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Sci Rep ; 11(1): 20289, 2021 10 13.
Artículo en Inglés | MEDLINE | ID: mdl-34645833

RESUMEN

Chagas disease (CD) continues to be a major public health burden in Latina America. Information on the interplay between COVID-19 and CD is lacking. Our aim was to assess clinical characteristics and in-hospital outcomes of patients with CD and COVID-19, and to compare it to non-CD patients. Consecutive patients with confirmed COVID-19 were included from March to September 2020. Genetic matching for sex, age, hypertension, diabetes mellitus and hospital was performed in a 4:1 ratio. Of the 7018 patients who had confirmed COVID-19, 31 patients with CD and 124 matched controls were included (median age 72 (64-80) years-old, 44.5% were male). At baseline, heart failure (25.8% vs. 9.7%) and atrial fibrillation (29.0% vs. 5.6%) were more frequent in CD patients than in the controls (p < 0.05). C-reactive protein levels were lower in CD patients compared with the controls (55.5 [35.7, 85.0] vs. 94.3 [50.7, 167.5] mg/dL). In-hospital management, outcomes and complications were similar between the groups. In this large Brazilian COVID-19 Registry, CD patients had a higher prevalence of atrial fibrillation and chronic heart failure compared with non-CD controls, with no differences in-hospital outcomes. The lower C-reactive protein levels in CD patients require further investigation.


Asunto(s)
COVID-19/complicaciones , Enfermedad de Chagas/patología , Hospitalización/tendencias , Anciano , Fibrilación Atrial , Brasil , Proteína C-Reactiva/análisis , COVID-19/patología , Enfermedad de Chagas/complicaciones , Enfermedad de Chagas/virología , Coinfección , Diabetes Mellitus , Femenino , Mortalidad Hospitalaria/tendencias , Hospitalización/estadística & datos numéricos , Hospitales , Humanos , Hipertensión , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Factores de Riesgo , SARS-CoV-2/patogenicidad
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