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1.

Clinical targeting of HIV capsid protein with a long-acting small molecule.

Link, John O; Rhee, Martin S; Tse, Winston C; Zheng, Jim; Somoza, John R; Rowe, William; Begley, Rebecca; Chiu, Anna; Mulato, Andrew; Hansen, Derek; Singer, Eric; Tsai, Luong K; Bam, Rujuta A; Chou, Chien-Hung; Canales, Eda; Brizgys, Gediminas; Zhang, Jennifer R; Li, Jiayao; Graupe, Michael; Morganelli, Philip; Liu, Qi; Wu, Qiaoyin; Halcomb, Randall L; Saito, Roland D; Schroeder, Scott D; Lazerwith, Scott E; Bondy, Steven; Jin, Debi; Hung, Magdeleine; Novikov, Nikolai; Liu, Xiaohong; Villaseñor, Armando G; Cannizzaro, Carina E; Hu, Eric Y; Anderson, Robert L; Appleby, Todd C; Lu, Bing; Mwangi, Judy; Liclican, Albert; Niedziela-Majka, Anita; Papalia, Giuseppe A; Wong, Melanie H; Leavitt, Stephanie A; Xu, Yili; Koditek, David; Stepan, George J; Yu, Helen; Pagratis, Nikos; Clancy, Sheila; Ahmadyar, Shekeba.

Nature; 584(7822): 614-618, 2020 08.

Artículo en Inglés | MEDLINE | ID: mdl-32612233

2.

Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi^® and Epclusa^®.

Link, John O; Taylor, James G; Trejo-Martin, Alejandra; Kato, Darryl; Katana, Ashley A; Krygowski, Evan S; Yang, Zheng-Yu; Zipfel, Sheila; Cottell, Jeromy J; Bacon, Elizabeth M; Tran, Chinh V; Yang, Cheng Y; Wang, Yujin; Wang, Kelly W; Zhao, Guangyu; Cheng, Guofeng; Tian, Yang; Gong, Ruoyu; Lee, Yu-Jen; Yu, Mei; Gorman, Eric; Mogalian, Erik; Perry, Jason K.

Bioorg Med Chem Lett; 29(16): 2415-2427, 2019 08 15.

Artículo en Inglés | MEDLINE | ID: mdl-31230974

3.

Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi^®.

Taylor, James G; Zipfel, Sheila; Ramey, Kyla; Vivian, Randy; Schrier, Adam; Karki, Kapil K; Katana, Ashley; Kato, Darryl; Kobayashi, Tetsuya; Martinez, Ruben; Sangi, Michael; Siegel, Dustin; Tran, Chinh V; Yang, Zheng-Yu; Zablocki, Jeff; Yang, Cheng Y; Wang, Yujin; Wang, Kelly; Chan, Katie; Barauskas, Ona; Cheng, Guofeng; Jin, Debi; Schultz, Brian E; Appleby, Todd; Villaseñor, Armando G; Link, John O.

Bioorg Med Chem Lett; 29(16): 2428-2436, 2019 08 15.

Artículo en Inglés | MEDLINE | ID: mdl-31133531

4.

Clinical Resistance to Velpatasvir (GS-5816), a Novel Pan-Genotypic Inhibitor of the Hepatitis C Virus NS5A Protein.

Lawitz, Eric J; Dvory-Sobol, Hadas; Doehle, Brian P; Worth, Angela S; McNally, John; Brainard, Diana M; Link, John O; Miller, Michael D; Mo, Hongmei.

Antimicrob Agents Chemother; 60(9): 5368-78, 2016 09.

Artículo en Inglés | MEDLINE | ID: mdl-27353271

5.

In Vitro Antiviral Activity and Resistance Profile Characterization of the Hepatitis C Virus NS5A Inhibitor Ledipasvir.

Cheng, Guofeng; Tian, Yang; Doehle, Brian; Peng, Betty; Corsa, Amoreena; Lee, Yu-Jen; Gong, Ruoyu; Yu, Mei; Han, Bin; Xu, Simin; Dvory-Sobol, Hadas; Perron, Michel; Xu, Yili; Mo, Hongmei; Pagratis, Nikos; Link, John O; Delaney, William.

Antimicrob Agents Chemother; 60(3): 1847-1853, 2016 Jan 11.

Artículo en Inglés | MEDLINE | ID: mdl-26824950

6.

Discovery of Hepatitis B Virus Surface Antigen Suppressor GS-8873.

Kato, Darryl; Choy, Regina Wai-Yan; Canales, Eda; Dick, Ryan A; Lake, April D; Shapiro, Nathan D; Chin, Elbert; Li, Jiayao; Zhang, Jennifer R; Wu, Qiaoyin; Saito, Roland D; Metobo, Sammy; Aktoudianakis, Evangelos; Schroeder, Scott D; Yang, Zheng-Yu; Glatt, Dylan M; Balsitis, Scott; Gamelin, Lindsay; Yu, Mei; Cheng, Guofeng; Delaney, William E; Link, John O.

ACS Med Chem Lett; 15(4): 546-554, 2024 Apr 11.

Artículo en Inglés | MEDLINE | ID: mdl-38628802

7.

A phase 1, randomized, placebo-controlled, 3-day, dose-ranging study of GS-5885, an NS5A inhibitor, in patients with genotype 1 hepatitis C.

Lawitz, Eric J; Gruener, Daniel; Hill, John M; Marbury, Thomas; Moorehead, Lisa; Mathias, Anita; Cheng, Guofeng; Link, John O; Wong, Kelly A; Mo, Hongmei; McHutchison, John G; Brainard, Diana M.

J Hepatol; 57(1): 24-31, 2012 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-22314425

8.

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model.

Yant, Stephen R; Mulato, Andrew; Hansen, Derek; Tse, Winston C; Niedziela-Majka, Anita; Zhang, Jennifer R; Stepan, George J; Jin, Debi; Wong, Melanie H; Perreira, Jill M; Singer, Eric; Papalia, Giuseppe A; Hu, Eric Y; Zheng, Jim; Lu, Bing; Schroeder, Scott D; Chou, Kevin; Ahmadyar, Shekeba; Liclican, Albert; Yu, Helen; Novikov, Nikolai; Paoli, Eric; Gonik, Daniel; Ram, Renee R; Hung, Magdeleine; McDougall, William M; Brass, Abraham L; Sundquist, Wesley I; Cihlar, Tomas; Link, John O.

Nat Med; 25(9): 1377-1384, 2019 09.

Artículo en Inglés | MEDLINE | ID: mdl-31501601

9.

Advances in cathepsin S inhibitor design.

Link, John O; Zipfel, Sheila.

Curr Opin Drug Discov Devel; 9(4): 471-82, 2006 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-16889230

10.

Direct binding of ledipasvir to HCV NS5A: mechanism of resistance to an HCV antiviral agent.

Kwon, Hyock Joo; Xing, Weimei; Chan, Katie; Niedziela-Majka, Anita; Brendza, Katherine M; Kirschberg, Thorsten; Kato, Darryl; Link, John O; Cheng, Guofeng; Liu, Xiaohong; Sakowicz, Roman.

PLoS One; 10(4): e0122844, 2015.

Artículo en Inglés | MEDLINE | ID: mdl-25856426

11.

Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection.

Link, John O; Taylor, James G; Xu, Lianhong; Mitchell, Michael; Guo, Hongyan; Liu, Hongtao; Kato, Darryl; Kirschberg, Thorsten; Sun, Jianyu; Squires, Neil; Parrish, Jay; Kellar, Terry; Yang, Zheng-Yu; Yang, Chris; Matles, Mike; Wang, Yujin; Wang, Kelly; Cheng, Guofeng; Tian, Yang; Mogalian, Erik; Mondou, Elsa; Cornpropst, Melanie; Perry, Jason; Desai, Manoj C.

J Med Chem; 57(5): 2033-46, 2014 03 13.

Artículo en Inglés | MEDLINE | ID: mdl-24320933

12.

Correction to Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection.

Link, John O; Taylor, James G; Xu, Lianhong; Mitchell, Michael; Guo, Hongyan; Liu, Hongtao; Kato, Darryl; Kirschberg, Thorsten; Sun, Jianyu; Squires, Neil; Parrish, Jay; Kellar, Terry; Yang, Zheng-Yu; Yang, Chris; Matles, Mike; Wang, Yujin; Wang, Kelly; Cheng, Guofeng; Tian, Yang; Mogalian, Erik; Mondou, Elsa; Cornpropst, Melanie; Perry, Jason; Desai, Manoj C.

J Med Chem; 59(16): 7696, 2016 08 25.

Artículo en Inglés | MEDLINE | ID: mdl-27529494

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