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1.
Multimodal mechanisms and enhanced efficiency of atrial fibrillation cardioversion by pulmonary delivery of a novel flecainide formulation.
J Cardiovasc Electrophysiol;
31(1): 205-213, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31749267
2.
Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology.
Proc Natl Acad Sci U S A;
113(49): E7880-E7889, 2016 12 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27864515
3.
Optimization of pyrrolamides as mycobacterial GyrB ATPase inhibitors: structure-activity relationship and in vivo efficacy in a mouse model of tuberculosis.
Antimicrob Agents Chemother;
58(1): 61-70, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24126580
4.
Thiazolopyridone ureas as DNA gyrase B inhibitors: optimization of antitubercular activity and efficacy.
Bioorg Med Chem Lett;
24(3): 870-9, 2014 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24405701
5.
Open-Label, Multicenter Study of Flecainide Acetate Oral Inhalation Solution for Acute Conversion of Recent-Onset, Symptomatic Atrial Fibrillation to Sinus Rhythm.
Circ Arrhythm Electrophysiol;
15(3): e010204, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35196871
6.
Assays, surrogates, and alternative technologies for a TB lead identification program targeting DNA gyrase ATPase.
J Biomol Screen;
20(2): 265-74, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25300873
7.
Left-Hand Side Exploration of Novel Bacterial Topoisomerase Inhibitors to Improve Selectivity against hERG Binding.
ACS Med Chem Lett;
6(7): 741-6, 2015 Jul 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-26191359
8.
Benzimidazoles: novel mycobacterial gyrase inhibitors from scaffold morphing.
ACS Med Chem Lett;
5(7): 820-5, 2014 Jul 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-25050172
9.
Novel N-linked aminopiperidine-based gyrase inhibitors with improved hERG and in vivo efficacy against Mycobacterium tuberculosis.
J Med Chem;
57(11): 4889-905, 2014 Jun 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-24809953
10.
4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity.
J Med Chem;
57(12): 5419-34, 2014 Jun 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-24871036
11.
Aminopyrazinamides: novel and specific GyrB inhibitors that kill replicating and nonreplicating Mycobacterium tuberculosis.
ACS Chem Biol;
8(3): 519-23, 2013 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23268609
12.
Methyl-thiazoles: a novel mode of inhibition with the potential to develop novel inhibitors targeting InhA in Mycobacterium tuberculosis.
J Med Chem;
56(21): 8533-42, 2013 Nov 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-24107081
13.
Thiazolopyridine ureas as novel antitubercular agents acting through inhibition of DNA Gyrase B.
J Med Chem;
56(21): 8834-48, 2013 Nov 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-24088190
14.
Azaindoles: noncovalent DprE1 inhibitors from scaffold morphing efforts, kill Mycobacterium tuberculosis and are efficacious in vivo.
J Med Chem;
56(23): 9701-8, 2013 Dec 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-24215368
15.
Adenosylcobalamin-dependent glutamate mutase: pre-steady-state kinetic methods for investigating reaction mechanism.
Methods Enzymol;
354: 380-99, 2002.
Artículo
en Inglés
| MEDLINE | ID: mdl-12418241
16.
Pre-steady-state kinetic studies on the Glu171Gln active site mutant of adenosylcobalamin-dependent glutamate mutase.
Biochemistry;
41(52): 15803-9, 2002 Dec 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-12501209
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