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1.

Multiplexed cellular profiling identifies an organoselenium compound as an inhibitor of CRM1-mediated nuclear export.

Jimenez, Lucia; Mayoral-Varo, Victor; Amenábar, Carlos; Ortega, Judit; Sequeira, João G N; Machuqueiro, Miguel; Mourato, Cristiana; Silvestri, Romano; Angeli, Andrea; Carta, Fabrizio; Supuran, Claudiu T; Megías, Diego; Ferreira, Bibiana I; Link, Wolfgang.

Traffic; 23(12): 587-599, 2022 12.

Artículo en Inglés | MEDLINE | ID: mdl-36353954

2.

FOXO1 represses PPARα-Mediated induction of FGF21 gene expression.

De Sousa-Coelho, Ana Luísa; Gacias, Mar; O'Neill, Brian T; Relat, Joana; Link, Wolfgang; Haro, Diego; Marrero, Pedro F.

Biochem Biophys Res Commun; 644: 122-129, 2023 02 12.

Artículo en Inglés | MEDLINE | ID: mdl-36640666

3.

Genetic analysis of global faba bean diversity, agronomic traits and selection signatures.

Skovbjerg, Cathrine Kiel; Angra, Deepti; Robertson-Shersby-Harvie, Tom; Kreplak, Jonathan; Keeble-Gagnère, Gabriel; Kaur, Sukhjiwan; Ecke, Wolfgang; Windhorst, Alex; Nielsen, Linda Kærgaard; Schiemann, Andrea; Knudsen, Jens; Gutierrez, Natalia; Tagkouli, Vasiliki; Fechete, Lavinia Ioana; Janss, Luc; Stougaard, Jens; Warsame, Ahmed; Alves, Sheila; Khazaei, Hamid; Link, Wolfgang; Torres, Ana Maria; O'Sullivan, Donal Martin; Andersen, Stig Uggerhøj.

Theor Appl Genet; 136(5): 114, 2023 Apr 19.

Artículo en Inglés | MEDLINE | ID: mdl-37074596

4.

Modulating undruggable targets to overcome cancer therapy resistance.

Passirani, Catherine; Vessières, Anne; La Regina, Giuseppe; Link, Wolfgang; Silvestri, Romano.

Drug Resist Updat; 60: 100788, 2022 01.

Artículo en Inglés | MEDLINE | ID: mdl-35168144

5.

mTORC2 Is the Major Second Layer Kinase Negatively Regulating FOXO3 Activity.

Jimenez, Lucia; Amenabar, Carlos; Mayoral-Varo, Victor; Mackenzie, Thomas A; Ramos, Maria C; Silva, Andreia; Calissi, Giampaolo; Grenho, Inês; Blanco-Aparicio, Carmen; Pastor, Joaquin; Megías, Diego; Ferreira, Bibiana I; Link, Wolfgang.

Molecules; 27(17)2022 Aug 24.

Artículo en Inglés | MEDLINE | ID: mdl-36080182

6.

Amino acid digestibility and metabolisable energy of spring and winter faba beans grown on two sites and effects of dehulling in caecectomised laying hens.

Siegert, Wolfgang; Ibrahim, Ahmad; Link, Wolfgang; Lux, Guido; Schmidtke, Knut; Hartung, Jens; Nautscher, Nadine; Rodehutscord, Markus.

J Sci Food Agric; 102(3): 920-930, 2022 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-34235756

7.

Paternal outcrossing success differs among faba bean genotypes and impacts breeding of synthetic cultivars.

Brünjes, Lisa; Link, Wolfgang.

Theor Appl Genet; 134(8): 2411-2427, 2021 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-33961063

8.

CRISPR/Cas9-mediated genome editing: From basic research to translational medicine.

Jacinto, Filipe V; Link, Wolfgang; Ferreira, Bibiana I.

J Cell Mol Med; 24(7): 3766-3778, 2020 04.

Artículo en Inglés | MEDLINE | ID: mdl-32096600

9.

FOXO transcription factors at the interface of metabolism and cancer.

Link, Wolfgang; Fernandez-Marcos, Pablo J.

Int J Cancer; 141(12): 2379-2391, 2017 12 15.

Artículo en Inglés | MEDLINE | ID: mdl-28631330

10.

A SNP-based consensus genetic map for synteny-based trait targeting in faba bean (Vicia faba L.).

Webb, Anne; Cottage, Amanda; Wood, Thomas; Khamassi, Khalil; Hobbs, Douglas; Gostkiewicz, Krystyna; White, Mark; Khazaei, Hamid; Ali, Mohamed; Street, Daniel; Duc, Gérard; Stoddard, Fred L; Maalouf, Fouad; Ogbonnaya, Francis C; Link, Wolfgang; Thomas, Jane; O'Sullivan, Donal M.

Plant Biotechnol J; 14(1): 177-85, 2016 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-25865502

11.

Moving to the core: spatiotemporal analysis of Forkhead box O (FOXO) and nuclear factor-κB (NF-κB) nuclear translocation.

Zanella, Fabian; Dos Santos, Nuno R; Link, Wolfgang.

Traffic; 14(3): 247-58, 2013 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-23231504

12.

TRIB2 as a biomarker for diagnosis and progression of melanoma.

Hill, Richard; Kalathur, Ravi Kiran Reddy; Colaço, Laura; Brandão, Ricardo; Ugurel, Selma; Futschik, Matthias; Link, Wolfgang.

Carcinogenesis; 36(4): 469-77, 2015 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-25586991

13.

Tribbles breaking bad: TRIB2 suppresses FOXO and acts as an oncogenic protein in melanoma.

Link, Wolfgang.

Biochem Soc Trans; 43(5): 1085-8, 2015 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-26517928

14.

Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition.

Tarrado-Castellarnau, Míriam; Cortés, Roldán; Zanuy, Miriam; Tarragó-Celada, Josep; Polat, Ibrahim H; Hill, Richard; Fan, Teresa W M; Link, Wolfgang; Cascante, Marta.

Pharmacol Res; 102: 218-34, 2015 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-26375988

15.

A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes.

Hill, Richard; Kalathur, Ravi Kiran Reddy; Callejas, Sergio; Colaço, Laura; Brandão, Ricardo; Serelde, Beatriz; Cebriá, Antonio; Blanco-Aparicio, Carmen; Pastor, Joaquín; Futschik, Matthias; Dopazo, Ana; Link, Wolfgang.

Breast Cancer Res; 16(6): 482, 2014 Dec 09.

Artículo en Inglés | MEDLINE | ID: mdl-25488803

16.

Immunology: Mind the immuno-connection gap.

Link, Wolfgang.

Nat Chem Biol; 13(6): 572-573, 2017 06.

Artículo en Inglés | MEDLINE | ID: mdl-28437396

17.

Knowledge-based drug discovery intensifies private appropriation of publicly financed research.

Link, Wolfgang.

Lancet Oncol; 19(8): 1017-1018, 2018 08.

Artículo en Inglés | MEDLINE | ID: mdl-30102212

18.

Protein localization in disease and therapy.

Hung, Mien-Chie; Link, Wolfgang.

J Cell Sci; 124(Pt 20): 3381-92, 2011 Oct 15.

Artículo en Inglés | MEDLINE | ID: mdl-22010196

19.

Biological characterization of ETP-46321 a selective and efficacious inhibitor of phosphoinositide-3-kinases.

Granda, Teresa G; Cebrián, David; Martínez, Sonia; Anguita, Patricia Villanueva; López, Estela Casas; Link, Wolfgang; Merino, Teresa; Pastor, Joaquín; Serelde, Beatriz G; Peregrina, Sandra; Palacios, Irene; Albarran, Maria Isabel; Cebriá, Antonio; Lorenzo, Milagros; Alonso, Patricia; Fominaya, Jesús; López, Ana Rodríguez; Bischoff, James R.

Invest New Drugs; 31(1): 66-76, 2013 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-22623067

20.

Pseudokinases, Tribbles Proteins and Cancer.

Velasco, Guillermo; Link, Wolfgang.

Cancers (Basel); 15(14)2023 Jul 09.

Artículo en Inglés | MEDLINE | ID: mdl-37509210

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Multiplexed cellular profiling identifies an organoselenium compound as an inhibitor of CRM1-mediated nuclear export.

FOXO1 represses PPARα-Mediated induction of FGF21 gene expression.

Genetic analysis of global faba bean diversity, agronomic traits and selection signatures.

Modulating undruggable targets to overcome cancer therapy resistance.

mTORC2 Is the Major Second Layer Kinase Negatively Regulating FOXO3 Activity.

Amino acid digestibility and metabolisable energy of spring and winter faba beans grown on two sites and effects of dehulling in caecectomised laying hens.

Paternal outcrossing success differs among faba bean genotypes and impacts breeding of synthetic cultivars.

CRISPR/Cas9-mediated genome editing: From basic research to translational medicine.

FOXO transcription factors at the interface of metabolism and cancer.

A SNP-based consensus genetic map for synteny-based trait targeting in faba bean (Vicia faba L.).

Moving to the core: spatiotemporal analysis of Forkhead box O (FOXO) and nuclear factor-κB (NF-κB) nuclear translocation.

TRIB2 as a biomarker for diagnosis and progression of melanoma.

Tribbles breaking bad: TRIB2 suppresses FOXO and acts as an oncogenic protein in melanoma.

Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition.

A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes.

Immunology: Mind the immuno-connection gap.

Knowledge-based drug discovery intensifies private appropriation of publicly financed research.

Protein localization in disease and therapy.

Biological characterization of ETP-46321 a selective and efficacious inhibitor of phosphoinositide-3-kinases.

Pseudokinases, Tribbles Proteins and Cancer.