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1.

Genomic origin, fragmentomics, and transcriptional properties of long cell-free DNA molecules in human plasma.

Che, Huiwen; Jiang, Peiyong; Choy, L Y Lois; Cheng, Suk Hang; Peng, Wenlei; Chan, Rebecca W Y; Liu, Jing; Zhou, Qing; Lam, W K Jacky; Yu, Stephanie C Y; Lau, So Ling; Leung, Tak Y; Wong, John; Wong, Vincent Wai-Sun; Wong, Grace L H; Chan, Stephen L; Chan, K C Allen; Lo, Y M Dennis.

Genome Res; 34(2): 189-200, 2024 Mar 20.

Artículo en Inglés | MEDLINE | ID: mdl-38408788

2.

Fragmentation landscape of cell-free DNA revealed by deconvolutional analysis of end motifs.

Zhou, Ze; Ma, Mary-Jane L; Chan, Rebecca W Y; Lam, W K Jacky; Peng, Wenlei; Gai, Wanxia; Hu, Xi; Ding, Spencer C; Ji, Lu; Zhou, Qing; Cheung, Peter P H; Yu, Stephanie C Y; Teoh, Jeremy Y C; Szeto, Cheuk-Chun; Wong, John; Wong, Vincent W S; Wong, Grace L H; Chan, Stephen L; Hui, Edwin P; Ma, Brigette B Y; Chan, Anthony T C; Chiu, Rossa W K; Chan, K C Allen; Lo, Y M Dennis; Jiang, Peiyong.

Proc Natl Acad Sci U S A; 120(17): e2220982120, 2023 04 25.

Artículo en Inglés | MEDLINE | ID: mdl-37075072

3.

Epigenetic analysis of cell-free DNA by fragmentomic profiling.

Zhou, Qing; Kang, Guannan; Jiang, Peiyong; Qiao, Rong; Lam, W K Jacky; Yu, Stephanie C Y; Ma, Mary-Jane L; Ji, Lu; Cheng, Suk Hang; Gai, Wanxia; Peng, Wenlei; Shang, Huimin; Chan, Rebecca W Y; Chan, Stephen L; Wong, Grace L H; Hiraki, Linda T; Volpi, Stefano; Wong, Vincent W S; Wong, John; Chiu, Rossa W K; Chan, K C Allen; Lo, Y M Dennis.

Proc Natl Acad Sci U S A; 119(44): e2209852119, 2022 11.

Artículo en Inglés | MEDLINE | ID: mdl-36288287

4.

Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models.

Chen, Meihui; Chan, Rebecca W Y; Cheung, Peter P H; Ni, Meng; Wong, Danny K L; Zhou, Ze; Ma, Mary-Jane L; Huang, Liangbo; Xu, Xinzhou; Lee, Wing-Shan; Wang, Guangya; Lui, Kathy O; Lam, W K Jacky; Teoh, Jeremy Y C; Ng, Chi-Fai; Jiang, Peiyong; Chan, K C Allen; Chiu, Rossa W K; Lo, Y M Dennis.

PLoS Genet; 18(7): e1010262, 2022 07.

Artículo en Inglés | MEDLINE | ID: mdl-35793278

5.

The Nexus of cfDNA and Nuclease Biology.

Han, Diana S C; Lo, Y M Dennis.

Trends Genet; 37(8): 758-770, 2021 08.

Artículo en Inglés | MEDLINE | ID: mdl-34006390

6.

Nuclease deficiencies alter plasma cell-free DNA methylation profiles.

Han, Diana S C; Ni, Meng; Chan, Rebecca W Y; Wong, Danny K L; Hiraki, Linda T; Volpi, Stefano; Jiang, Peiyong; Lui, Kathy O; Chan, K C Allen; Chiu, Rossa W K; Lo, Y M Dennis.

Genome Res; 31(11): 2008-2021, 2021 11.

Artículo en Inglés | MEDLINE | ID: mdl-34470801

7.

Single-molecule sequencing reveals a large population of long cell-free DNA molecules in maternal plasma.

Yu, Stephanie C Y; Jiang, Peiyong; Peng, Wenlei; Cheng, Suk Hang; Cheung, Y T Tommy; Tse, O Y Olivia; Shang, Huimin; Poon, Liona C; Leung, Tak Y; Chan, K C Allen; Chiu, Rossa W K; Lo, Y M Dennis.

Proc Natl Acad Sci U S A; 118(50)2021 12 14.

Artículo en Inglés | MEDLINE | ID: mdl-34873045

8.

Genome-wide detection of cytosine methylation by single molecule real-time sequencing.

Tse, O Y Olivia; Jiang, Peiyong; Cheng, Suk Hang; Peng, Wenlei; Shang, Huimin; Wong, John; Chan, Stephen L; Poon, Liona C Y; Leung, Tak Y; Chan, K C Allen; Chiu, Rossa W K; Lo, Y M Dennis.

Proc Natl Acad Sci U S A; 118(5)2021 02 02.

Artículo en Inglés | MEDLINE | ID: mdl-33495335

9.

The Biology of Cell-free DNA Fragmentation and the Roles of DNASE1, DNASE1L3, and DFFB.

Han, Diana S C; Ni, Meng; Chan, Rebecca W Y; Chan, Vicken W H; Lui, Kathy O; Chiu, Rossa W K; Lo, Y M Dennis.

Am J Hum Genet; 106(2): 202-214, 2020 02 06.

Artículo en Inglés | MEDLINE | ID: mdl-32004449

10.

Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction.

Chan, Rebecca W Y; Serpas, Lee; Ni, Meng; Volpi, Stefano; Hiraki, Linda T; Tam, Lai-Shan; Rashidfarrokhi, Ali; Wong, Priscilla C H; Tam, Lydia H P; Wang, Yueyang; Jiang, Peiyong; Cheng, Alice S H; Peng, Wenlei; Han, Diana S C; Tse, Patty P P; Lau, Pik Ki; Lee, Wing-Shan; Magnasco, Alberto; Buti, Elisa; Sisirak, Vanja; AlMutairi, Nora; Chan, K C Allen; Chiu, Rossa W K; Reizis, Boris; Lo, Y M Dennis.

Am J Hum Genet; 107(5): 882-894, 2020 11 05.

Artículo en Inglés | MEDLINE | ID: mdl-33022220

11.

Detection and characterization of jagged ends of double-stranded DNA in plasma.

Jiang, Peiyong; Xie, Tingting; Ding, Spencer C; Zhou, Ze; Cheng, Suk Hang; Chan, Rebecca W Y; Lee, Wing-Shan; Peng, Wenlei; Wong, John; Wong, Vincent W S; Chan, Henry L Y; Chan, Stephen L; Poon, Liona C Y; Leung, Tak Y; Chan, K C Allen; Chiu, Rossa W K; Lo, Y M Dennis.

Genome Res; 30(8): 1144-1153, 2020 08.

Artículo en Inglés | MEDLINE | ID: mdl-32801148

12.

Comparison of Single Molecule, Real-Time Sequencing and Nanopore Sequencing for Analysis of the Size, End-Motif, and Tissue-of-Origin of Long Cell-Free DNA in Plasma.

Yu, Stephanie C Y; Deng, Jiaen; Qiao, Rong; Cheng, Suk Hang; Peng, Wenlei; Lau, So Ling; Choy, L Y Lois; Leung, Tak Y; Wong, John; Wong, Vincent Wai-Sun; Wong, Grace L H; Jiang, Peiyong; Chiu, Rossa W K; Chan, K C Allen; Lo, Y M Dennis.

Clin Chem; 69(2): 168-179, 2023 02 01.

Artículo en Inglés | MEDLINE | ID: mdl-36322427

13.

Fragment Ends of Circulating Microbial DNA as Signatures for Pathogen Detection in Sepsis.

Wang, Guangya; Lam, W K Jacky; Ling, Lowell; Ma, Mary-Jane L; Ramakrishnan, Saravanan; Chan, Don C T; Lee, Wing-Shan; Cheng, Suk Hang; Chan, Rebecca W Y; Yu, Stephanie C Y; Tse, Irene O L; Wong, Wai Tat; Jiang, Peiyong; Chiu, Rossa W K; Allen Chan, K C; Lo, Y M Dennis.

Clin Chem; 69(2): 189-201, 2023 02 01.

Artículo en Inglés | MEDLINE | ID: mdl-36576350

14.

Droplet digital PCR is a cost-effective method for analyzing long cell-free DNA in maternal plasma: Application in preeclampsia.

Gai, Wanxia; Yu, Stephanie C Y; Chan, W T Charlotte; Peng, Wenlei; Lau, So Ling; Leung, Tak Y; Jiang, Peiyong; Chan, K C Allen; Lo, Y M Dennis.

Prenat Diagn; 43(11): 1385-1393, 2023 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-37655424

15.

Identification and characterization of extrachromosomal circular DNA in maternal plasma.

Sin, Sarah T K; Jiang, Peiyong; Deng, Jiaen; Ji, Lu; Cheng, Suk Hang; Dutta, Anindya; Leung, Tak Y; Chan, K C Allen; Chiu, Rossa W K; Lo, Y M Dennis.

Proc Natl Acad Sci U S A; 117(3): 1658-1665, 2020 01 21.

Artículo en Inglés | MEDLINE | ID: mdl-31900366

16.

Cell-free DNA for Colorectal Cancer Screening.

Lo, Y M Dennis.

N Engl J Med; 390(11): 1047-1050, 2024 Mar 14.

Artículo en Inglés | MEDLINE | ID: mdl-38477993

17.

Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin.

Sun, Kun; Jiang, Peiyong; Cheng, Suk Hang; Cheng, Timothy H T; Wong, John; Wong, Vincent W S; Ng, Simon S M; Ma, Brigette B Y; Leung, Tak Y; Chan, Stephen L; Mok, Tony S K; Lai, Paul B S; Chan, Henry L Y; Sun, Hao; Chan, K C Allen; Chiu, Rossa W K; Lo, Y M Dennis.

Genome Res; 29(3): 418-427, 2019 03.

Artículo en Inglés | MEDLINE | ID: mdl-30808726

18.

Single-Molecule Sequencing Enables Long Cell-Free DNA Detection and Direct Methylation Analysis for Cancer Patients.

Choy, L Y Lois; Peng, Wenlei; Jiang, Peiyong; Cheng, Suk Hang; Yu, Stephanie C Y; Shang, Huimin; Olivia Tse, O Y; Wong, John; Wong, Vincent Wai Sun; Wong, Grace L H; Lam, W K Jacky; Chan, Stephen L; Chiu, Rossa W K; Chan, K C Allen; Lo, Y M Dennis.

Clin Chem; 68(9): 1151-1163, 2022 09 01.

Artículo en Inglés | MEDLINE | ID: mdl-35587130

19.

Dnase1l3 deletion causes aberrations in length and end-motif frequencies in plasma DNA.

Serpas, Lee; Chan, Rebecca W Y; Jiang, Peiyong; Ni, Meng; Sun, Kun; Rashidfarrokhi, Ali; Soni, Chetna; Sisirak, Vanja; Lee, Wing-Shan; Cheng, Suk Hang; Peng, Wenlei; Chan, K C Allen; Chiu, Rossa W K; Reizis, Boris; Lo, Y M Dennis.

Proc Natl Acad Sci U S A; 116(2): 641-649, 2019 01 08.

Artículo en Inglés | MEDLINE | ID: mdl-30593563

20.

Single Cell and Plasma RNA Sequencing for RNA Liquid Biopsy for Hepatocellular Carcinoma.

Vong, Joaquim S L; Ji, Lu; Heung, Macy M S; Cheng, Suk Hang; Wong, John; Lai, Paul B S; Wong, Vincent W S; Chan, Stephen L; Chan, Henry L Y; Jiang, Peiyong; Chan, K C Allen; Chiu, Rossa W K; Lo, Y M Dennis.

Clin Chem; 67(11): 1492-1502, 2021 11 01.

Artículo en Inglés | MEDLINE | ID: mdl-34463757

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