RESUMEN
OBJECTIVES: To evaluate the quality of life and related demographic factors in long-term survivors of childhood non-Hodgkin's lymphoma (NHL). METHODS: A retrospective analysis was performed on the medical and demographic data of the NHL patients who received treatment in the Sun Yat-sen University Cancer Center and achieved long-term survival at follow-up, with an age of <18 years at initial diagnosis and a present age of ≥18 years. A questionnaire survey was performed using 36-Item Short-Form Health Survey (SF-36) and the symptom subscale of the Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (QLQ-C30). The health status of long-term survivors of NHL was evaluated by comparing the scores of various dimensions of the SF-36 scale of general adult population in the United States (American norm) and those of the SF-36 scale of general adult population in Hong Kong, China (Hong Kong norm). The correlation between the score of each dimension of the scale and demographic characteristics was evaluated. The symptoms of long-term NHL survivors were evaluated according to the score of QLQ-C30 scale. RESULTS: A total of 23 patients with NHL with complete follow-up data were enrolled. The pathological types included diffuse large B-cell lymphoma in 10 patients, Burkitt lymphoma in 4 patients, T-cell lymphoblastoma in 5 patients, B-cell lymphoblastoma in 3 patients, and natural killer/T cell lymphoma in 1 patient. All patients received the chemotherapy regimen containing anthracyclines and alkylating agents. The median present age was 26.2 years (range: 16.9-55.8 years), and the median age at initial diagnosis was 10.4 years (range: 2.4-17.6 years). Among the 23 patients, 6 were married and had children and 2 had chronic diseases. There was no significant difference between the long-term survivors and the US norm in role physical, general health, role-emotional, and mental health (P>0.05), while the long-term survivors had significantly better scores of the other dimensions than the US norm (P<0.05). Similar results were obtained for the comparison between the long-term survivors and the China Hong Kong norm. Age at initial diagnosis was negatively correlated with the scores of social functioning, role physical, and general health in the SF-36 scale (P<0.05), and the present age of patients was positively correlated with the score of physical functioning and was negatively correlated with the score of general health (P<0.05). The urban and rural distribution of patients was related to the general health status (P<0.05). In addition, the long-term survivors of childhood NHL had relatively low scores of the symptom domain of QLQ-C30, and few moderate or severe symptoms were found. CONCLUSIONS: Long-term survivors of childhood NHL tend to have a good overall health status, with no significant differences compared with the general population. Age at initial diagnosis is the main demographic factor that affects patients' quality of life. Citation.
Asunto(s)
Linfoma no Hodgkin , Linfoma , Adolescente , Adulto , Humanos , Linfoma no Hodgkin/tratamiento farmacológico , Persona de Mediana Edad , Calidad de Vida , Estudios Retrospectivos , Sobrevivientes , Adulto JovenRESUMEN
The static chamber-gas chromatography method was applied to observe CO2 fluxes across the water-air interface from different aquaculture systems, including four groups of mesocosms, i.e., blank control system (CK), monoculture system of Sebastes schlegelii (F), monoculture system of Chlamys farreri (B) and polyculture system of S. schlegelii and C. farreri (FB). Meanwhile, the physical, chemical and biological indices of the water were measured. The results showed that the group CK was a stable CO2 source, with the mean flux of 12.42 mg·m-2·h-1. The group B was a CO2 source during the early and middle periods of the experiment and a CO2 sink at the end of the experiment, with the mean flux during the experiment being 10.95 mg·m-2·h-1. The change trends of CO2 flux in the group F and FB were generally consistent, acting as CO2 sources in the early period and as CO2 sinks subsequently. The mean fluxes of those two groups during the expe-riment were -3.53 and -10.49 mg·m-2·h-1, respectively. Water pH was a good predictor for CO2 flux across the water-air interface according to the result of regression analysis, with pH value of 8.25 as the critical threshold between efflux and influx. The net primary production of water column was the main factor influencing the CO2 flux, indicating that phytoplankton might be the main internal force regulating the CO2 flux across the water-air interface. Our results indicated that C. farreri at present stocking density in the polyculture system could promote phytoplankton biomass as well as primary production and therefore enhance the CO2 sink function.