Contact urticaria due to phenoxyethanol in an aftershave.

The occurrence of pruritus immediately after application of an aftershave product is usually due to irritant contact dermatitis. We report a case of contact urticaria in a male patient, produced by an aftershave product containing phenoxyethanol.

[Vitiligo. Treatment of 12 cases with topical tacrolimus]. / Vitíligo. Tratamiento de 12 casos con tacrolimus tópico.

INTRODUCTION: Vitiligo is a frequent dyschromia, characterized by achromic macules that reflect the absence of melanocytes. The cause of this selective destruction seems to be due to an autoimmune phenomenon. Tacrolimus is an immunomodulator produced by Streptomyces tsukubaensis, whose topical use has been approved for atopic dermatitis. It has been tested in other dermatoses where immunological phenomena are involved. MATERIAL AND METHODS: During the period from September 1, 2003 to April 30, 2004, an open study was carried out on 12 cases of vitiligo treated with topical tacrolimus 0.1 % twice a day. The degree of repigmentation was analyzed using digital photography at the initial visit, and at three and six months. The response in each case was taken into consideration, as well as the response by treated area. Possible adverse effects during the treatment period were also noted. RESULTS: 50 % of the patients treated showed repigmentation with good (50 %-75 %) or excellent (> 75 %) improvement after 6 months. All of the patients with facial involvement achieved repigmentation of over 50 % in this location. Repigmentation in all cases took place homogeneously and centripetally, rather than in a perifollicular pattern. Repigmentation began before three months of treatment had elapsed in 10 patients, and after three months in the remaining two. We did not find any evidence of adverse effects except pruritus in the eyelid area in two patients during the first week of treatment. CONCLUSION: We believe that tacrolimus 0.1 % applied topically for a minimum of six months may be a valid alternative in the treatment of vitiligo in the facial area, especially the eyelids, where other therapeutic modes are not recommended because of the possible side effects.

[Neonatal lupus erythematosus: 4 cases and clinical review]. / Lupus eritematoso neonatal: 4 casos y revisión clínica.

Neonatal lupus erythematosus (NLE) is an infrequent disease in newborns caused by the transplacental passage of maternal Anti-Ro/SSA, Anti-La/SSB and/or Anti-U1 RNP antibodies. The most common manifestations are cutaneous and cardiac. We carried out a retrospective study of cases of NLE diagnosed in the last 10 years at the Hospital Universitario Insular in Gran Canaria. Complete data was obtained for 4 patients. Three cases had circulating Anti-Ro antibodies in the mother and in the newborns, while in the fourth case they were Anti-RNP. Two mothers were diagnosed with systemic lupus, one with mixed connective tissue disease and the other with leucocytoclastic vasculitis. The skin lesions consisted of urticaria-like and desquamative lesions. One patient presented with ulceration. The histological study of the urticaria-like lesions showed a non-specific perivascular infiltrate; the desquamative lesions were consistent with subacute lupus erythematosus.

Vitíligo. Tratamiento de 12 casos con tacrolimus tópico / Vitiligo. Treatment of 12 cases with topical tacrolimus

La lipoidoproteinosis es una enfermedad poco frecuente, debida al depósito de un material hialino PAS+ diastasa resistente en la piel y en el tracto respiratorio, aunque también puede depositarse en órganos internos, de forma generalmente asintomática. La manifestación clínica más temprana es la ronquera. La sintomatología cutánea es más tardía, en forma de lesiones hiperqueratósicas localizadas en tronco, codos, axilas, ingles, dorso de manos, palmas y plantas. Una lesión típica de la enfermedad es la blefarosis moniliforme, que consiste en pápulas arrosariadas en el borde libre de párpados. Es también característica la presencia de calcificaciones intracraneales en forma de coma en los lóbulos temporales. El curso de la enfermedad es progresivo, con una esperanza de vida normal. Afecta por igual a hombres y mujeres con una distribución mundial. El diagnóstico se basa en la sintomatología y la histología. No existe hasta el momento un tratamiento eficaz de la enfermedad. Presentamos un caso de lipoidoproteinosis en una mujer de 23 años, con características clínicas e histológicas típicas

Lipoid proteinosis is an infrequent disease characterized by the deposition of a PAS-positive diastase-resistant hyaline material in the skin and respiratory tract, although it can also be deposited in internal organs, in a generally asymptomatic manner. The earliest clinical manifestation is hoarseness. Clinical cutaneous manifestations come later, in the form of hyperkeratotic lesions located on the trunk, elbows, axillae, groins, backs of hands, palms and soles. A lesion typical of the disease is moniliform blepharosis, which consists of beaded papules along the eyelid margins. Also characteristic is the presence of comma-shaped intracranial calcifications in the temporal lobes. The course of the disease is progressive, with a normal life expectancy. It affects men and women equally, with worldwide distribution. The diagnosis is based on the clinical symptoms and the histology. At this time, there is no effective treatment for the disease. We present a case of lipoid proteinosis in a 23-year-old woman, with typical clinical and histological characteristics

Lupus eritematoso neonatal: 4 casos y revisión clínica / Neonatal lupus erythematosus: 4 cases and clinical review

El lupus eritematoso neonatal (LEN) es una enfermedad poco frecuente del recién nacido debido al paso transplacentario de anticuerpos maternos anti-Ro/SSA, anti-La/ SSB y/o anti-U1RNP en la que las afectaciones cutáneas y cardiacas son las más destacadas. Realizamos un estudio retrospectivo de casos diagnosticados de LEN en los últimos 10 años en el Hospital Universitario Insular de Gran Canaria en el que se obtuvieron datos completos de 4 enfermos. En 3 casos se presentaron anticuerpos circulantes anti-Ro en la madre y en los neonatos, mientras que en el otro era anti-RNP. Dos madres estaban diagnosticadas de lupus sistémico, una de enfermedad mixta del tejido conjuntivo y otra de vasculitis leucocitoclástica. Las lesiones cutáneas consistieron en lesiones urticariformes y descamativas. Un paciente presentó ulceración. El estudio histológico de las lesiones urticariformes mostró un infiltrado perivascular inespecífico; las lesiones descamativas fueron compatibles con lupus eritematoso subagudo

Neonatal lupus erythematosus (NLE) is an infrequent disease in newborns caused by the transplacental passage of maternal Anti-Ro/SSA, Anti-La/SSB and/or Anti-U1 RNP antibodies. The most common manifestations are cutaneous and cardiac. We carried out a retrospective study of cases of NLE diagnosed in the last 10 years at the Hospital Universitario Insular in Gran Canaria. Complete data was obtained for 4 patients. Three cases had circulating Anti-Ro antibodies in the mother and in the newborns, while in the fourth case they were Anti-RNP. Two mothers were diagnosed with systemic lupus, one with mixed connective tissue disease and the other with leucocytoclastic vasculitis. The skin lesions consisted of urticaria-like and desquamative lesions. One patient presented with ulceration. The histological study of the urticaria-like lesions showed a non-specific perivascular infiltrate; the desquamative lesions were consistent with subacute lupus erythematosus