Detalles de la búsqueda
1.
Characterization of tritiated JNJ-GluN2B-5 (3-[3H] 1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyridin-1-yl)ethanone), a high affinity GluN2B radioligand with selectivity over sigma receptors.
J Neurochem;
2024 May 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-38770633
2.
Discovery and SAR studies of 2-alkyl-3-phenyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepines as 5-HT7/2 inhibitors leading to the identification of a clinical candidate.
Bioorg Med Chem Lett;
31: 127669, 2021 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33171218
3.
Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor.
J Pharmacol Exp Ther;
372(3): 339-353, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31818916
4.
Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8.
J Pharmacol Exp Ther;
357(2): 394-414, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26989142
5.
Preclinical characterization of substituted 6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one P2X7 receptor antagonists.
Bioorg Med Chem Lett;
26(2): 257-261, 2016 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26707399
6.
A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects.
J Pharmacol Exp Ther;
352(3): 590-601, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25583879
7.
Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia.
J Pharmacol Exp Ther;
354(3): 471-82, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-26177655
8.
Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists.
Bioorg Med Chem Lett;
25(16): 3157-63, 2015 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26099534
9.
Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432.
J Pharmacol Exp Ther;
351(3): 628-41, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25271258
10.
Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions.
ACS Med Chem Lett;
15(4): 486-492, 2024 Apr 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-38628796
11.
Evaluating EEG complexity metrics as biomarkers for depression.
Psychophysiology;
60(8): e14274, 2023 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-36811526
12.
Discovery of a Series of Substituted 1H-((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators.
J Med Chem;
66(4): 2877-2892, 2023 02 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36757100
13.
Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder.
J Pharmacol Exp Ther;
342(2): 429-40, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22570363
14.
Indole- and benzothiophene-based histamine H3 antagonists.
Bioorg Med Chem Lett;
20(21): 6226-30, 2010 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20843691
15.
Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists.
Bioorg Med Chem Lett;
20(9): 2755-60, 2010 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20382018
16.
Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.
Bioorg Med Chem Lett;
20(14): 4210-4, 2010 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20561786
17.
Putative role of GPR139 on sleep modulation using pharmacological and genetic rodent models.
Eur J Pharmacol;
882: 173256, 2020 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32531213
18.
Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793.
ACS Med Chem Lett;
11(10): 2002-2009, 2020 Oct 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33062185
19.
Design, Synthesis, and Preclinical Evaluation of 3-Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5-b]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders.
J Med Chem;
63(17): 9181-9196, 2020 09 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32787105
20.
Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans.
Transl Psychiatry;
10(1): 308, 2020 09 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32895369