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1.
Opt Express ; 28(21): 30478-30488, 2020 Oct 12.
Artículo en Inglés | MEDLINE | ID: mdl-33115048

RESUMEN

We demonstrated an optical fiber sensor based on a cascaded fiber Fabry-Perot interferometer (FPI)-regenerated fiber Bragg grating (RFBG) for simultaneous measurement of temperature and strain under high temperature environments. The FPI is manufactured from a ∼74 µm long hollow core silica tube (HCST) sandwiched between two single mode fibers (SMFs). The RFBG is inscribed in one of the SMF arms which is embedded inside an alundum tube, making it insensitive to the applied strain on the entire fiber sensor, just in case the temperature and strain recovery process are described using the strain-free RFBG instead of a characteristic due-parameter matrix. This feature is intended for thermal compensation for the FPI structure that is sensitive to both temperature and strain. In the characterization tests, the proposed device has exhibited a temperature sensitivity ∼ 18.01 pm/°C in the range of 100 °C - 1000 °C and excellent linear response to strain in the range of 300 °C - 1000 °C. The measured strain sensitivity is as high as ∼ 2.17 pm/µÉ› for a detection range from 0 µÉ› to 450 µÉ› at 800 °C, which is ∼ 1.5 times that of a FPI-RFBG without the alundum tube.

2.
J Org Chem ; 83(3): 1422-1430, 2018 02 02.
Artículo en Inglés | MEDLINE | ID: mdl-29322774

RESUMEN

A visible-light-induced decarboxylation coupling/intramolecular cyclization is reported. The one-pot synthesis system provides mild, efficient, and atom economical access to the synthesis of 4-aryl-2-quinolinone derivatives. It is notable that the necessary oxidant in the traditional decarboxylation coupling is replaced by the visible-light irradiation in this paper. In addition, the HBV inhibitor is synthesized by the one-pot synthesis system in an atom economical manner.

3.
Sensors (Basel) ; 17(8)2017 Jul 27.
Artículo en Inglés | MEDLINE | ID: mdl-28749437

RESUMEN

We have experimentally demonstrated an optical fiber Mach-Zehnder interferometer (MZI) structure formed by a few-mode photonic crystal fiber (PCF) for curvature measurement and inscribed a fiber Bragg grating (FBG) in the PCF for the purpose of simultaneously measuring temperature. The structure consists of a PCF sandwiched between two multi-mode fibers (MMFs). Bending experimental results show that the proposed sensor has a sensitivity of -1.03 nm/m-1 at a curvature range from 10 m-1 to 22.4 m-1, and the curvature sensitivity of the embedded FBG was -0.003 nm/m-1. Temperature response experimental results showed that the MZI's wavelength, λa, has a sensitivity of 60.3 pm/°C, and the FBG's Bragg wavelength, λb, has sensitivity of 9.2 pm/°C in the temperature range of 8 to 100 °C. As such, it can be used for simultaneous measurement of curvature and temperature over ranges of 10 m-1 to 22.4 m-1 and 8 °C to 100 °C, respectively. The results show that the embedded FBG can be a good indicator to compensate the varying ambient temperature during a curvature measurement.

4.
Materials (Basel) ; 15(6)2022 Mar 21.
Artículo en Inglés | MEDLINE | ID: mdl-35329789

RESUMEN

In this paper, the 12k T-700TM Multiaxial-Warp-Knitting-Needle (MWK-N) C/SiC composite and pin were designed and fabricated using the isothermal chemical vapor infiltration (ICVI) method. The composite's microstructure and mechanical properties were examined by subjection to tensile and interlaminar shear tests. Three types of double-shear tests were conducted for C/SiC pins, including shear loading perpendicularly, along, and at 45° off-axial to the lamination. The fracture surface of the tensile and shear failure specimens was observed under scanning electronic microscope (SEM). The relationships between the composite's microstructure, mechanical properties, and damage mechanisms were established. The composite's average tensile strength was σuts = 68.3 MPa and the average interlaminar shear strength was τu = 38.7 MPa. For MWK-N-C/SiC pins, the double-shear strength was τu = 76.5 MPa, 99.7 MPa, and 79.6 MPa for test types I, II, and III, respectively. Compared with MWK-C/SiC pins, the double-shear strength of MWK-N-C/SiC pins all decreased, i.e., 26.7%, 50.8%, and 8% for test types I, II, and III, respectively. The MWK-N-C/SiC composite and pins possessed high interlaminar shear strength and double-shear strength, due to the needled fiber in the thickness direction, low porosity (10-15%), and high composite density (2.0 g/cm3).

5.
Materials (Basel) ; 14(20)2021 Oct 15.
Artículo en Inglés | MEDLINE | ID: mdl-34683693

RESUMEN

In this paper, the SiC/SiC high-pressure turbine twin guide vanes were fabricated using the chemical vapor infiltration (CVI) method. Cyclic thermal shock tests at different target temperatures (i.e., 1400, 1450, and 1480 °C) in a gas environment were conducted to investigate the damage mechanisms and failure modes. During the thermal shock test, large spalling areas appeared on the leading edge and back region. After 400 thermal shock cycles, the spalling area of the coating at the basin and back region of the guide vane was more than 30%, and the whole guide vane turned gray, due to the formation of SiO2. When the thermal shock temperature increased from 1400 to 1450 and 1480 °C, the spalling area of the basin and the back region of the guide vane did not increase significantly, but the delamination occurred at the tenon, upper surface of the guide vane near the trailing edge of the guide vane. Through the X-ray Computed Tomography (XCT) analysis for the guide vanes before and after thermal shock, there was no obvious damage inside of guide vanes. The oxidation of SiC coating and the formation of SiO2 protects the internal fibers from oxidation and damage. Further investigation on the effect of thermal shock on the mechanical properties of SiC/SiC composites should be conducted in the future.

6.
Nat Commun ; 11(1): 5962, 2020 11 24.
Artículo en Inglés | MEDLINE | ID: mdl-33235205

RESUMEN

The abuse potential of ketamine limits its clinical application, but the precise mechanism remains largely unclear. Here we discovered that ketamine significantly remodels the endocannabinoid-related lipidome and activates 2-arachidonoylglycerol (2-AG) signaling in the dorsal striatum (caudate nucleus and putamen, CPu) of mice. Elevated 2-AG in the CPu is essential for the psychostimulant and reinforcing effects of ketamine, whereas blockade of the cannabinoid CB1 receptor, a predominant 2-AG receptor, attenuates ketamine-induced remodeling of neuronal dendrite structure and neurobehaviors. Ketamine represses the transcription of the monoacylglycerol lipase (MAGL) gene by promoting the expression of PRDM5, a negative transcription factor of the MAGL gene, leading to increased 2-AG production. Genetic overexpression of MAGL or silencing of PRDM5 expression in the CPu robustly reduces 2-AG production and ketamine effects. Collectively, endocannabinoid signaling plays a critical role in mediating the psychostimulant and reinforcing properties of ketamine.


Asunto(s)
Ácidos Araquidónicos/metabolismo , Proteínas de Unión al ADN , Endocannabinoides/metabolismo , Glicéridos/metabolismo , Ketamina/farmacología , Monoacilglicerol Lipasas , Transducción de Señal/efectos de los fármacos , Factores de Transcripción , Animales , Agonistas de Receptores de Cannabinoides/metabolismo , Núcleo Caudado/metabolismo , Proteínas de Unión al ADN/genética , Proteínas de Unión al ADN/metabolismo , Expresión Génica , Regulación de la Expresión Génica , Ratones , Monoacilglicerol Lipasas/genética , Monoacilglicerol Lipasas/metabolismo , Neuronas/metabolismo , Receptor Cannabinoide CB1/efectos de los fármacos , Receptor Cannabinoide CB1/metabolismo , Trastornos Relacionados con Sustancias/genética , Trastornos Relacionados con Sustancias/metabolismo , Factores de Transcripción/genética , Factores de Transcripción/metabolismo
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