RESUMEN
The single dose pharmacokinetics (PK) of marbofloxacin was compared with repeated intravenous (IV) administrations in six healthy goats at the dose rate of 2â¯mg/kg body weight at 24â¯h interval for 5â¯days. Blood samples were collected at times: 5, 15, 30â¯min and 1, 2, 4, 6, 9, 12, 24, 36, 48 and 72â¯h post drug administration. Plasma drug concentrations were determined by High Performance Liquid Chromatography and concentration-time data were subjected to non-compartment analysis. The MIC and MBC of marbofloxacin against Escherichia (E.) coli and Pasteurella (P.) multocida in Mueller Hinton Broth were determined by broth microdilution method. The t1/2elmâ¯=â¯4.37⯱â¯0.18â¯h and ClBâ¯=â¯0.29⯱â¯0.01 following single administration were not significantly different from t1/2elmâ¯=â¯5.11⯱â¯0.22â¯h and ClBâ¯=â¯0.26⯱â¯0.01â¯mL/kg/h after repeated administrations of marbofloxacin. Accumulation index (AIâ¯=â¯1.1) indicated no accumulation of marbofloxacin following repeated IV administrations up to 5â¯days. The respective MICs of marbofloxacin against E. coli and P. multocida were 0.03⯵g/mL and 0.4⯵g/mL. The AUC0-24h/MIC ratios were 226.64⯱â¯7.21â¯h for E. coli and 16.99⯱â¯0.541â¯h for P. multocida. PK/PD integration indicated that marbofloxacin daily dose of 2â¯mg/kg is appropriate for treating E. coli (MICâ¯≤â¯0.03⯵g/mL) infections. However, a higher dose of 6â¯mg/kg/day is suggested to obtain clinical cure against diseases caused by P. multocida having MIC90â¯=â¯0.12⯵g/mL in goat species.