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1.
Appl Opt ; 61(28): 8454-8461, 2022 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-36256160

RESUMEN

In the area of public safety and crime prevention, some research based on deep learning has achieved success in the detection of prohibited items for x-ray security inspection. However, the number of parameters and computational consumption of most object detection methods based on deep learning are huge, which makes the hardware requirements of these methods extremely high and limits their applications. In this paper, a lightweight prohibited item detection method based on YOLOV4 is proposed for x-ray security inspection. First, the MobilenetV3 is used to replace the backbone network of YOLOV4, and the depthwise separable convolution is used to optimize the neck and head of YOLOV4 to reduce the number of parameters and computational consumption. Second, an adaptive spatial-and-channel attention block is designed to optimize the neck of YOLOV4 in order to improve the feature extraction capability of our method and maintain the detection accuracy. Third, the focal loss is utilized to avoid the class imbalance problem during the training process. Finally, the method is evaluated on our real x-ray pseudocolor image dataset with YOLOV4 and YOLOV4-tiny. For the overall performance, the mean average precision of our method is 4.98% higher than YOLOV4-tiny and 0.07% lower than YOLOV4. The number of parameters and computational consumption of our method are slightly higher than YOLOV4-tiny and much lower than YOLOV4.


Asunto(s)
Rayos X
2.
Gastroenterology ; 150(3): 707-19, 2016 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-26582088

RESUMEN

BACKGROUND & AIMS: Obesity and alcohol consumption contribute to steatohepatitis, which increases the risk for hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCCs). Mouse hepatocytes that express HCV-NS5A in liver up-regulate the expression of Toll-like receptor 4 (TLR4), and develop liver tumors containing tumor-initiating stem-like cells (TICs) that express NANOG. We investigated whether the TLR4 signals to NANOG to promote the development of TICs and tumorigenesis in mice placed on a Western diet high in cholesterol and saturated fat (HCFD). METHODS: We expressed HCV-NS5A from a transgene (NS5A Tg) in Tlr4-/- (C57Bl6/10ScN), and wild-type control mice. Mice were fed a HCFD for 12 months. TICs were identified and isolated based on being CD133+, CD49f+, and CD45-. We obtained 142 paraffin-embedded sections of different stage HCCs and adjacent nontumor areas from the same patients, and performed gene expression, immunofluorescence, and immunohistochemical analyses. RESULTS: A higher proportion of NS5A Tg mice developed liver tumors (39%) than mice that did not express HCV NS5A after the HCFD (6%); only 9% of Tlr4-/- NS5A Tg mice fed HCFD developed liver tumors. Livers from NS5A Tg mice fed the HCFD had increased levels of TLR4, NANOG, phosphorylated signal transducer and activator of transcription (pSTAT3), and TWIST1 proteins, and increases in Tlr4, Nanog, Stat3, and Twist1 messenger RNAs. In TICs from NS5A Tg mice, NANOG and pSTAT3 directly interact to activate expression of Twist1. Levels of TLR4, NANOG, pSTAT3, and TWIST were increased in HCC compared with nontumor tissues from patients. CONCLUSIONS: HCFD and HCV-NS5A together stimulated TLR4-NANOG and the leptin receptor (OB-R)-pSTAT3 signaling pathways, resulting in liver tumorigenesis through an exaggerated mesenchymal phenotype with prominent Twist1-expressing TICs.


Asunto(s)
Transformación Celular Neoplásica/metabolismo , Proteínas de Homeodominio/metabolismo , Neoplasias Hepáticas/metabolismo , Hígado/metabolismo , Células Madre Neoplásicas/metabolismo , Enfermedad del Hígado Graso no Alcohólico/metabolismo , Proteínas Nucleares/metabolismo , Factor de Transcripción STAT3/metabolismo , Receptor Toll-Like 4/metabolismo , Proteína 1 Relacionada con Twist/metabolismo , Adulto , Anciano , Anciano de 80 o más Años , Animales , Apolipoproteínas E/genética , Línea Celular , Movimiento Celular , Autorrenovación de las Células , Transformación Celular Neoplásica/genética , Transformación Celular Neoplásica/patología , Dieta Alta en Grasa , Modelos Animales de Enfermedad , Transición Epitelial-Mesenquimal , Femenino , Regulación Neoplásica de la Expresión Génica , Proteínas de Homeodominio/genética , Humanos , Hígado/patología , Neoplasias Hepáticas/genética , Neoplasias Hepáticas/patología , Masculino , Ratones Endogámicos C57BL , Ratones Noqueados , Persona de Mediana Edad , Proteína Homeótica Nanog , Células Madre Neoplásicas/patología , Enfermedad del Hígado Graso no Alcohólico/genética , Enfermedad del Hígado Graso no Alcohólico/patología , Proteínas Nucleares/genética , Fenotipo , Fosforilación , Regiones Promotoras Genéticas , Factor de Transcripción STAT3/genética , Transducción de Señal , Factores de Tiempo , Receptor Toll-Like 4/deficiencia , Receptor Toll-Like 4/genética , Proteína 1 Relacionada con Twist/genética , Proteínas no Estructurales Virales/genética , Proteínas no Estructurales Virales/metabolismo
3.
Environ Monit Assess ; 187(1): 4104, 2015 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-25391462

RESUMEN

Agricultural decision-making to control nonpoint source (NPS) water pollution may not be efficiently implemented, if there is no appropriate cost-benefit analysis on agricultural management practices. This paper presents an interval-fuzzy linear programming (IFLP) model to deal with the trade-off between agricultural revenue, NPS pollution control, and alternative practices through land adjustment for Wuchuan catchment, a typical agricultural area in Jiulong River watershed, Fujian Province of China. From the results, the lower combination of practice 1, practice 2, practice 3, and practice 7 with the land area of 12.6, 5.2, 145.2, and 85.3 hm(2), respectively, could reduce NPS pollution load by 10%. The combination yields an income of 98,580 Chinese Yuan/a. If the pollution reduction is 15%, the higher combination need practice 1, practice 2, practice 3, practice 5, and practice 7 with the land area of 54.4, 23.6, 18.0, 6.3, and 85.3 hm(2), respectively. The income of this combination is 915,170 Chinese Yuan/a. The sensitivity analysis of IFLP indicates that the cost-effective practices are ranked as follows: practice 7 > practice 2 > practice 1 > practice 5 > practice 3 > practice 6 > practice 4. In addition, the uncertainties in the agriculture NPS pollution control system could be effectively quantified by the IFLP model. Furthermore, to accomplish a reasonable and applicable project of land-use adjustment, decision-makers could also integrate above solutions with their own experience and other information.


Asunto(s)
Agricultura/métodos , Contaminación del Agua/prevención & control , China , Análisis Costo-Beneficio , Monitoreo del Ambiente , Ríos/química , Incertidumbre , Contaminación del Agua/análisis
4.
Mol Ther Oncol ; 32(3): 200824, 2024 Sep 19.
Artículo en Inglés | MEDLINE | ID: mdl-39035202

RESUMEN

Limited therapeutic options are available for patients with breast cancer brain metastases (BCBM), and thus there is an urgent need for novel treatment approaches. We previously engineered an effective oncolytic herpes simplex virus 1 (oHSV) expressing a full-length anti-CD47 monoclonal antibody (mAb) with a human IgG1 scaffold (OV-αCD47-G1) that was used to treat both ovarian cancer and glioblastoma. Here, we demonstrate that the combination of OV-αCD47-G1 and temozolomide (TMZ) improve outcomes in preclinical models of BCBM. The combination of TMZ with OV-αCD47-G1 synergistically increased macrophage phagocytosis against breast tumor cells and led to greater activation of NK cell cytotoxicity. In addition, the combination of OV-αCD47-G1 with TMZ significantly prolonged the survival of tumor-bearing mice when compared with TMZ or OV-αCD47-G1 alone. Combination treatment with the mouse counterpart of OV-αCD47-G1, termed OV-A4-IgG2b, also enhanced mouse macrophage phagocytosis, NK cell cytotoxicity, and survival in an immunocompetent model of mice bearing BCBM compared with TMZ or OV-A4-IgG2b alone. Collectively, these results suggest that OV-αCD47-G1 combined with TMZ should be explored in patients with BCBM.

5.
J Gastroenterol Hepatol ; 27 Suppl 2: 19-22, 2012 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-22320911

RESUMEN

Cancer stem cells (tumor-initiating stem-like cells: TISCs) are resistant to chemotherapy and are associated with metastatic hepatocellular carcinoma (HCC), which is commonly observed in hepatitis C virus (HCV)-infected patients with obesity or alcohol abuse. However, it is unknown whether the TLR4-NANOG pathway serves as a universal oncogenic signaling in the genesis of TISCs and HCC. We aimed to determine whether Tlr4 is a putative proto-oncogene for TISCs in liver oncogenesis due to different etiologies and how Tlr4 is regulated at the transcriptional and epigenetic levels. CD133+/CD49f+ TISCs were isolated using FACS from HCC developed in HCV Core Tg mice fed alcohol, diethylnitrosamine-treated mice, and alcoholic patients with or without HCV infection. CD133+/CD49f+ cells isolated from the animal models and patients are tumorigenic both in vitro and in a xenograft model, and Tlr4 or Nanog silencing with shRNA attenuates their tumor initiating property. Functional oncogene screening of a cDNA library identified the organ size control pathway targets Yap1 and AKT activator Igf2bp3 as NANOG-dependent genes that inhibit transforming growth factor-ß signaling in TISCs. Tlr4 expression is higher in TISCs compared with CD133-/CD49f+ cells. Taken together, Tlr4 may be a universal proto-oncogene responsible for the genesis of TLR4-NANOG dependent TISCs, and this pathway serves as a novel therapeutic target for HCC.


Asunto(s)
Carcinoma Hepatocelular/etiología , Transformación Celular Neoplásica/patología , Complicaciones de la Diabetes/etiología , Hepatitis C/complicaciones , Hepatopatías Alcohólicas/complicaciones , Neoplasias Hepáticas/etiología , Células Madre Neoplásicas/patología , Animales , Carcinoma Hepatocelular/metabolismo , Carcinoma Hepatocelular/patología , Carcinoma Hepatocelular/virología , Transformación Celular Neoplásica/metabolismo , Transformación Celular Viral , Complicaciones de la Diabetes/metabolismo , Complicaciones de la Diabetes/patología , Hepatitis C/metabolismo , Hepatitis C/patología , Proteínas de Homeodominio/metabolismo , Humanos , Hepatopatías Alcohólicas/metabolismo , Hepatopatías Alcohólicas/patología , Neoplasias Hepáticas/metabolismo , Neoplasias Hepáticas/patología , Neoplasias Hepáticas/virología , Proteína Homeótica Nanog , Células Madre Neoplásicas/metabolismo , Células Madre Neoplásicas/virología , Proto-Oncogenes Mas , Medición de Riesgo , Factores de Riesgo , Transducción de Señal , Receptor Toll-Like 4/metabolismo
6.
ISA Trans ; 122: 135-145, 2022 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-33992417

RESUMEN

This paper presents a closed-loop time-varying continuous-time recursive subspace-based prediction method utilizing principle angles rotation. A simple linear mapping can be provided by generalized Poisson moment functionals, which can deal with the time-derivatives problems of input-output Hankel matrices. The parity space employed in fault detection field is adopted instead of using the observable subspace. The system matrices are estimated consistently by the instrumental variable method and principal component analysis, which solves the identification problems of biased results for the system operating in closed-loop with a feedback controller. The system matrices are predicted by the principle angles rotation of the signal subspaces spanned from the extended observability matrices. The effectiveness of the proposed method is illustrated by the numerical simulations and real applications.

7.
Comput Intell Neurosci ; 2022: 8172466, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35341189

RESUMEN

For public security and crime prevention, the detection of prohibited items in X-ray security inspection based on deep learning has attracted widespread attention. However, the pseudocolor image dataset is scarce due to security, which brings an enormous challenge to the detection of prohibited items in X-ray security inspection. In this paper, a data augmentation method for prohibited item X-ray pseudocolor images in X-ray security inspection is proposed. Firstly, we design a framework of our method to achieve the dataset augmentation using the datasets with and without prohibited items. Secondly, in the framework, we design a spatial-and-channel attention block and a new base block to compose our X-ray Wasserstein generative adversarial network model with gradient penalty. The model directly generates high-quality dual-energy X-ray data instead of pseudocolor images. Thirdly, we design a composite strategy to composite the generated and real dual-energy X-ray data with background data into a new X-ray pseudocolor image, which can simulate the real overlapping relationship among items. Finally, two object detection models with and without our data augmentation method are applied to verify the effectiveness of our method. The experimental results demonstrate that our method can achieve the data augmentation for prohibited item X-ray pseudocolor images in X-ray security inspection effectively.


Asunto(s)
Atención , Rayos X
8.
Comput Intell Neurosci ; 2022: 5371350, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35087581

RESUMEN

For personal safety and crime prevention, some research studies based on deep learning have achieved success in the object detection of X-ray security inspection. However, the research on dangerous liquid detection is still scarce, and most research studies are focused on the detection of some prohibited and common items. In this paper, a lightweight dangerous liquid detection method based on the Depthwise Separable convolution for X-ray security inspection is proposed. Firstly, a dataset of seven common dangerous liquids with multiple postures in two detection environments is established. Secondly, we propose a novel detection framework using the dual-energy X-ray data instead of pseudocolor images as the objects to be detected, which improves the detection accuracy and realizes the parallel operation of detection and imaging. Thirdly, in order to ensure the detection accuracy and reduce the computational consumption and the number of parameters, based on the Depthwise Separable convolution and the Squeeze-and-Excitation block, a lightweight object location network and a lightweight dangerous liquid classification network are designed as the backbone networks of our method to achieve the location and classification of the dangerous liquids, respectively. Finally, a semiautomatic labeling method is proposed to improve the efficiency of data labeling. Compared with the existing methods, the experimental results demonstrate that our method has better performance and wider applicability.


Asunto(s)
Proyectos de Investigación , Rayos X
9.
Math Biosci Eng ; 19(5): 5269-5292, 2022 03 24.
Artículo en Inglés | MEDLINE | ID: mdl-35430864

RESUMEN

To improve the convergence speed and solution precision of the standard Salp Swarm Algorithm (SSA), a hybrid Salp Swarm Algorithm based on Dimension-by-dimension Centroid Opposition-based learning strategy, Random factor and Particle Swarm Optimization's social learning strategy (DCORSSA-PSO) is proposed. Firstly, a dimension-by-dimension centroid opposition-based learning strategy is added in the food source update stage of SSA to increase the population diversity and reduce the inter-dimensional interference. Secondly, in the followers' position update equation of SSA, constant 1 is replaced by a random number between 0 and 1 to increase the randomness of the search and the ability to jump out of local optima. Finally, the social learning strategy of PSO is also added to the followers' position update equation to accelerate the population convergence. The statistical results on ten classical benchmark functions by the Wilcoxon test and Friedman test show that compared with SSA and other well-known optimization algorithms, the proposed DCORSSA-PSO has significantly improved the precision of the solution and the convergence speed, as well as its robustness. The DCORSSA-PSO is applied to system reliability optimization design based on the T-S fault tree. The simulation results show that the failure probability of the designed system under the cost constraint is less than other algorithms, which illustrates that the application of DCORSSA-PSO can effectively improve the design level of reliability optimization.


Asunto(s)
Algoritmos , Benchmarking , Simulación por Computador , Probabilidad , Reproducibilidad de los Resultados
10.
Hepatology ; 52(2): 480-92, 2010 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-20683948

RESUMEN

UNLABELLED: Hepatocellular carcinoma (HCC) occurs in a significant number of patients with hepatitis C virus (HCV) infection. HCV causes double-strand DNA breaks and enhances the mutation frequency of proto-oncogenes and tumor suppressors. However, the underlying mechanisms for these oncogenic events are still elusive. Here, we studied the role of c-Jun, signal transducer and activator of transcription 3 (STAT3), and nitric oxide (NO) in spontaneous and diethylnitrosamine (DEN)-initiated and/or phenobarbital (Pb)-promoted HCC development using HCV core transgenic (Tg) mice. The viral core protein induces hepatocarcinogenesis induction as a tumor initiator under promotion by Pb treatment alone. Conditional knockout of c-jun and stat3 in hepatocytes achieves a nearly complete, additive effect on prevention of core-induced spontaneous HCC or core-enhanced HCC incidence caused by DEN/Pb. Core protein induces hepatocyte proliferation and the expression of inflammatory cytokines (interleukin-6, tumor necrosis factor-alpha, interleukin-1) and inducible NO synthase (iNOS); the former is dependent on c-Jun and STAT3, and the latter on c-Jun. Oxidative DNA damage repair activity is impaired by the HCV core protein due to reduced DNA glycosylase activity for the excision of 8-oxo-2'-deoxyguanosine. This impairment is abrogated by iNOS inhibition or c-Jun deficiency, but aggravated by the NO donor or iNOS-inducing cytokines. The core protein also suppresses apoptosis mediated by Fas ligand because of c-Jun-dependent Fas down-regulation. CONCLUSION: These results indicate that the HCV core protein potentiates chemically induced HCC through c-Jun and STAT3 activation, which in turn, enhances cell proliferation, suppresses apoptosis, and impairs oxidative DNA damage repair, leading to hepatocellular transformation.


Asunto(s)
Carcinoma Hepatocelular/virología , Reparación del ADN , Hepacivirus , Péptidos y Proteínas de Señalización Intracelular/fisiología , Neoplasias Hepáticas/virología , Óxido Nítrico/fisiología , Péptido Hidrolasas/fisiología , Factor de Transcripción STAT3/fisiología , Transducción de Señal , Animales , Complejo del Señalosoma COP9 , Humanos , Ratones , Ratones Transgénicos , Oxidación-Reducción
11.
J Nanosci Nanotechnol ; 11(6): 4733-8, 2011 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-21770099

RESUMEN

The purpose of this research was to investigate chitosan-based composite sponge containing silver nanoparticles (Ag NPs) for wound dressing application. The composite sponge was prepared by a freeze-drying technique, and then immersed in AgNO3 solution with different concentration and autoclaved at 15 psi, 121 degrees C for 15 min for the formation of Ag NPs. The composite sponge containing Ag NPs was characterized by UV-vis spectra, XRD and SEM. The characteristic peaks of Ag in the UV-vis spectra and the XRD pattern revealed the formation of Ag-NPs. The SEM image showed that the silver particles homogeneously distributed on the surface of the composite sponge with an average particle diameter of about 60-80 nm. The contents of silver determined by ICP Single-channel scanning spectrometer were 0.032, 0.096 and 0.166 weight percentage, respectively, when the composite sponge was correspondingly treated with AgNO3 at concentrations of 0.1, 0.25 and 0.5 mM. The results of enzymic degradation in vitro indicated that the Ag-NPs could obviously promote the degradation of the composite sponge. The bacteriostatic and bactericidal properties of the new sponge were preliminarily studied in vitro by using S. aureus E. coli and P. aeruginosa as test microorganisms. The test results demonstrated that the new Ag NPs-loaded chitosan-based composite sponge possessed not only bacteriostatic, but also bactericidal activity against these test bacteria.


Asunto(s)
Antibacterianos/química , Vendajes , Quitosano/química , Nanopartículas del Metal/química , Plata/química , Antibacterianos/administración & dosificación , Bacterias/efectos de los fármacos , Pruebas de Sensibilidad Microbiana , Microscopía Electrónica de Rastreo , Plata/administración & dosificación , Espectrofotometría Ultravioleta , Difracción de Rayos X
12.
Kaohsiung J Med Sci ; 37(2): 121-127, 2021 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-33022894

RESUMEN

Cullin 4B (CUL4B) was reported to be closely related to the progression of some tumors, but its function in clear cell renal cell carcinoma (ccRCC) has not been reported. Our present study found CUL4B was upregulated in ccRCC, and CUL4B knockdown markedly inhibited ccRCC cell growth and induced apoptosis. In addition, CUL4B knockdown markedly inhibited antiapoptotic proteins' expression in ccRCC cells, including Mcl-1 and Bcl-2, and silenced CUL4B also induced the cleavages of PARP, an important index of apoptosis. We also confirmed microRNA-217 (miR-217) was downregulated in ccRCC tumor tissues, and negatively correlated with CUL4B expression. Further investigations revealed miR-217 targeted CUL4B and markedly inhibited its expression in ccRCC cells. In addition, overexpression of miR-217 by mimics significantly suppressed ccRCC cell growth. In contrast, enforced expression of CUL4B significantly abolished miR-217-induced cell survival inhibition in ccRCC cells. In conclusion, our present results suggested targeting miR-217-CUL4B axis would be a promising strategy for ccRCC treatment.


Asunto(s)
Apoptosis , Carcinoma de Células Renales/genética , Carcinoma de Células Renales/patología , Proteínas Cullin/metabolismo , Neoplasias Renales/genética , Neoplasias Renales/patología , MicroARNs/metabolismo , Apoptosis/genética , Secuencia de Bases , Línea Celular Tumoral , Proliferación Celular/genética , Supervivencia Celular/genética , Regulación Neoplásica de la Expresión Génica , Técnicas de Silenciamiento del Gen , Humanos , MicroARNs/genética
13.
J Virol ; 83(23): 12590-600, 2009 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-19793824

RESUMEN

Hepatitis C virus (HCV) infection is associated with the development of hepatocellular carcinoma and probably also non-Hodgkin's B-cell lymphoma. The molecular mechanisms of HCV-associated carcinogenesis are unknown. Here we demonstrated that peripheral blood mononuclear cells obtained from hepatitis C patients and hepatocytes infected with HCV in vitro showed frequent chromosomal polyploidy. HCV infection or the expression of viral core protein alone in hepatocyte culture or transgenic mice inhibited mitotic spindle checkpoint function because of reduced Rb transcription and enhanced E2F-1 and Mad2 expression. The silencing of E2F-1 by RNA interference technology restored the function of mitotic checkpoint in core-expressing cells. Taken together, these data suggest that HCV infection may inhibit the mitotic checkpoint to induce polyploidy, which likely contributes to neoplastic transformation.


Asunto(s)
Hepacivirus/fisiología , Hepatocitos/virología , Interacciones Huésped-Patógeno , Leucocitos Mononucleares/virología , Poliploidía , Replicación Viral , Animales , Proteínas de Unión al Calcio/biosíntesis , Proteínas de Ciclo Celular/biosíntesis , Factor de Transcripción E2F1/biosíntesis , Regulación de la Expresión Génica , Silenciador del Gen , Humanos , Proteínas Mad2 , Ratones , Ratones Transgénicos , Proteínas Represoras/biosíntesis , Proteína de Retinoblastoma/biosíntesis
14.
RSC Adv ; 9(49): 28409-28413, 2019 Sep 09.
Artículo en Inglés | MEDLINE | ID: mdl-35529618

RESUMEN

1,1-Difluoroethylated aromatics are of great importance in medicinal chemistry and related fields. 1,1-Difluoroethyl chloride (CH3CF2Cl), a cheap and abundant industrial raw material, is viewed as an ideal 1,1-difluoroethylating reagent, but the direct introduction of the difluoroethyl (CF2CH3) group onto aromatic rings using CH3CF2Cl has not been successfully accomplished. Herein, we disclose a nickel-catalyzed 1,1-difluoroethylation of arylboronic acids with CH3CF2Cl for the synthesis of (1,1-difluoroethyl)arenes.

15.
Chemosphere ; 70(9): 1660-8, 2008 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-17869322

RESUMEN

Urban parks are an integral component of healthy urban living. Since they are frequently visited, an understanding of the environmental quality of these urban facilities is crucial. Here, a study was conducted on the contamination of soils in the parks of Beijing. Organochlorine pesticides (OCPs), which have the potential to cause endocrine disturbances, were considered study objectives. Hexachlorocyclohexanes (HCHs) were found at concentrations of 0.2490-197.0 ng g(-1) and dichlorodiphenyltrichloroethanes (DDTs) were found at concentrations of 5.942-1039 ng g(-1) in the soils investigated. The preliminary pollution assessment indicated that DDTs have caused high pollution levels in the soils of some parks. Analysis of the sources of contamination showed that HCHs in the soils were derived from an old mixed source of technical HCHs and lindane and that DDTs, which were suspected to have recent application to the soils at some sites, were derived mainly from a mixture of technical DDTs and dicofol containing DDT impurities. An independent sample t-test proved that pesticides containing DDTs had been used in large amounts in the soils of parks before 1983 (p<0.05) and that the levels of DDTs in the soils of parks administered by the Beijing municipal government were significantly higher than the levels in those administered by the district government (p<0.05). However, the main difference in this situation needs to be further studied. This study suggested that open spaces like urban parks were not as sound as was expected and that there was potential for exposure of visitors/workers in the parks to organochlorine pesticides.


Asunto(s)
Hexaclorociclohexano/análisis , Hidrocarburos Clorados/análisis , Plaguicidas/análisis , Contaminantes del Suelo/análisis , China , Ciudades , DDT/análisis , Monitoreo del Ambiente/métodos , Geografía , Instalaciones Públicas , Recreación
16.
J Environ Sci (China) ; 20(5): 599-606, 2008.
Artículo en Inglés | MEDLINE | ID: mdl-18575114

RESUMEN

This study tested and evaluated the agricultural non-point source (AGNPS) model for the Wuchuan catchment, a typical agricultural area in the Jiulong River watershed, Fujian Province, China. The AGNPS model was calibrated and validated for the study area with observed data on ten storms. The data on eight storms in 2002 were used for calibration while data on two storms were used for validation of the model. Considering the lack of water quality data over a long-term series, a novel method, comparing an internal nested catchment with its surrounding catchment, was used to supplement the less long-term series data. Dual calibration and validation of the AGNPS model was obtained by this comparison. The results indicate that the correlation coefficients were 0.99 and 0.98 for runoff, 0.94 and 0.95 for the peak runoff rate of the large catchment and the small catchment, respectively, and 0.76 for the sediment of the small catchment only. Each pair of correlation coefficients is homogeneous for the same event for the two catchments. With the exception of the sediment yield and particulate phosphorus, the peak runoff rate and other nutrients were well predicted. Sensitivity analysis showed that the Soil Conservation Service curve number and rainfall quantity were the most sensitive parameters, which resulted in high output variations. Erosivity and other parameters had little influence on the hydrological and quality outputs.


Asunto(s)
Monitoreo del Ambiente/métodos , Modelos Teóricos , Ríos , Contaminantes Químicos del Agua/análisis , Agricultura , China , Geografía , Sedimentos Geológicos/análisis , Nitrógeno/análisis , Fósforo/análisis , Reproducibilidad de los Resultados
17.
ISA Trans ; 83: 165-175, 2018 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-30170841

RESUMEN

A novel method for nuclear norm subspace identification of continuous-time stochastic systems based on distribution theory is proposed. The time-derivative problem of the system is solved by using random distribution theory, which is the key to obtain the input-output algebraic equation in the time-domain. Due to the fact that the system encounters the stochastic noise, we design a Kalman filter to achieve the state estimation and noise reduction. Nuclear norm minimization is constructed to optimize the system order in the process of subspace identification. Further, the optimization problem is solved by the alternating direction method of multipliers. Simulation results are provided to show the effectiveness of the proposed method.

18.
PeerJ ; 5: e3924, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-29085746

RESUMEN

BACKGROUND: Repetitive species-specific sound enables the identification of the presence and behavior of soniferous species by acoustic means. Passive acoustic monitoring has been widely applied to monitor the spatial and temporal occurrence and behavior of calling species. METHODS: Underwater biological sounds in the Pearl River Estuary, China, were collected using passive acoustic monitoring, with special attention paid to fish sounds. A total of 1,408 suspected fish calls comprising 18,942 pulses were qualitatively analyzed using a customized acoustic analysis routine. RESULTS: We identified a diversity of 66 types of fish sounds. In addition to single pulse, the sounds tended to have a pulse train structure. The pulses were characterized by an approximate 8 ms duration, with a peak frequency from 500 to 2,600 Hz and a majority of the energy below 4,000 Hz. The median inter-pulsepeak interval (IPPI) of most call types was 9 or 10 ms. Most call types with median IPPIs of 9 ms and 10 ms were observed at times that were exclusive from each other, suggesting that they might be produced by different species. According to the literature, the two section signal types of 1 + 1 and 1 + N10 might belong to big-snout croaker (Johnius macrorhynus), and 1 + N19 might be produced by Belanger's croaker (J. belangerii). DISCUSSION: Categorization of the baseline ambient biological sound is an important first step in mapping the spatial and temporal patterns of soniferous fishes. The next step is the identification of the species producing each sound. The distribution pattern of soniferous fishes will be helpful for the protection and management of local fishery resources and in marine environmental impact assessment. Since the local vulnerable Indo-Pacific humpback dolphin (Sousa chinensis) mainly preys on soniferous fishes, the fine-scale distribution pattern of soniferous fishes can aid in the conservation of this species. Additionally, prey and predator relationships can be observed when a database of species-identified sounds is completed.

19.
PeerJ ; 4: e1695, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-26893973

RESUMEN

Background. Knowledge of species-specific vocalization characteristics and their associated active communication space, the effective range over which a communication signal can be detected by a conspecific, is critical for understanding the impacts of underwater acoustic pollution, as well as other threats. Methods. We used a two-dimensional cross-shaped hydrophone array system to record the whistles of free-ranging Indo-Pacific humpback dolphins (Sousa chinensis) in shallow-water environments of the Pearl River Estuary (PRE) and Beibu Gulf (BG), China. Using hyperbolic position fixing, which exploits time differences of arrival of a signal between pairs of hydrophone receivers, we obtained source location estimates for whistles with good signal-to-noise ratio (SNR ≥10 dB) and not polluted by other sounds and back-calculated their apparent source levels (ASL). Combining with the masking levels (including simultaneous noise levels, masking tonal threshold, and the Sousa auditory threshold) and the custom made site-specific sound propagation models, we further estimated their active communication space (ACS). Results. Humpback dolphins produced whistles with average root-mean-square ASL of 138.5 ± 6.8 (mean ± standard deviation) and 137.2 ± 7.0 dB re 1 µPa in PRE (N = 33) and BG (N = 209), respectively. We found statistically significant differences in ASLs among different whistle contour types. The mean and maximum ACS of whistles were estimated to be 14.7 ± 2.6 (median ± quartile deviation) and 17.1± 3.5 m in PRE, and 34.2 ± 9.5 and 43.5 ± 12.2 m in BG. Using just the auditory threshold as the masking level produced the mean and maximum ACSat of 24.3 ± 4.8 and 35.7 ± 4.6 m for PRE, and 60.7 ± 18.1 and 74.3 ± 25.3 m for BG. The small ACSs were due to the high ambient noise level. Significant differences in ACSs were also observed among different whistle contour types. Discussion. Besides shedding some light for evaluating appropriate noise exposure levels and information for the regulation of underwater acoustic pollution, these baseline data can also be used for aiding the passive acoustic monitoring of dolphin populations, defining the boundaries of separate groups in a more biologically meaningful way during field surveys, and guiding the appropriate approach distance for local dolphin-watching boats and research boat during focal group following.

20.
ISA Trans ; 58: 165-72, 2015 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-26051965

RESUMEN

This paper deals with the ultra-fast formation control problem of high-order discrete-time multi-agent systems. Using the local neighbor-error knowledge, a novel ultra-fast protocol with multi-step predictive information and self-feedback term is proposed. The asymptotic convergence factor is improved by a power of q+1 compared to the routine protocol. To some extent, the ultra-fast algorithm overcomes the influence of communication topology to the convergence speed. Furthermore, some sufficient conditions are given herein. The ones decouple the design of the synchronizing gains from the detailed graph properties, and explicitly reveal how the agent dynamic and the communication graph jointly affect the ultra-fast formationability. Finally, some simulations are worked out to illustrate the effectiveness of our theoretical results.

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