing Robust 3D Ionomer Networks in the Catalyst Layer to Achieve Stable Water Electrolysis for Green Hydrogen Production.

The widespread application of proton exchange membrane water electrolyzers (PEMWEs) is hampered by insufficient lifetime caused by degradation of the anode catalyst layer (ACL). Here, an important degradation mechanism has been identified, attributed to poor mechanical stability causing the mass transfer channels to be blocked by ionomers under operating conditions. By using liquid-phase atomic force microscopy, we directly observed that the ionomers were randomly distributed (RD) in the ACL, which occupied the mass transfer channels due to swelling, creeping, and migration properties. Interestingly, we found that alternating treatments of the ACL in different water/temperature environments resulted in forming three-dimensional ionomer networks (3D INs) in the ACL, which increased the mechanical strength of microstructures by 3 times. Benefitting from the efficient and stable mass transfer channels, the lifetime was improved by 19 times. A low degradation rate of approximately 3.0 µV/h at 80 °C and a high current density of 2.0 A/cm2 was achieved on a 50 cm2 electrolyzer. These data demonstrated a forecasted lifetime of 80 000 h, approaching the 2026 DOE lifetime target. This work emphasizes the importance of the mechanical stability of the ACL and offers a general strategy for designing and developing a durable PEMWE.

Taurine prevented cell cycle arrest and restored neurotrophic gene expression in arsenite-treated SH-SY5Y cells.

The study investigated the effect of taurine on cell viability and neurotrophic gene expression in arsenite-treated human neuroblastoma SH-SY5Y cells. Arsenite-induced intracellular reactive oxygen species (ROS) and interrupted cell cycle in SH-SY5Y cells. In addition, arsenite reduced mitochondria membrane potential (MMP) and decreased neurotrophic gene expressions such as n-myc downstream-regulated gene 4 (NDRG-4), brain-derived neurotrophic factor (BDNF) and sirtuin-1 (SIRT-1) in SH-SY5Y cells. In parallel, taurine prevented cell cycle, restored MMP and reduced the intracellular ROS level, and taurine recovered NDRG-4, BDNF and SIRT-1 gene expressions in arsenite-treated SH-SY5Y cells while taurine alone has no effect on these parameters.

Electrooxidation of methanol in an alkaline fuel cell: determination of the nature of the initial adsorbate.

It is essential to correctly determine the nature of the initial adsorbate in order to calculate the pathway for any given reaction. Recent literature provides conflicting information on the first step in the methanol decomposition pathway. This work sets out to establish what role the solution and the surface have to play in the initial adsorption-deprotonation process. Density functional theory (DFT) calculations, in combination with a cluster-continuum model approach are used to resolve the nature of the adsorbing species. We show that methanol is the dominant species in solution over methoxide, and also has a smaller barrier to adsorption. The nature of the surface species is revealed to be a methanol-OH complex.

Enhanced Proton Transport of ß″-Al2O3 Modified by LiAlO2 as a High-Performance Electrolyte for a Low-Temperature Solid Oxide Fuel Cell and an Electrolyzer.

ß″-Al2O3 has been proven as a fast ionic conductor in solid batteries due to its unique structure. In this work, ß″-Al2O3 was further modified by LiAlO2 and employed as the electrolyte material for low-temperature solid oxide fuel cells and electrolyzers, i.e., proton-conducting ceramic fuel cells and electrolysis cells, named as PCFC and PCEC, respectively. At 550 °C, thanks to this superior electrolyte with a remarkable conductivity of 0.161 S·cm-1, the PCFC reached a high power density up to 1029 mW·cm-2, and the PCEC demonstrated a significant current density of 1.49 A·cm-2 at a low operation voltage of 2.0 V. It has been found that the introduction of the LiAlO2 phase into ß″-Al2O3 reduces the total impedance, while it increases the oxygen vacancy concentration and thus promotes the proton transport process with the reduced activation energy. This work provides a new approach for exploring two-dimensional materials with high-ionic conductivity that can be applied for solid oxide fuel cells and water electrolyzers and more wider power-to-X devices such as electrosynthesis for green ammonia production.

Cross-linked solid-liquid interfaces enable a fast proton transport in the aluminate heterostructure electrolyte.

Having a highly-conductive protonic electrolyte is an essential requirement of developing solid ceramic fuel cell (SCFC) operated below 600 °C. Proton transport in solid electrolyte structure occurs via a bulk conduction mechanism in conventional SCFC, which may not be so efficient; therefore we have developed a fast proton conducting NaAlO2/LiAlO2 (NAO-LAO) heterostructure electrolyte, achieving the ionic conductivity of 0.23 S cm-1 thanks to its rich cross-linked solid-liquid interfaces; the SCFC employing this new developed electrolyte showed a maximum power density of 844 mW cm-2 at 550 °C, and the fuel cell could still operate at even lower temperatures down to 370 °C, although the output reduced to 90 mW cm-2. The proton-hydration liquid layer promoted the formation of cross-linked solid-liquid interfaces in the NAO-LAO electrolyte, which promoted the construction of solid-liquid hybrid proton transportation channels and effectively reduced polarization loss, leading to high proton conduction at even lower temperatures. This work provides an efficient design approach for developing enabling electrolytes with high proton conductivity for SCFCs to be operated at relatively lower temperatures (300-600 °C) than traditional solid oxide fuel cells which operate above 750 °C.