Distance Matters: Correlation of Hepatocellular Carcinoma Nodule Distance to Overall Survival.

INTRODUCTION: Hepatocellular carcinoma (HCC) may occur with several simultaneous tumor foci in the liver (multifocal HCC). Molecular biology indicated that the larger the distance between two tumor nodules, the more those two nodules differed in their genetic composition. Therefore, we explored whether the overall survival (OS) of patients with HCC depends on the mutual distance of the HCC nodules. METHODS: In a retrospective study of 92 patients, CT/MRI images and survival data of the patients were collected. Based on the CT or MRI images at the time of diagnosis, the size of each tumor, the distance between the centers (center distance), and adjacent edges (edge distance) of the tumor nodules were measured, respectively. These data, combined with the number of tumor nodules and clinical characteristics, were compared with the patient's OS data. RESULTS: As expected, the average tumor diameter was significantly associated with patient survival in univariate Cox regression analysis (p = 0.00028, hazard ratio [HR] = 1.2). However, in multivariate analysis, the average center distance (p = 0.036, HR = 1.18) and average edge distance (p = 0.033, HR = 0.84) were also significantly associated with survival. CONCLUSION: Thus, not only the size of multiple HCC lesions but also their distance is important for the prognosis of patients with HCC. This may be of particular interest in patients with two nodules and BCLC B and C stages for the selection of therapeutic modalities and/or procedures.

Percutaneous radiofrequency ablation near large vessels in beagle livers: the impact of time and distance on the ablation zone.

PURPOSE: To investigate the effects of ablation time and distance between the radiofrequency ablation (RFA) electrode tip and a large vessel on the ablation zone in beagle livers. METHODS: Sixty-one percutaneous RFA coagulation zones were created near large vessels in 10 beagle livers in vivo. The ablated lesions were divided into four groups based on ablation time and distance between the electrode tip and a large vessel (group A, 3 min 0.5 cm; group B, 3 min 0 cm; group C, 5 min 0.5 cm; group D, 5 min 0 cm). The ablated area, long-axis diameters, short-axis diameters, and vessel wall injury were examined. RESULTS: With a fixed ablation time, the ablation zone created with the electrode tip at 0.5 cm from the large vessel was significantly larger than at 0 cm (p < .05). At a fixed distance between the electrode tip and vessel, the ablation zone created for 5 min was significantly larger than for 3 min (p < .05). The frequency of vessel wall injury in the 0 cm groups was significantly higher than that in the 0.5 cm groups (37.5% vs. 6.9%; p = .003, odds ratio, 7.43). The ratio of width to depth (Dw/Dz) was larger in the 0.5 cm groups than in the 0 cm groups (p < .001). CONCLUSION: The ablation zone increased with longer ablation times and greater distances between the RFA tip and large vessels for perivascular lesions. The distance between the needle tip and blood vessels is an important factor that affects the overall ablation outcome.

Sevoflurane preconditioning attenuates myocardial ischemia/reperfusion injury via caveolin-3-dependent cyclooxygenase-2 inhibition.

BACKGROUND: The inhaled anesthetic sevoflurane has been demonstrated to protect against myocardial ischemia/reperfusion (MI/R) injury via mechanisms involving AMP-activated protein kinase (AMPK) and caveolin-3 (Cav-3). However, the relative contributions of AMPK and Cav-3 to sevoflurane preconditioning (SF-PreCon)-mediated cardioprotection and their precise underlying mechanisms of action remain incompletely understood. METHODS AND RESULTS: SF-PreCon (consisting of 3 cycles of 15-minute exposure to 2% sevoflurane before 30 minutes of MI) decreased MI/R injury in wild-type mice (caspase-3 activity, -29.1%; infarct size, -20.2%; and left ventricular end diastolic pressure, -33.8%). In cardiac-specific AMPKα2 dominant-negative overexpressing mice, the cardioprotective effect of SF-PreCon was largely retained (caspase-3 activity, -26.7%; infarct size, -16.7%; and left ventricular end-diastolic pressure, -25.9%; P<0.01). In contrast, SF-PreCon failed to significantly protect Cav-3 knockout mice against MI/R injury (P>0.05). SF-PreCon significantly decreased MI/R-induced superoxide generation in wild-type (-43.6%) and AMPK dominant-negative overexpressing mice (-35.5%; P<0.01) but not in Cav-3 knockout mice. SF-PreCon did not affect nicotinamide adenine dinucleotide phosphate oxidase expression but significantly inhibited cyclooxygenase-2 expression in wild-type (-38.7%) and AMPK dominant-negative overexpressing mice (-35.8%) but not in Cav-3 knockout mice. CONCLUSIONS: We demonstrate for the first time SF-PreCon mediates cardioprotection against MI/R injury via caveolin-3-dependent cyclooxygenase-2 inhibition and antioxidative effects.

A system for efficient and sustainable cogeneration of water and electricity: Temperature difference induced by photothermal conversion and evaporative cooling.

Solar energy, with its sustainable properties, has garnered considerable attention for its potential to produce green electricity and clean water. This paper proposes a multistage energy transfer co-generation system (MWCNTs-covered thermoelectric module with aerogel and cooler, AC-CTEM) combining power generation and evaporative cooling. On the light-absorbing surface, the hot side of a thermoelectric module is covered with a hydrophobic coating made of PDMS and MWCNT. The cold side transfers heat to the evaporation zone using a heat sink. Aerogel evaporators are cross-linked with chitosan and polyurethane, which reduces the enthalpy of evaporation and facilitates efficient interfacial evaporation to remove heat and return it to refrigeration. Additionally, with the addition of Fresnel lenses and wind energy to the enhancement device, the system achieved an evaporation rate of 3.445 kg m-2 h-1 and an open-circuit voltage of 201.12 mV under 1 kW m-2 solar irradiation. The AC-CTEM system also demonstrated long-term stability and effectiveness in treating various types of non-potable water. Furthermore, we demonstrated the practical utility of the system by successfully cultivating grass seeds and powering electronic equipment. The AC-CTEM system exemplifies a practical energy-saving approach for the development of highly efficient co-generation systems.

Enhanced visible light responsive piezoelectric photocatalysis based on Bi2S3 coated BaTiO3 nanorods heterostructures.

Although the presence of the built-in electric field will solve the problem of carrier complexation in photocatalytic systems to some extent. However, free carriers will quickly shield the stabilized electric field and lose its effect. Therefore, how to introduce the dynamic piezoelectric field into the photocatalytic system has become an imminent problem. Herein, we developed an overcoated, visible light responsive, piezoelectric-assisted photocatalytic system by depositing Bi2S3 photocatalysts with a narrow-band system onto the surface of highly piezo-responsive BaTiO3 nanorods (BTO NRs). The heterojunction structure, bound by Bi-O chemical bonding, enhances carrier transport efficiency under the influence of the piezoelectric field. In the degradation experiments, the first-order rate constant for the degradation of chlortetracycline hydrochloride (CTC) in the BTO NRs/Bi2S3 system with the optimal complex ratio was 0.0276 min-1, which was 3.1 and 7.8 times higher than that of BTO NRs and Bi2S3, respectively. Additionally, we deduced the degradation pathways of CTC through a combination of Density functional theory (DFT) calculations and Liquid Chromatograph Mass Spectrometer (LC-MS), evaluating the toxicity of the intermediates. This complex system, featuring a highly photo-responsive semiconductor as a photo-acceptor deposited on a piezoelectric semiconductor surface providing a dynamic built-in electric field, enhances carrier separation efficiency under optimal light energy utilization conditions. These findings present novel and effective strategies for addressing two primary challenges in photocatalytic systems: low spectral utilization and significant photogenerated carrier complexation.

An adhesive, stretchable, and freeze-resistant conductive hydrogel strain sensor for handwriting recognition and depth motion monitoring.

Wearable electronics based on conductive hydrogels (CHs) offer remarkable flexibility, conductivity, and versatility. However, the flexibility, adhesiveness, and conductivity of traditional CHs deteriorate when they freeze, thereby limiting their utility in challenging environments. In this work, we introduce a PHEA-NaSS/G hydrogel that can be conveniently fabricated into a freeze-resistant conductive hydrogel by weakening the hydrogen bonds between water molecules. This is achieved through the synergistic interaction between the charged polar end group (-SO3-) and the glycerol-water binary solvent system. The conductive hydrogel is simultaneously endowed with tunable mechanical properties and conductive pathways by the modulation caused by varying material compositions. Due to the uniform interconnectivity of the network structure resulting from strong intermolecular interactions and the enhancement effect of charged polar end-groups, the resulting hydrogel exhibits 174 kPa tensile strength, 2105 % tensile strain, and excellent sensing ability (GF = 2.86, response time: 121 ms), and the sensor is well suited for repeatable and stable monitoring of human motion. Additionally, using the Full Convolutional Network (FCN) algorithm, the sensor can be used to recognize English letter handwriting with an accuracy of 96.4 %. This hydrogel strain sensor provides a simple method for creating multi-functional electronic devices, with significant potential in the fields of multifunctional electronics such as soft robotics, health monitoring, and human-computer interaction.

Design of carboxymethyl cellulose/alginate aerogels with anti-fouling and light-driven self-cleaning for enhanced oily wastewater remediation.

With the increase of oily wastewater discharge and the growing demand for clean water supply, high throughput green materials for oil-water separation with anti-pollution and self-cleaning ability are urgently needed. Herein, the polysaccharide-based composite aerogels of CMC/SA@TiO2-MWCNTs (CSTM) with fast photo-driven self-cleaning ability have been prepared by a simple freeze-drying and ionic cross-linking strategy. The introduction of TiO2 /MWCNTs nanocomposites effectively improves the underwater oleophobic and mechanical properties of polysaccharide aerogels and enables their photo-driven self-cleaning ability for efficient oil-water separation and purification of complex oily wastewater. For immiscible oil-water mixtures, a high separation flux of about 7650 L m-2 h-1 and a separation efficiency of up to 99.9 % was obtained. For surfactant-stabilized oil-in-water emulsion, a flux of 3952 L m-2 h-1 was achieved with a separation efficiency of up to 99.3 %. More importantly, the excellent photoluminescent self-cleaning ability and low oil adhesion contribute to the high contamination resistance, excellent reusability, and robust durability of CSTM aerogel. With the advantages of simple preparation, remarkable performance, and recyclability, this aerogel is expected to provide a green, economical, and scalable solution for the purification of oily wastewater.

Wide-humidity, anti-freezing and stretchable multifunctional conductive carboxymethyl cellulose-based hydrogels for flexible wearable strain sensors and arrays.

Hydrogels play an important role in the design and fabrication of wearable sensors with outstanding flexibility, high sensitivity and versatility. Since hydrogels lose and absorb water during changes in humidity and temperature, it is critical and challenging to obtain hydrogels that function properly under different environmental conditions. Herein, a dual network hydrogel based on tannic acid (TA) reinforced polyacrylamide (PAM) and sodium carboxymethylcellulose (CMC) was constructed, while the introduction of the green solvents Solketal and LiCl endowed the hydrogel with greater possibilities for further modification to improve the water content and consistency of the mechanical properties over 30-90 % RH. This composite hydrogel (PTSL) has long-term stability, excellent mechanical strength, and freezing resistance. As strain sensors, they are linear over the entire strain range (R2 = 0.994) and have a high sensitivity (GF = 2.52 over 0-680 % strain range). Furthermore, the hydrogel's exceptional electrical conductivity and freezing resistance are a result of the synergistic effect of Solketal and LiCl, which intensifies the contact between the water molecules and the colloidal phase. This research could address the suitability of hydrogels over a wide range of humidity and temperature, suggesting great applications for smart flexible wearable electronics in harsh environmental conditions.

Development of biomass aerogels with aligned channels: For continuous treatment of oily wastewater and solar-powered oil evaporation.

A biomass CS/CNTs@MTMS (MCCS) aerogel with both aligned channel network, superhydrophobicity, and photothermal conversion ability was prepared by a green and facile strategy of directed freeze-drying and chemical vapor deposition using chitosan (CS), carbon nanotubes (CNTs), and methyltrimethoxysilane (MTMS) as the building materials. Capacity to adsorb a large variety of oils and organic solvents, with an adsorption capacity of up to 34-83 g/g. After 10 cycles, the adsorption capacity of MCCS remained at 94 % of the initial capacity, providing excellent reusability. In addition, due to its unique network of aligned channels, the MCCS can continuously separate oil and water, making it a sustainable oil-water separator. More interestingly, the MCCS aerogel has excellent photothermal conversion capabilities, and it was utilized to evaporate oil collected during the oil-water separation process using solar energy. This work provides an opportunity to design novel self-cleaning photothermally driven oil-water separation biomass materials with superhydrophobicity-strong lipophilicity.

Polyvinyl alcohol /chitosan biomimetic hydrogel enhanced by MXene for excellent electromagnetic shielding and pressure sensing.

Traditional electromagnetic shielding materials are difficult to realize practical applications due to excessive fillers, poor mechanical properties, and difficulty in preservation, etc. Hydrogel is a biomaterial with good biocompatibility and sustainability, which not only can overcome the aforementioned issues, but its biomimetic hierarchical porous structure also enables multifunctional applications. In this paper, a honeycomb-like unidirectional porous wall structured hydrogel is prepared by a simple freeze-thaw cycle and salting out method. Polyvinyl alcohol (PVA) and chitosan (CS) form a double cross-linked network (DN) enhanced by MXene, resulting in excellent mechanical and flexibility. Due to the synergistic effects of MXene, water, Fe3O4, abundant interfaces and micrometer porous wall structure, the electromagnetic shielding performance is enhanced. EMI SE increases by 30.7 dB as the MXene concentration increases from 0 to 1.5 wt%, and EMI SE increases from 7.9 to 66.7 dB as the water content increases from 0 to 76 %. Besides this, we encapsulate the hydrogel into a simple sensor, the signal response is rapid, the response /recovery time is 50/100 ms respectively, and it exhibits good sensitivity (0.0187 kPa-1). Different signals are generated based on variations in pressure, which holds significant importance for the development of wearable flexible sensors and information encoding.

Efficacy and Safety of HepaSphere Drug-Eluting Bead Transarterial Chemoembolization Combined with Hepatic Arterial Infusion Chemotherapy as the Second-Line Treatment in Advanced Hepatocellular Carcinoma.

Purpose: Recently, hepatic arterial infusion chemotherapy (HAIC) has also gained popularity for hepatocellular carcinoma (HCC). Several studies have compared HAIC and Transarterial chemoembolization (TACE). However, comparisons between TACE plus HAIC and HAIC are rarely reported. Here, we evaluated the performance of HepaSphere DEB-TACE combined with HAIC (Hepa-HAIC) compared to HAIC in patients with advanced HCC. Patients and Methods: In this retrospective study, we enrolled 167 patients diagnosed with advanced HCC and treated at Peking University Cancer Hospital from May 2018 to May 2022. The cohort comprised 74 patients who received HepaSphere DEB-TACE combined with HAIC-FOLFOX (Hepa-HAIC) and 93 patients who received HAIC-FOLFOX. Over 60% of patients received prior treatments. To avoid selection bias, propensity score matching was applied to the efficacy and safety analyses. The primary endpoints are progression-free survival (PFS) and overall survival (OS); the secondary endpoints include objective response rate (ORR), disease control rate (DCR), and safety. Results: Propensity-matching yielded 48 pairs, and group baselines were almost equal after matching. Median PFS and median OS were both higher in the matched Hepa-HAIC cohort (median PFS: 8.9 vs 5.8 months, p = 0.035; median OS: 22.4 vs 9.5 months, p = 0.027), which was consistent with pre-matching analysis. The ORR in the Hepa-HAIC and HAIC cohorts was 75.0% and 37.5%, respectively; the DCR was 93.8% after Hepa-HAIC and 81.3% after HAIC. There was no treatment-related death. Grade 3-4 ALT elevation was more frequent in the Hepa-HAIC group (33.3% vs 8.3%, p = 0.003), while vomiting was more frequent in the HAIC group (29.2% vs 12.5%, p = 0.084). Conclusion: The Hepa-HAIC group is superior to the HAIC group in metrics of PFS, OS, ORR, and DCR, which indicates the combination of HepaSphere DEB-TACE and HAIC may lead to improved outcomes with a comparable safety profile in advanced HCC.

High-dose oxaliplatin induces severe hypersensitivity reactions and high recurrence rates during rechallenge in patients treated with hepatic arterial infusion chemotherapy.

AIM: To analyze the risk factors for oxaliplatin (OXA)-induced severe hypersensitivity reactions and identify the recurrence rate of the reactions after an OXA rechallenge in patients treated with hepatic arterial infusion chemotherapy (HAIC). METHODS: Among the 2251 patients treated with HAIC (OXA), 84 patients with gastrointestinal cancer who displayed hypersensitivity reactions between May 2013 and May 2022 were included in this study. Among the 84 patients, 23 (27.4%) developed severe anaphylactic reactions (grade III/IV), and 61 (72.6%) developed grade I/II reactions. We explored the risk factors for severe OXA-induced hypersensitivity reactions. Twenty-seven patients with grade I/II reactions underwent retreatment (HAIC with OXA), and the recurrence rate of the hypersensitivity reactions was determined. A multivariate logistic regression model was used to analyze the risk factors for OXA-induced hypersensitivity reaction. RESULTS: In the study, multivariate analysis indicated that the dose of OXA (odds ratio [OR] 3.077, 95 % confidence interval [CI] 1.106-8.558, p = 0.031) was an independent risk factor for OXA-induced severe hypersensitivity reactions. Twenty-seven patients with non-severe hypersensitivity reactions underwent retreatment HAIC with OXA and 14 (51.9 %) experienced HSR recurrence, including 2 (7.4 %) who experienced hypersensitivity shock. CONCLUSIONS: The administration of OXA doses is a risk factor for OXA-induced severe hypersensitivity reactions in patients treated with HAIC (OXA). Rechallenging HAIC with OXA appears to be associated with a higher recurrence rate of the HSR.

Lymphotoxin-α is a novel adiponectin expression suppressor following myocardial ischemia/reperfusion.

Recent clinical observations demonstrate adiponectin (APN), an adipocytokine with potent cardioprotective actions, is significantly reduced following myocardial ischemia/reperfusion (MI/R). However, mechanisms responsible for MI/R-induced hypoadiponectinemia remain incompletely understood. Adult male mice were subjected to 30-min MI followed by varying reperfusion periods. Adipocyte APN mRNA and protein expression and plasma APN and TNFα concentrations were determined. APN expression/production began to decline 3 h after reperfusion (reaching nadir 12 h after reperfusion), returning to control levels 7 days after reperfusion. Plasma TNFα levels began to increase 1 h after reperfusion, peaking at 3 h and returning to control levels 24 h after reperfusion. TNFα knockout significantly increased plasma APN levels 12 h after reperfusion but failed to improve APN expression/production 72 h after reperfusion. In contrast, TNF receptor-1 (TNFR1) knockout significantly restored APN expression 12 and 72 h after reperfusion, suggesting that other TNFR1 binding cytokines contribute to MI/R-induced APN suppression. Among many cytokines increased after MI/R, lymphotoxin-α (LTα) was the only cytokine remaining elevated 24-72 h after reperfusion. LTα knockout did not augment APN levels 12 h post-reperfusion, but did so by 72 h. Finally, in vitro treatment of adipocytes with TNFα and LTα at concentrations seen in MI/R plasma additively inhibited APN expression/production in TNFR1-dependent fashion. Our study demonstrates for the first time that LTα is a novel suppressor of APN expression and contributes to the sustained hypoadiponectinemia following MI/R. Combining anti-TNFα with anti-LTα strategies may achieve the best effects restoring APN in MI/R patients.

Supported photocatalyst for Cr (VI) conversion and removal of organic pollutants.

The photocatalytic property of available semiconductor catalysts still suffers from some urgent problems, such as the high excitation energy, easy agglomeration of powders, or weak recycling property. Therefore, developing novel visible light-supported catalysts and catalyst loading have aroused great attention recently. In this work, a novel Ag3PO4/BiVO4/MWCNTs@Cotton functional fabric was prepared by introducing Ag3PO4 as a plasma resonance photocatalyst and MWCNTs with cotton as composite substrates. Not only did the introduction of Ag3PO4 and MWCNTs effectively strengthen the application ability of BiVO4, but also inhibited the recombination of carriers, and promoted the transport of carriers according to spectroscopic and electrochemical tests. Degradation tests remained that Ag3PO4/BiVO4/MWCNTs @cotton retained the high photocatalytic efficiency of the powder catalyst, along with the degradation degree of active blue KN-R (50mg/L) as well as Cr (VI) (20mg/L) could reach more than 90% within 120 min. What's more, the functional fabric has gained excellent performance in degrading pollutants for 5 cycles. Meanwhile, the prepared BiVO4 is consistent with the band structure and electron density calculated theoretically by the GGA-PBE function. Free radical trapping and scavenging experiments exhibited that functional fabrics could produce active substances such as h+,·O2-, and·OH, among which the first two are the main active substances in the reaction. To sum up, this study is an effective attempt based on the existing problems of photocatalysts together with providing some study directions for the development of photocatalytic technology in the future.

Establishment of a novel system for photothermal removal of ampicillin under near-infrared irradiation: Persulfate activation, mechanism, pathways and bio-toxicology.

One of the most effective ways to address the problems of low solar spectrum utilization in photocatalysis and the high cost of persulfate activation technology is to create a cost-effective synergistic photothermal persulfate system. In this work, a brand-new composite catalyst called ZnFe2O4/Fe3O4@MWCNTs (ZFC) was developed to activate PDS (K2S2O8) from the aforementioned basis. ZFC's surface temperature could unbelievably reach 120.6 °C in 150 s together with the degrading synergistic system solution temperature could reach 48 °C under near-infrared light (NIR) in 30 min, thus accelerating the ZFC/PDS decolorization rate for reactive blue KN-R (150 mg/L) to 95% in 60 min. Furthermore, the ZFC's ferromagnetism bore it with good cycling performance, allowing it to maintain an 85% decolorization rate even after 5 cycles with OH·, SO4-·, 1O2, and O2-· dominating the degrading process. In the meantime, the DFT calculations of the kinetic constants for the entire process of S2O82- adsorption on Fe3O4 in dye degradation solution were in agreement with the outcomes of the experimental pseudo-first-order kinetic fitting. By analyzing the particular degradation route of ampicillin (50 mg/L) and the possible environmental impact of the intermediate using LC-MS and the toxicological analysis software (T.E.S.T.), respectively, it was shown that this system might function as an environmentally friendly method for removing antibiotics. This work may provide some productive research lines for the creation of a photothermal persulfate synergistic system and suggest fresh approaches to water treatment technology.

MOFFeCo/B-CN composites achieve efficient degradation of antibiotics in a non-homogeneous concurrent photocatalytic-persulfate activation system.

We synthesized an MFeCoB0.4CNx% (MOF-Fe/Co nanosheets/boron-doped g-C3N4) composite catalyst for enhancing the concurrent photocatalytic-persulfate activation (CPPA) system and achieved efficient degradation of antibiotics. The role of MOF-Fe/Co is to activate persulfate, while boron-doped g-C3N4 can generate photogenerated electrons for the reduction of Co3+/Fe3+ to enhance the regeneration of the active center. The rate constant for Tetracycline degradation by the CPPA system was 4.74 and 7.54 times higher than the photocatalytic and persulfate-activated systems, respectively. This composite was shown to be practical and economically viable for antibiotic degradation. The degradation behavior was explored based on experiments, and molecular orbitals and Fukui functions were obtained by density functional theory calculations. Mechanisms were investigated using reactive oxygen species trapping studies and electron spin resonance, and the process was explained in terms of the charge population and electron density difference of MOF-Fe/Co nanosheets. The CPPA system is an ecologically benign technology for removing antibiotic-related risks to the environment and human health.

A Novel Nomogram for Predicting the Overall Survival in Patients with Unresectable HCC after TACE plus Hepatic Arterial Infusion Chemotherapy.

BACKGROUND AND AIM: Transarterial chemoembolization combined with hepatic arterial infusion chemotherapy (TACE-HAIC) has shown encouraging efficacy in the treatment of unresectable hepatocellular carcinoma (HCC). We aimed to develop a novel nomogram to predict overall survival (OS) of patients with unresectable HCC treated with TACE-HAIC. METHODS: A total of 591 patients with unresectable HCC treated with TACE-HAIC between May 2009 and September 2020 were enrolled. These patients were randomly divided into training and validation cohorts. The independent prognostic factors were identified with Cox proportional hazards model. The model's discriminative ability and accuracy were validated using concordance index (C-index), calibration plots, the area under the time-dependent receiver operating characteristic curve (AUC) and decision curve analyses (DCAs). RESULTS: The median OS was 15.6 months. A nomogram was established based on these factors, including tumor size, vein invasion, extrahepatic metastasis, tumor number, alpha fetoprotein (AFP), and albumin-bilirubin (ALBI), to predict OS for patients with unresectable HCC treated with TACE-HAIC. The C-index of the nomogram were 0.717 in the training cohort and 0.724 in validation cohort. The calibration plots demonstrated good agreement between the predicted outcomes and the actual observations. The AUC values were better than those of three conventional staging systems. The results of DCA indicated that the nomogram may have clinical usefulness. The patients in the low-risk group had a longer OS than those in intermediate-risk and high-risk groups (P<0.001). CONCLUSION: A prognostic nomogram was developed and validated to assist clinicians in accurately predicting the OS of patients with unresectable HCC after TACE-HAIC.

Facile fabrication of BiOIO3/MIL-88B heterostructured photocatalysts for removal of pollutants under visible light irradiation.

In this work, a Z-scheme heterojunction of BiOIO3/MIL-88B was constructed via two steps solvothermal method. Various characterization techniques showed that this Z-scheme heterojunction is an effective strategy to promote spatial charge separation, and the catalytic performance was evaluated by degrading simulated organic pollutants. Herein, the BiOIO3/MIL-88B composites exhibited an exceptional removal rate for Reactive Blue 19 and tetracycline hydrochloride (TC) under visible light irradiation, which was approximately 3.28 and 4.22 times higher than the pristine BiOIO3, respectively. Additionally, the analysis of photocatalysis mechanism showed that the active species O2- and OH could strongly affect the degradation of tetracycline hydrochloride (TC) in the studied system. Furthermore, the degradation process of TC was tracked and detected by identifying intermediates produced in the reaction system. It is anticipated that this research can deepen the understanding of BiOIO3/MIL-88B heterojunction structure to remove organic contaminants and provide a strategy for applying photocatalytic technology in the practical industry.

Recent advances in Co-based co-catalysts for efficient photocatalytic hydrogen generation.

Recent progress in photocatalytic hydrogen generation reaction highlights the critical role of co-catalysts in enhancing the solar-to-fuel conversion efficiency of diverse band-matched semiconductors. Because of the compositional flexibility, adjustable microstructure, tunable crystal phase and facet, cobalt-based co-catalysts have stimulated tremendous attention as they have high potential to promote hydrogen evolution reaction. However, a comprehensive review that specifically focuses on these promising materials has not been reported so far. Therefore, this present review emphasizes the recent progress in the pursuing of highly efficient Co-based co-catalysts for water splitting, and the advances in such materials are summarized through the analysis of structure-activity relationships. The fundamental principles of photocatalytic hydrogen production are profoundly outlined, followed by an elaborate discussion on the crucial parameters influencingthe reaction kinetics. Then, the co-catalytic reactivities of various Co-based materials involving Co, Co oxides, Co hydroxides, Co sulfides, Co phosphides and Co molecular complexes, etc, are thoroughly discussed when they are coupled with host semiconductors, with an insight towards the ultimateobjective of achieving a rationally designed photocatalyst for enhancing water splitting reaction dynamics. Finally, the current challenge and future perspective of Co-based co-catalysts as the promising noble-metal alternative materials for solar hydrogen generation are proposed and discussed.

Construction of perylene diimide/CuS supramolecular heterojunction for the highly efficient visible light-driven environmental remediation.

Developing photocatalysts that are inexpensive and efficient in degrading pollutants are essential for environmental remediation. Herein, a novel system of perylene diimide (PDI)/CuS p-n heterojunction was synthesized by a two-step self-assembly strategy for removal of tetracycline in waste water. Results showed that PDI/CuS-10% exhibited highest photocatalytic behavior. The apparent rate constants for tetracycline (TC) degradation for the blend were 5.27 and 2.68 times higher than that of CuS or PDI, respectively. The enhancement of photocatalytic activity was mainly attributed to the π-π stacking and p-n junction, which can accelerate the separation of the photo-generated h+-e- pairs. Besides, the light absorption of PDI/CuS from 800 to 200 nm was significantly enhanced and the absorption edge even reached the near-infrared region, which also played an important role in providing desired photocatalytic properties. Surprisingly, PDI/CuS could maintain high catalytic activity even after 5 cycles under simulated conditions, indicating that the composite had high potential for practical applications. Owing to high efficiency, low cost and wide application range, the PDI/CuS nanocomposites are promising candidates for environmental remediation.