1.
J Org Chem
; 83(15): 7860-7866, 2018 08 03.
Artículo
en Inglés
| MEDLINE
| ID: mdl-29972639
RESUMEN
We develop a palladium-catalyzed H/D exchange reaction with 8-aminoquinoline as the directing group as well as D2O as the source of deuterium atom and solvent. This reaction achieves selectively H/D exchange at the ortho-C-H of aromatic amides and the ß-C-H of aliphatic amide. Ortho-deuterated aromatic acids and ß-deuterated aliphatic acids are obtained by removal of the directing group. And a possible mechanism is also proposed.